Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation

Molecular Pharmaceutics

Volumn 11, Issue 4, 2014, Pages 1250-1258

  Yang, Qi ^a   Jones, Stephen W ^b   Parker, Christina L ^a   Zamboni, William C ^a,b   Bear, James E ^a,b   Lai, Samuel K ^a,c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c USA and North Carolina State University   (United States)

Author keywords

drug delivery; nanoparticles; PEG conformation; PEG density; poly(ethylene glycol)

Indexed keywords

MACROGOL; MACROGOL DERIVATIVE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCULATION TIME; CLEARANCE; COATED PARTICLE; CONFORMATION; CONTROLLED STUDY; DENSITY; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; HUMAN CELL; HYDRODYNAMICS; IMMUNE EVASION; IMMUNOCOMPETENT CELL; LEUKOCYTE; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SYNTHESIS; SYSTEMIC CIRCULATION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CHEMISTRY; IMMUNOLOGY; METABOLISM;

ANIMALS; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; LEUKOCYTES; MACROPHAGES; MICE; MICE, INBRED BALB C; NANOPARTICLES; POLYETHYLENE GLYCOLS;

EID: 84897977496     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400703d     Document Type: Article

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