HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates

Journal of the American College of Cardiology

Volumn 61, Issue 11, 2013, Pages 1192-1201

  Boink, Gerard J J ^a,b,c   Duan, Lian ^a,d,e   Nearing, Bruce D ^f   Shlapakova, Iryna N ^a   Sosunov, Eugene A ^a   Anyukhovsky, Evgeny P ^a   Bobkov, Eugene ^a   Kryukova, Yelena ^a   Ozgen, Nazira ^a   Danilo, Peter ^a   Cohen, Ira S ^g   Verrier, Richard L ^d,f   Robinson, Richard B ^a   Rosen, Michael R ^a,g  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d CHINESE PLA GENERAL HOSPITAL   (China)

^e SECOND MILITARY MEDICAL UNIVERSITY   (China)

^f HARVARD MEDICAL SCHOOL   (United States)

^g STONY BROOK UNIVERSITY   (United States)

Author keywords

Gene therapy; HCN channels; Heart block; Pacemakers; Sodium channels

Indexed keywords

ADENOVIRUS VECTOR; ADRENALIN; CARDIOVASCULAR AGENT; GREEN FLUORESCENT PROTEIN; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; SKELETAL MUSCLE SODIUM CHANNEL 1; UNCLASSIFIED DRUG; HCN2 POTASSIUM CHANNEL; ION CHANNEL; MUSCLE PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; GENE CONSTRUCT; GENE OVEREXPRESSION; GENE TRANSFER; HEART; HEART LEFT BUNDLE BRANCH; HEART MUSCLE POTENTIAL; HEART PACING; HEART RATE; HEART RHYTHM; IN VIVO STUDY; MONGREL DOG; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SINUS NODE; VENTRICULAR PACEMAKER; ANIMAL; DOG; GENETICS; HEART MUSCLE CONDUCTION SYSTEM; PHYSIOLOGY;

ANIMALS; DOGS; GENE TRANSFER TECHNIQUES; HEART CONDUCTION SYSTEM; HEART RATE; ION CHANNELS; MUSCLE PROTEINS;

MLCS; MLOWN;

EID: 84877127645     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.12.031     Document Type: Article

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