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Volumn 108, Issue , 2014, Pages 171-187

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

Author keywords

CDDO; CYP2A5; ENTPD5; Hepatoproteome; ITRAQ; Nrf2

Indexed keywords

BARDOXOLONE METHYL; BIOLOGICAL MARKER; COMPLEMENTARY DNA; CYTOCHROME P450 1A2; CYTOCHROME P450 2A5; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE TYPE 5; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE A4; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M3; GLUTATHIONE TRANSFERASE P1; PHOSPHATASE; PROTEOME; RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; CYTOSKELETON PROTEIN; KEAP1 PROTEIN, MOUSE; METHYL 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OATE; NFE2L2 PROTEIN, MOUSE; OLEANOLIC ACID; OXIDOREDUCTASE; PROTEIN KINASE B; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 84902289343     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2014.05.007     Document Type: Article
Times cited : (64)

References (58)
  • 1
    • 12444257799 scopus 로고    scopus 로고
    • Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
    • Itoh K., Wakabayashi N., Katoh Y., Ishii T., O'Connor T., Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 2003, 8:379-391.
    • (2003) Genes Cells , vol.8 , pp. 379-391
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    O'Connor, T.5    Yamamoto, M.6
  • 2
    • 33750613056 scopus 로고    scopus 로고
    • Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
    • Tong K.I., Kobayashi A., Katsuoka F., Yamamoto M. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. Biol Chem 2006, 387:1311-1320.
    • (2006) Biol Chem , vol.387 , pp. 1311-1320
    • Tong, K.I.1    Kobayashi, A.2    Katsuoka, F.3    Yamamoto, M.4
  • 3
    • 77953290236 scopus 로고    scopus 로고
    • Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
    • Kitteringham N.R., Abdullah A., Walsh J., Randle L., Jenkins R.E., Sison R., et al. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. J. Proteome 2010, 73:1612-1631.
    • (2010) J. Proteome , vol.73 , pp. 1612-1631
    • Kitteringham, N.R.1    Abdullah, A.2    Walsh, J.3    Randle, L.4    Jenkins, R.E.5    Sison, R.6
  • 4
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa R.K., Mai K.H., Srisuma S., Kensler T.W., Yamamoto M., Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 2002, 62:5196-5203.
    • (2002) Cancer Res , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 5
    • 0035836698 scopus 로고    scopus 로고
    • An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen
    • Chan K., Han X.D., Kan Y.W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci U S A 2001, 98:4611-4616.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4611-4616
    • Chan, K.1    Han, X.D.2    Kan, Y.W.3
  • 6
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • Enomoto A., Itoh K., Nagayoshi E., Haruta J., Kimura T., O'Connor T., et al. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 2001, 59:169-177.
    • (2001) Toxicol Sci , vol.59 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3    Haruta, J.4    Kimura, T.5    O'Connor, T.6
  • 7
    • 52649098886 scopus 로고    scopus 로고
    • The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
    • Xu W., Hellerbrand C., Kohler U.A., Bugnon P., Kan Y.W., Werner S., et al. The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest 2008, 88:1068-1078.
    • (2008) Lab Invest , vol.88 , pp. 1068-1078
    • Xu, W.1    Hellerbrand, C.2    Kohler, U.A.3    Bugnon, P.4    Kan, Y.W.5    Werner, S.6
  • 9
    • 9444249870 scopus 로고    scopus 로고
    • The transcription factor NRF2 protects against pulmonary fibrosis
    • Cho H.Y., Reddy S.P., Yamamoto M., Kleeberger S.R. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004, 18:1258-1260.
    • (2004) FASEB J , vol.18 , pp. 1258-1260
    • Cho, H.Y.1    Reddy, S.P.2    Yamamoto, M.3    Kleeberger, S.R.4
  • 10
    • 67349202556 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling
    • Sriram N., Kalayarasan S., Sudhandiran G. Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling. Pulm Pharmacol Ther 2009, 22:221-236.
    • (2009) Pulm Pharmacol Ther , vol.22 , pp. 221-236
    • Sriram, N.1    Kalayarasan, S.2    Sudhandiran, G.3
  • 11
    • 33846264538 scopus 로고    scopus 로고
    • Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis
    • Khor T.O., Huang M.T., Kwon K.H., Chan J.Y., Reddy B.S., Kong A.N. Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res 2006, 66:11580-11584.
    • (2006) Cancer Res , vol.66 , pp. 11580-11584
    • Khor, T.O.1    Huang, M.T.2    Kwon, K.H.3    Chan, J.Y.4    Reddy, B.S.5    Kong, A.N.6
  • 12
    • 33749263503 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray
    • Hu R., Xu C., Shen G., Jain M.R., Khor T.O., Gopalkrishnan A., et al. Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray. Life Sci 2006, 79:1944-1955.
