메뉴 건너뛰기




Volumn 262, Issue Part B, 2014, Pages 111-120

Glial cells in amyotrophic lateral sclerosis

Author keywords

Astroglia; C9ORF72; EAAT2; Excitotoxicity; Inflammation; MCT1; Microglia; Oligodendroglia; RNA; Transporters

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; EXCITATORY AMINO ACID TRANSPORTER 2; GLIAL FIBRILLARY ACIDIC PROTEIN; MONOCARBOXYLATE TRANSPORTER 4; TAR DNA BINDING PROTEIN; VESICULAR GLUTAMATE TRANSPORTER 1;

EID: 84908176097     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.05.015     Document Type: Review
Times cited : (180)

References (105)
  • 1
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B., Bennett J.L., Krieger C., Tetzlaff W., Rossi F.M. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 2007, 10:1538-1543.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 2
    • 0035833937 scopus 로고    scopus 로고
    • Immune reactivity in a mouse model of familial ALS correlates with disease progression
    • Alexianu M.E., Kozovska M., Appel S.H. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 2001, 57:1282-1289.
    • (2001) Neurology , vol.57 , pp. 1282-1289
    • Alexianu, M.E.1    Kozovska, M.2    Appel, S.H.3
  • 7
    • 55749110043 scopus 로고    scopus 로고
    • CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    • Beers D.R., Henkel J.S., Zhao W., Wang J., Appel S.H. CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:15558-15563.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 15558-15563
    • Beers, D.R.1    Henkel, J.S.2    Zhao, W.3    Wang, J.4    Appel, S.H.5
  • 8
    • 79957528028 scopus 로고    scopus 로고
    • Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
    • Beers D.R., Henkel J.S., Zhao W., Wang J., Huang A., Wen S., Liao B., Appel S.H. Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain 2011, 134:1293-1314.
    • (2011) Brain , vol.134 , pp. 1293-1314
    • Beers, D.R.1    Henkel, J.S.2    Zhao, W.3    Wang, J.4    Huang, A.5    Wen, S.6    Liao, B.7    Appel, S.H.8
  • 9
    • 0034636493 scopus 로고    scopus 로고
    • Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
    • Bergles D.E., Roberts J.D., Somogyi P., Jahr C.E. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 2000, 405:187-191.
    • (2000) Nature , vol.405 , pp. 187-191
    • Bergles, D.E.1    Roberts, J.D.2    Somogyi, P.3    Jahr, C.E.4
  • 14
    • 33645533489 scopus 로고    scopus 로고
    • Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice
    • Chi L., Ke Y., Luo C., Li B., Gozal D., Kalyanaraman B., Liu R. Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice. Stem Cells 2006, 24:34-43.
    • (2006) Stem Cells , vol.24 , pp. 34-43
    • Chi, L.1    Ke, Y.2    Luo, C.3    Li, B.4    Gozal, D.5    Kalyanaraman, B.6    Liu, R.7
  • 20
  • 21
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    • Di Giorgio F.P., Carrasco M.A., Siao M.C., Maniatis T., Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 2007, 10:608-614.
    • (2007) Nat. Neurosci. , vol.10 , pp. 608-614
    • Di Giorgio, F.P.1    Carrasco, M.A.2    Siao, M.C.3    Maniatis, T.4    Eggan, K.5
  • 24
    • 0027473452 scopus 로고
    • Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis
    • Engelhardt J.I., Tajti J., Appel S.H. Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch. Neurol. 1993, 50:30-36.
    • (1993) Arch. Neurol. , vol.50 , pp. 30-36
    • Engelhardt, J.I.1    Tajti, J.2    Appel, S.H.3
  • 25
    • 84877832189 scopus 로고    scopus 로고
    • Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis
    • Estes P.S., Daniel S.G., McCallum A.P., Boehringer A.V., Sukhina A.S., Zwick R.A., Zarnescu D.C. Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis. Dis. Model. Mech. 2013, 6:721-733.
    • (2013) Dis. Model. Mech. , vol.6 , pp. 721-733
    • Estes, P.S.1    Daniel, S.G.2    McCallum, A.P.3    Boehringer, A.V.4    Sukhina, A.S.5    Zwick, R.A.6    Zarnescu, D.C.7
  • 26
    • 80052928827 scopus 로고    scopus 로고
    • Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis
    • Ferraiuolo L., Higginbottom A., Heath P.R., Barber S., Greenald D., Kirby J., Shaw P.J. Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain 2011, 134:2627-2641.
