Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium

Cardiovascular Research

Volumn 81, Issue 3, 2009, Pages 528-535

  Protas, Lev ^a   Dun, Wen ^a   Jia, Zhiheng ^c   Lu, Jia ^b   Bucchi, Annalisa ^a   Kumari, Sindhu ^b   Chen, Ming ^a   Cohen, Ira S ^b,c   Rosen, Michael R ^a   Entcheva, Emilia ^b,c   Robinson, Richard B ^a  

^a Columbia University ^*  (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Arrhythmia; Conduction; Gene therapy; Mapping; Na+ channel

Indexed keywords

POTASSIUM ION; SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; ELECTROPHYSIOLOGY; GENE THERAPY; HEART CONDUCTION; HEART DEPOLARIZATION; HEART EXCITATION; MEMBRANE DEPOLARIZATION; MUSCLE FIBER CULTURE; NEWBORN; NEWBORN PERIOD; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT; REENTRY ARRHYTHMIA; SYNCYTIUM;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; ARRHYTHMIAS, CARDIAC; CELLS, CULTURED; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEART VENTRICLES; HUMANS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUTAGENESIS, SITE-DIRECTED; MYOCYTES, CARDIAC; POINT MUTATION; POTASSIUM; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; TIME FACTORS;

EID: 59449088179     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn290     Document Type: Article

References (29)

1. Allessie MA, Boyden PA, Camm AJ, Kleber AG, Lab MJ, Legato MJ et al. Pathophysiology and prevention of atrial fibrillation. Circulation 2001;103:769-777.
2. Wit AL, Janse MJ. The Ventricular Arrhythmias of Ischemia and Infarction, Electrophysiological Mechanisms. Mt. Kisco, Futura Publishing; 1993.
3. Rosen MR, Brink PR, Cohen IS, Danilo P Jr, Robinson RB, Rosen AB et al. Regenerative therapies in electrophysiology and pacing. J Interv Card Electrophysiol 2008;22:87-98.
4. Pinto JM, Boyden PA. Electrical remodeling in ischemia and infarction. Cardiovasc Res 1999;42:284-297.
5. Wasson S, Reddy HK, Dohrmann ML. Current perspectives of electrical remodeling and its therapeutic implications. J Cardiovasc Pharmacol Ther 2004;9:129-144.
6. Baba S, Dun W, Cabo C, Boyden PA. Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia. Circulation 2005;112:2386-2396.
7. Spear JF, Michelson EL, Moore EN. Cellular electrophysiologic characteristics of chronically infarcted myocardium in dogs susceptible to sustained ventricular tachyarrhythmias. J Am Coll Cardiol 1983;1:1099-1110.
8. Zhang Y, Hartmann HA, Satin J. Glycosylation influences voltage-dependent gating of cardiac and skeletal muscle sodium channels. J Membr Biol 1999;171:195-207.
9. Bennett ES. Channel activation voltage alone is directly altered in an isoform-specific manner by Na(v1.4) and Na(v1.5) cytoplasmic linkers. J Membr Biol 2004;197:155-168.
10. Ca,L via ventricular Y2 receptors. Am J Physiol 1999;277:H940-H946.
11. Yin L, Bien H, Entcheva E. Scaffold topography alters intracellular calcium dynamics in cultured cardiomyocyte networks. Am J Physiol Heart Circ Physiol 2004;287:H1276-H1285.
12. Satin J, Kyle JW, Chen M, Bell P, Cribbs LL, Fozzard HA et al. A mutant of TTX-resistant cardiac sodium channels with TTX- sensitive properties. Science 1992;256:1202-1205.
13. Qu J, Barbuti A, Protas L, Santoro B, Cohen IS, Robinson RB. HCN2 overexpression in newborn adult ventricular myocytes: distinct effects on gating excitability. Circ Res 2001;89:e8-e14.
14. Meiry G, Reisner Y, Feld Y, Goldberg S, Rosen M, Ziv N et al. Evolution of action potential propagation and repolarization in cultured neonatal rat ventricular myocytes. J Cardiovasc Electrophysiol 2001;12:1269-1277.
15. Binah O, Dolnikov K, Sadan O, Shilkrut M, Zeevi-Levin N, Amit M et al. Functional and developmental properties of human embryonic stem cells-derived cardiomyocytes. J Electrocardiol 2007;40:S192-S196.
16. Bien H, Yin L, Entcheva E. Calcium instabilities in mammalian cardiomyocyte networks. Biophys J 2006;90:2628-2640.
17. Chung CY, Bien H, Entcheva E. The role of cardiac tissue alignment in modulating electrical function. J Cardiovasc Electrophysiol 2007;18:1323-1329.
18. Entcheva E, Bien H. Macroscopic optical mapping of excitation in cardiac cell networks with ultra-high spatiotemporal resolution. Prog Biophys Mol Biol 2006;92:232-257.
19. Robinson RB. Action potential characteristics of rat cardiac cells do not change with time in culture. J Mol Cell Cardiol 1982;14:367-370.
20. Zhang JF, Robinson RB, Siegelbaum SA. Sympathetic neurons mediate developmental change in cardiac sodium channel gating through long-term neurotransmitter action. Neuron 1992;9:97-103.
21. Robinson RB, Legato MJ. Maintained differentiation in rat cardiac monolayer cultures: Tetrodotoxin sensitivity and ultrastructure. J Mol Cell Cardiol 1980;12:493-498.
22. Schanne OF, Ruiz-Ceretti E, Rivard C, Chartier D. Determinants of electrical activity in clusters of cultured cardiac cells from neonatal rats. J Mol Cell Cardiol 1977;9:269-283.
23. Max, normalizes activation and is antiarrhyhmic. (Abstract). Heart Rhythm 2008;5:S115.
24. Filatov GN, Pinter MJ, Rich MM. Resting potential-dependent regulation of the voltage sensitivity of sodium channel gating in rat skeletal muscle in vivo. J Gen Physiol 2005;126:161-172.
25. Ji S, Sun W, George AL Jr, Horn R, Barchi RL. Voltage-dependent regulation of modal gating in the rat SkM1 sodium channel expressed in Xenopus oocytes. J Gen Physiol 1994;104:625-643.
26. Nattel S, Shiroshita-Takeshita A, Brundel BJ, Rivard L. Mechanisms of atrial fibrillation: lessons from animal models. Prog Cardiovasc Dis 2005;48:9-28.
27. The Sicilian gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. Circulation 1991;84:1831-1851.
28. Reddy VY, Reynolds MR, Neuzil P, Richardson AW, Taborsky M, Jongnarangsin K et al. Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med 2007;357:2657-2665.
29. Peters NS, Coromilas J, Severs NJ, Wit AL. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation 1997;95:988-996.