Nuclear Factor-kappaB-Mediated Endothelin Receptor Up-Regulation Increases Renal Artery Contractility in Rats

Basic and Clinical Pharmacology and Toxicology

Volumn 113, Issue 6, 2013, Pages 401-410

  Xie, Yan Hua ^a   Wang, Si Wang ^a   Zhang, Yaping ^b   Edvinsson, Lars ^c   Xu, Cang Bao ^b,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA ACTIN; CYCLOHEXIMIDE; DACTINOMYCIN; ELONGATION FACTOR 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; SARAFOTOXIN S6C; 4(2'-AMINOETHYL)AMINO-1,8-DIMETHYLIMIDAZO(1,2-A)QUINOXALINE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; IMIDAZOLE DERIVATIVE; LEUPEPTIN; QUINOXALINE DERIVATIVE; SARAFOTOXINS S6; VIPER VENOM;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RENAL ARTERY; SMOOTH MUSCLE FIBER; UBIQUITINATION; ANIMAL; DRUG EFFECTS; KIDNEY ARTERY; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UPREGULATION; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

RATTUS;

ANIMALS; CYCLOHEXIMIDE; DACTINOMYCIN; IMIDAZOLES; LEUPEPTINS; MALE; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; ORGAN CULTURE TECHNIQUES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RENAL ARTERY; SIGNAL TRANSDUCTION; UP-REGULATION; VASOCONSTRICTION; VIPER VENOMS;

EID: 84887822325     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12123     Document Type: Article

References (36)

