메뉴 건너뛰기




Volumn 12, Issue 1, 2014, Pages 136-151

Synthetic triterpenoids can protect against toxicity without reducing the efficacy of treatment with carboplatin and paclitaxel in experimental lung cancer

Author keywords

Carboplatin toxicity; CDDO methyl ester; Lung cancer; Nrf2; Reactive oxygen species; Triterpenoid

Indexed keywords

BARDOXOLONE ETHYL AMIDE; BARDOXOLONE IMIDAZOLIDE; BARDOXOLONE METHYL; CARBOPLATIN; PACLITAXEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; TRITERPENOID; UNCLASSIFIED DRUG;

EID: 84895447247     PISSN: None     EISSN: 15593258     Source Type: Journal    
DOI: 10.2203/dose-response.13-018.Liby     Document Type: Article
Times cited : (10)

References (42)
  • 1
    • 79954416526 scopus 로고    scopus 로고
    • The cytoprotective role of the keap1-nrf2 pathway
    • Baird L and Dinkova-Kostova AT. 2011. The cytoprotective role of the keap1-nrf2 pathway. Arch Toxicol 85:241-272
    • (2011) Arch Toxicol , vol.85 , pp. 241-272
    • Baird, L.1    Dinkova-Kostova, A.T.2
  • 2
    • 33847695241 scopus 로고    scopus 로고
    • The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore
    • Brookes PS, Morse K, Ray D, Tompkins A, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R and Bernstein SH. 2007. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore. Cancer Res 67:1793-1802
    • (2007) Cancer Res , vol.67 , pp. 1793-1802
    • Brookes, P.S.1    Morse, K.2    Ray, D.3    Tompkins, A.4    Young, S.M.5    Hilchey, S.6    Salim, S.7    Konopleva, M.8    Andreeff, M.9    Phipps, R.10    Bernstein, S.H.11
  • 6
    • 63549121490 scopus 로고    scopus 로고
    • Nrf2 and keap1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes JD and McMahon M. 2009. Nrf2 and keap1 mutations: Permanent activation of an adaptive response in cancer. Trends Biochem Sci 34:176-188
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 7
    • 67349247003 scopus 로고    scopus 로고
    • Transcription factor nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
    • Higgins LG, Kelleher MO, Eggleston IM, Itoh K, Yamamoto M and Hayes JD. 2009. Transcription factor nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicol Appl Pharmacol 237:267-280
    • (2009) Toxicol Appl Pharmacol , vol.237 , pp. 267-280
    • Higgins, L.G.1    Kelleher, M.O.2    Eggleston, I.M.3    Itoh, K.4    Yamamoto, M.5    Hayes, J.D.6
  • 9
    • 0037041248 scopus 로고    scopus 로고
    • A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production
    • Honda T, Honda Y, Favaloro FG, Jr., Gribble GW, Suh N, Place AE, Rendi MH and Sporn MB. 2002. A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production. Bioorg Med Chem Lett 12:1027-1030
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 1027-1030
    • Honda, T.1    Honda, Y.2    Favaloro Jr., F.G.3    Gribble, G.W.4    Suh, N.5    Place, A.E.6    Rendi, M.H.7    Sporn, M.B.8
  • 10
    • 0033590265 scopus 로고    scopus 로고
    • Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages
    • Honda T, Rounds BV, Bore L, Favaloro FG, Jr., Gribble GW, Suh N, Wang Y and Sporn MB. 1999. Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages. Bioorg Med Chem Lett 9:3429-3434
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 3429-3434
    • Honda, T.1    Rounds, B.V.2    Bore, L.3    Favaloro Jr., F.G.4    Gribble, G.W.5    Suh, N.6    Wang, Y.7    Sporn, M.B.8
  • 12
    • 4444281592 scopus 로고    scopus 로고
    • Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid
    • Ikeda T, Nakata Y, Kimura F, Sato K, Anderson K, Motoyoshi K, Sporn M and Kufe D. 2004. Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid. Mol Cancer Ther 3:39-45
    • (2004) Mol Cancer Ther , vol.3 , pp. 39-45
    • Ikeda, T.1    Nakata, Y.2    Kimura, F.3    Sato, K.4    Anderson, K.5    Motoyoshi, K.6    Sporn, M.7    Kufe, D.8
  • 13
