메뉴 건너뛰기




Volumn 19, Issue 5, 2014, Pages 426-438

Gene therapy for restoring heart rhythm

Author keywords

Cardiac arrhythmias; Cardiac electrophysiology; Gene therapy; Heart disease; Ion channels; Molecular biology; Pacemakers

Indexed keywords

ADENOVIRUS VECTOR; CYCLIC AMP; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; KRUPPEL LIKE FACTOR 4; LENTIVIRUS VECTOR; MYC PROTEIN; ORGANIC CATION TRANSPORTER 3; TRANSCRIPTION FACTOR SOX2; VIRUS VECTOR; CARDIOVASCULAR AGENT;

EID: 84907912579     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248414528575     Document Type: Review
Times cited : (9)

References (72)
  • 1
    • 84867401976 scopus 로고    scopus 로고
    • Trends in permanent pacemaker implantation in the United States from 1993 to 2009: Increasing complexity of patients and procedures
    • Greenspon AJ, Patel JD, Lau E, et al. Trends in permanent pacemaker implantation in the United States from 1993 to 2009: Increasing complexity of patients and procedures. J Am Coll Cardiol. 2012;60(16):1540-1545.
    • (2012) J Am Coll Cardiol , vol.60 , Issue.16 , pp. 1540-1545
    • Greenspon, A.J.1    Patel, J.D.2    Lau, E.3
  • 2
    • 15844398311 scopus 로고    scopus 로고
    • Long term complications in single and dual chamber pacing are influenced by surgical experience and patient morbidity
    • Eberhardt F, Bode F, Bonnemeier H, et al. Long term complications in single and dual chamber pacing are influenced by surgical experience and patient morbidity. Heart. 2005;91(4):500-506.
    • (2005) Heart , vol.91 , Issue.4 , pp. 500-506
    • Eberhardt, F.1    Bode, F.2    Bonnemeier, H.3
  • 3
    • 0037414095 scopus 로고    scopus 로고
    • Left ventricular septal and apex pacing for optimal pump function in canine hearts
    • Peschar M, de SH, Michels KJ, Reneman RS, Prinzen FW. Left ventricular septal and apex pacing for optimal pump function in canine hearts. J Am Coll Cardiol. 2003;41(7):1218-1226.
    • (2003) J Am Coll Cardiol , vol.41 , Issue.7 , pp. 1218-1226
    • Peschar, M.1    De, S.H.2    Michels, K.J.3    Reneman, R.S.4    Prinzen, F.W.5
  • 4
    • 80051766535 scopus 로고    scopus 로고
    • Chronic ventricular pacing in children: Toward prevention of pacinginduced heart disease
    • van Geldorp IE, Vanagt WY, Prinzen FW, Delhaas T. Chronic ventricular pacing in children: Toward prevention of pacinginduced heart disease. Heart Fail Rev. 2011;16(3):305-314.
    • (2011) Heart Fail Rev , vol.16 , Issue.3 , pp. 305-314
    • Van Geldorp, I.E.1    Vanagt, W.Y.2    Prinzen, F.W.3    Delhaas, T.4
  • 5
    • 11144357199 scopus 로고    scopus 로고
    • Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers
    • Potapova I, Plotnikov A, Lu Z, et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ Res. 2004;94(7):952-959.
    • (2004) Circ Res , vol.94 , Issue.7 , pp. 952-959
    • Potapova, I.1    Plotnikov, A.2    Lu, Z.3
  • 6
    • 34547886502 scopus 로고    scopus 로고
    • Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart
    • Plotnikov AN, Shlapakova I, Szabolcs MJ, et al. Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart. Circulation. 2007;116(7):706-713.
    • (2007) Circulation , vol.116 , Issue.7 , pp. 706-713
    • Plotnikov, A.N.1    Shlapakova, I.2    Szabolcs, M.J.3
  • 7
    • 70450218389 scopus 로고    scopus 로고
    • Coupling an HCN2 expressing cell to a myocyte creates a pacing two cell syncytium
    • Valiunas V, Kanaporis G, Valiuniene L, et al. Coupling an HCN2 expressing cell to a myocyte creates a pacing two cell syncytium. J Physiol. 2009;587(pt 21):5211-5226.