    • (2011) Brain , vol.134 , pp. 2627-2641
    • Ferraiuolo, L.1    Higginbottom, A.2    Heath, P.R.3    Barber, S.4    Greenald, D.5    Kirby, J.6    Shaw, P.J.7
  • 31
    • 0034651102 scopus 로고    scopus 로고
    • Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
    • Gong Y.H., Parsadanian A.S., Andreeva A., Snider W.D., Elliott J.L. Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration. J. Neurosci. 2000, 20:660-665.
    • (2000) J. Neurosci. , vol.20 , pp. 660-665
    • Gong, Y.H.1    Parsadanian, A.S.2    Andreeva, A.3    Snider, W.D.4    Elliott, J.L.5
  • 33
    • 55049120934 scopus 로고    scopus 로고
    • Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
    • Gowing G., Philips T., Van Wijmeersch B., Audet J.N., Dewil M., Van Den Bosch L., Billiau A.D., Robberecht W., Julien J.P. Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase. J. Neurosci. 2008, 28:10234-10244.
    • (2008) J. Neurosci. , vol.28 , pp. 10234-10244
    • Gowing, G.1    Philips, T.2    Van Wijmeersch, B.3    Audet, J.N.4    Dewil, M.5    Van Den Bosch, L.6    Billiau, A.D.7    Robberecht, W.8    Julien, J.P.9
  • 35
    • 0141618315 scopus 로고    scopus 로고
    • Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
    • Guo H., Lai L., Butchbach M.E., Stockinger M.P., Shan X., Bishop G.A., Lin C.L. Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice. Hum. Mol. Genet. 2003, 12:2519-2532.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2519-2532
    • Guo, H.1    Lai, L.2    Butchbach, M.E.3    Stockinger, M.P.4    Shan, X.5    Bishop, G.A.6    Lin, C.L.7
  • 40
    • 33644821966 scopus 로고    scopus 로고
    • The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
    • Henkel J.S., Beers D.R., Siklos L., Appel S.H. The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS. Mol. Cell. Neurosci. 2006, 31:427-437.
    • (2006) Mol. Cell. Neurosci. , vol.31 , pp. 427-437
    • Henkel, J.S.1    Beers, D.R.2    Siklos, L.3    Appel, S.H.4
  • 44
    • 39849103473 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
    • Jaarsma D., Teuling E., Haasdijk E.D., De Zeeuw C.I., Hoogenraad C.C. Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J. Neurosci. 2008, 28:2075-2088.
    • (2008) J. Neurosci. , vol.28 , pp. 2075-2088
    • Jaarsma, D.1    Teuling, E.2    Haasdijk, E.D.3    De Zeeuw, C.I.4    Hoogenraad, C.C.5
  • 45
    • 0038147334 scopus 로고    scopus 로고
    • A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results
    • Kalra S., Genge A., Arnold D.L. A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2003, 4:22-26.
    • (2003) Amyotroph. Lateral Scler. Other Motor Neuron Disord. , vol.4 , pp. 22-26
    • Kalra, S.1    Genge, A.2    Arnold, D.L.3
  • 46
    • 78449269355 scopus 로고    scopus 로고
    • NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration
    • Kang S.H., Fukaya M., Yang J.K., Rothstein J.D., Bergles D.E. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron 2010, 68:668-681.
    • (2010) Neuron , vol.68 , pp. 668-681
    • Kang, S.H.1    Fukaya, M.2    Yang, J.K.3    Rothstein, J.D.4    Bergles, D.E.5
  • 48
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar B.K., Llado J., Sherkat N., Rothstein J.D., Gage F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003, 301:839-842.
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 49
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • Kawamata T., Akiyama H., Yamada T., McGeer P.L. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am. J. Pathol. 1992, 140:691-707.
    • (1992) Am. J. Pathol. , vol.140 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 50
    • 69449095509 scopus 로고    scopus 로고
    • Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells
    • Keller A.F., Gravel M., Kriz J. Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells. Glia 2009, 57:1130-1142.