1. Adamczak M, Wiecek A. Ischemic nephropathy - pathogenesis and treatment. Nefrologia 2012;32:432-8.
2. Bougle A, Duranteau J. Pathophysiology of sepsis-induced acute kidney injury: the role of global renal blood flow and renal vascular resistance. Contrib Nephrol 2011;174:89-97.
3. Fenhammar J, Andersson A, Forestier J, Weitzberg E, Sollevi A, Hjelmqvist H et al. Endothelin receptor a antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs. PLoS ONE 2011;6:e21534.
4. Fenhammar J, Andersson A, Frithiof R, Forestier J, Weitzberg E, Sollevi A et al. The endothelin receptor antagonist tezosentan improves renal microcirculation in a porcine model of endotoxemic shock. Acta Anaesthesiol Scand 2008;52:1385-93.
5. Ucar A, Yahyayev A, Agayev A, Yanar F, Bakan S, Bulakci M et al. Severe spasm of the renal artery after blunt abdominal trauma simulating end-organ infarction. Case Report Med 2010;2010:207152.
6. Ino T, Shimazaki S, Kaneko K, Yabuta K, Yamaguchi H. Multiple spasms of renal arteries following percutaneous transluminal renal angioplasty in children. Pediatr Nephrol 1994;8:129-30.
7. Ogita S, Tokiwa K, Takahashi T. Renal artery spasm: a cause of acute renal failure following abdominal surgery for neuroblastoma. J Pediatr Surg 1989;24:215-7.
8. Rodriguez-Pascual F, Busnadiego O, Lagares D, Lamas S. Role of endothelin in the cardiovascular system. Pharmacol Res 2011;63:463-72.
9. Largo R, Gomez-Garre D, Liu XH, Alonso J, Blanco J, Plaza JJ et al. Endothelin-1 upregulation in the kidney of uninephrectomized spontaneously hypertensive rats and its modification by the angiotensin-converting enzyme inhibitor quinapril. Hypertension 1997;29:1178-85.
10. Xu CB, Sun Y, Edvinsson L. Cardiovascular risk factors regulate the expression of vascular endothelin receptors. Pharmacol Ther 2010;127:148-55.
11. Lawrence T. The nuclear factor nf-kappab pathway in inflammation. Cold Spring Harb Perspect Biol 2009;1:a001651.
12. Campese VM, Park J. Hmg-coa reductase inhibitors and renal function. Clin J Am Soc Nephrol 2007;2:1100-3.
13. Wan X, Fan L, Hu B, Yang J, Li X, Chen X et al. Small interfering rna targeting ikkbeta prevents renal ischemia-reperfusion injury in rats. Am J Physiol Renal Physiol 2011;300:F857-63.
14. Xie YH, Wang SW, Zhang Y, Edvinsson L, Xu CB. Up-regulation of g-protein-coupled receptors for endothelin and thromboxane by lipid-soluble smoke particles in renal artery of rat. Basic Clin Pharmacol Toxicol 2010;107:803-12.
15. Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW et al. Bms-345541 is a highly selective inhibitor of i kappa b kinase that binds at an allosteric site of the enzyme and blocks nf-kappa b-dependent transcription in mice. J Biol Chem 2003;278:1450-6.
16. Panno ML, Giordano F, Rizza P, Pellegrino M, Zito D, Giordano C et al. Bergapten induces er depletion in breast cancer cells through smad4-mediated ubiquitination. Breast Cancer Res Treat 2012;136:443-55.
17. Sheng X, Wei Q, Jiang L, Li X, Gao Y, Wang L. Different degree in proteasome malfunction has various effects on root growth possibly through preventing cell division and promoting autophagic vacuolization. PLoS ONE 2012;7:e45673.
18. Zhang Y, Adner M, Cardell LO. Interleukin-1beta attenuates endothelin b receptor-mediated airway contractions in a murine in vitro model of asthma: roles of endothelin converting enzyme and mitogen-activated protein kinase pathways. Clin Exp Allergy 2004;34:1480-7.
19. Diekmann F, Zart R, Thone-Reineke C, Bauer C, Neumayer HH, Hocher B. Regulation of the renal endothelin system in the two-kidney, one clip renal hypertensive rat. J Cardiovasc Pharmacol 2000;36:S191-4.
20. Kelsen S, Hall JE, Chade AR. Endothelin-a receptor blockade slows the progression of renal injury in experimental renovascular disease. Am J Physiol Renal Physiol 2011;301:F218-25.
21. Vogel C, Marcotte EM. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet 2012;13:227-32.
22. Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol 2011;9:e1001144.
23. Gygi SP, Rochon Y, Franza BR, Aebersold R. Correlation between protein and mrna abundance in yeast. Mol Cell Biol 1999;19:1720-30.
24. Guo Y, Xiao P, Lei S, Deng F, Xiao GG, Liu Y et al. How is mrna expression predictive for protein expression? A correlation study on human circulating monocytes. Acta Biochim Biophys Sin (Shanghai) 2008;40:426-36.
25. Rapoport RM, Zuccarello M. Endothelin(a)-endothelin(b) receptor cross-talk and endothelin receptor binding. J Pharm Pharmacol 2011;63:1373-7.
26. Bornfeldt KE, Krebs EG. Crosstalk between protein kinase a and growth factor receptor signaling pathways in arterial smooth muscle. Cell Signal 1999;11:465-77.
27. Chang JH, Ryang YS, Morio T, Lee SK, Chang EJ. Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing nf-kappab activation. Mol Cells 2004;18:177-85.
28. Saeed A, Herlitz H, Nowakowska-Fortuna E, Nilsson U, Alhadad A, Jensen G et al. Oxidative stress and endothelin-1 in atherosclerotic renal artery stenosis and effects of renal angioplasty. Kidney Blood Press Res 2011;34:396-403.
29. Jones WK, Brown M, Ren X, He S, McGuinness M. Nf-kappab as an integrator of diverse signaling pathways: the heart of myocardial signaling? Cardiovasc Toxicol 2003;3:229-54.
30. Lan W, Petznick A, Heryati S, Rifada M, Tong L. Nuclear factor-kappab: central regulator in ocular surface inflammation and diseases. Ocul Surf 2012;10:137-48.
31. Pamukcu B, Lip GY, Shantsila E. The nuclear factor-kappa b pathway in atherosclerosis: a potential therapeutic target for atherothrombotic vascular disease. Thromb Res 2011;128:117-23.
32. Herfs M, Hubert P, Poirrier AL, Vandevenne P, Renoux V, Habraken Y et al. Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy. Am J Respir Cell Mol Biol 2012;47:67-79.
33. Conger JD, Robinette JB, Schrier RW. Smooth muscle calcium and endothelium-derived relaxing factor in the abnormal vascular responses of acute renal failure. J Clin Invest 1988;82:532-7.
34. Nilsson D, Wackenfors A, Gustafsson L, Ugander M, Paulsson P, Ingemansson R et al. Endothelin receptor-mediated vasodilatation: effects of organ culture. Eur J Pharmacol 2008;579:233-40.
35. Fan J, Unoki H, Iwasa S, Watanabe T. Role of endothelin-1 in atherosclerosis. Ann N Y Acad Sci 2000;902:84-93; discussion 93-84.
36. Guan Z, Inscho EW. Endothelin and the renal vasculature. Contrib Nephrol 2011;172:35-49.