    • (2009) J Physiol , vol.587 , pp. 5211-5226
    • Valiunas, V.1    Kanaporis, G.2    Valiuniene, L.3
  • 8
    • 5044221669 scopus 로고    scopus 로고
    • Electromechanical integration of cardiomyocytes derived from human embryonic stem cells
    • Kehat I, Khimovich L, Caspi O, et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol. 2004;22(10):1282-1289.
    • (2004) Nat Biotechnol , vol.22 , Issue.10 , pp. 1282-1289
    • Kehat, I.1    Khimovich, L.2    Caspi, O.3
  • 9
    • 84857563595 scopus 로고    scopus 로고
    • Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior
    • Mandel Y, Weissman A, Schick R, et al. Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior. Circulation. 2012; 125(7):883-893.
    • (2012) Circulation , vol.125 , Issue.7 , pp. 883-893
    • Mandel, Y.1    Weissman, A.2    Schick, R.3
  • 11
    • 79959566380 scopus 로고    scopus 로고
    • Regenerative therapies in electrophysiology and pacing: Introducing the next steps
    • Boink GJ, Rosen MR. Regenerative therapies in electrophysiology and pacing: Introducing the next steps. J Interv Card Electrophysiol. 2011;31(1):3-16.
    • (2011) J Interv Card Electrophysiol , vol.31 , Issue.1 , pp. 3-16
    • Boink, G.J.1    Rosen, M.R.2
  • 12
    • 0027133238 scopus 로고
    • Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo
    • Kass-Eisler A, Falck-Pedersen E, Alvira M, et al. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci U S A. 1993; 90(24):11498-11502.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.24 , pp. 11498-11502
    • Kass-Eisler, A.1    Falck-Pedersen, E.2    Alvira, M.3
  • 13
    • 0029936764 scopus 로고    scopus 로고
    • Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
    • Tripathy SK, Black HB, Goldwasser E, Leiden JM. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat Med. 1996;2(5):545-550.
    • (1996) Nat Med , vol.2 , Issue.5 , pp. 545-550
    • Tripathy, S.K.1    Black, H.B.2    Goldwasser, E.3    Leiden, J.M.4
  • 14
    • 0042885512 scopus 로고    scopus 로고
    • Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and arteries in vivo: A comparative study with adenovirus vectors
    • Vassalli G, Bueler H, Dudler J, von Segesser LK, Kappenberger L. Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and arteries in vivo: A comparative study with adenovirus vectors. Int J Cardiol. 2003;90(2-3):229-238.
    • (2003) Int J Cardiol , vol.90 , Issue.2-3 , pp. 229-238
    • Vassalli, G.1    Bueler, H.2    Dudler, J.3    Von Segesser, L.K.4    Kappenberger, L.5
  • 15
    • 84892924162 scopus 로고    scopus 로고
    • Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: Analysis of recurrent cardiovascular events and mortality
    • Zsebo K, Yaroshinsky A, Rudy JJ, et al. Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: Analysis of recurrent cardiovascular events and mortality. Circ Res. 2014;114(1):101-108.
    • (2014) Circ Res , vol.114 , Issue.1 , pp. 101-108
    • Zsebo, K.1    Yaroshinsky, A.2    Rudy, J.J.3
  • 16
    • 84880559842 scopus 로고    scopus 로고
    • Overcoming preexisting humoral immunity to AAV using capsid decoys
    • Mingozzi F, Anguela XM, Pavani G, et al. Overcoming preexisting humoral immunity to AAV using capsid decoys. Sci Transl Med. 2013;5(194):194ra92.
    • (2013) Sci Transl Med , vol.5 , Issue.194 , pp. 194ra92
    • Mingozzi, F.1    Anguela, X.M.2    Pavani, G.3
  • 17
    • 79961032369 scopus 로고    scopus 로고
    • Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure
    • Jessup M, Greenberg B, Mancini D, et al. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation. 2011;124(3):304-313.
    • (2011) Circulation , vol.124 , Issue.3 , pp. 304-313
    • Jessup, M.1    Greenberg, B.2    Mancini, D.3
  • 18
    • 0034756451 scopus 로고    scopus 로고
    • Expanding AAV packaging capacity with trans-splicing or overlapping vectors: A quantitative comparison
    • Duan D, Yue Y, Engelhardt JF. Expanding AAV packaging capacity with trans-splicing or overlapping vectors: A quantitative comparison. Mol Ther. 2001;4(4):383-391.
