SCOPUS 정보 검색 플랫폼

Volumn 12, Issue 39, 2014, Pages 7659-7672

Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification

(3) Sahn, James J a Granger, Brett A a Martin, Stephen F a

a University of Texas at Austin (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIZATIONS; MULTICOMPONENT ASSEMBLY; SMALL MOLECULES;

MOLECULAR LIBRARY; ORGANIC COMPOUND;

CATALYSIS; CHEMISTRY; CYCLIZATION; HUMAN; MOLECULAR LIBRARY;

CATALYSIS; CYCLIZATION; HUMANS; ORGANIC CHEMICALS; SMALL MOLECULE LIBRARIES;

EID: 84907880518 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/c4ob00835a Document Type: Article

Times cited : (43)

References (128)

1
- 84885003207
- Solid phase peptide synthesis was first reported in 1963
- D. M. Huryn L. O. Resnick P. Wipf J. Med. Chem. 2013 56 7161 7176
- (2013) J. Med. Chem. , vol.56 , pp. 7161-7176
- Huryn, D.M.¹ Resnick, L.O.² Wipf, P.³

2
- 20744456789
- R. B. Merrifield J. Am. Chem. Soc. 1963 85 2149 2154
- (1963) J. Am. Chem. Soc. , vol.85 , pp. 2149-2154
- Merrifield, R.B.¹

3
- 0022699646
- R. B. Merrifield Science 1986 232 341 347
- (1986) Science , vol.232 , pp. 341-347
- Merrifield, R.B.¹

4
- 0025893762
- A. Furka Int. J. Pept. Protein Res. 1991 37 487
- (1991) Int. J. Pept. Protein Res. , vol.37 , pp. 487
- Furka, A.¹

5
- 0026419328
- K. S. Lam S. E. Salmon E. M. Hersh V. J. Hruby W. M. Kazmierski R. J. Knapp Nature 1991 354 82 84
- (1991) Nature , vol.354 , pp. 82-84
- Lam, K.S.¹ Salmon, S.E.² Hersh, E.M.³ Hruby, V.J.⁴ Kazmierski, W.M.⁵ Knapp, R.J.⁶

6
- 42949160050
- D. J. Newman J. Med. Chem. 2008 51 2589 2599
- (2008) J. Med. Chem. , vol.51 , pp. 2589-2599
- Newman, D.J.¹

7
- 77952477596
- M. E. Welsch S. A. Snyder B. R. Stockwell Curr. Opin. Chem. Biol. 2010 14 347 361
- (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 347-361
- Welsch, M.E.¹ Snyder, S.A.² Stockwell, B.R.³

8
- 0035289779
- C. A. Lipinski F. Lombardo B. W. Dominy P. J. Feeney Adv. Drug Delivery Rev. 2001 46 3 26
- (2001) Adv. Drug Delivery Rev. , vol.46 , pp. 3-26
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

9
- 0037030653
- D. F. Veber S. R. Johnson H. Y. Cheng B. R. Smith K. W. Ward K. D. Kopple J. Med. Chem. 2002 45 2615 2623
- (2002) J. Med. Chem. , vol.45 , pp. 2615-2623
- Veber, D.F.¹ Johnson, S.R.² Cheng, H.Y.³ Smith, B.R.⁴ Ward, K.W.⁵ Kopple, K.D.⁶

10
- 0012115005
- K. Watkins Chem. Eng. News 2001 79 30 42
- (2001) Chem. Eng. News , vol.79 , pp. 30-42
- Watkins, K.¹

11
- 71049126548
- F. Lovering J. Bikker C. Humblet J. Med. Chem. 2009 52 6752 6756
- (2009) J. Med. Chem. , vol.52 , pp. 6752-6756
- Lovering, F.¹ Bikker, J.² Humblet, C.³

12
- 60749120878
- J. D. Sunderhaus S. F. Martin Chem.-Eur. J. 2009 15 1300 1308
- (2009) Chem.-Eur. J. , vol.15 , pp. 1300-1308
- Sunderhaus, J.D.¹ Martin, S.F.²

13
- 14944383798
- F. E. Koehn G. T. Carter Nat. Rev. Drug Discovery 2005 4 206 220
- (2005) Nat. Rev. Drug Discovery , vol.4 , pp. 206-220
- Koehn, F.E.¹ Carter, G.T.²

14
- 4544233786
- C. Gaul J. T. Njardarson D. Shan D. C. Dorn K. D. Wu W. P. Tong X. Y. Huang M. A. Moore S. J. Danishefsky J. Am. Chem. Soc. 2004 126 11326 11337
- (2004) J. Am. Chem. Soc. , vol.126 , pp. 11326-11337
- Gaul, C.¹ Njardarson, J.T.² Shan, D.³ Dorn, D.C.⁴ Wu, K.D.⁵ Tong, W.P.⁶ Huang, X.Y.⁷ Moore, M.A.⁸ Danishefsky, S.J.⁹

15
- 42449139634
- M. Kaiser S. Wetzel K. Kumar H. Waldmann Cell Mol. Life Sci. 2008 65 1186 1201
- (2008) Cell Mol. Life Sci. , vol.65 , pp. 1186-1201
- Kaiser, M.¹ Wetzel, S.² Kumar, K.³ Waldmann, H.⁴

16
- 80855156740
- S. Wetzel R. S. Bon K. Kumar H. Waldmann Angew. Chem., Int. Ed. 2011 50 10800 10826
- (2011) Angew. Chem., Int. Ed. , vol.50 , pp. 10800-10826
- Wetzel, S.¹ Bon, R.S.² Kumar, K.³ Waldmann, H.⁴