    • (2009) Glia , vol.57 , pp. 1130-1142
    • Keller, A.F.1    Gravel, M.2    Kriz, J.3
  • 51
    • 0034622930 scopus 로고    scopus 로고
    • Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells
    • Kondo T., Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 2000, 289:1754-1757.
    • (2000) Science , vol.289 , pp. 1754-1757
    • Kondo, T.1    Raff, M.2
  • 52
    • 0025868659 scopus 로고
    • Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain
    • Kushner P.D., Stephenson D.T., Wright S. Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain. J. Neuropathol. Exp. Neurol. 1991, 50:263-277.
    • (1991) J. Neuropathol. Exp. Neurol. , vol.50 , pp. 263-277
    • Kushner, P.D.1    Stephenson, D.T.2    Wright, S.3
  • 55
    • 43449086380 scopus 로고    scopus 로고
    • Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
    • Lepore A.C., Dejea C., Carmen J., Rauck B., Kerr D.A., Sofroniew M.V., Maragakis N.J. Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration. Exp. Neurol. 2008, 211:423-432.
    • (2008) Exp. Neurol. , vol.211 , pp. 423-432
    • Lepore, A.C.1    Dejea, C.2    Carmen, J.3    Rauck, B.4    Kerr, D.A.5    Sofroniew, M.V.6    Maragakis, N.J.7
  • 56
    • 54949126674 scopus 로고    scopus 로고
    • Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
    • Lepore A.C., Rauck B., Dejea C., Pardo A.C., Rao M.S., Rothstein J.D., Maragakis N.J. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat. Neurosci. 2008, 11:1294-1301.
    • (2008) Nat. Neurosci. , vol.11 , pp. 1294-1301
    • Lepore, A.C.1    Rauck, B.2    Dejea, C.3    Pardo, A.C.4    Rao, M.S.5    Rothstein, J.D.6    Maragakis, N.J.7
  • 57
    • 0033485920 scopus 로고    scopus 로고
    • Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)
    • Levine J.B., Kong J., Nadler M., Xu Z. Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS). Glia 1999, 28:215-224.
    • (1999) Glia , vol.28 , pp. 215-224
    • Levine, J.B.1    Kong, J.2    Nadler, M.3    Xu, Z.4
  • 58
    • 84863845583 scopus 로고    scopus 로고
    • Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
    • Liao B., Zhao W., Beers D.R., Henkel J.S., Appel S.H. Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS. Exp. Neurol. 2012, 237:147-152.
    • (2012) Exp. Neurol. , vol.237 , pp. 147-152
    • Liao, B.1    Zhao, W.2    Beers, D.R.3    Henkel, J.S.4    Appel, S.H.5
  • 60
    • 77955649302 scopus 로고    scopus 로고
    • Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis
    • Meissner F., Molawi K., Zychlinsky A. Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:13046-13050.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 13046-13050
    • Meissner, F.1    Molawi, K.2    Zychlinsky, A.3
  • 64
    • 0028264346 scopus 로고
    • Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis
    • Nagy D., Kato T., Kushner P.D. Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis. J. Neurosci. Res. 1994, 38:336-347.
    • (1994) J. Neurosci. Res. , vol.38 , pp. 336-347
    • Nagy, D.1    Kato, T.2    Kushner, P.D.3
  • 66
    • 0034765498 scopus 로고    scopus 로고
    • Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration
    • Nguyen M.D., Julien J.P., Rivest S. Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. Ann. Neurol. 2001, 50:630-639.
    • (2001) Ann. Neurol. , vol.50 , pp. 630-639
    • Nguyen, M.D.1    Julien, J.P.2    Rivest, S.3
  • 67
    • 80055074312 scopus 로고    scopus 로고
    • Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo
    • Papadeas S.T., Kraig S.E., O'Banion C., Lepore A.C., Maragakis N.J. Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:17803-17808.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 17803-17808
    • Papadeas, S.T.1    Kraig, S.E.2    O'Banion, C.3    Lepore, A.C.4    Maragakis, N.J.5
  • 68
    • 68049110630 scopus 로고    scopus 로고
    • Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice
    • Park S., Kim H.T., Yun S., Kim I.S., Lee J., Lee I.S., Park K.I. Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice. Exp. Mol. Med. 2009, 41:487-500.