    • (2001) Mol Ther , vol.4 , Issue.4 , pp. 383-391
    • Duan, D.1    Yue, Y.2    Engelhardt, J.F.3
  • 19
    • 84862025459 scopus 로고    scopus 로고
    • Directed evolution of novel adeno-associated viruses for therapeutic gene delivery
    • Bartel MA, Weinstein JR, Schaffer DV. Directed evolution of novel adeno-associated viruses for therapeutic gene delivery. Gene Ther. 2012;19(6):694-700.
    • (2012) Gene Ther , vol.19 , Issue.6 , pp. 694-700
    • Bartel, M.A.1    Weinstein, J.R.2    Schaffer, D.V.3
  • 20
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996;272(5259):263-267.
    • (1996) Science , vol.272 , Issue.5259 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 21
    • 34547559614 scopus 로고    scopus 로고
    • Gene therapy to inhibit the calcium channel beta subunit: Physiological consequences and pathophysiological effects in models of cardi ac hypertrophy
    • Cingolani E, Ramirez Correa GA, Kizana E, et al. Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardi ac hypertrophy. Circ Res. 2007;101(2):166-175.
    • (2007) Circ Res , vol.101 , Issue.2 , pp. 166-175
    • Cingolani, E.1    Ramirez, C.G.A.2    Kizana, E.3
  • 22
    • 44349097011 scopus 로고    scopus 로고
    • Lentiviral vectormediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats
    • Niwano K, Arai M, Koitabashi N, et al. Lentiviral vectormediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats. Mol Ther. 2008;16(6):1026-1032.
    • (2008) Mol Ther , vol.16 , Issue.6 , pp. 1026-1032
    • Niwano, K.1    Arai, M.2    Koitabashi, N.3
  • 24
    • 79954692758 scopus 로고    scopus 로고
    • Ex vivo gene transfer and correction for cell-based therapies
    • Naldini L. Ex vivo gene transfer and correction for cell-based therapies. Nat Rev Genet. 2011;12(5):301-315.
    • (2011) Nat Rev Genet , vol.12 , Issue.5 , pp. 301-315
    • Naldini, L.1
  • 25
    • 84856954338 scopus 로고    scopus 로고
    • Gene transfer for ocular neovascularization and macular edema
    • Campochiaro PA. Gene transfer for ocular neovascularization and macular edema. Gene Ther. 2012;19(2):121-126.
    • (2012) Gene Ther , vol.19 , Issue.2 , pp. 121-126
    • Campochiaro, P.A.1
  • 26
    • 84878746252 scopus 로고    scopus 로고
    • Characterization of lentiviral vector production using microwell suspension cultures of HEK293T-derived producer cells
    • Guy HM, McCloskey L, Lye GJ, Mitrophanous KA, Mukhopadhyay TK. Characterization of lentiviral vector production using microwell suspension cultures of HEK293T-derived producer cells. Hum Gene Ther Methods. 2013;24(2):125-139.
    • (2013) Hum Gene Ther Methods , vol.24 , Issue.2 , pp. 125-139
    • Guy, H.M.1    McCloskey, L.2    Lye, G.J.3    Mitrophanous, K.A.4    Mukhopadhyay, T.K.5
  • 28
    • 67649104033 scopus 로고    scopus 로고
    • What keeps us ticking:Afunny current, a calcium clock, or both?
    • Lakatta EG, DiFrancesco D.What keeps us ticking:Afunny current, a calcium clock, or both? J Mol Cell Cardiol. 2009;47(2):157-170.
    • (2009) J Mol Cell Cardiol , vol.47 , Issue.2 , pp. 157-170
    • Lakatta, E.G.1    Difrancesco, D.2
  • 29
    • 33645985504 scopus 로고    scopus 로고
    • Pacemaker current and automatic rhythms: Toward a molecular understanding
    • Clancy CE, Kass RS, eds. Berlin, Germany: Springer-Verlag
    • Cohen IS, Robinson RB. Pacemaker current and automatic rhythms: Toward a molecular understanding. In: Clancy CE, Kass RS, eds. Basis and Treatment of Cardiac Arrhythmias. Berlin, Germany: Springer-Verlag; 2006:41-72.
