Rational design of targeted cancer therapeutics through the multiconjugation of folate and cleavable siRNA to RAFT-synthesized (HPMA-s-APMA) copolymers

Biomacromolecules

Volumn 11, Issue 2, 2010, Pages 505-514

  York, Adam W ^a   Huang, Faqing ^b   McCormick, Charles L ^a,b  

^a Virginia Polytechnic Institute and State University   (United States)

^b The University of Southern Mississippi   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPROPYL; ANTISENSE; CANCER CELLS; CANCER THERAPEUTICS; DEGREE OF CONJUGATIONS; DISULFIDE EXCHANGE; FOLATES; GENE DELIVERY; METHACRYLAMIDES; POLYACRYLAMIDE GEL ELECTROPHORESIS; POTENTIAL UTILITY; PRIMARY AMINES; RATIONAL DESIGN; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SMALL INTERFERING RNA (SIRNA); SULFHYDRYL; UV-VIS SPECTROSCOPY;

COPOLYMERIZATION; ELECTROPHORESIS; FUNCTIONAL POLYMERS; GENE TRANSFER; ORGANIC POLYMERS; PLASTIC PRODUCTS; SULFUR COMPOUNDS; ULTRAVIOLET SPECTROSCOPY;

RNA;

3 (2 PYRIDYLDITHIO)PROPIONIC ACID N HYDROXYSUCCINIMIDE ESTER; ACRYLAMIDE DERIVATIVE; AMINE; COPOLYMER; DISULFIDE; FOLIC ACID; N (2 HYDROXYPROPYL)METHACRYLAMIDE N (3 AMINOPROPYL)METHACRYLAMIDE; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER GENE THERAPY; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; DRUG DESIGN; GENE TARGETING; NONVIRAL GENE DELIVERY SYSTEM; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; PRIORITY JOURNAL; REVERSIBLE ADDITION FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; ULTRAVIOLET SPECTROSCOPY;

ACRYLAMIDES; ACRYLIC RESINS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; FOLIC ACID; HUMANS; NEOPLASMS; ORGANOMETALLIC COMPOUNDS; RNA, SMALL INTERFERING;

EID: 76249125385     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm901249n     Document Type: Article

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