Quantifying processes determining the free concentration of phenanthrene in basal cytotoxicity assays

Chemical Research in Toxicology

Volumn 25, Issue 2, 2012, Pages 436-445

  Kramer, Nynke I ^a   Krismartina, Mirna ^a   Rico Rico, Ángeles ^a,b   Blaauboer, Bas J ^a   Hermens, Joop L M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b INIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; PHENANTHRENE; PLASMA PROTEIN;

ANIMAL CELL; ARTICLE; BAGG ALBINO MOUSE; CYTOTOXICITY TEST; EVAPORATION; GILL; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF QUANTITATION; MOUSE; NONHUMAN; PARTITION COEFFICIENT; RAINBOW TROUT; SERUM; SOLID PHASE MICROEXTRACTION;

ADSORPTION; ANIMALS; CELL LINE; CELL SURVIVAL; CULTURE MEDIA; FISHES; MICE; MODELS, THEORETICAL; NIH 3T3 CELLS; PHENANTHRENES; PLASTICS; TOXICITY TESTS;

EID: 84859736499     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200479k     Document Type: Article

References (57)

1. Balls, M., Bogni, A., Bremer, S., Casati, S., Coecke, S., Eskes, C., Prieto, P., Sabbioni, E., Worth, A., Zuang, V., Barratt, M., Blaauboer, B., Botham, P., Combes, R., Doehmer, J., Fentem, J., Liebsch, M., and Spielmann, H. (2002) Alternative (non-animal) methods for chemicals testing: Current status and future prospects. ATLA Altern. Lab. Anim. 30 (S1), 1-125.
2. European Commission (2006) Regulation (EC) No 1907/2006 of the European Parliament and of the council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Official J. Eur. Union L396/1, 1-849.
3. Ekwall, B. (1999) Overview of the final MEIC results: II. The in vitro-in vivo evaluation, including the selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans. Toxicol. in Vitro 13, 665-673. (Pubitemid 29354194)
4. Schirmer, K. (2006) Proposal to improve vertebrate cell cultures to establish them as substitutes for the regulatory testing of chemicals and effluents using fish. Toxicology 224, 163-183. (Pubitemid 44026467)
5. Segner, H. (2004) Cytotoxicity assays with fish cells as an alternative to the acute lethality test with fish. ATLA Altern. Lab. Anim. 32, 375-382. (Pubitemid 40139214)
6. Gennari, A., Van Den Berghe, C., Casati, S., Castell, J., Clemedson, C., Coecke, S., Colombo, A., Curren, R., Dal Negro, G., Goldberg, A., Gosmore, C., Hartung, T., Langezaal, I., Lessigiarska, I., Maas, W., Mangelsdorf, I., Parchment, R., Prieto, P., Sintes, J. R., Ryan, M., Schmuck, G., Stitzel, K., Stokes, W., Vericat, J.-A., and Gribaldo, L. (2004) Strategies to replace in vivo acute systemic toxicity testing: The report and recommendations of ECVAM workshop 50. ATLA Altern. Lab. Anim. 32, 437-459. (Pubitemid 40139222)
7. Kramer, N. I., Hermens, J. L. M., and Schirmer, K. (2009) The influence of modes of action and physicochemical properties of chemicals on the correlation between in vitro and acute fish toxicity data. Toxicol. in Vitro 23, 1372-1379.
8. Escher, B. I., and Hermens, J. L. M. (2004) Internal exposure: Linking bioavailability to effects. Environ. Sci. Technol. 38, 455A-462A. (Pubitemid 39578627)
9. Herve, F., Urien, S., Albengres, E., Duche, J.-C., and Tillement, J.-P. (1994) Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding. Clin. Pharmacokinet. 26, 44-58. (Pubitemid 24029186)
10. Gulden, M., Morchel, S., Tahan, S., and Seibert, H. (2002) Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicol. 175, 201-213. (Pubitemid 34615714)
11. Heringa, M. B., Schreurs, R. H. M. M., Busser, F., van der Saag, P. T., van der Burg, B., and Hermens, J. L. M. (2004) Toward more useful in vitro toxicity data with measured free concentrations. Environ. Sci. Technol. 38, 6263-6270. (Pubitemid 39578638)
12. Hestermann, E. V., Stegeman, J. J., and Hahn, M. E. (2000) Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays. Toxicol. Sci. 53, 316-325. (Pubitemid 30100149)
13. Seibert, H., Morchel, S., and Gulden, M. (2002) Factors influencing nominal effective concentrations of chemical compounds in vitro: Medium protein concentration. Toxicol. in Vitro 16, 289-297. (Pubitemid 34521703)
14. Riedl, J., and Altenburger, R. (2007) Physicochemical substance properties as indicators for unreliable exposure in microplate-based bioassays. Chemosphere 67, 2210-2220. (Pubitemid 46441398)
