Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28- oic-acid and related synthetic triterpenoids in prostate cancer

Cancer Research

Volumn 68, Issue 8, 2008, Pages 2927-2933

  Hyer, Marc L ^a,d   Shi, Ranxin ^a   Krajewska, Maryla ^a   Meyer, Colin ^b   Lebedeva, Irina V ^c   Fisher, Paul B ^c   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

^b Reata Pharmaceuticals Inc   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID IMIDAZOLE DERIVATIVE; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID METHYL ESTER; CASPASE 10; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; DEATH RECEPTOR 4; DEATH RECEPTOR 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; SMALL INTERFERING RNA; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN LNCAP; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; NUDE RAT; PRIORITY JOURNAL; PROSTATE CANCER; RAT; TUMOR VOLUME; TUMOR XENOGRAFT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; MALE; OLEANOLIC ACID; PROSTATIC NEOPLASMS; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, NEOPLASM; RNA, SMALL INTERFERING;

EID: 42349083382     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-5759     Document Type: Article

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