    • 0141815939 scopus 로고    scopus 로고
    • The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance
    • Ikeda T, Sporn M, Honda T, Gribble GW and Kufe D. 2003. The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance. Cancer Res 63:5551-5558
    • (2003) Cancer Res , vol.63 , pp. 5551-5558
    • Ikeda, T.1    Sporn, M.2    Honda, T.3    Gribble, G.W.4    Kufe, D.5
  • 14
    • 0034077629 scopus 로고    scopus 로고
    • The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism
    • Ito Y, Pandey P, Place A, Sporn MB, Gribble GW, Honda T, Kharbanda S and Kufe D. 2000. The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism. Cell Growth Differ 11:261-267
    • (2000) Cell Growth Differ , vol.11 , pp. 261-267
    • Ito, Y.1    Pandey, P.2    Place, A.3    Sporn, M.B.4    Gribble, G.W.5    Honda, T.6    Kharbanda, S.7    Kufe, D.8
  • 15
    • 0035037586 scopus 로고    scopus 로고
    • The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism
    • Ito Y, Pandey P, Sporn MB, Datta R, Kharbanda S and Kufe D. 2001. The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. Mol Pharmacol 59:1094-1099
    • (2001) Mol Pharmacol , vol.59 , pp. 1094-1099
    • Ito, Y.1    Pandey, P.2    Sporn, M.B.3    Datta, R.4    Kharbanda, S.5    Kufe, D.6
  • 16
    • 74049120454 scopus 로고    scopus 로고
    • Nrf2: Friend or foe for chemoprevention?
    • Kensler TW and Wakabayashi N. 2010. Nrf2: Friend or foe for chemoprevention? Carcinogenesis 31:90-99
    • (2010) Carcinogenesis , vol.31 , pp. 90-99
    • Kensler, T.W.1    Wakabayashi, N.2
  • 17
    • 79955829428 scopus 로고    scopus 로고
    • Cddo-imidazolide induces DNA damage, G2/M arrest and apoptosis in brca1-mutated breast cancer cells
    • Kim EH, Deng CX, Sporn MB and Liby KT. 2011. Cddo-imidazolide induces DNA damage, G2/M arrest and apoptosis in brca1-mutated breast cancer cells. Cancer Prev Res 4:425-434
    • (2011) Cancer Prev Res , vol.4 , pp. 425-434
    • Kim, E.H.1    Deng, C.X.2    Sporn, M.B.3    Liby, K.T.4
  • 20
    • 76549112866 scopus 로고    scopus 로고
    • Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice
    • Liby K, Risingsong R, Royce DB, Williams CR, Ma T, Yore MM and Sporn MB. 2009. Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice. Cancer Prev Res 2:1050-1058
    • (2009) Cancer Prev Res , vol.2 , pp. 1050-1058
    • Liby, K.1    Risingsong, R.2    Royce, D.B.3    Williams, C.R.4    Ma, T.5    Yore, M.M.6    Sporn, M.B.7
  • 22
    • 84867055462 scopus 로고    scopus 로고
    • Synthetic oleanane triterpenoids: Multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease
    • Liby KT and Sporn MB. 2012. Synthetic oleanane triterpenoids: Multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. Pharmacol Rev 64:972-1003
    • (2012) Pharmacol Rev , vol.64 , pp. 972-1003
    • Liby, K.T.1    Sporn, M.B.2
  • 23
    • 0034458577 scopus 로고    scopus 로고
    • Xenograft models of premalignant breast disease
    • Miller FR. 2000. Xenograft models of premalignant breast disease. J Mammary Gland Biol Neoplasia 5:379-391
    • (2000) J Mammary Gland Biol Neoplasia , vol.5 , pp. 379-391
    • Miller, F.R.1
  • 24
    • 0027688586 scopus 로고
    • The MCF10 family of spontaneously immortalized human breast epithelial cell lines: Models of neoplastic progression
    • Pauley RJ, Soule HD, Tait L, Miller FR, Wolman SR, Dawson PJ and Heppner GH. 1993. The MCF10 family of spontaneously immortalized human breast epithelial cell lines: Models of neoplastic progression. Eur J Cancer Prev 2 Suppl 3:67-76
    • (1993) Eur J Cancer Prev , vol.2 , Issue.SUPPL. 3 , pp. 67-76
    • Pauley, R.J.1    Soule, H.D.2    Tait, L.3    Miller, F.R.4    Wolman, S.R.5    Dawson, P.J.6    Heppner, G.H.7
  • 26
    • 77957221943 scopus 로고    scopus 로고