    • (2006) Basis and Treatment of Cardiac Arrhythmias , pp. 41-72
    • Cohen, I.S.1    Robinson, R.B.2
  • 30
    • 0012457490 scopus 로고    scopus 로고
    • Hyperpolarization-activated cation currents: From molecules to physiological function
    • Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Ann Rev Physiol. 2003;65:453-480.
    • (2003) Ann Rev Physiol , vol.65 , pp. 453-480
    • Robinson, R.B.1    Siegelbaum, S.A.2
  • 31
    • 33645324479 scopus 로고    scopus 로고
    • High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells
    • Vinogradova TM, Lyashkov AE, Zhu W, et al. High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res. 2006;98(4):505-514.
    • (2006) Circ Res , vol.98 , Issue.4 , pp. 505-514
    • Vinogradova, T.M.1    Lyashkov, A.E.2    Zhu, W.3
  • 32
    • 0024598929 scopus 로고
    • Muscarinic modulation of cardiac rate at low acetylcholine concentrations
    • DiFrancesco D, Ducouret P, Robinson RB. Muscarinic modulation of cardiac rate at low acetylcholine concentrations. Science. 1989;243(4891):669-671.
    • (1989) Science , vol.243 , Issue.4891 , pp. 669-671
    • Difrancesco, D.1    Ducouret, P.2    Robinson, R.B.3
  • 33
    • 77649123846 scopus 로고    scopus 로고
    • The role of the funny current in pacemaker activity
    • DiFrancesco D. The role of the funny current in pacemaker activity. Circ Res. 2010;106(3):434-446.
    • (2010) Circ Res , vol.106 , Issue.3 , pp. 434-446
    • Difrancesco, D.1
  • 34
    • 34547107585 scopus 로고    scopus 로고
    • Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current
    • Mattick P, Parrington J, Odia E, et al. Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current. J Physiol. 2007;582(pt 3):1195-1203.
    • (2007) J Physiol , vol.582 , pp. 1195-1203
    • Mattick, P.1    Parrington, J.2    Odia, E.3
  • 35
    • 47249125756 scopus 로고    scopus 로고
    • Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells
    • Younes A, Lyashkov AE, Graham D, et al. Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells. J Biol Chem. 2008;283(21):14461-14468.
    • (2008) J Biol Chem , vol.283 , Issue.21 , pp. 14461-14468
    • Younes, A.1    Lyashkov, A.E.2    Graham, D.3
  • 36
    • 0037452985 scopus 로고    scopus 로고
    • An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node
    • Maier SK, Westenbroek RE, Yamanushi TT, et al. An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci U S A. 2003;100(6):3507-3512.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.6 , pp. 3507-3512
    • Maier, S.K.1    Westenbroek, R.E.2    Yamanushi, T.T.3
  • 38
    • 0035816618 scopus 로고    scopus 로고
    • HCN2 over-expression in newborn and adult ventricular myocytes: Distinct effects on gating and excitability
    • Qu J, BarbutiA, Protas L, Santoro B, Cohen IS, Robinson RB. HCN2 over-expression in newborn and adult ventricular myocytes: distinct effects on gating and excitability. Circ Res. 2001;89(1):e8-e14.
    • (2001) Circ Res , vol.89 , Issue.1 , pp. e8-e14
    • Qu, J.1    Barbuti, A.2    Protas, L.3    Santoro, B.4    Cohen, I.S.5    Robinson, R.B.6
  • 39
    • 59449088179 scopus 로고    scopus 로고
    • Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium
    • Protas L, DunW, Jia Z, et al. Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium. Cardiovasc Res. 2009;81(3):528-535.
    • (2009) Cardiovasc Res , vol.81 , Issue.3 , pp. 528-535
    • Protas, L.1    Dun, W.2    Jia, Z.3
  • 40
    • 44449156318 scopus 로고    scopus 로고
    • Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer
    • Boink GJ, Verkerk AO, van Amersfoorth SC, et al. Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer. J Gene Med. 2008;10(5):487-497.