17
- 3042799070
- M. D. Burke S. L. Schreiber Angew. Chem., Int. Ed. 2004 43 46 58
- (2004) Angew. Chem., Int. Ed. , vol.43 , pp. 46-58
- Burke, M.D.¹ Schreiber, S.L.²

18
- 0024239320
- For examples of natural product-like and drug-like compounds prepared by DOS, see
- B. E. Evans K. E. Rittle M. G. Bock R. M. DiPardo R. M. Freidinger W. L. Whitter G. F. Lundell D. F. Veber P. S. Anderson R. S. Chang et al. J. Med. Chem. 1988 31 2235 2246
- (1988) J. Med. Chem. , vol.31 , pp. 2235-2246
- Evans, B.E.¹ Rittle, K.E.² Bock, M.G.³ Dipardo, R.M.⁴ Freidinger, R.M.⁵ Whitter, W.L.⁶ Lundell, G.F.⁷ Veber, D.F.⁸ Anderson, P.S.⁹ Chang, R.S.¹⁰

19
- 0742304177
- I. S. Young M. A. Kerr Org. Lett. 2004 6 139 141
- (2004) Org. Lett. , vol.6 , pp. 139-141
- Young, I.S.¹ Kerr, M.A.²

20
- 8744279305
- L. A. Wessjohann E. Ruijter Top. Curr. Chem. 2005 243 137 184
- (2005) Top. Curr. Chem. , vol.243 , pp. 137-184
- Wessjohann, L.A.¹ Ruijter, E.²

21
- 48149108752
- For examples of lead compounds discovered through BIOS, see
- C. Cordier D. Morton S. Murrison A. Nelson C. O'Leary-Steele Nat. Prod. Rep. 2008 25 719 737
- (2008) Nat. Prod. Rep. , vol.25 , pp. 719-737
- Cordier, C.¹ Morton, D.² Murrison, S.³ Nelson, A.⁴ O'Leary-Steele, C.⁵

22
- 33746047675
- For examples of lead compounds identified via DOS, see
- A. Nören-Müller I. Reis-Corrêa H. Prinz C. Rosenbaum K. Saxena H. J. Schwalbe D. Vestweber G. Cagna S. Schunk O. Schwarz H. Schiewe H. Waldmann Proc. Natl. Acad. Sci. U. S. A. 2006 103 10606 10611
- (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 10606-10611
- Nören-Müller, A.¹ Reis-Corrêa, I.² Prinz, H.³ Rosenbaum, C.⁴ Saxena, K.⁵ Schwalbe, H.J.⁶ Vestweber, D.⁷ Cagna, G.⁸ Schunk, S.⁹ Schwarz, O.¹⁰ Schiewe, H.¹¹ Waldmann, H.¹²

23
- 33644839988
- D. S. Tan Nat. Chem. Biol. 2005 1 74 84
- (2005) Nat. Chem. Biol. , vol.1 , pp. 74-84
- Tan, D.S.¹

24
- 84863143111
- R. W. Heidebrecht Jr. C. Mulrooney C. P. Austin R. H. Barker Jr. J. A. Beaudoin K. C. Cheng E. Comer S. Dandapani J. Dick J. R. Duvall E. H. Ekland D. A. Fidock M. E. Fitzgerald M. Foley R. Guha P. Hinkson M. Kramer A. K. Lukens D. Masi L. A. Marcaurelle X. Z. Su C. J. Thomas M. Weiwer R. C. Wiegand D. Wirth M. Xia J. Yuan J. Zhao M. Palmer B. Munoz S. Schreiber ACS Med. Chem. Lett. 2012 3 112 117
- (2012) ACS Med. Chem. Lett. , vol.3 , pp. 112-117
- Heidebrecht, R.W.¹ Mulrooney, C.² Austin, C.P.³ Barker, R.H.⁴ Beaudoin, J.A.⁵ Cheng, K.C.⁶ Comer, E.⁷ Dandapani, S.⁸ Dick, J.⁹ Duvall, J.R.¹⁰ Ekland, E.H.¹¹ Fidock, D.A.¹² Fitzgerald, M.E.¹³ Foley, M.¹⁴ Guha, R.¹⁵ Hinkson, P.¹⁶ Kramer, M.¹⁷ Lukens, A.K.¹⁸ Masi, D.¹⁹ Marcaurelle, L.A.²⁰ more..

25
- 84890597202
- Wiley-VCH, Wienheim, For some recent reviews of MCRs, see
- Multicomponent Reactions, ed., J. Zhu, and, H. Beinaymé, Wiley-VCH, Wienheim, 2005
- (2005) Multicomponent Reactions
- Zhu, J.¹ Beinaymé, H.²

26
- 84862175237
- A. Dömling K. Wang W. Wang Chem. Rev. 2012 112 3083 3135
- (2012) Chem. Rev. , vol.112 , pp. 3083-3135
- Dömling, A.¹ Wang, K.² Wang, W.³

27
- 0141757224
- A. J. von Wangelin A. J. H. Neumann D. Gördes S. Klaus D. Strübing M. Beller Chem.-Eur. J. 2003 9 4286 4294
- (2003) Chem.-Eur. J. , vol.9 , pp. 4286-4294
- Von Wangelin, A.J.¹ Neumann, A.J.H.² Gördes, D.³ Klaus, S.⁴ Strübing, D.⁵ Beller, M.⁶

28
- 0042745386
- R. V. A. Orru M. de Greef Synthesis 2003 1471 1499
- (2003) Synthesis , pp. 1471-1499
- Orru, R.V.A.¹ De Greef, M.²

