Synthesis of fused triazolo-imidazole derivatives by sequential van Leusen/alkyne-azide cycloaddition reactions

Tetrahedron Letters

Volumn 46, Issue 52, 2005, Pages 9053-9056

  Gracias, Vijaya ^a   Darczak, Daria ^a   Gasiecki, Alan F ^a   Djuric, Stevan W ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Cycloaddition; Imidazole; Multicomponent reactions; Van Leusen

Indexed keywords

ALKYNE DERIVATIVE; AZIDE; IMIDAZOLE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CYCLOADDITION; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 28244440237     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.10.090     Document Type: Article

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22. 3): δ 5.01 (br s, 1H), 5.66 (br s, 1H), 7.30-7.39 (m, 4H), 7.50-7.60 (m, 4H), 7.85 (s, 1H), 8.10 (m, 1H), 8.16 (s, 1H); MS (ESI): m/z 300 (M+H).
23. V.V. Rostovtsev, L.G. Green, V.V. Fokin, and K.B. Sharpless Angew. Chem., Int. Ed. 41 2002 2596 2599
24. 3): δ 2.48 (s, 3H), 4.97 (br s, 1H), 5.29 (br s, 1H), 7.26-7.32 (m, 4H), 7.47-7.53 (m, 4H), 7.76 (s, 1H), 8.04 (d, J = 6.0 Hz, 1H); MS (ESI): m/z 314 (M+H).