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Volumn 8, Issue 11, 2011, Pages 656-666

The road to biological pacing

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; CALCIUM ION; CALMODULIN; CASPASE 3; CD3 ANTIGEN; CONNEXIN 43; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HERMES ANTIGEN; IMMUNOGLOBULIN G; PHOSPHODIESTERASE; POTASSIUM CHANNEL; SODIUM CHANNEL; SODIUM ION;

EID: 80055025823     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2011.120     Document Type: Review
Times cited : (106)

References (75)
  • 3
    • 0017982649 scopus 로고
    • Ionic mechanisms of pacemaker activity in cardiac Purkinje fibers
    • Tsien, R.W. & Carpenter, D.O. Ionic mechanisms of pacemaker activity in cardiac Purkinje fibers. Fed. Proc. 37, 2127-2131 (1978).
    • (1978) Fed. Proc. , vol.37 , pp. 2127-2131
    • Tsien, R.W.1    Carpenter, D.O.2
  • 4
    • 0036021103 scopus 로고    scopus 로고
    • Cardiac HCN channels structure, function, and modulation
    • Biel, M., Schneider, A. & Wahl, C. Cardiac HCN channels structure, function, and modulation. Trends Cardiovasc. Med. 12, 206-212 (2002).
    • (2002) Trends Cardiovasc. Med. , vol.12 , pp. 206-212
    • Biel, M.1    Schneider, A.2    Wahl, C.3
  • 5
    • 33750450141 scopus 로고    scopus 로고
    • Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state
    • DOI 10.1161/01.RES.0000247933.66532.0b, PII 0000301220061027000011
    • Bogdanov, K.Y. et al. Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circ. Res. 99, 979-987 (2006). (Pubitemid 44657801)
    • (2006) Circulation Research , vol.99 , Issue.9 , pp. 979-987
    • Bogdanov, K.Y.1    Maltsev, V.A.2    Vinogradova, T.M.3    Lyashkov, A.E.4    Spurgeon, H.A.5    Stern, M.D.6    Lakatta, E.G.7
  • 6
    • 0019393640 scopus 로고
    • A study of the ionic nature of the pacemaker current in calf Purkinje fibres
    • DiFrancesco, D. A study of the ionic nature of the pacemaker current in calf Purkinje fibres. J. Physiol. 314, 377-393 (1981).
    • (1981) J. Physiol. , vol.314 , pp. 377-393
    • Difrancesco, D.1
  • 7
    • 0025977991 scopus 로고
    • f) to generation of spontaneous activity in rabbit sino-atrial node myocytes
    • f) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J. Physiol. 434, 23-40 (1991).
    • (1991) J. Physiol. , vol.434 , pp. 23-40
    • Difrancesco, D.1
  • 8
    • 77949379471 scopus 로고    scopus 로고
    • A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker
    • Lakatta, E.G., Maltsev, V.A. & Vinogradova, T.M. A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ. Res. 106, 659-673 (2010).
    • (2010) Circ. Res. , vol.106 , pp. 659-673
    • Lakatta, E.G.1    Maltsev, V.A.2    Vinogradova, T.M.3
  • 9
    • 67649104033 scopus 로고    scopus 로고
    • What keeps us ticking: A funny current, a calcium clock, or both?
    • Lakatta, E.G. & DiFrancesco, D. What keeps us ticking: a funny current, a calcium clock, or both? J. Mol. Cell. Cardiol. 47, 157-170 (2009).
    • (2009) J. Mol. Cell. Cardiol. , vol.47 , pp. 157-170
    • Lakatta, E.G.1    Difrancesco, D.2
  • 10
    • 61949243173 scopus 로고    scopus 로고
    • Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation
    • Joung, B. et al. Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation. Circulation 119, 788-796 (2009).