29
- 0037391570
- J. Zhu Eur. J. Org. Chem. 2003 1133 1144
- (2003) Eur. J. Org. Chem. , pp. 1133-1144
- Zhu, J.¹

30
- 28244440237
- V. Gracias D. Darczak A. F. Gasiecki S. W. Djuric Tetrahedron Lett. 2005 46 9053 9056
- (2005) Tetrahedron Lett. , vol.46 , pp. 9053-9056
- Gracias, V.¹ Darczak, D.² Gasiecki, A.F.³ Djuric, S.W.⁴

31
- 33746272686
- N. Kumagai G. Muncipinto S. L. Schreiber Angew. Chem., Int. Ed. 2006 45 3635 3638
- (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 3635-3638
- Kumagai, N.¹ Muncipinto, G.² Schreiber, S.L.³

32
- 36849027181
- T. P. Ribelin A. S. Judd I. Akritopoulou-Zanze R. F. Henry J. L. Cross D. N. Whittern S. W. Djuric Org. Lett. 2007 9 5119 5122
- (2007) Org. Lett. , vol.9 , pp. 5119-5122
- Ribelin, T.P.¹ Judd, A.S.² Akritopoulou-Zanze, I.³ Henry, R.F.⁴ Cross, J.L.⁵ Whittern, D.N.⁶ Djuric, S.W.⁷

33
- 78650822243
- L. Banfi A. Basso L. Giardini R. Riva V. Rocca G. Guanti Eur. J. Org. Chem. 2011 100 109
- (2011) Eur. J. Org. Chem. , pp. 100-109
- Banfi, L.¹ Basso, A.² Giardini, L.³ Riva, R.⁴ Rocca, V.⁵ Guanti, G.⁶

34
- 84866244616
- F. Medda C. Hulme Tetrahedron Lett. 2012 5593 5596
- (2012) Tetrahedron Lett. , pp. 5593-5596
- Medda, F.¹ Hulme, C.²

35
- 53549112039
- T. E. Nielsen S. L. Schreiber Angew. Chem., Int. Ed. 2008 120 52 61
- (2008) Angew. Chem., Int. Ed. , vol.120 , pp. 52-61
- Nielsen, T.E.¹ Schreiber, S.L.²

36
- 0024244212
- S. F. Martin L. S. Geraci Tetrahedron Lett. 1988 29 6725 6728
- (1988) Tetrahedron Lett. , vol.29 , pp. 6725-6728
- Martin, S.F.¹ Geraci, L.S.²

37
- 0001140234
- S. F. Martin J. E. Hunter B. Benage L. S. Geraci M. Mortimore J. Am. Chem. Soc. 1991 113 6161 6171
- (1991) J. Am. Chem. Soc. , vol.113 , pp. 6161-6171
- Martin, S.F.¹ Hunter, J.E.² Benage, B.³ Geraci, L.S.⁴ Mortimore, M.⁵

38
- 0023747588
- For reviews of the terminology of tandem reactions, see
- S. F. Martin B. Benage J. E. Hunter J. Am. Chem. Soc. 1988 110 5925 5927
- (1988) J. Am. Chem. Soc. , vol.110 , pp. 5925-5927
- Martin, S.F.¹ Benage, B.² Hunter, J.E.³

39
- 33750173220
- L. F. Tietze U. Beifuss Angew. Chem., Int. Ed. Engl. 1993 32 131 163
- (1993) Angew. Chem., Int. Ed. Engl. , vol.32 , pp. 131-163
- Tietze, L.F.¹ Beifuss, U.²

40
- 0001053365
- S. E. Denmark A. Thorarensen Chem. Rev. 1996 96 137 165
- (1996) Chem. Rev. , vol.96 , pp. 137-165
- Denmark, S.E.¹ Thorarensen, A.²

41
- 33750977591
- K. C. Nicolaou D. J. Edmonds P. G. Bulger Angew. Chem., Int. Ed. 2006 45 7134 7186
- (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 7134-7186
- Nicolaou, K.C.¹ Edmonds, D.J.² Bulger, P.G.³

42
- 34250021382
- A. Padwa S. K. Burr Tetrahedron 2007 63 5341 5378
- (2007) Tetrahedron , vol.63 , pp. 5341-5378
- Padwa, A.¹ Burr, S.K.²

43
- 84872244061
- For reviews on MCAPs, see
- H. Pellissier Chem. Rev. 2013 113 442 524
- (2013) Chem. Rev. , vol.113 , pp. 442-524
- Pellissier, H.¹

44
- 84856557094
- J. R. Donald B. A. Granger S. Hardy J. J. Sahn S. F. Martin Heterocycles 2012 84 1089 1112
- (2012) Heterocycles , vol.84 , pp. 1089-1112
- Donald, J.R.¹ Granger, B.A.² Hardy, S.³ Sahn, J.J.⁴ Martin, S.F.⁵

45
- 84885068977
- S. F. Martin Adv. Heterocycl. Chem. 2013 110 73 117
- (2013) Adv. Heterocycl. Chem. , vol.110 , pp. 73-117
- Martin, S.F.¹

46
- 82255173962
- A. McNally C. K. Prier D. W. C. MacMillan Science 2011 334 1114 1117
- (2011) Science , vol.334 , pp. 1114-1117
- McNally, A.¹ Prier, C.K.² MacMillan, D.W.C.³

47
- 0003916113
- John Wiley & Sons, New York
- The Chemistry of Heterocyclic Compounds, vol. 59: Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products, ed. A. Padwa and W. H. Pearson, John Wiley & Sons, New York, 2002
- (2002) The Chemistry of Heterocyclic Compounds, Vol. 59: Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products
- Padwa, A.¹ Pearson, W.H.²