    • (2009) Exp. Mol. Med. , vol.41 , pp. 487-500
    • Park, S.1    Kim, H.T.2    Yun, S.3    Kim, I.S.4    Lee, J.5    Lee, I.S.6    Park, K.I.7
  • 69
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
    • Pellerin L., Magistretti P.J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:10625-10629.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 71
    • 79951704433 scopus 로고    scopus 로고
    • Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
    • Philips T., Robberecht W. Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. Lancet Neurol. 2011, 10:253-263.
    • (2011) Lancet Neurol. , vol.10 , pp. 253-263
    • Philips, T.1    Robberecht, W.2
  • 73
    • 0034733968 scopus 로고    scopus 로고
    • Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
    • Poloni M., Facchetti D., Mai R., Micheli A., Agnoletti L., Francolini G., Mora G., Camana C., Mazzini L., Bachetti T. Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci. Lett. 2000, 287:211-214.
    • (2000) Neurosci. Lett. , vol.287 , pp. 211-214
    • Poloni, M.1    Facchetti, D.2    Mai, R.3    Micheli, A.4    Agnoletti, L.5    Francolini, G.6    Mora, G.7    Camana, C.8    Mazzini, L.9    Bachetti, T.10
  • 74
    • 0035873076 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
    • Pramatarova A., Laganiere J., Roussel J., Brisebois K., Rouleau G.A. Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment. J. Neurosci. 2001, 21:3369-3374.
    • (2001) J. Neurosci. , vol.21 , pp. 3369-3374
    • Pramatarova, A.1    Laganiere, J.2    Roussel, J.3    Brisebois, K.4    Rouleau, G.A.5
  • 75
    • 0242485280 scopus 로고    scopus 로고
    • Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain
    • Rafiki A., Boulland J.L., Halestrap A.P., Ottersen O.P., Bergersen L. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neuroscience 2003, 122:677-688.
    • (2003) Neuroscience , vol.122 , pp. 677-688
    • Rafiki, A.1    Boulland, J.L.2    Halestrap, A.P.3    Ottersen, O.P.4    Bergersen, L.5
  • 76
    • 79956221125 scopus 로고    scopus 로고
    • NG2-glia as multipotent neural stem cells: fact or fantasy?
    • Richardson W.D., Young K.M., Tripathi R.B., McKenzie I. NG2-glia as multipotent neural stem cells: fact or fantasy?. Neuron 2011, 70:661-673.
    • (2011) Neuron , vol.70 , pp. 661-673
    • Richardson, W.D.1    Young, K.M.2    Tripathi, R.B.3    McKenzie, I.4
  • 78
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein J.D., Martin L.J., Kuncl R.W. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N. Engl. J. Med. 1992, 326:1464-1468.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 81
    • 67349164383 scopus 로고    scopus 로고
    • A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice
    • Saxena S., Cabuy E., Caroni P. A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nat. Neurosci. 2009, 12:627-636.
    • (2009) Nat. Neurosci. , vol.12 , pp. 627-636
    • Saxena, S.1    Cabuy, E.2    Caroni, P.3
  • 82
    • 0029812020 scopus 로고    scopus 로고
    • Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis
    • Schiffer D., Cordera S., Cavalla P., Migheli A. Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis. J. Neurol. Sci. 1996, 139:27-33. (Suppl.).
    • (1996) J. Neurol. Sci. , vol.139 , pp. 27-33
    • Schiffer, D.1    Cordera, S.2    Cavalla, P.3    Migheli, A.4
  • 84
    • 77958022745 scopus 로고    scopus 로고
    • Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
    • Shan X., Chiang P.M., Price D.L., Wong P.C. Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:16325-16330.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 16325-16330
    • Shan, X.1    Chiang, P.M.2    Price, D.L.3    Wong, P.C.4
  • 85
    • 58149242839 scopus 로고    scopus 로고
    • Subcutaneous IGF-1 is not beneficial in 2-year ALS trial
    • Sorenson E.J., et al. Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology 2008, 71:1770-1775.
    • (2008) Neurology , vol.71 , pp. 1770-1775
    • Sorenson, E.J.1
  • 86
    • 56749154435 scopus 로고    scopus 로고
    • Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS
    • Suzuki M., McHugh J., Tork C., Shelley B., Hayes A., Bellantuono I., Aebischer P., Svendsen C.N. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Mol. Ther. 2008, 16:2002-2010.