15. Schirmer, K., Chan, A. G. J., Greenberg, B. M., Dixon, D. G., and Bols, N. C. (1997) Methodology for demonstrating and measuring the photocytotoxicity of fluoranthene to fish cells in culture. Toxicol. in Vitro 11, 107-119. (Pubitemid 27252962)
16. Schreiber, R., Altenburger, R., Paschke, A., and Kuster, E. (2008) How to deal with lipophilic and volatile organic substances in microtiter plate assays. Environ. Toxicol. Chem. 27, 1676-1682.
17. Gulden, M., Morchel, S., and Seibert, H. (2001) Factors influencing nominal effective concentrations of chemical compounds in vitro: Cell concentration. Toxicol. in Vitro 15, 233-243. (Pubitemid 32476833)
18. Margolis, J. M., and Obach, R. S. (2003) Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: Implications for relating in vitro inhibition data to in vivo drug interactions. Drug Metab. Dispos. 31, 606-611. (Pubitemid 36444170)
19. Heringa, M. B., and Hermens, J. L. M. (2003) Measurement of free concentrations using negligible depletion-solid phase micro-extraction (nd-SPME). Trends Anal. Chem. 22, 575-587. (Pubitemid 41685806)
20. Oravcova, J., Bohs, B., and Lindner, W. (1996) Drug-protein binding studies new trends in analytical and experimental methodology. J. Chromatogr., B 677, 1-28.
21. Arthur, C. L., and Pawliszyn, J. (1990) Solid phase microextraction with thermal desorption using fused silica optical fibers. Anal. Chem. 62, 2145-2148.
22. Lord, H., and Pawliszyn, J. (2000) Evolution of solid-phase microextraction technology. J. Chromatogr., A 885, 153-193. (Pubitemid 30392476)
23. Ulrich, S. (2000) Solid-phase microextraction in biomedical analysis. J. Chromatogr., A 902, 167-194.
24. Escher, B. I., Berg, M., Muhlemann, J., Schwarz, M. A. A., Hermens, J. L. M., Vaes, W. H. J., and Schwarzenbach, R. P. (2002) Determination of liposome/water partition coefficients of organic acids and bases by solid-phase microextraction. Analyst 127, 42-48. (Pubitemid 34081629)
25. Heringa, M. B., Pastor, D., Algra, J., Vaes, W. H. J., and Hermens, J. L. M. (2002) Negligible depletion solid-phase micro-extraction with radiolabeled analytes to study free concentrations and protein binding: An example with [3H]estradiol. Anal. Chem. 74, 5993-5997.
26. Musteata, F. M., Pawliszyn, J., Qian, M. G., Wu, J.-T., and Miwa, G. T. (2006) Determination of drug plasma protein binding by solid phase microextraction. J. Pharm. Sci. 95, 1712-1722. (Pubitemid 44229578)
27. Vaes, W. H. J., Urrestarazu Ramos, E., Verhaar, H. J. M., Seinen, W., and Hermens, J. L. M. (1996) Measurement of the free concentration using solid-phase microextraction: Binding to protein. Anal. Chem. 68, 4463-4467.
28. Yuan, H., Ranatunga, R., Carr, P. W., and Pawliszyn, J. (1999) Determination of equilibrium constant of alkylbenzenes binding to bovine serum albumin by solid phase microextraction. Analyst 124, 1443-1448. (Pubitemid 29488422)
29. Austin, R. P., Barton, P., Mohmed, S., and Riley, R. J. (2005) The binding of drugs to hepatocytes and its relationship to physicochemical properties. Drug Metab. Dispos. 33, 419-425. (Pubitemid 40279943)
30. Gulden, M., and Seibert, H. (2003) In vitro-in vivo extrapolation: Estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro. Toxicol. 189, 211-222. (Pubitemid 36773857)
31. Verwei, M., van Burgsteden, J. A., Krul, C. A. M., van de Sandt, J. J. M., and Freidig, A. P. (2006) Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. Toxicol. Lett. 165, 79-87. (Pubitemid 43867181)
32. DeBruyn, A. M. H., and Gobas, F. A. P. C (2007) The sorptive capacity of animal protein. Environ. Toxicol. Chem. 26, 1803-1808. (Pubitemid 47373193)
33. Schirmer, K., Dixon, D. G., Greenberg, B. M., and Bols, N. C. (1998) Ability of 16 priority PAHs to be directly cytotoxic to a cell line from the rainbow trout gill. Toxicol. 127, 129-141. (Pubitemid 28341823)
34. Schwarzenbach, R. P., Gschwend, P. M., and Imboden, D. M. (2003) Environmental Organic Chemistry, 2nd ed., John Wiley and Sons, New York, NY.
35. Kramer, N. I., Van Eijkeren, J. C. H., and Hermens, J. L. M. (2007) Influence of albumin on sorption kinetics in solid-phase microextraction: Consequences for chemical analyses and uptake processes. Anal. Chem. 79, 6941-6948. (Pubitemid 47438672)
36. Jonker, M. T. O., and Van Der Heijden, S. A. (2007) Bioconcentration factor hydrophobicity cutoff: An artificial phenomenon reconstructed. Environ. Sci. Technol. 41, 7363-7369. (Pubitemid 350071647)