48
- 35548975293
- J. D. Sunderhaus C. Dockendorff S. F. Martin Org. Lett. 2007 9 4223 4226
- (2007) Org. Lett. , vol.9 , pp. 4223-4226
- Sunderhaus, J.D.¹ Dockendorff, C.² Martin, S.F.³

49
- 67650230007
- For a review of the Huisgen dipolar cycloaddition, see
- J. D. Sunderhaus C. Dockendorff S. F. Martin Tetrahedron 2009 65 6454 6469
- (2009) Tetrahedron , vol.65 , pp. 6454-6469
- Sunderhaus, J.D.¹ Dockendorff, C.² Martin, S.F.³

50
- 51649102031
- For alternate syntheses of 1,2,3-triazolo-1,4-benzodiazepines, see
- C. D. Hein X.-M. Liu D. Wang Pharm. Res. 2008 25 2216 2230
- (2008) Pharm. Res. , vol.25 , pp. 2216-2230
- Hein, C.D.¹ Liu, X.-M.² Wang, D.³

51
- 34247199436
- M. Alajarín J. Cabrera A. Pastor J. M. Villalgordo Tetrahedron Lett. 2007 48 3495 3499
- (2007) Tetrahedron Lett. , vol.48 , pp. 3495-3499
- Alajarín, M.¹ Cabrera, J.² Pastor, A.³ Villalgordo, J.M.⁴

52
- 84883791216
- H. H. Nguyen T. A. Palazzo M. J. Kurth Org. Lett. 2013 15 4492 4495
- (2013) Org. Lett. , vol.15 , pp. 4492-4495
- Nguyen, H.H.¹ Palazzo, T.A.² Kurth, M.J.³

53
- 79952143764
- J. R. Donald S. F. Martin Org. Lett. 2011 13 852 855
- (2011) Org. Lett. , vol.13 , pp. 852-855
- Donald, J.R.¹ Martin, S.F.²

54
- 84856854675
- J. R. Donald R. R. Wood S. F. Martin ACS Comb. Sci. 2012 14 135 143
- (2012) ACS Comb. Sci. , vol.14 , pp. 135-143
- Donald, J.R.¹ Wood, R.R.² Martin, S.F.³

55
- 84986431080
- J. V. Cooney B. D. Beaver W. E. McEwen J. Heterocycl. Chem. 1985 22 635 642
- (1985) J. Heterocycl. Chem. , vol.22 , pp. 635-642
- Cooney, J.V.¹ Beaver, B.D.² McEwen, W.E.³

56
- 80052461336
- S. Moylan J. Staples S. A. Ward J. Rogerson D. J. Stein M. Berk J. Clin. Psychopharmacology 2011 31 647 652
- (2011) J. Clin. Psychopharmacology , vol.31 , pp. 647-652
- Moylan, S.¹ Staples, J.² Ward, S.A.³ Rogerson, J.⁴ Stein, D.J.⁵ Berk, M.⁶

57
- 0037366605
- D. A. Horton G. T. Bourne M. L. Smythe Chem. Rev. 2003 103 893 930
- (2003) Chem. Rev. , vol.103 , pp. 893-930
- Horton, D.A.¹ Bourne, G.T.² Smythe, M.L.³

58
- 84885675970
- O. Mirguet R. Gosmini J. Toum C. A. Clement M. Barnathan J. M. Brusq J. E. Mordaunt R. M. Grimes M. Crowe O. Pineau M. Ajakane A. Daugan P. Jeffrey L. Cutler A. C. Haynes N. N. Smithers C. W. Chung P. Bamborough I. J. Uings A. Lewis J. Witherington N. Parr R. K. Prinjha E. Nicodeme J. Med. Chem. 2013 56 7501 7515
- (2013) J. Med. Chem. , vol.56 , pp. 7501-7515
- Mirguet, O.¹ Gosmini, R.² Toum, J.³ Clement, C.A.⁴ Barnathan, M.⁵ Brusq, J.M.⁶ Mordaunt, J.E.⁷ Grimes, R.M.⁸ Crowe, M.⁹ Pineau, O.¹⁰ Ajakane, M.¹¹ Daugan, A.¹² Jeffrey, P.¹³ Cutler, L.¹⁴ Haynes, A.C.¹⁵ Smithers, N.N.¹⁶ Chung, C.W.¹⁷ Bamborough, P.¹⁸ Uings, I.J.¹⁹ Lewis, A.²⁰ more..

59
- 84907871558
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=686964

60
- 0345357773
- J. G. Herman S. B. Baylin N. Engl. J. Med. 2003 349 2042 2054
- (2003) N. Engl. J. Med. , vol.349 , pp. 2042-2054
- Herman, J.G.¹ Baylin, S.B.²

61
- 84907871557
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=651717

62
- 84866414261
- E. C. Dykhuizen L. C. Carmody N. Tolliday G. R. Crabtree M. A. Palmer J. Biomol. Screening 2012 17 1221 1230
- (2012) J. Biomol. Screening , vol.17 , pp. 1221-1230
- Dykhuizen, E.C.¹ Carmody, L.C.² Tolliday, N.³ Crabtree, G.R.⁴ Palmer, M.A.⁵

63
- 84907871556
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=624491

64
- 33646135276
- M. K. Paul A. K. Mukhopadhyay Int. J. Med. Sci. 2004 1 101 115
- (2004) Int. J. Med. Sci. , vol.1 , pp. 101-115
- Paul, M.K.¹ Mukhopadhyay, A.K.²

