Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy

Journal of Controlled Release

Volumn 195, Issue , 2014, Pages 162-175

  Novo, Luís ^a   Rizzo, Larissa Y ^b   Golombek, Susanne K ^b   Dakwar, George R ^c   Lou, Bo ^a   Remaut, Katrien ^c   Mastrobattista, Enrico ^a   Van Nostrum, Cornelus F ^a   Jahnen Dechent, Wilhelm ^d   Kiessling, Fabian ^b   Braeckmans, Kevin ^c   Lammers, Twan ^a,b,e   Hennink, Wim E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c GHENT UNIVERSITY   (Belgium)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Biocompatibility; Biodistribution; EPR; Gene delivery; Nanoparticle; Polymer

Indexed keywords

NANOPARTICLES; PARAMAGNETIC RESONANCE; POLYMERS;

BIODISTRIBUTIONS; CARRIER SYSTEMS; GENE DELIVERY; POLYPLEXES;

BIOCOMPATIBILITY;

DEANOL; DRUG CARRIER; MACROGOL; N (2 HYDROXYPROPYL)METHACRYLAMIDE; N (3 AMINOPROPYL)METHACRYLAMIDE HYDROCHLORIDE; N [2 (2 PYRIDYLDITHIO)]ETHYL METHACRYLAMIDE; N,N' DIMETHYLAMINOETHANOL; PLASMID DNA; POLY(HYDROXYPROPYL METHACRYLAMIDE); POLYCATION; POLYMER; UNCLASSIFIED DRUG; DNA; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCULATION TIME; CYTOTOXICITY; ELECTRON SPIN RESONANCE; FEMALE; FLUORESCENCE IMAGING; GENE TARGETING; GENE THERAPY; HISTOLOGY; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VIVO GENE TRANSFER; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MTT ASSAY; NONHUMAN; TERATOGENICITY; TRANSGENE; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG STABILITY; EMBRYOLOGY; GENE TRANSFER; GENETICS; METABOLISM; NEOPLASM; NUDE MOUSE; PARTICLE SIZE; PLASMID; TISSUE DISTRIBUTION; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DRUG STABILITY; EMBRYO, NONMAMMALIAN; FEMALE; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE, NUDE; NEOPLASMS; PARTICLE SIZE; PLASMIDS; POLYMERS; TISSUE DISTRIBUTION; ZEBRAFISH;

EID: 84908509457     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.08.028     Document Type: Article

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