A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: Direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

Molecular Pharmacology

Volumn 69, Issue 4, 2006, Pages 1182-1193

  Samudio, Ismael ^a   Konopleva, Marina ^a   Pelicano, Helene ^a   Huang, Peng ^a   Frolova, Olga ^a   Bornmann, William ^a   Ying, Yunming ^a   Evans, Randall ^a   Contractor, Rooha ^a   Andreeff, Michael ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARDIOLIPIN; CASPASE; CYCLOSPORIN A; CYTOCHROME C; EDETIC ACID; GLUTATHIONE; METHYL 2 CYANO 3,12 DIOXOOLEAN 1,9 DIENE 28 OATE; OLEANOLIC ACID DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BREATHING; CELL MEMBRANE; CELL PERMEABILIZATION; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ELECTRON TRANSPORT; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY;

APOPTOSIS; CARDIOLIPINS; CELL LINE; CELL MEMBRANE PERMEABILITY; ELECTRON TRANSPORT; HUMANS; INTRACELLULAR MEMBRANES; MITOCHONDRIA;

EID: 33645108498     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.018051     Document Type: Article

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