65
- 84907871555
- Accessed on 3/25/2014
- Accessed on 3/25/2014: http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=624491#aDescription

66
- 84907871554
- Accessed on 3/25/2014
- Accessed on 3/25/2014: http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=624491#aDescription

67
- 0034002793
- F. P. Kuhajda Nutrition 2000 16 202 208
- (2000) Nutrition , vol.16 , pp. 202-208
- Kuhajda, F.P.¹

68
- 80052242415
- B. A. Granger K. Kaneda S. F. Martin Org. Lett. 2011 13 4542 4545
- (2011) Org. Lett. , vol.13 , pp. 4542-4545
- Granger, B.A.¹ Kaneda, K.² Martin, S.F.³

69
- 84907871553
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=652104

70
- 33749632259
- M. Neumann D. M. Sampathu L. K. Kwong A. C. Truax M. C. Micsenyi T. T. Chou J. Bruce T. Schuck M. Grossman C. M. Clark L. F. McCluskey B. L. Miller E. Masliah I. R. Mackenzie H. Feldman W. Feiden H. A. Kretzschmar J. Q. Trojanowski V. M.-Y. Lee Science 2006 314 130 133
- (2006) Science , vol.314 , pp. 130-133
- Neumann, M.¹ Sampathu, D.M.² Kwong, L.K.³ Truax, A.C.⁴ Micsenyi, M.C.⁵ Chou, T.T.⁶ Bruce, J.⁷ Schuck, T.⁸ Grossman, M.⁹ Clark, C.M.¹⁰ McCluskey, L.F.¹¹ Miller, B.L.¹² Masliah, E.¹³ Mackenzie, I.R.¹⁴ Feldman, H.¹⁵ Feiden, W.¹⁶ Kretzschmar, H.A.¹⁷ Trojanowski, J.Q.¹⁸ Lee, V.M.-Y.¹⁹

71
- 79958807861
- S. Hardy S. F. Martin Org. Lett. 2011 13 3102 3105
- (2011) Org. Lett. , vol.13 , pp. 3102-3105
- Hardy, S.¹ Martin, S.F.²

72
- 0001499034
- R. Madsen C. Roberts B. Fraser-Reid J. Org. Chem. 1995 60 7920 7926
- (1995) J. Org. Chem. , vol.60 , pp. 7920-7926
- Madsen, R.¹ Roberts, C.² Fraser-Reid, B.³

73
- 84907871552
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=652116

74
- 84870379165
- B. H. Lok S. N. Powell Clin. Cancer Res. 2012 18 6400 6406
- (2012) Clin. Cancer Res. , vol.18 , pp. 6400-6406
- Lok, B.H.¹ Powell, S.N.²

75
- 84880917274
- B. H. Lok A. C. Carley B. Tchang S. N. Powell Oncogene 2013 32 3552 3558
- (2013) Oncogene , vol.32 , pp. 3552-3558
- Lok, B.H.¹ Carley, A.C.² Tchang, B.³ Powell, S.N.⁴

76
- 0037131243
- R. Verma L. Aravind R. Oania W. H. McDonald J. R. Yates 3rd E. V. Koonin R. J. Deshaies Science 2002 298 611 615
- (2002) Science , vol.298 , pp. 611-615
- Verma, R.¹ Aravind, L.² Oania, R.³ McDonald, W.H.⁴ Yates, J.R.⁵ Koonin, E.V.⁶ Deshaies, R.J.⁷

77
- 84907871551
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=652257

78
- 20844450998
- M. T. Bedford S. Richard Mol. Cell 2005 18 263 272
- (2005) Mol. Cell , vol.18 , pp. 263-272
- Bedford, M.T.¹ Richard, S.²

79
- 84864125680
- M. B. Dillon D. A. Bachovchin S. J. Brown M. G. Finn H. Rosen B. F. Cravatt K. A. Mowen ACS Chem. Biol. 2012 7 1198 1204
- (2012) ACS Chem. Biol. , vol.7 , pp. 1198-1204
- Dillon, M.B.¹ Bachovchin, D.A.² Brown, S.J.³ Finn, M.G.⁴ Rosen, H.⁵ Cravatt, B.F.⁶ Mowen, K.A.⁷

80
- 84907871550
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=652105

81
- 84872242924
- M. I. Davis A. T. Sasaki M. Shen B. M. Emerling N. Thorne S. Michael R. Pragani M. Boxer K. Sumita K. Takeuchi D. S. Auld Z. Li L. C. Cantley A. Simeonov PLoS One 2013 8 e54127
- (2013) PLoS One , vol.8 , pp. 54127
- Davis, M.I.¹ Sasaki, A.T.² Shen, M.³ Emerling, B.M.⁴ Thorne, N.⁵ Michael, S.⁶ Pragani, R.⁷ Boxer, M.⁸ Sumita, K.⁹ Takeuchi, K.¹⁰ Auld, D.S.¹¹ Li, Z.¹² Cantley, L.C.¹³ Simeonov, A.¹⁴

82
- 84855580902
- B. A. Granger K. Kaneda S. F. Martin ACS Comb. Sci. 2011 14 75 79
- (2011) ACS Comb. Sci. , vol.14 , pp. 75-79
- Granger, B.A.¹ Kaneda, K.² Martin, S.F.³

83
- 0015252246
- J. W. Van Dyke Jr. H. J. Havera R. D. Johnson H. Vidrio A. Viveros J. Med. Chem. 1972 15 91 94
- (1972) J. Med. Chem. , vol.15 , pp. 91-94
- Van Dyke, J.W.¹ Havera, H.J.² Johnson, R.D.³ Vidrio, H.⁴ Viveros, A.⁵