    • (2006) Life Sci , vol.79 , pp. 1944-1955
    • Hu, R.1    Xu, C.2    Shen, G.3    Jain, M.R.4    Khor, T.O.5    Gopalkrishnan, A.6
  • 13
    • 33845523674 scopus 로고    scopus 로고
    • Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice
    • Nair S., Xu C., Shen G., Hebbar V., Gopalakrishnan A., Hu R., et al. Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Toxicol Lett 2007, 168:21-39.
    • (2007) Toxicol Lett , vol.168 , pp. 21-39
    • Nair, S.1    Xu, C.2    Shen, G.3    Hebbar, V.4    Gopalakrishnan, A.5    Hu, R.6
  • 14
    • 0032491276 scopus 로고    scopus 로고
    • Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
    • Honda T., Rounds B.V., Gribble G.W., Suh N., Wang Y., Sporn M.B. Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages. Bioorg Med Chem Lett 1998, 8:2711-2714.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 2711-2714
    • Honda, T.1    Rounds, B.V.2    Gribble, G.W.3    Suh, N.4    Wang, Y.5    Sporn, M.B.6
  • 15
    • 0033590265 scopus 로고    scopus 로고
    • Novel synthetic oleanane triterpenoids: a series of highly active inhibitors of nitric oxide production in mouse macrophages
    • Honda T., Rounds B.V., Bore L., Favaloro F.G., Gribble G.W., Suh N., et al. Novel synthetic oleanane triterpenoids: a series of highly active inhibitors of nitric oxide production in mouse macrophages. Bioorg Med Chem Lett 1999, 9:3429-3434.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 3429-3434
    • Honda, T.1    Rounds, B.V.2    Bore, L.3    Favaloro, F.G.4    Gribble, G.W.5    Suh, N.6
  • 16
    • 12444337488 scopus 로고    scopus 로고
    • The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo
    • Place A.E., Suh N., Williams C.R., Risingsong R., Honda T., Honda Y., et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res 2003, 9:2798-2806.
    • (2003) Clin Cancer Res , vol.9 , pp. 2798-2806
    • Place, A.E.1    Suh, N.2    Williams, C.R.3    Risingsong, R.4    Honda, T.5    Honda, Y.6
  • 17
    • 20144383831 scopus 로고    scopus 로고
    • Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
    • Dinkova-Kostova A.T., Liby K.T., Stephenson K.K., Holtzclaw W.D., Gao X., Suh N., et al. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Proc Natl Acad Sci U S A 2005, 102:4584-4589.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4584-4589
    • Dinkova-Kostova, A.T.1    Liby, K.T.2    Stephenson, K.K.3    Holtzclaw, W.D.4    Gao, X.5    Suh, N.6
  • 18
    • 21144431523 scopus 로고    scopus 로고
    • The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling
    • Liby K., Hock T., Yore M.M., Suh N., Place A.E., Risingsong R., et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res 2005, 65:4789-4798.
    • (2005) Cancer Res , vol.65 , pp. 4789-4798
    • Liby, K.1    Hock, T.2    Yore, M.M.3    Suh, N.4    Place, A.E.5    Risingsong, R.6
  • 19
    • 33846786713 scopus 로고    scopus 로고
    • Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
    • Yates M.S., Tauchi M., Katsuoka F., Flanders K.C., Liby K.T., Honda T., et al. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther 2007, 6:154-162.
    • (2007) Mol Cancer Ther , vol.6 , pp. 154-162
    • Yates, M.S.1    Tauchi, M.2    Katsuoka, F.3    Flanders, K.C.4    Liby, K.T.5    Honda, T.6
  • 21
    • 84874616957 scopus 로고    scopus 로고
    • The extinguished BEACON of bardoxolone: not a Monday morning quarterback story
    • Tayek J.A., Kalantar-Zadeh K. The extinguished BEACON of bardoxolone: not a Monday morning quarterback story. Am J Nephrol 2013, 37:208-211.
    • (2013) Am J Nephrol , vol.37 , pp. 208-211
    • Tayek, J.A.1    Kalantar-Zadeh, K.2
  • 22
    • 84867055462 scopus 로고    scopus 로고
    • Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease
    • Liby K.T., Sporn M.B. Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. Pharmacol Rev 2012, 64:972-1003.