    • (2008) Mol. Ther. , vol.16 , pp. 2002-2010
    • Suzuki, M.1    McHugh, J.2    Tork, C.3    Shelley, B.4    Hayes, A.5    Bellantuono, I.6    Aebischer, P.7    Svendsen, C.N.8
  • 88
    • 84880217322 scopus 로고    scopus 로고
    • Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
    • Tong J., Huang C., Bi F., Wu Q., Huang B., Liu X., Li F., Zhou H., Xia X.G. Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats. EMBO J. 2013, 32:1917-1926.
    • (2013) EMBO J. , vol.32 , pp. 1917-1926
    • Tong, J.1    Huang, C.2    Bi, F.3    Wu, Q.4    Huang, B.5    Liu, X.6    Li, F.7    Zhou, H.8    Xia, X.G.9
  • 89
    • 78649757441 scopus 로고    scopus 로고
    • NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease
    • Tripathi R.B., Rivers L.E., Young K.M., Jamen F., Richardson W.D. NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease. J. Neurosci. 2010, 30:16383-16390.
    • (2010) J. Neurosci. , vol.30 , pp. 16383-16390
    • Tripathi, R.B.1    Rivers, L.E.2    Young, K.M.3    Jamen, F.4    Richardson, W.D.5
  • 90
    • 1842471942 scopus 로고    scopus 로고
    • Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study
    • Turner M.R., Cagnin A., Turkheimer F.E., Miller C.C., Shaw C.E., Brooks D.J., Leigh P.N., Banati R.B. Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol. Dis. 2004, 15:601-609.
    • (2004) Neurobiol. Dis. , vol.15 , pp. 601-609
    • Turner, M.R.1    Cagnin, A.2    Turkheimer, F.E.3    Miller, C.C.4    Shaw, C.E.5    Brooks, D.J.6    Leigh, P.N.7    Banati, R.B.8
  • 91
    • 77950528523 scopus 로고    scopus 로고
    • Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice
    • Turner B.J., Ackerley S., Davies K.E., Talbot K. Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice. Hum. Mol. Genet. 2010, 19:815-824.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 815-824
    • Turner, B.J.1    Ackerley, S.2    Davies, K.E.3    Talbot, K.4
  • 92
    • 67649486844 scopus 로고    scopus 로고
    • The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis
    • Wang L., Sharma K., Grisotti G., Roos R.P. The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis. Neurobiol. Dis. 2009, 35:234-240.
    • (2009) Neurobiol. Dis. , vol.35 , pp. 234-240
    • Wang, L.1    Sharma, K.2    Grisotti, G.3    Roos, R.P.4
  • 93
    • 78650550891 scopus 로고    scopus 로고
    • Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice
    • Wang L., Gutmann D.H., Roos R.P. Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice. Hum. Mol. Genet. 2011, 20:286-293.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 286-293
    • Wang, L.1    Gutmann, D.H.2    Roos, R.P.3
  • 97
    • 33747047814 scopus 로고    scopus 로고
    • The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
    • Wu D.C., Re D.B., Nagai M., Ischiropoulos H., Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12132-12137.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 12132-12137
    • Wu, D.C.1    Re, D.B.2    Nagai, M.3    Ischiropoulos, H.4    Przedborski, S.5
  • 102
    • 84864928300 scopus 로고    scopus 로고
    • Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
    • Zhao W., Beers D.R., Liao B., Henkel J.S., Appel S.H. Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol. Dis. 2012, 48:418-428.
    • (2012) Neurobiol. Dis. , vol.48 , pp. 418-428
    • Zhao, W.1    Beers, D.R.2    Liao, B.3    Henkel, J.S.4    Appel, S.H.5
  • 103
    • 84882289585 scopus 로고    scopus 로고
    • Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis
    • Zhao W., Beers D.R., Appel S.H. Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis. J. Neuroimmune Pharmacol. 2013, 8:888-899.
    • (2013) J. Neuroimmune Pharmacol. , vol.8 , pp. 888-899
    • Zhao, W.1    Beers, D.R.2    Appel, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.