Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model

Circulation

Volumn 114, Issue 10, 2006, Pages 1000-1011

  Tse, Hung Fat ^a   Xue, Tian ^c,d   Lau, Chu Pak ^a   Siu, Chung Wah ^a,c   Wang, Kai ^a   Zhang, Qing Yong ^a   Tomaselli, Gordon F ^b   Akar, Fadi G ^b   Li, Ronald A ^a,c,d,e  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SHRINERS HOSPITALS FOR CHILDREN NORTHERN CALIFORNIA   (United States)

Author keywords

Engineering; Ion channels; Pacemakers; Sinoatrial node; Therapy

Indexed keywords

ADENOVIRUS VECTOR; CATECHOLAMINE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; ION CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL HEART PACEMAKER; BIOARTIFICIAL ORGAN; CONTROLLED STUDY; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; GENE MAPPING; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC ENGINEERING; GUINEA PIG; HEART ARRHYTHMIA; HEART AUTOMATICITY; HEART CONDUCTION; HEART MUSCLE CELL; HEART RHYTHM; NONHUMAN; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; SICK SINUS SYNDROME; SINUS NODE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ARRHYTHMIA; BIOARTIFICIAL ORGANS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; GENE TRANSFER TECHNIQUES; GUINEA PIGS; HEART RATE; ION CHANNELS; MICE; PACEMAKER, ARTIFICIAL; SICK SINUS SYNDROME; SINOATRIAL NODE; SWINE; SWINE, MINIATURE;

EID: 33748508208     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.615385     Document Type: Article

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