    • Synthetic triterpenoids attenuate cytotoxic retinal injury: Cross-talk between nrf2 and pi3k/akt signaling through inhibition of the lipid phosphatase pten
    • Pitha-Rowe I, Liby K, Royce D and Sporn M. 2009. Synthetic triterpenoids attenuate cytotoxic retinal injury: Cross-talk between nrf2 and pi3k/akt signaling through inhibition of the lipid phosphatase pten. Invest Ophthalmol Vis Sci 50:5339-5347
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 5339-5347
    • Pitha-Rowe, I.1    Liby, K.2    Royce, D.3    Sporn, M.4
  • 28
    • 84861147473 scopus 로고    scopus 로고
    • A comprehensive survey of ras mutations in cancer
    • Prior IA, Lewis PD and Mattos C. 2012. A comprehensive survey of ras mutations in cancer. Cancer Res 72:2457-2467
    • (2012) Cancer Res , vol.72 , pp. 2457-2467
    • Prior, I.A.1    Lewis, P.D.2    Mattos, C.3
  • 31
    • 84882236393 scopus 로고    scopus 로고
    • Targeting the transcription factor nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease
    • Ruiz S, Pergola PE, Zager RA and Vaziri ND. 2013. Targeting the transcription factor nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int 83:1029-1041
    • (2013) Kidney Int , vol.83 , pp. 1029-1041
    • Ruiz, S.1    Pergola, P.E.2    Zager, R.A.3    Vaziri, N.D.4
  • 33
    • 33745852174 scopus 로고    scopus 로고
    • Dichotomies in cancer research: Some suggestions for a new synthesis
    • Sporn MB. 2006. Dichotomies in cancer research: Some suggestions for a new synthesis. Nat Clin Pract Oncol 3:364-373
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 364-373
    • Sporn, M.B.1
  • 34
    • 84864348569 scopus 로고    scopus 로고
    • Nrf2 and cancer: The good, the bad and the importance of context
    • Sporn MB and Liby KT. 2012. Nrf2 and cancer: The good, the bad and the importance of context. Nat Rev Cancer 12:564-571
    • (2012) Nat Rev Cancer , vol.12 , pp. 564-571
    • Sporn, M.B.1    Liby, K.T.2
  • 35
    • 79953242026 scopus 로고    scopus 로고
    • New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress
    • Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM and Gribble GW. 2011. New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J Nat Prod 74:537-545
    • (2011) J Nat Prod , vol.74 , pp. 537-545
    • Sporn, M.B.1    Liby, K.T.2    Yore, M.M.3    Fu, L.4    Lopchuk, J.M.5    Gribble, G.W.6
  • 36
    • 0034534734 scopus 로고    scopus 로고
    • Progression of premalignant MCF10at generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers
    • Strickland LB, Dawson PJ, Santner SJ and Miller FR. 2000. Progression of premalignant MCF10at generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers. Breast Cancer Res Treat 64:235-240
    • (2000) Breast Cancer Res Treat , vol.64 , pp. 235-240
    • Strickland, L.B.1    Dawson, P.J.2    Santner, S.J.3    Miller, F.R.4
  • 38
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
    • Trachootham D, Alexandre J and Huang P. 2009. Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat Rev Drug Discov 8:579-591
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 40
    • 84875181661 scopus 로고    scopus 로고
    • Oxidants, antioxidants and the current incurability of metastatic cancers
    • Watson J. 2013. Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol 3:120144
    • (2013) Open Biol , vol.3 , pp. 120144
    • Watson, J.1
  • 42
    • 0007142725 scopus 로고
    • Activation of the ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain a mouse
    • You M, Candrian U, Maronpot RR, Stoner GD and Anderson MW. 1989. Activation of the ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain a mouse. Proc Natl Acad Sci U S A 86:3070-3074
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 3070-3074
    • You, M.1    Candrian, U.2    Maronpot, R.R.3    Stoner, G.D.4    Anderson, M.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.