    • (2009) Circulation , vol.119 , pp. 788-796
    • Joung, B.1
  • 11
    • 0012457490 scopus 로고    scopus 로고
    • Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function
    • DOI 10.1146/annurev.physiol.65.092101.142734
    • Robinson, R.B. & Siegelbaum, S.A. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu. Rev. Physiol. 65, 453-480 (2003). (Pubitemid 38249163)
    • (2003) Annual Review of Physiology , vol.65 , pp. 453-480
    • Robinson, R.B.1    Siegelbaum, S.A.2
  • 12
    • 64749110218 scopus 로고    scopus 로고
    • Molecular architecture of the human sinus node: Insights into the function of the cardiac pacemaker
    • Chandler, N.J. et al. Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation 119, 1562-1575 (2009).
    • (2009) Circulation , vol.119 , pp. 1562-1575
    • Chandler, N.J.1
  • 15
    • 0000166139 scopus 로고
    • Cases of diseases of the heart accompanied with pathological observations
    • Adams, R. Cases of diseases of the heart accompanied with pathological observations. Dublin Hospital Reports 4, 353-453 (1827).
    • (1827) Dublin Hospital Reports , vol.4 , pp. 353-453
    • Adams, R.1
  • 16
  • 17
    • 0001422435 scopus 로고
    • Resuscitation of the heart in ventricular standstill by external electric stimulation
    • Zoll, P.M. Resuscitation of the heart in ventricular standstill by external electric stimulation. N. Engl. J. Med. 247, 768-771 (1952).
    • (1952) N. Engl. J. Med. , vol.247 , pp. 768-771
    • Zoll, P.M.1
  • 18
    • 0001290795 scopus 로고
    • An intracardiac pacemaker for Stokes-Adams seizures
    • Furman, S. & Schwedel, J.B. An intracardiac pacemaker for Stokes-Adams seizures. N. Engl. J. Med. 261, 943-947 (1959).
    • (1959) N. Engl. J. Med. , vol.261 , pp. 943-947
    • Furman, S.1    Schwedel, J.B.2
  • 22
    • 0033638599 scopus 로고    scopus 로고
    • Autonomic nervous system-controlled cardiac pacing: A comparison between intracardiac impedance signal and muscle sympathetic nerve activity
    • Binggeli, C. et al. Autonomic nervous system-controlled cardiac pacing: a comparison between intracardiac impedance signal and muscle sympathetic nerve activity. Pacing Clin. Electrophysiol. 23, 1632-1637 (2000).
    • (2000) Pacing Clin. Electrophysiol. , vol.23 , pp. 1632-1637
    • Binggeli, C.1
  • 23
    • 77951934901 scopus 로고    scopus 로고
    • In the wireless era: Leadless pacing
    • Lee, K.L. In the wireless era: leadless pacing. Expert Rev. Cardiovasc. Ther. 8, 171-174 (2010).
    • (2010) Expert Rev. Cardiovasc. Ther. , vol.8 , pp. 171-174
    • Lee, K.L.1
  • 24
    • 4444305851 scopus 로고    scopus 로고
    • Genes, stem cells and biological pacemakers
    • DOI 10.1016/j.cardiores.2004.05.012, PII S0008636304002342
    • Rosen, M.R., Brink, P.R., Cohen, I.S. & Robinson, R.B. Genes, stem cells and biological pacemakers. Cardiovasc. Res. 64, 12-23 (2004). (Pubitemid 39208919)
    • (2004) Cardiovascular Research , vol.64 , Issue.1 , pp. 12-23
    • Rosen, M.R.1    Brink, P.R.2    Cohen, I.S.3    Robinson, R.B.4
  • 25
    • 34447306926 scopus 로고    scopus 로고
    • HCN-encoded pacemaker channels: From physiology and biophysics to bioengineering
    • DOI 10.1007/s00232-006-0881-9
    • Siu, C.W., Lieu, D.K. & Li, R.A. HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J. Membr. Biol. 214, 115-122 (2006). (Pubitemid 47063504)
    • (2006) Journal of Membrane Biology , vol.214 , Issue.3 , pp. 115-122
    • Siu, C.-W.1    Lieu, D.K.2    Li, R.A.3
  • 26
    • 40349092932 scopus 로고    scopus 로고
    • Biological pacemakers as a therapy for cardiac arrhythmias
    • DOI 10.1097/HCO.0b013e3282f30416, PII 0000157320080100000009
    • Marbán, E. & Cho, H.C. Biological pacemakers as a therapy for cardiac arrhythmias. Curr. Opin. Cardiol. 23, 46-54 (2008). (Pubitemid 351339795)
    • (2008) Current Opinion in Cardiology , vol.23 , Issue.1 , pp. 46-54
    • Marban, E.1    Cho, H.C.2
  • 27
    • 80055044502 scopus 로고    scopus 로고
    • Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block [poster PO01-25]
    • Cingolani, E. et al. Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block [poster PO01-25]. Heart Rhythm 8, S112 (2011).