    • (2008) J Gene Med , vol.10 , Issue.5 , pp. 487-497
    • Boink, G.J.1    Verkerk, A.O.2    Van Amersfoorth, S.C.3
  • 41
    • 84874864465 scopus 로고    scopus 로고
    • Organ explants culture of neonatal rat ventricles: A new model to study gene and cell therapy
    • den Haan AD, Veldkamp MW, Bakker D, et al. Organ explants culture of neonatal rat ventricles: A new model to study gene and cell therapy. PLoS One. 2013;8(3):e59290.
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e59290
    • Den Haan, A.D.1    Veldkamp, M.W.2    Bakker, D.3
  • 42
    • 77956651346 scopus 로고    scopus 로고
    • Engineering a biological pacemaker: In vivo, in vitro and in silico models
    • Robinson RB. Engineering a biological pacemaker: In vivo, in vitro and in silico models. Drug Discov Today Dis Models. 2009;6(3):93-98.
    • (2009) Drug Discov Today Dis Models , vol.6 , Issue.3 , pp. 93-98
    • Robinson, R.B.1
  • 43
    • 34247590280 scopus 로고    scopus 로고
    • Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria
    • Hoogaars WM, Engel A, Brons JF, et al. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007;21(9):1098-1112.
    • (2007) Genes Dev , vol.21 , Issue.9 , pp. 1098-1112
    • Hoogaars, W.M.1    Engel, A.2    Brons, J.F.3
  • 44
    • 84861354654 scopus 로고    scopus 로고
    • T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells
    • Bakker ML, Boink GJ, Boukens BJ, et al. T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells. Cardiovasc Res. 2012;94(3):439-449.
    • (2012) Cardiovasc Res , vol.94 , Issue.3 , pp. 439-449
    • Bakker, M.L.1    Boink, G.J.2    Boukens, B.J.3
  • 45
    • 84872192083 scopus 로고    scopus 로고
    • Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18
    • Kapoor N, Liang W, Marban E, Cho HC. Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol. 2013;31(1):54-62.
    • (2013) Nat Biotechnol , vol.31 , Issue.1 , pp. 54-62
    • Kapoor, N.1    Liang, W.2    Marban, E.3    Cho, H.C.4
  • 46
    • 0037068468 scopus 로고    scopus 로고
    • Gene therapy: Biological pacemaker created by gene transfer
    • Miake J, Marban E, Nuss HB. Gene therapy: Biological pacemaker created by gene transfer. Nature. 2002;419(6903):132-133.
    • (2002) Nature , vol.419 , Issue.6903 , pp. 132-133
    • Miake, J.1    Marban, E.2    Nuss, H.B.3
  • 47
    • 0037975497 scopus 로고    scopus 로고
    • Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominantnegative suppression
    • Miake J, Marban E, Nuss HB. Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominantnegative suppression. J Clin Invest. 2003;111(10):1529-1536.
    • (2003) J Clin Invest , vol.111 , Issue.10 , pp. 1529-1536
    • Miake, J.1    Marban, E.2    Nuss, H.B.3
  • 48
    • 0031023511 scopus 로고    scopus 로고
    • Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells
    • Robinson RB, Yu H, Chang F, Cohen IS. Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells. Pflugers Arch. 1997;433(4):533-535.
    • (1997) Pflugers Arch , vol.433 , Issue.4 , pp. 533-535
    • Robinson, R.B.1    Yu, H.2    Chang, F.3    Cohen, I.S.4
  • 49
    • 33748479239 scopus 로고    scopus 로고
    • Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker
    • Bucchi A, Plotnikov AN, Shlapakova I, et al. Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker. Circulation. 2006;114(10):992-999.
    • (2006) Circulation , vol.114 , Issue.10 , pp. 992-999
    • Bucchi, A.1    Plotnikov, A.N.2    Shlapakova, I.3
  • 50
    • 63849105634 scopus 로고    scopus 로고
    • In vitro characterization of HCN channel kinetics and frequency-dependence in myocytes predicts biological pacemaker functionality
    • Zhao X, Bucchi A, Oren RV, et al. In vitro characterization of HCN channel kinetics and frequency-dependence in myocytes predicts biological pacemaker functionality. J Physiol. 2009; 587(pt 7):1513-1525.
    • (2009) J Physiol , vol.587 , pp. 1513-1525
    • Zhao, X.1    Bucchi, A.2    Oren, R.V.3
  • 51
    • 34247129909 scopus 로고    scopus 로고
    • Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels
    • Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 2007;115(14):1839-1850.