84
- 0019723170
- B. E. Maryanoff D. F. McComsey R. J. Taylor Jr. J. F. Gardocki J. Med. Chem. 1981 24 79 88
- (1981) J. Med. Chem. , vol.24 , pp. 79-88
- Maryanoff, B.E.¹ McComsey, D.F.² Taylor, R.J.³ Gardocki, J.F.⁴

85
- 84907871549
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=651820

86
- 84893499467
- Z. Hu K. H. Lan S. He M. Swaroop X. Hu N. Southall W. Zheng T. J. Liang Antimicrob. Agents Chemother. 2014 58 995 1004
- (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 995-1004
- Hu, Z.¹ Lan, K.H.² He, S.³ Swaroop, M.⁴ Hu, X.⁵ Southall, N.⁶ Zheng, W.⁷ Liang, T.J.⁸

87
- 84882798997
- J. Kuethe Y. L. Zhong N. Yasuda G. Beutner K. Linn M. Kim B. Marcune S. D. Dreher G. Humphrey T. Pei Org. Lett. 2013 15 4174 4177
- (2013) Org. Lett. , vol.15 , pp. 4174-4177
- Kuethe, J.¹ Zhong, Y.L.² Yasuda, N.³ Beutner, G.⁴ Linn, K.⁵ Kim, M.⁶ Marcune, B.⁷ Dreher, S.D.⁸ Humphrey, G.⁹ Pei, T.¹⁰

88
- 84880052052
- B. A. Granger Z. Wang K. Kaneda Z. Fang S. F. Martin ACS Comb. Sci. 2013 15 379 386
- (2013) ACS Comb. Sci. , vol.15 , pp. 379-386
- Granger, B.A.¹ Wang, Z.² Kaneda, K.³ Fang, Z.⁴ Martin, S.F.⁵

89
- 84355161438
- Z. Wang K. Kaneda Z. Fang S. F. Martin Tetrahedron Lett. 2012 53 477 479
- (2012) Tetrahedron Lett. , vol.53 , pp. 477-479
- Wang, Z.¹ Kaneda, K.² Fang, Z.³ Martin, S.F.⁴

90
- 24744434242
- ed. J. E. Saxton, Wiley-Interscience, New York
- R. T. Brown, in Indoles, ed., J. E. Saxton, Wiley-Interscience, New York, 1983
- (1983) Indoles
- Brown, R.T.¹

91
- 84907871548
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=651971

92
- 84889686091
- F. S. Buckner N. C. Waters V. M. Avery Int. J. Parasitol. Drugs Drug Resist. 2012 2 230 235
- (2012) Int. J. Parasitol. Drugs Drug Resist. , vol.2 , pp. 230-235
- Buckner, F.S.¹ Waters, N.C.² Avery, V.M.³

93
- 84864183301
- S. Shibata J. R. Gillespie R. M. Ranade C. Y. Koh J. E. Kim J. U. Laydbak F. H. Zucker W. G. Hol C. L. Verlinde F. S. Buckner E. Fan J. Med. Chem. 2012 55 6342 6351
- (2012) J. Med. Chem. , vol.55 , pp. 6342-6351
- Shibata, S.¹ Gillespie, J.R.² Ranade, R.M.³ Koh, C.Y.⁴ Kim, J.E.⁵ Laydbak, J.U.⁶ Zucker, F.H.⁷ Hol, W.G.⁸ Verlinde, C.L.⁹ Buckner, F.S.¹⁰ Fan, E.¹¹

94
- 0038404617
- A. Stich M. P. Barrett S. Krishna Trends Parasitol. 2003 19 195 197
- (2003) Trends Parasitol. , vol.19 , pp. 195-197
- Stich, A.¹ Barrett, M.P.² Krishna, S.³

95
- 84907871547
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=720580

96
- 42449154473
- Poxviridae: The viruses and their replication
- ed. D. M. Knipe et al., Lippincott Williams & Wilkins, Philadelphia
- B. Moss, Poxviridae: The viruses and their replication, in Fields Virology, ed., D. M. Knipe, et al., Lippincott Williams & Wilkins, Philadelphia, 2007
- (2007) Fields Virology
- Moss, B.¹

97
- 34249985456
- A. W. Rimoin N. Kisalu B. Kebela-Ilunga T. Mukaba L. L. Wright P. Formenty N. D. Wolfe R. L. Shongo F. Tshioko E. Okitolonda J. J. Muyembe R. Ryder H. Meyer Emerg. Infect. Dis. 2007 13 934 937
- (2007) Emerg. Infect. Dis. , vol.13 , pp. 934-937
- Rimoin, A.W.¹ Kisalu, N.² Kebela-Ilunga, B.³ Mukaba, T.⁴ Wright, L.L.⁵ Formenty, P.⁶ Wolfe, N.D.⁷ Shongo, R.L.⁸ Tshioko, F.⁹ Okitolonda, E.¹⁰ Muyembe, J.J.¹¹ Ryder, R.¹² Meyer, H.¹³

98
- 84891565155
- Wiley-VCH Verlag GmbH & Co. KGaA
- Y. Wang, in Bioactive Heterocyclic Compound Classes, Wiley-VCH Verlag GmbH & Co. KGaA, 2012, pp. 99-114
- (2012) Bioactive Heterocyclic Compound Classes , pp. 99-114
- Wang, Y.¹