    • (2011) Heart Rhythm , vol.8
    • Cingolani, E.1
  • 29
    • 0035970079 scopus 로고    scopus 로고
    • Gradient model versus mosaic model of the sinoatrial node
    • Zhang, H., Holden, A.V. & Boyett, M.R. Gradient model versus mosaic model of the sinoatrial node. Circulation 103, 584-588 (2001). (Pubitemid 32116245)
    • (2001) Circulation , vol.103 , Issue.4 , pp. 584-588
    • Zhang, H.1    Holden, A.V.2    Boyett, M.R.3
  • 30
    • 33645985504 scopus 로고    scopus 로고
    • Pacemaker current and automatic rhythms: Toward a molecular understanding
    • Cohen, I.S. & Robinson, R.B. Pacemaker current and automatic rhythms: toward a molecular understanding. Handb. Exp. Pharmacol. 171, 41-71 (2006).
    • (2006) Handb. Exp. Pharmacol. , vol.171 , pp. 41-71
    • Cohen, I.S.1    Robinson, R.B.2
  • 31
    • 0035816618 scopus 로고    scopus 로고
    • HCN2 overexpression in newborn and adult ventricular myocytes: Distinct effects on gating and excitability
    • Qu, J. et al. HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitability. Circ. Res. 89, E8-E14 (2001).
    • (2001) Circ. Res. , vol.89
    • Qu, J.1
  • 34
    • 70450218389 scopus 로고    scopus 로고
    • Coupling an HCN2-expressing cell to a myocyte creates a two-cell pacing unit
    • Valiunas, V. et al. Coupling an HCN2-expressing cell to a myocyte creates a two-cell pacing unit. J. Physiol. 587, 5211-5226 (2009).
    • (2009) J. Physiol. , vol.587 , pp. 5211-5226
    • Valiunas, V.1
  • 36
    • 84863116825 scopus 로고    scopus 로고
    • Implantation of sinoatrial node cells into canine right ventricle:biological pacing appears limited by the substrate
    • doi:10.3727/096368911X565038
    • Zhang, H. et al. Implantation of sinoatrial node cells into canine right ventricle:biological pacing appears limited by the substrate. Cell Transplant. doi:10.3727/096368911X565038.
    • Cell Transplant.
    • Zhang, H.1
  • 37
    • 80055033032 scopus 로고
    • Contribution a l'etude de l'automatisme et de la conduction dans le Coeur
    • Rylant, M. Contribution a l'etude de l'automatisme et de la conduction dans le Coeur. Bull. Acad. Med. Belgique 7, 161-200 (1927).
    • (1927) Bull. Acad. Med. Belgique , vol.7 , pp. 161-200
    • Rylant, M.1
  • 38
    • 78651155378 scopus 로고
    • Failure of sino-atrial nodal transplantation for the treatment of experimental complete heart block in dogs
    • Starzl, T.E., Hermann, G., Axtell, H.K., Marchioro, T.L. & Waddell, W.R. Failure of sino-atrial nodal transplantation for the treatment of experimental complete heart block in dogs. J. Thorac. Cardiovasc. Surg. 46, 201-205 (1963).