    • (2007) Circulation , vol.115 , Issue.14 , pp. 1839-1850
    • Xue, T.1    Siu, C.W.2    Lieu, D.K.3    Lau, C.P.4    Tse, H.F.5    Li, R.A.6
  • 52
    • 0037469231 scopus 로고    scopus 로고
    • Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes
    • Er F, Larbig R, Ludwig A, et al. Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes. Circulation. 2003;107(3):485-489.
    • (2003) Circulation , vol.107 , Issue.3 , pp. 485-489
    • Er, F.1    Larbig, R.2    Ludwig, A.3
  • 53
    • 38649111338 scopus 로고    scopus 로고
    • HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with If blockade
    • Plotnikov AN, Bucchi A, Shlapakova I, et al. HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with If blockade. Heart Rhythm. 2008;5(2):282-288.
    • (2008) Heart Rhythm , vol.5 , Issue.2 , pp. 282-288
    • Plotnikov, A.N.1    Bucchi, A.2    Shlapakova, I.3
  • 54
    • 0032518565 scopus 로고    scopus 로고
    • Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA
    • Edelberg JM, Aird WC, Rosenberg RD. Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J Clin Invest. 1998;101(2):337-343.
    • (1998) J Clin Invest , vol.101 , Issue.2 , pp. 337-343
    • Edelberg, J.M.1    Aird, W.C.2    Rosenberg, R.D.3
  • 55
  • 56
    • 77953329702 scopus 로고    scopus 로고
    • Adenylate-Cyclase VI transforms ventricular cardiomyocytes into biological pacemaker cells
    • Ruhparwar A, Kallenbach K, Klein G, et al. Adenylate-Cyclase VI transforms ventricular cardiomyocytes into biological pacemaker cells. Tissue Eng Part A. 2010;16(6):1867-1872.
    • (2010) Tissue Eng Part A , vol.16 , Issue.6 , pp. 1867-1872
    • Ruhparwar, A.1    Kallenbach, K.2    Klein, G.3
  • 57
    • 84860517343 scopus 로고    scopus 로고
    • Ca2+-activated adenylyl cyclase I introduces Ca2+-dependence to b-adrenergic stimulation of HCN2 current
    • Kryukova Y, Protas L, Robinson RB. Ca2+-activated adenylyl cyclase I introduces Ca2+-dependence to b-adrenergic stimulation of HCN2 current. J Mol Cell Cardiol. 2012;52(6):1233-1239.
    • (2012) J Mol Cell Cardiol , vol.52 , Issue.6 , pp. 1233-1239
    • Kryukova, Y.1    Protas, L.2    Robinson, R.B.3
  • 58
    • 0038148777 scopus 로고    scopus 로고
    • If-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells
    • Bucchi A, Baruscotti M, Robinson RB, DiFrancesco D. If-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells. J Mol Cell Cardiol. 2003;35(8):905-913.
    • (2003) J Mol Cell Cardiol , vol.35 , Issue.8 , pp. 905-913
    • Bucchi, A.1    Baruscotti, M.2    Robinson, R.B.3    Difrancesco, D.4
  • 59
    • 0037418162 scopus 로고    scopus 로고
    • Expression and function of a biological pacemaker in canine heart
    • Qu J, Plotnikov AN, Danilo PJ, et al. Expression and function of a biological pacemaker in canine heart. Circulation. 2003;107(8): 1106-1109.
    • (2003) Circulation , vol.107 , Issue.8 , pp. 1106-1109
    • Qu, J.1    Plotnikov, A.N.2    Danilo, P.J.3
  • 60
    • 10744224778 scopus 로고    scopus 로고
    • Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates
    • Plotnikov AN, Sosunov EA, Qu J, et al. Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates. Circulation. 2004;109(4):506-512.
    • (2004) Circulation , vol.109 , Issue.4 , pp. 506-512
    • Plotnikov, A.N.1    Sosunov, E.A.2    Qu, J.3
  • 61
    • 84877127645 scopus 로고    scopus 로고
    • HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates
    • Boink GJ, Duan L, Nearing BD, et al. HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates. J Am Coll Cardiol. 2013;61(11):1192-1201.
