Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 342, Issue 1, 2012, Pages 119-130

  Verissimo, Carla S ^a   Cheng, Sou ^b   Puigvert, Jordi C ^a   Qin, Yu ^a   Vroon, Anne ^b   Van Deutekom, Judith ^b   Price, Leo S ^a   Danen, Erik H J ^a   Van De Water, Bob ^a   Fitzsimons, Carlos P ^c   Vreugdenhil, Erno ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b Prosensa Therapeutics BV   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; COUMARIN DERIVATIVE; DOUBLECORTIN LIKE KINASE; MICROTUBULE ASSOCIATED PROTEIN; N ACETYL ASPARTYLGLUTAMYLVALYLASPARTIC ACID 7 AMIDO 4 METHYLCOUMARIN; PHOSPHATIDYLSERINE; PHOSPHOTRANSFERASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHEMOSENSITIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOUBLECORTIN LIKE KINASE GENE; DRUG POTENTIATION; ENZYME ACTIVITY; EXPLORATORY RESEARCH; GENE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MICROTUBULE; MOUSE; NEUROBLASTOMA CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN TRANSPORT;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SYNERGISM; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOCHONDRIA; NEUROBLASTOMA; PHOSPHATIDYLSERINES; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; VINBLASTINE; VINCA ALKALOIDS; VINCRISTINE;

EID: 84862495436     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.188813     Document Type: Article

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