Diversity-oriented synthesis yields a novel lead for the treatment of malaria

ACS Medicinal Chemistry Letters

Volumn 3, Issue 2, 2012, Pages 112-117

  Heidebrecht, Richard W ^a,c   Mulrooney, Carol ^a   Austin, Christopher P ^b   Barker, Robert H ^g   Beaudoin, Jennifer A ^a   Cheng, Ken Chih Chien ^b   Comer, Eamon ^a   Dandapani, Sivaraman ^a   Dick, Justin ^c   Duvall, Jeremy R ^a   Ekland, Eric H ^d   Fidock, David A ^d   Fitzgerald, Mark E ^a   Foley, Michael ^a   Guha, Rajarshi ^b   Hinkson, Paul ^g   Kramer, Martin ^g   Lukens, Amanda K ^a,c   Masi, Daniela ^a   Marcaurelle, Lisa A ^a   Su, Xin Zhuan ^e   Thomas, Craig J ^b   Weïwer, Michel ^a   Wiegand, Roger C ^a,c   Wirth, Dyann ^a,c   Xia, Menghang ^b   Yuan, Jing ^e   Zhao, Jinghua ^b   Palmer, Michelle ^a   Munoz, Benito ^a   Schreiber, Stuart ^a,f   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d Howard Hughes Medical Institute   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^f HARVARD UNIVERSITY   (United States)

^g GENZYME CORPORATION   (United States)

Author keywords

diversity oriented synthesis; high throughput screening; infectious disease; macrocycle; malaria; molecular libraries probe production centers; phenotypic screen; stereochemical structure?activity relationships

Indexed keywords

ANTIMALARIAL AGENT; CARBAMIC ACID DERIVATIVE; ML 238; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; GENETIC SCREENING; HEMOLYSIS; MALARIA; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

PLASMODIUM FALCIPARUM;

EID: 84863143111     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200244k     Document Type: Article

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