    • (1963) J. Thorac. Cardiovasc. Surg. , vol.46 , pp. 201-205
    • Starzl, T.E.1    Hermann, G.2    Axtell, H.K.3    Marchioro, T.L.4    Waddell, W.R.5
  • 39
    • 0008024265 scopus 로고
    • Pedicle grafting of the sino-auricular node to the right ventricle for the treatment of complete atrioventricular block
    • Ernst, R.W. Pedicle grafting of the sino-auricular node to the right ventricle for the treatment of complete atrioventricular block. J. Thorac. Surg. 44, 681-698 (1962).
    • (1962) J. Thorac. Surg. , vol.44 , pp. 681-698
    • Ernst, R.W.1
  • 41
    • 0032518565 scopus 로고    scopus 로고
    • 2 adrenergic receptor cDNA
    • Edelberg, J.M., Aird, W.C. & Rosenberg, R.D. Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J. Clin. Invest. 101, 337-343 (1998). (Pubitemid 28067330)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.2 , pp. 337-343
    • Edelberg, J.M.1    Aird, W.C.2    Rosenberg, R.D.3
  • 42
    • 0034773335 scopus 로고    scopus 로고
    • Molecular enhancement of porcine cardiac chronotropy
    • Edelberg, J.M., Huang, D.T., Josephson, M.E. & Rosenberg, R.D. Molecular enhancement of porcine cardiac chronotropy. Heart 86, 559-562 (2001). (Pubitemid 32999871)
    • (2001) Heart , vol.86 , Issue.5 , pp. 559-562
    • Edelberg, J.M.1    Huang, D.T.2    Josephson, M.E.3    Rosenberg, R.D.4
  • 43
    • 0036230245 scopus 로고    scopus 로고
    • Transplanted fet al cardiomyocytes as cardiac pacemaker
    • Ruhpawar, A. et al. Transplanted fet al cardiomyocytes as cardiac pacemaker. Eur. J. Cardiothorac. Surg. 21, 853-857 (2002).
    • (2002) Eur. J. Cardiothorac. Surg. , vol.21 , pp. 853-857
    • Ruhpawar, A.1
  • 44
    • 77953329702 scopus 로고    scopus 로고
    • Adenylate-cyclase VI transforms ventricular cardiomyocytes into biological pacemaker cells
    • Ruhparwar, A. et al. Adenylate-cyclase VI transforms ventricular cardiomyocytes into biological pacemaker cells. Tissue Eng. Part A 16, 1867-1872 (2010).
    • (2010) Tissue Eng. Part A , vol.16 , pp. 1867-1872
    • Ruhparwar, A.1
  • 46
    • 47249125756 scopus 로고    scopus 로고
    • Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells
    • Younes, A. et al. Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells. J. Biol. Chem. 283, 14461-14468 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 14461-14468
    • Younes, A.1
  • 47
    • 84857189410 scopus 로고    scopus 로고
    • A key role of Ca2+-activated adenylyl cyclase i in Ca2+-dependence of β-adrenergic modulation of pacemaker current [abstract 2330]
    • Kryukova, Y. & Robinson, R.B. A key role of Ca2+-activated adenylyl cyclase I in Ca2+-dependence of β-adrenergic modulation of pacemaker current [abstract 2330]. Circulation 120, S625 (2009).
    • (2009) Circulation , vol.120
    • Kryukova, Y.1    Robinson, R.B.2
  • 48
    • 80055056395 scopus 로고    scopus 로고
    • Introducing the Ca2+-stimulated adenylyl cyclase AC1 into HCN2-based biological pacemakers enhances their function [abstractA16415]
    • Boink, G.J. et al. Introducing the Ca2+-stimulated adenylyl cyclase AC1 into HCN2-based biological pacemakers enhances their function [abstractA16415]. Circulation 122, A16415 (2010).