    • (2012) Pharmacol Rev , vol.64 , pp. 972-1003
    • Liby, K.T.1    Sporn, M.B.2
  • 23
    • 0033777347 scopus 로고    scopus 로고
    • A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma
    • Wang Y., Porter W.W., Suh N., Honda T., Gribble G.W., Leesnitzer L.M., et al. A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. Mol Endocrinol 2000, 14:1550-1556.
    • (2000) Mol Endocrinol , vol.14 , pp. 1550-1556
    • Wang, Y.1    Porter, W.W.2    Suh, N.3    Honda, T.4    Gribble, G.W.5    Leesnitzer, L.M.6
  • 24
    • 33750976014 scopus 로고    scopus 로고
    • The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells
    • Liby K., Voong N., Williams C.R., Risingsong R., Royce D.B., Honda T., et al. The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells. Clin Cancer Res 2006, 12:4288-4293.
    • (2006) Clin Cancer Res , vol.12 , pp. 4288-4293
    • Liby, K.1    Voong, N.2    Williams, C.R.3    Risingsong, R.4    Royce, D.B.5    Honda, T.6
  • 25
    • 42349104546 scopus 로고    scopus 로고
    • Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3
    • Ahmad R., Raina D., Meyer C., Kufe D. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. Cancer Res 2008, 68:2920-2926.
    • (2008) Cancer Res , vol.68 , pp. 2920-2926
    • Ahmad, R.1    Raina, D.2    Meyer, C.3    Kufe, D.4
  • 26
    • 33645693409 scopus 로고    scopus 로고
    • A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells
    • Shishodia S., Sethi G., Konopleva M., Andreeff M., Aggarwal B.B. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. Clin Cancer Res 2006, 12:1828-1838.
    • (2006) Clin Cancer Res , vol.12 , pp. 1828-1838
    • Shishodia, S.1    Sethi, G.2    Konopleva, M.3    Andreeff, M.4    Aggarwal, B.B.5
  • 27
    • 33845976705 scopus 로고    scopus 로고
    • Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179
    • Ahmad R., Raina D., Meyer C., Kharbanda S., Kufe D. Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. J Biol Chem 2006, 281:35764-35769.
    • (2006) J Biol Chem , vol.281 , pp. 35764-35769
    • Ahmad, R.1    Raina, D.2    Meyer, C.3    Kharbanda, S.4    Kufe, D.5
  • 28
    • 33846253173 scopus 로고    scopus 로고
    • The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta
    • Yore M.M., Liby K.T., Honda T., Gribble G.W., Sporn M.B. The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta. Mol Cancer Ther 2006, 5:3232-3239.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3232-3239
    • Yore, M.M.1    Liby, K.T.2    Honda, T.3    Gribble, G.W.4    Sporn, M.B.5
  • 29
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 1997, 236:313-322.
    • (1997) Biochem Biophys Res Commun , vol.236 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3    Ishii, T.4    Igarashi, K.5    Katoh, Y.6
  • 30
    • 0035870298 scopus 로고    scopus 로고
    • The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
    • McMahon M., Itoh K., Yamamoto M., Chanas S.A., Henderson C.J., McLellan L.I., et al. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res 2001, 61:3299-3307.
    • (2001) Cancer Res , vol.61 , pp. 3299-3307
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Chanas, S.A.4    Henderson, C.J.5    McLellan, L.I.6
  • 33
    • 66749112860 scopus 로고    scopus 로고
    • Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
    • Yates M.S., Tran Q.T., Dolan P.M., Osburn W.O., Shin S., McCulloch C.C., et al. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis 2009, 30:1024-1031.
    • (2009) Carcinogenesis , vol.30 , pp. 1024-1031
    • Yates, M.S.1    Tran, Q.T.2    Dolan, P.M.3    Osburn, W.O.4    Shin, S.5    McCulloch, C.C.6
  • 34
    • 21444443478 scopus 로고    scopus 로고
    • MatInspector and beyond: promoter analysis based on transcription factor binding sites
    • Cartharius K., Frech K., Grote K., Klocke B., Haltmeier M., Klingenhoff A., et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 2005, 21:2933-2942.
    • (2005) Bioinformatics , vol.21 , pp. 2933-2942
    • Cartharius, K.1    Frech, K.2    Grote, K.3    Klocke, B.4    Haltmeier, M.5    Klingenhoff, A.6
  • 35
    • 80053130888 scopus 로고    scopus 로고
    • Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis
    • Lu H., Cui W., Klaassen C.D. Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicol Appl Pharmacol 2011, 256:122-135.
