Steric stabilization of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes mediates prolonged circulation and tumor targeting in mice

Journal of Gene Medicine

Volumn 6, Issue 1, 2004, Pages 64-75

  Verbaan, F J ^a   Oussoren, C ^a   Snel, C J ^a   Crommelin, D J A ^a   Hennink, W E ^a   Storm, G ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Biodistribution; Gene delivery; Poly(2 (dimethylamino)ethyl methacrylate); Poly(ethylene glycol); Polyplex; Steric stabilization; Surface grafting

Indexed keywords

ALBUMIN; BETA GALACTOSIDASE; COPOLYMER; MACROGOL; MACROGOL 20000; PLASMID DNA; POLY[2 (DIMETHYLAMINOETHYL)METHACRYLATE]; POLYMETHACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG; DNA; DRUG CARRIER; MACROGOL DERIVATIVE; METHACRYLIC ACID DERIVATIVE; NYLON; POLY(2 (DIMETHYLAMINO)ETHYL METHACRYLATE); POLY(2-(DIMETHYLAMINO)ETHYL METHACRYLATE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BODY DISTRIBUTION; CANCER CELL CULTURE; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CIRCULATION TIME; COLLOID; CONTROLLED STUDY; DISEASE MODEL; DRUG TARGETING; ERYTHROCYTE; FEMALE; GENE TRANSFER; GENETIC TRANSFECTION; IN VITRO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE CHARGE; ADENOCARCINOMA; ANIMAL; ANIMAL DISEASE; BAGG ALBINO MOUSE; CHEMISTRY; EXPERIMENTAL NEOPLASM; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; PLASMID;

ADENOCARCINOMA; ANIMALS; COLLOIDS; DNA; DRUG CARRIERS; FEMALE; GENE TRANSFER TECHNIQUES; INFUSIONS, INTRAVENOUS; METHACRYLATES; MICE; MICE, INBRED BALB C; NEOPLASMS, EXPERIMENTAL; NYLONS; PLASMIDS; POLYETHYLENE GLYCOLS; TRANSFECTION;

EID: 4043152644     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.475     Document Type: Article

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