99
- 38349114737
- B. M. Smith J. M. Smith J. H. Tsai J. A. Schultz C. A. Gilson S. A. Estrada R. R. Chen D. M. Park E. B. Prieto C. S. Gallardo D. Sengupta P. I. Dosa J. A. Covel A. Ren R. R. Webb N. R. A. Beeley M. Martin M. Morgan S. Espitia H. R. Saldana C. Bjenning K. T. Whelan A. J. Grottick F. Menzaghi W. J. Thomsen J. Med. Chem. 2007 51 305 313
- (2007) J. Med. Chem. , vol.51 , pp. 305-313
- Smith, B.M.¹ Smith, J.M.² Tsai, J.H.³ Schultz, J.A.⁴ Gilson, C.A.⁵ Estrada, S.A.⁶ Chen, R.R.⁷ Park, D.M.⁸ Prieto, E.B.⁹ Gallardo, C.S.¹⁰ Sengupta, D.¹¹ Dosa, P.I.¹² Covel, J.A.¹³ Ren, A.¹⁴ Webb, R.R.¹⁵ Beeley, N.R.A.¹⁶ Martin, M.¹⁷ Morgan, M.¹⁸ Espitia, S.¹⁹ Saldana, H.R.²⁰ more..

100
- 0028312466
- For a review of applications of RCM to heterocycle synthesis, see
- A. O. Plunkett Nat. Prod. Rep. 1994 11 581 590
- (1994) Nat. Prod. Rep. , vol.11 , pp. 581-590
- Plunkett, A.O.¹

101
- 2942589152
- Aldehydes 88 and 89 were prepared using the following methods
- A. Deiters S. F. Martin Chem. Rev. 2004 104 2199 2238
- (2004) Chem. Rev. , vol.104 , pp. 2199-2238
- Deiters, A.¹ Martin, S.F.²

102
- 0001267078
- D. L. Comins J. D. Brown J. Org. Chem. 1984 49 1078 1083
- (1984) J. Org. Chem. , vol.49 , pp. 1078-1083
- Comins, D.L.¹ Brown, J.D.²

103
- 58149114909
- T. Rawalpally Y. Ji A. Shankar W. Edward J. Allen Y. Jian T. P. Cleary M. E. Pierce Org. Process Res. Dev. 2008 12 1293 1298
- (2008) Org. Process Res. Dev. , vol.12 , pp. 1293-1298
- Rawalpally, T.¹ Ji, Y.² Shankar, A.³ Edward, W.⁴ Allen, J.⁵ Jian, Y.⁶ Cleary, T.P.⁷ Pierce, M.E.⁸

104
- 79956146241
- J. J. Sahn J. Y. Su S. F. Martin Org. Lett. 2011 13 2590 2593
- (2011) Org. Lett. , vol.13 , pp. 2590-2593
- Sahn, J.J.¹ Su, J.Y.² Martin, S.F.³

105
- 84866056989
- J. J. Sahn S. F. Martin ACS Comb. Sci. 2012 14 496 502
- (2012) ACS Comb. Sci. , vol.14 , pp. 496-502
- Sahn, J.J.¹ Martin, S.F.²

106
- 46549101525
- T. Jeffery Tetrahedron Lett. 1985 26 2667 2670
- (1985) Tetrahedron Lett. , vol.26 , pp. 2667-2670
- Jeffery, T.¹

107
- 0000581455
- D. L. Comins M. A. Weglarz J. Org. Chem. 1991 56 2506 2512
- (1991) J. Org. Chem. , vol.56 , pp. 2506-2512
- Comins, D.L.¹ Weglarz, M.A.²

108
- 0025782704
- S. V. D'Andrea E. T. Michalson J. P. Freeman C. G. Chidester J. Szmuszkovicz J. Org. Chem. 1991 56 3133 3137
- (1991) J. Org. Chem. , vol.56 , pp. 3133-3137
- D'Andrea, S.V.¹ Michalson, E.T.² Freeman, J.P.³ Chidester, C.G.⁴ Szmuszkovicz, J.⁵

109
- 0037138650
- D. R. Spring S. Krishnan H. E. Blackwell S. L. Schreiber J. Am. Chem. Soc. 2002 124 1354 1363
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 1354-1363
- Spring, D.R.¹ Krishnan, S.² Blackwell, H.E.³ Schreiber, S.L.⁴

110
- 81255153648
- J. J. Sahn S. F. Martin Tetrahedron Lett. 2011 52 6855 6858
- (2011) Tetrahedron Lett. , vol.52 , pp. 6855-6858
- Sahn, J.J.¹ Martin, S.F.²

111
- 0014711382
- A. E. Jacobson M. Mokotoff J. Med. Chem. 1970 13 7 9
- (1970) J. Med. Chem. , vol.13 , pp. 7-9
- Jacobson, A.E.¹ Mokotoff, M.²

112
- 0019505374
- P. H. Mazzocchi B. C. Stahly J. Med. Chem. 1981 24 457 462
- (1981) J. Med. Chem. , vol.24 , pp. 457-462
- Mazzocchi, P.H.¹ Stahly, B.C.²

113
- 0028016320
- UNC Chapel Hill-Director, Bryan Roth, PhD
- Y. L. Chen D. Liston J. Nielsen D. Chapin A. Dunaiskis K. Hedberg J. Ives J. Johnson Jr. S. Jones J. Med. Chem. 1994 37 1996 2000
- (1994) J. Med. Chem. , vol.37 , pp. 1996-2000
- Chen, Y.L.¹ Liston, D.² Nielsen, J.³ Chapin, D.⁴ Dunaiskis, A.⁵ Hedberg, K.⁶ Ives, J.⁷ Johnson, J.⁸ Jones, S.⁹