    • (2011) Toxicol Appl Pharmacol , vol.256 , pp. 122-135
    • Lu, H.1    Cui, W.2    Klaassen, C.D.3
  • 36
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005, 102:15545-15550.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3    Mukherjee, S.4    Ebert, B.L.5    Gillette, M.A.6
  • 37
    • 42449111723 scopus 로고    scopus 로고
    • NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet
    • Tanaka Y., Aleksunes L.M., Yeager R.L., Gyamfi M.A., Esterly N., Guo G.L., et al. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J Pharmacol Exp Ther 2008, 325:655-664.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 655-664
    • Tanaka, Y.1    Aleksunes, L.M.2    Yeager, R.L.3    Gyamfi, M.A.4    Esterly, N.5    Guo, G.L.6
  • 38
    • 70349140473 scopus 로고    scopus 로고
    • Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide
    • Shin S., Wakabayashi J., Yates M.S., Wakabayashi N., Dolan P.M., Aja S., et al. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol 2009, 620:138-144.
    • (2009) Eur J Pharmacol , vol.620 , pp. 138-144
    • Shin, S.1    Wakabayashi, J.2    Yates, M.S.3    Wakabayashi, N.4    Dolan, P.M.5    Aja, S.6
  • 39
    • 34247371476 scopus 로고    scopus 로고
    • Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2
    • Abu-Bakar A., Lamsa V., Arpiainen S., Moore M.R., Lang M.A., Hakkola J. Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2. Drug Metab Dispos 2007, 35:787-794.
    • (2007) Drug Metab Dispos , vol.35 , pp. 787-794
    • Abu-Bakar, A.1    Lamsa, V.2    Arpiainen, S.3    Moore, M.R.4    Lang, M.A.5    Hakkola, J.6
  • 40
    • 13044304201 scopus 로고    scopus 로고
    • Nrf2 is essential for protection against acute pulmonary injury in mice
    • Chan K., Kan Y.W. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci U S A 1999, 96:12731-12736.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12731-12736
    • Chan, K.1    Kan, Y.W.2
  • 42
    • 84874615691 scopus 로고    scopus 로고
    • Rationale and trial design of bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes: the occurrence of renal events (BEACON)
    • de Zeeuw D., Akizawa T., Agarwal R., Audhya P., Bakris G.L., Chin M., et al. Rationale and trial design of bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes: the occurrence of renal events (BEACON). Am J Nephrol 2013, 37:212-222.
    • (2013) Am J Nephrol , vol.37 , pp. 212-222
    • de Zeeuw, D.1    Akizawa, T.2    Agarwal, R.3    Audhya, P.4    Bakris, G.L.5    Chin, M.6
  • 43
    • 84884339141 scopus 로고    scopus 로고
    • Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study
    • Bar-Or A., Gold R., Kappos L., Arnold D.L., Giovannoni G., Selmaj K., et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study. J Neurol 2013, 260:2297-2305.
    • (2013) J Neurol , vol.260 , pp. 2297-2305
    • Bar-Or, A.1    Gold, R.2    Kappos, L.3    Arnold, D.L.4    Giovannoni, G.5    Selmaj, K.6
  • 44
    • 0037447898 scopus 로고    scopus 로고
    • Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione
    • Vasiliou V., Qamar L., Pappa A., Sophos N.A., Petersen D.R. Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione. Arch Biochem Biophys 2003, 413:164-171.
    • (2003) Arch Biochem Biophys , vol.413 , pp. 164-171
    • Vasiliou, V.1    Qamar, L.2    Pappa, A.3    Sophos, N.A.4    Petersen, D.R.5
  • 45
    • 78149243703 scopus 로고    scopus 로고
    • Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression
    • Yeligar S.M., Machida K., Kalra V.K. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem 2010, 285:35359-35373.
    • (2010) J Biol Chem , vol.285 , pp. 35359-35373
    • Yeligar, S.M.1    Machida, K.2    Kalra, V.K.3
  • 46
    • 77957237159 scopus 로고    scopus 로고
    • Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
    • Malhotra D., Portales-Casamar E., Singh A., Srivastava S., Arenillas D., Happel C., et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res 2010, 38:5718-5734.
    • (2010) Nucleic Acids Res , vol.38 , pp. 5718-5734
    • Malhotra, D.1    Portales-Casamar, E.2    Singh, A.3    Srivastava, S.4    Arenillas, D.5    Happel, C.6
  • 47
    • 33746038942 scopus 로고    scopus 로고
    • The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells
    • Ji Y., Lee H.J., Goodman C., Uskokovic M., Liby K., Sporn M., et al. The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells. Mol Cancer Ther 2006, 5:1452-1458.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1452-1458
    • Ji, Y.1    Lee, H.J.2    Goodman, C.3    Uskokovic, M.4    Liby, K.5    Sporn, M.6
  • 48
    • 0037444161 scopus 로고    scopus 로고
    • Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling
    • Suh N., Roberts A.B., Birkey Reffey S., Miyazono K., Itoh S., ten Dijke P., et al. Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Cancer Res 2003, 63:1371-1376.
