HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with If blockade

Heart Rhythm

Volumn 5, Issue 2, 2008, Pages 282-288

  Plotnikov, Alexei N ^a   Bucchi, Annalisa ^a   Shlapakova, Iryna ^a   Danilo Jr , Peter ^a   Brink, Peter R ^b   Robinson, Richard B ^a   Cohen, Ira S ^a,b   Rosen, Michael R ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Biological pacemaking; Cardiac ion channels; Electronic pacemakers; HCN channel chimeras; Ivabradine; Ventricular tachycardia

Indexed keywords

ADENOVIRUS VECTOR; ION CHANNEL; IVABRADINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL HEART PACEMAKER; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; COMPLETE HEART BLOCK; CONTROLLED STUDY; DOG; DRUG EFFECT; ELECTROCARDIOGRAM; GENE CONSTRUCT; HEART MUSCLE CELL; HEART VENTRICLE TACHYCARDIA; HOLTER MONITORING; HUMAN; HUMAN CELL; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; RAT; SINUS RHYTHM; STEADY STATE;

ANIMALS; BENZAZEPINES; CALCIUM CHANNELS; CARDIAC PACING, ARTIFICIAL; CARDIOVASCULAR AGENTS; CATHETER ABLATION; DEFIBRILLATORS, IMPLANTABLE; DOGS; ELECTROPHYSIOLOGY; MALE; MUSCLE CELLS; RATS; RISK FACTORS; TACHYCARDIA, VENTRICULAR;

EID: 38649111338     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2007.09.028     Document Type: Article

References (31)

1. 2-adrenergic receptor cDNA. J Clin Invest 101 (1998) 337-343
2. Edelberg J.M., Huang D.T., Josephson M.E., et al. Molecular enhancement of porcine cardiac chronotropy. Heart 86 (2001) 559-562
3. Miake J., Marbán E., and Nuss H.B. Gene therapy: biological pacemaker created by gene transfer. Nature 419 (2002) 132-133
4. Kehat I., Khimovich L., Caspi O., et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22 (2004) 1282-1289
5. Tse H.F., Xue T., Lau C.P., et al. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation 114 (2006) 1000-1011
6. Qu J., Plotnikov A.N., Danilo Jr. P., et al. Expression and function of a biological pacemaker in canine heart. Circulation 107 (2003) 1106-1109
7. Plotnikov A.N., Sosunov E.A., Qu J., et al. Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates. Circulation 109 (2004) 506-512
8. Bucchi A., Plotnikov A.N., Shlapakova I., et al. Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker. Circulation 114 (2006) 992-999
9. Potapova I., Plotnikov A., Lu Z., et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ Res 94 (2004) 952-959
10. Plotnikov A.P., Shlapakova I., Szabolcs M.J., et al. Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart. Circulation 116 (2007) 706-713
11. Bois P., Bescond J., Renaudon B., et al. Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br J Pharmacol 118 (1996) 1051-1057
12. Thollon C., Bedut S., Villeneuve N., et al. Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity. Br J Pharmacol 150 (2007) 37-46
13. Bucchi A., Tognati A., Milanesi R., et al. Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. J Physiol 572 (2006) 335-346
14. 2-Adrenergic receptor actions in neonatal and adult rat ventricular myocytes. Circ Res 76 (1995) 40-52
15. Ellingsen O., Davidoff A.J., Prasad S.K., et al. Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function. Am J Physiol 265 (1993) H747-H754
16. Qu J., Barbuti A., Protas L., et al. HCN2 over-expression in newborn and adult ventricular myocytes: distinct effects on gating and excitability. Circ Res 89 (2001) e8-e14
17. Wang J., Chen S., and Siegelbaum S.A. Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. J Gen Physiol 118 (2001) 237-250
18. f channels by ivabradine. J Gen Physiol 120 (2002) 1-13
19. DiFrancesco D., and Camm J.A. Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs 64 (2004) 1757-1765
20. f inhibitor, in stable angina. A randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107 (2003) 817-823
21. DiFrancesco D. Block and activation of the pace-maker channel in calf Purkinje fibres: effects of potassium, caesium and rubidium. J Physiol 329 (1982) 485-507
22. DiFrancesco D. Pacemaker mechanisms in cardiac tissue. Ann Rev Physiol 55 (1993) 455-472
23. Cohen I.S., and Robinson R.B. Pacemaker current and automatic rhythms: toward a molecular understanding. Handb Exp Pharmacol 171 (2006) 41-71
24. 2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circ Res 99 (2006) 979-987
25. Lyashkov A.E., Juhaszova M., Dobrzynski H., et al. Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size. Circ Res 100 (2007) 1723-1731
26. Cabo C., and Wit A.L. Cellular electrophysiologic mechanisms of cardiac arrhythmias. Cardiol Clin 15 (1997) 517-538
27. Olshansky B., Okumura K., Hess P.G., et al. Demonstration of an area of slow conduction in human atrial flutter. J Am Coll Cardiol 16 (1990) 1639-1648
28. Waldo A.L., Plumb V.J., Arciniegas J.G., et al. Transient entrainment and interruption of the atrioventricular bypass pathway type of paroxysmal atrial tachycardia. A model for understanding and identifying reentrant arrhythmias. Circulation 67 (1983) 73-83
29. Kowey P.R., Waxman H.L., Greenspon A., et al. Value of electrophysiologic testing in patients with previous myocardial infarction and nonsustained ventricular tachycardia. Philadelphia Arrhythmia Group. Am J Cardiol 65 (1990) 594-598
30. Iwai S., Markowitz S.M., Stein K.M., et al. Response to adenosine differentiates focal from macroreentrant atrial tachycardia: validation using three-dimensional electroanatomic mapping. Circulation 106 (2002) 2793-2799
31. Vos M.A., Gorgels A.P., Leunissen J.D., et al. Further observations to confirm the arrhythmia mechanism-specific effects of flunarizine. J Cardiovasc Pharmacol 19 (1992) 682-690