    • (2010) Circulation , vol.122
    • Boink, G.J.1
  • 49
    • 0037068468 scopus 로고    scopus 로고
    • Gene therapy: Biological pacemaker created by gene transfer
    • Miake, J., Marbán, E., Nuss, H.B. Biological pacemaker created by gene transfer. Nature 419, 132-133 (2002). (Pubitemid 35025436)
    • (2002) Nature , vol.419 , Issue.6903 , pp. 132-133
    • Miake, J.1    Marban, E.2    Nuss, H.B.3
  • 50
    • 0037975497 scopus 로고    scopus 로고
    • Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression
    • DOI 10.1172/JCI200317959
    • Miake, J., Marbán, E. & Nuss, H.B. Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative-suppression. J. Clin. Invest. 111, 1529-1536 (2003). (Pubitemid 38063285)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.10 , pp. 1529-1536
    • Miake, J.1    Marban, E.2    Nuss, H.B.3
  • 53
    • 33748508208 scopus 로고    scopus 로고
    • Bioartificial sinus node constructed via invivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model
    • Tse, H.F. et al. Bioartificial sinus node constructed via invivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation 114, 1000-1011 (2006).
    • (2006) Circulation , vol.114 , pp. 1000-1011
    • Tse, H.F.1
  • 54
    • 38649111338 scopus 로고    scopus 로고
    • HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade
    • Plotnikov, A.N. et al. HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade. Heart Rhythm 5, 282-288 (2008).
    • (2008) Heart Rhythm , vol.5 , pp. 282-288
    • Plotnikov, A.N.1
  • 56
    • 59049091825 scopus 로고    scopus 로고
    • Epicardial border zone overexpression of skelet al muscle sodium channel, SkM1, normalizes activation, preserves conduction and suppresses ventricular arrhythmia: An insilico, invivo, invitro study
    • Lau, D.H. et al. Epicardial border zone overexpression of skelet al muscle sodium channel, SkM1, normalizes activation, preserves conduction and suppresses ventricular arrhythmia: an insilico, invivo, invitro study. Circulation 119, 19-27 (2009).
    • (2009) Circulation , vol.119 , pp. 19-27
    • Lau, D.H.1
  • 57
    • 59449088179 scopus 로고    scopus 로고
    • Expression of skelet al but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium
    • Protas, L. et al. Expression of skelet al but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium. Cardiovasc. Res. 81, 528-535 (2009).
    • (2009) Cardiovasc. Res. , vol.81 , pp. 528-535
    • Protas, L.1
  • 58
    • 77956880792 scopus 로고    scopus 로고
    • Cardiac expression of skelet al muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction
    • Coronel, R. et al. Cardiac expression of skelet al muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction. Heart Rhythm 7, 1104-1110 (2010).
    • (2010) Heart Rhythm , vol.7 , pp. 1104-1110
    • Coronel, R.1
  • 59
    • 80055049233 scopus 로고    scopus 로고
    • HCN2/SkM1 gene transfer into the canine left bundle branch induces highly stable biological pacing at physiological beating rates [abstract AB24-2]
    • Boink, G.J. et al. HCN2/SkM1 gene transfer into the canine left bundle branch induces highly stable biological pacing at physiological beating rates [abstract AB24-2]. Heart Rhythm 8, S54 (2011).