    • (2003) Cancer Res , vol.63 , pp. 1371-1376
    • Suh, N.1    Roberts, A.B.2    Birkey Reffey, S.3    Miyazono, K.4    Itoh, S.5    ten Dijke, P.6
  • 49
    • 79955763790 scopus 로고    scopus 로고
    • Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARgamma, and HO-1
    • Wu Q.Q., Wang Y., Senitko M., Meyer C., Wigley W.C., Ferguson D.A., et al. Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARgamma, and HO-1. Am J Physiol Renal Physiol 2011, 300:F1180-F1192.
    • (2011) Am J Physiol Renal Physiol , vol.300
    • Wu, Q.Q.1    Wang, Y.2    Senitko, M.3    Meyer, C.4    Wigley, W.C.5    Ferguson, D.A.6
  • 50
    • 77952332154 scopus 로고    scopus 로고
    • Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver
    • Lamsa V., Levonen A.L., Leinonen H., Yla-Herttuala S., Yamamoto M., Hakkola J. Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver. Chem Res Toxicol 2010, 23:977-985.
    • (2010) Chem Res Toxicol , vol.23 , pp. 977-985
    • Lamsa, V.1    Levonen, A.L.2    Leinonen, H.3    Yla-Herttuala, S.4    Yamamoto, M.5    Hakkola, J.6
  • 51
    • 78650178488 scopus 로고    scopus 로고
    • Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2
    • Yokota S., Higashi E., Fukami T., Yokoi T., Nakajima M. Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2. Biochem Pharmacol 2011, 81:289-294.
    • (2011) Biochem Pharmacol , vol.81 , pp. 289-294
    • Yokota, S.1    Higashi, E.2    Fukami, T.3    Yokoi, T.4    Nakajima, M.5
  • 52
    • 33845984936 scopus 로고    scopus 로고
    • Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers
    • Hakooz N., Hamdan I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007, 8:9-15.
    • (2007) Curr Drug Metab , vol.8 , pp. 9-15
    • Hakooz, N.1    Hamdan, I.2
  • 53
    • 8744262844 scopus 로고    scopus 로고
    • Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers
    • Satarug S., Nishijo M., Ujjin P., Vanavanitkun Y., Baker J.R., Moore M.R. Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers. Environ Health Perspect 2004, 112:1512-1518.
    • (2004) Environ Health Perspect , vol.112 , pp. 1512-1518
    • Satarug, S.1    Nishijo, M.2    Ujjin, P.3    Vanavanitkun, Y.4    Baker, J.R.5    Moore, M.R.6
  • 54
    • 84878223795 scopus 로고    scopus 로고
    • Cytochrome P450 2A5 and bilirubin: mechanisms of gene regulation and cytoprotection
    • Kim S.D., Antenos M., Squires E.J., Kirby G.M. Cytochrome P450 2A5 and bilirubin: mechanisms of gene regulation and cytoprotection. Toxicol Appl Pharmacol 2013, 270:129-138.
    • (2013) Toxicol Appl Pharmacol , vol.270 , pp. 129-138
    • Kim, S.D.1    Antenos, M.2    Squires, E.J.3    Kirby, G.M.4
  • 55
    • 28144445947 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
    • Okawa H., Motohashi H., Kobayashi A., Aburatani H., Kensler T.W., Yamamoto M. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun 2006, 339:79-88.
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 79-88
    • Okawa, H.1    Motohashi, H.2    Kobayashi, A.3    Aburatani, H.4    Kensler, T.W.5    Yamamoto, M.6
  • 57
    • 78650885452 scopus 로고    scopus 로고
    • The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway
    • Fang M., Shen Z., Huang S., Zhao L., Chen S., Mak T.W., et al. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 2010, 143:711-724.
    • (2010) Cell , vol.143 , pp. 711-724
    • Fang, M.1    Shen, Z.2    Huang, S.3    Zhao, L.4    Chen, S.5    Mak, T.W.6
  • 58
    • 67649961350 scopus 로고    scopus 로고
    • Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest
    • Read R., Hansen G., Kramer J., Finch R., Li L., Vogel P. Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest. Vet Pathol 2009, 46:491-504.
    • (2009) Vet Pathol , vol.46 , pp. 491-504
    • Read, R.1    Hansen, G.2    Kramer, J.3    Finch, R.4    Li, L.5    Vogel, P.6


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