114
- 23044437134
- A. Marrazzo F. Caraci E. T. Salinaro T. P. Su A. Copani G. Ronsisvalle NeuroReport 2005 16 1223 1226
- (2005) NeuroReport , vol.16 , pp. 1223-1226
- Marrazzo, A.¹ Caraci, F.² Salinaro, E.T.³ Su, T.P.⁴ Copani, A.⁵ Ronsisvalle, G.⁶

115
- 0034524088
- K. Yamada T. Nabeshima Pharmacol. Ther. 2000 88 93 113
- (2000) Pharmacol. Ther. , vol.88 , pp. 93-113
- Yamada, K.¹ Nabeshima, T.²

116
- 70349116879
- T. Maurice T. P. Su Pharmacol. Ther. 2009 124 195 206
- (2009) Pharmacol. Ther. , vol.124 , pp. 195-206
- Maurice, T.¹ Su, T.P.²

117
- 84920051671
- Springer, New York
- Sigma Receptors: Chemistry, Cell Biology and Clinical Implications, ed., R. R. Matsumoto, W. D. Bowen, and, T.-P. Su, Springer, New York, 2007
- (2007) Sigma Receptors: Chemistry, Cell Biology and Clinical Implications
- Matsumoto, R.R.¹ Bowen, W.D.² Su, T.-P.³

118
- 79960099287
- J. Xu C. Zeng W. Chu F. Pan J. M. Rothfuss F. Zhang Z. Tu D. Zhou D. Zeng S. Vangveravong F. Johnston D. Spitzer K. C. Chang R. S. Hotchkiss W. G. Hawkins K. T. Wheeler R. H. Mach Nat. Commun. 2011 2 380
- (2011) Nat. Commun. , vol.2 , pp. 380
- Xu, J.¹ Zeng, C.² Chu, W.³ Pan, F.⁴ Rothfuss, J.M.⁵ Zhang, F.⁶ Tu, Z.⁷ Zhou, D.⁸ Zeng, D.⁹ Vangveravong, S.¹⁰ Johnston, F.¹¹ Spitzer, D.¹² Chang, K.C.¹³ Hotchkiss, R.S.¹⁴ Hawkins, W.G.¹⁵ Wheeler, K.T.¹⁶ Mach, R.H.¹⁷

119
- 84897400532
- Y.-S. Huang H.-L. Lu L.-J. Zhang Z. Wu Med. Res. Rev. 2013 34 532 566
- (2013) Med. Res. Rev. , vol.34 , pp. 532-566
- Huang, Y.-S.¹ Lu, H.-L.² Zhang, L.-J.³ Wu, Z.⁴

120
- 84884480040
- R. H. Mach C. Zeng W. G. Hawkins J. Med. Chem. 2013 56 7137 7160
- (2013) J. Med. Chem. , vol.56 , pp. 7137-7160
- Mach, R.H.¹ Zeng, C.² Hawkins, W.G.³

121
- 84907871546
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=624417

122
- 84870606111
- A. Kirkpatrick J. Heo R. Abrol W. A. Goddard 3rd Proc. Natl. Acad. Sci. U. S. A. 2012 109 19988 19993
- (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 19988-19993
- Kirkpatrick, A.¹ Heo, J.² Abrol, R.³ Goddard, W.A.⁴

123
- 84907871545
- Accessed on 3/25/2014
- Accessed on 3/25/2014: http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=624417#aDescription

124
- 33845552740
- W. E. Parham C. K. Bradsher Acc. Chem. Res. 1982 15 300 305
- (1982) Acc. Chem. Res. , vol.15 , pp. 300-305
- Parham, W.E.¹ Bradsher, C.K.²

125
- 84870051116
- R. Boulahjar A. Ouach C. Matteo S. Bourg M. Ravache R. l. Guével S. Marionneau T. Oullier O. Lozach L. Meijer C. Guguen-Guillouzo S. Lazar M. Akssira Y. Troin G. Guillaumet S. Routier J. Med. Chem. 2012 55 9589 9606
- (2012) J. Med. Chem. , vol.55 , pp. 9589-9606
- Boulahjar, R.¹ Ouach, A.² Matteo, C.³ Bourg, S.⁴ Ravache, M.⁵ Guével, R.L.⁶ Marionneau, S.⁷ Oullier, T.⁸ Lozach, O.⁹ Meijer, L.¹⁰ Guguen-Guillouzo, C.¹¹ Lazar, S.¹² Akssira, M.¹³ Troin, Y.¹⁴ Guillaumet, G.¹⁵ Routier, S.¹⁶

126
- 84907871544
- Accessed on 3/25/2014
- Accessed on 3/25/2014: https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=602438

127
- 33744965754
- H. Jia A. Bagherzadeh B. Hartzoulakis A. Jarvis M. Lohr S. Shaikh R. Aqil L. Cheng M. Tickner D. Esposito R. Harris P. C. Driscoll D. L. Selwood I. C. Zachary J. Biol. Chem. 2006 281 13493 13502
- (2006) J. Biol. Chem. , vol.281 , pp. 13493-13502
- Jia, H.¹ Bagherzadeh, A.² Hartzoulakis, B.³ Jarvis, A.⁴ Lohr, M.⁵ Shaikh, S.⁶ Aqil, R.⁷ Cheng, L.⁸ Tickner, M.⁹ Esposito, D.¹⁰ Harris, R.¹¹ Driscoll, P.C.¹² Selwood, D.L.¹³ Zachary, I.C.¹⁴

128
- 84882088781
- Academic Press, Boston
- E. H. Kerns and L. Di, Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization, Academic Press, Boston, 2008
- (2008) Drug-like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization
- Kerns, E.H.¹ Di, L.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.