    • (2013) J Am Coll Cardiol , vol.61 , Issue.11 , pp. 1192-1201
    • Boink, G.J.1    Duan, L.2    Nearing, B.D.3
  • 62
    • 84864487119 scopus 로고    scopus 로고
    • Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2
    • Boink GJ, Nearing BD, Shlapakova IN, et al. Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2. Circulation. 2012;126(5):528-536.
    • (2012) Circulation , vol.126 , Issue.5 , pp. 528-536
    • Boink, G.J.1    Nearing, B.D.2    Shlapakova, I.N.3
  • 63
    • 33748508208 scopus 로고    scopus 로고
    • Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model
    • Tse HF, Xue T, Lau CP, et al. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation. 2006;114(10):1000-1011.
    • (2006) Circulation , vol.114 , Issue.10 , pp. 1000-1011
    • Tse, H.F.1    Xue, T.2    Lau, C.P.3
  • 64
    • 84864490550 scopus 로고    scopus 로고
    • Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block
    • Cingolani E, Yee K, Shehata M, et al. Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block. Heart Rhythm. 2012;9(8):1310-1318.
    • (2012) Heart Rhythm , vol.9 , Issue.8 , pp. 1310-1318
    • Cingolani, E.1    Yee, K.2    Shehata, M.3
  • 65
    • 60649086907 scopus 로고    scopus 로고
    • Pacemaker activity of the human sinoatrial node: Role of the hyperpolarization-activated current, I(f)
    • Verkerk AO, van Ginneken AC, Wilders R. Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f). Int J Cardiol. 2009;132(3):318-336.
    • (2009) Int J Cardiol , vol.132 , Issue.3 , pp. 318-336
    • Verkerk, A.O.1    Van Ginneken, A.C.2    Wilders, R.3
  • 66
    • 34047252011 scopus 로고    scopus 로고
    • Adenoviral gene transfer of HCN4 creates a genetic pacemaker in pigs with complete atrioventricular block
    • Cai J, Yi FF, Li YH, et al. Adenoviral gene transfer of HCN4 creates a genetic pacemaker in pigs with complete atrioventricular block. Life Sci. 2007;80(19):1746-1753.
    • (2007) Life Sci , vol.80 , Issue.19 , pp. 1746-1753
    • Cai, J.1    Yi, F.F.2    Li, Y.H.3
  • 67
    • 84863781575 scopus 로고    scopus 로고
    • Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy
    • Lu J, Wang HZ, Jia Z, et al. Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy. J Cardiovasc Pharmacol. 2012;60(1):88-99.
    • (2012) J Cardiovasc Pharmacol , vol.60 , Issue.1 , pp. 88-99
    • Lu, J.1    Wang, H.Z.2    Jia, Z.3
  • 69
    • 84867150744 scopus 로고    scopus 로고
    • Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction
    • Boink GJ, Lu J, Driessen HE, et al. Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction. Circ Arrhythm Electrophysiol. 2012; 5(4):831-840.
    • (2012) Circ Arrhythm Electrophysiol , vol.5 , Issue.4 , pp. 831-840
    • Boink, G.J.1    Lu, J.2    Driessen, H.E.3
  • 70
    • 60549094264 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block
    • Yokokawa M, Ohnishi S, Ishibashi-Ueda H, et al. Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block. Cell Transplant. 2008;17(10-11):1145-1155.
    • (2008) Cell Transplant , vol.17 , Issue.10-11 , pp. 1145-1155
    • Yokokawa, M.1    Ohnishi, S.2    Ishibashi-Ueda, H.3
  • 71
    • 27644485078 scopus 로고    scopus 로고
    • Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures
    • Beeres SL, Atsma DE, van der Laarse A, et al. Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures. J Am Coll Cardiol. 2005; 46(10):1943-1952.
    • (2005) J Am Coll Cardiol , vol.46 , Issue.10 , pp. 1943-1952
    • Beeres, S.L.1    Atsma, D.E.2    Van Der Laarse, A.3
  • 72
    • 35648974723 scopus 로고    scopus 로고
    • Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts
    • Pijnappels DA, van TJ, de Vries AA, et al. Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts. Circulation. 2007;116(18): 2018-2028.
    • (2007) Circulation , vol.116 , Issue.18 , pp. 2018-2028
    • Pijnappels, D.A.1    Van, T.J.2    De Vries, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.