37. Alaee, M., Whittal, R. M., and Strachan, W. M. J. (1996) The effect of water temperature and composition on Henry's law constants for various PAH's. Chemosphere 32, 1153-1164. (Pubitemid 26093241)
38. Denizot, F., and Lang, R. (1986) Rapid colorimetric assay for cell growth and survival - Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 89, 271-277. (Pubitemid 16080782)
39. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
40. Ter Laak, T. L., Durjava, M., Struijs, J., and Hermens, J. L. M. (2005) Solid phase dosing and sampling technique to determine partition coefficients of hydrophobic chemicals in complex matrixes. Environ. Sci. Technol. 39, 3736-3742. (Pubitemid 40705498)
41. De Maagd, P. G. J., Ten Hulscher, D. T. H. E. M., Van Den Heuvel, H., Opperhuizen, A., and Sijm, D. T. H. M. (1998) Physicochemical properties of polycyclic aromatic hydrocarbons: Aqueous solubilities, n-octanol/water partition coefficients, and Henry's law constants. Environ. Toxicol. Chem. 17, 251-257. (Pubitemid 28063808)
42. Peters, T., Jr. (1996) All About Albumin: Biochemistry, Genetics, and Medical Applications, Academic Press, San Diego, CA.
43. 2 enriched headspace. Chemosphere 32, 1513-1526. (Pubitemid 26140498)
44. Mayer, P., Nyholm, N., Verbruggen, E. M. J., Hermens, J. L. M., and Tolls, J. (2000) Algal growth inhibition test in filled, closed bottles for volatile and sorptive materials. Environ. Toxicol. Chem. 19, 2551-2556.
45. Thellen, C., Blaise, C., and Roy, Y. H. C. (1989) Round robin testing with the Selanastrum capricornutum microlate toxicity assay. Hydrobiologia 188/189, 259-268.
46. Eisentraeger, A., Dott, W., Klein, J., and Hahn, S. (2003) Comparative studies on algal toxicity testing using fluorometic microplate and Erlenmeyer flask growth-inhibition assays. Ecotoxicol. Environ. Saf. 54, 346-354. (Pubitemid 36315873)
47. Muijs, B., and Jonker, M. T. O. (2009) Temperature-dependent bioaccumulation of polycyclic aromatic hydrocarbons. Environ. Sci. Technol. 43, 4517-4523.
48. Coecke, S., Balls, M., Bowe, G., Davis, J., Gstraunthaler, G., Hartung, T., Hay, R., Merten, O.-., Price, A., Schechtman, L., Stacey, G., and Stokes, W. (2005) Guidance on good cell culture practice: A report on the second ECVAM task force on good cell culture practice. ATLA Altern. Lab. Anim. 33, 261-287. (Pubitemid 40964979)
49. Ackermann, G. E., and Fent, K. (1998) The adaptation of the permanent fish cell lines PLHC-1 and RTG-2 to FCS-free media results in similar growth rates compared to FCS-containing conditions. Mar. Environ. Res. 46, 363-367. (Pubitemid 28434852)
50. Bopp, S. K., Bols, N. C., and Schirmer, K. (2006) Development of a solvent-free, solid-phase in vitro bioassay using vertebrate cells. Environ. Toxicol. Chem. 25, 1390-1398. (Pubitemid 44669899)
51. Brown, R. S., Akhtar, P., Akerman, J., Hampel, L., Kozin, I. S., Villerius, L. A., and Klamer, H. J. C. (2001) Partition controlled delivery of hydrophobic substances in toxicity tests using poly-(dimethylsiloxane) (PDMS) films. Environ. Sci. Technol. 35, 4097-4102.
52. Gerofke, A., Komp, P., and McLachlan, M. S. (2004) Stir bar contamination: A method to establish and maintain constant water concentrations of poorly water-soluble chemicals in bioconcentration experiments. Water Res. 38, 3411-3419. (Pubitemid 38987720)
53. Kramer, N. I., Busser, F. J. M., Oosterwijk, M. T. T., Schirmer, K., Escher, B. I., and Hermens, J. L. M. (2010) Development of a partition-controlled dosing system for cell assays. Chem. Res. Toxicol. 23, 1806-1814.
54. Mori, M., and Wakabayashi, M. (2000) Cytotoxicity evaluation of synthesized chemicals using suspension-cultured fish cells. Fish. Sci. 66, 871-875.
55. Smith, K. E. C., Oostingh, G. J., and Mayer, P. (2010) Passive dosing for producing defined and constant exposure of hydrophobic organic compounds during in vitro toxicity tests. Chem. Res. Toxicol. 23, 55-65.
56. Gulden, M., and Seibert, H. (2005) Impact of bioavailability on the correlation between in vitro cytotoxic and in vivo acute fish toxic concentrations of chemicals. Aquat. Toxicol. 72, 327-337. (Pubitemid 40545849)
57. Goss, K.-U., and Schwarzenbach, R. P. (2001) Linear free energy relationships used to evaluate equilibrium partitioning of organic compounds. Environ. Sci. Technol. 35, 1-9. (Pubitemid 32048399)