    • (2011) Heart Rhythm , vol.8
    • Boink, G.J.1
  • 60
    • 33750203720 scopus 로고    scopus 로고
    • Gene transfer of a synthetic pacemaker channel into the heart: A novel strategy for biological pacing
    • DOI 10.1161/CIRCULATIONAHA.106.634865, PII 0000301720061017000006
    • Kashiwakura, Y., Cho, H.C., Barth, A.S., Azene, E. & Marbán, E. Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing. Circulation 114, 1682-1686 (2006). (Pubitemid 44607115)
    • (2006) Circulation , vol.114 , Issue.16 , pp. 1682-1686
    • Kashiwakura, Y.1    Cho, H.C.2    Barth, A.S.3    Azene, E.4    Marban, E.5
  • 62
    • 61949300076 scopus 로고    scopus 로고
    • Functional cardiomyocytes derived from human induced pluripotent stem cells
    • Zhang, J. et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ. Res. 104, e30-e41 (2009).
    • (2009) Circ. Res. , vol.104
    • Zhang, J.1
  • 63
    • 78649521024 scopus 로고    scopus 로고
    • Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus
    • Novak, A. et al. Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus. Cell Reprogram. 12, 665-678 (2010).
    • (2010) Cell Reprogram. , vol.12 , pp. 665-678
    • Novak, A.1
  • 64
    • 79952273710 scopus 로고    scopus 로고
    • Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy
    • Efe, J.E. et al. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat. Cell Biol. 13, 215-222 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 215-222
    • Efe, J.E.1
  • 65
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren, L. et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618-630 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1
  • 66
    • 77955321344 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    • Leda, M. et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375-386 (2010).
    • (2010) Cell , vol.142 , pp. 375-386
    • Leda, M.1
  • 67
    • 79957855295 scopus 로고    scopus 로고
    • Induced pluripotent stem cells-a cautionary note
    • Mummery, C. Induced pluripotent stem cells-a cautionary note. N. Engl. J. Med. 364, 2160-2162 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2160-2162
    • Mummery, C.1
  • 68
    • 79952261648 scopus 로고    scopus 로고
    • Stem cells: The dark side of induced pluripotency
    • Pera, M.F. Stem cells: the dark side of induced pluripotency. Nature 471, 46-47 (2011).
    • (2011) Nature , vol.471 , pp. 46-47
    • Pera, M.F.1
  • 69
    • 78650178537 scopus 로고    scopus 로고
    • Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal
    • Shlapakova, I.N. et al. Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal. Heart Rhythm 7, 1835-1840 (2010).
    • (2010) Heart Rhythm , vol.7 , pp. 1835-1840
    • Shlapakova, I.N.1
  • 70
    • 34247590394 scopus 로고    scopus 로고
    • Creation of a biological pacemaker by cell fusion
    • DOI 10.1161/01.RES.0000265845.04439.78, PII 0000301220070427000005
    • Cho, H.C., Kashiwakura, Y. & Marbán, E. Creation of a biological pacemaker by cell fusion. Circ. Res. 100, 1112-1115 (2007). (Pubitemid 46684124)
    • (2007) Circulation Research , vol.100 , Issue.8 , pp. 1112-1115
    • Cho, H.C.1    Kashiwakura, Y.2    Marban, E.3
  • 71
    • 23044470376 scopus 로고    scopus 로고
    • Methods for examining stem cells in post-ischemic and transplanted hearts
    • Rezai, N. et al. Methods for examining stem cells in post-ischemic and transplanted hearts. Methods Mol. Med. 112, 223-238 (2005).
    • (2005) Methods Mol. Med. , vol.112 , pp. 223-238
    • Rezai, N.1
  • 72
    • 78650491628 scopus 로고    scopus 로고
    • Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential
    • Proulx, M.K. et al. Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential. J. Biomed. Mater. Res. A. 96, 301-312 (2011).
    • (2011) J. Biomed. Mater. Res. A. , vol.96 , pp. 301-312
    • Proulx, M.K.1
  • 75
    • 80055042892 scopus 로고
    • Climbing mount everest is work for supermen
    • 18 March
    • Climbing Mount Everest is work for supermen. New York Times (18 March 1923).
    • (1923) New York Times


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.