RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination

Oncogene

Volumn 32, Issue 30, 2013, Pages 3552-3558

  Lok, B H ^a,b   Carley, A C ^a,c   Tchang, B ^a,d   Powell, S N ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Weill Cornell Medical Center   (United States)

^d Downstate Health Sciences University   (United States)

Author keywords

BRCA1; BRCA2; PALB2; RAD51; RAD52; Synthetic lethality

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; PARTNER AND LOCALIZER OF BRCA2 PROTEIN; PROTEIN; RAD51 PROTEIN; RAD52 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE S PHASE; CELL DIVISION; CELL SURVIVAL; CONTROLLED STUDY; HOMOLOGOUS RECOMBINATION; HUMAN; IONIZING RADIATION; PRIORITY JOURNAL;

CELL LINE, TUMOR; CELL SURVIVAL; DNA REPAIR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GENES, BRCA1; GENES, BRCA2; GENES, LETHAL; HOMOLOGOUS RECOMBINATION; HUMANS; NUCLEAR PROTEINS; RAD51 RECOMBINASE; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEINS;

EID: 84880917274     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.391     Document Type: Article

References (35)

1. Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov 2011; 10: 351-364.
2. Iglehart JD, Silver DP. Synthetic Lethality-A New Direction in Cancer-Drug Development. N Engl J Med 2009; 361: 189-191.
3. Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 123-134.
4. Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005; 434: 913-917. (Pubitemid 40559005)
5. Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917-921. (Pubitemid 40559006)
6. Baumann P, West SC. Role of the human RAD51 protein in homologous recombination and double-stranded-break repair. Trends Biochem Sci 1998; 23: 247-251. (Pubitemid 28343368)
7. Sonoda E, Sasaki MS, Buerstedde JM, Bezzubova O, Shinohara A, Ogawa H et al. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J 1998; 17: 598-608. (Pubitemid 28045499)
8. Shinohara A, Ogawa T. Stimulation by Rad52 of yeast Rad51-mediated recombination. Nature 1998; 391: 404-407. (Pubitemid 28093517)
9. Holloman WK. Unraveling the mechanism of BRCA2 in homologous recombination. Nat Struct Mol Biol 2011; 18: 748-754.
10. Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 1997; 386: 804-810. (Pubitemid 27181248)
11. Feng Z, Scott SP, Bussen W, Sharma GG, Guo G, Pandita TK et al. From the Cover Rad52 inactivation is synthetically lethal with BRCA2 deficiency. Proc Natl Acad Sci USA 2011; 108: 686-691.
12. McIlwraith MJ, Van Dyck E, Masson JY, Stasiak AZ, Stasiak A, West SC. Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins. J Mol Biol 2000; 304: 151-164.
13. Stark JM, Pierce AJ, Oh J, Pastink A, Jasin M. Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol 2004; 24: 9305-9316. (Pubitemid 39391669)
14. Bennardo N, Cheng A, Huang N, Stark JM. Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PloS Genet 2008; 4: e1000110.
15. Wang WY, Twu CW, Chen HH, Jan JS, Jiang RS, Chao JY et al. Plasma EBV DNA clearance rate as a novel prognostic marker for metastatic/recurrent nasopharyngeal carcinoma. Clin Cancer Res 2010; 16: 1016-1024.
16. Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci USA. 2009; 106: 7155-7160.
17. Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell 2006; 22: 719-729.
18. Zhang F, Fan Q, Ren K, Andreassen PR. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol Cancer Res 2009; 7: 1110-1118.
19. Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B et al. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol 2009; 19: 524-529.
20. Rahman N, Seal S, Thompson D, Kelly P, Renwick A, Elliott A et al. PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet 2007; 39: 165-167. (Pubitemid 46184346)
21. Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009; 324: 217.
22. Erkko H, Xia B, Nikkila J, Schleutker J, Syrjakoski K, Mannermaa A et al. A recurrent mutation in PALB2 in Finnish cancer families. Nature 2007; 446: 316-319. (Pubitemid 46426155)
23. Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT et al. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol 2004; 24: 708-718. (Pubitemid 38057922)
24. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997; 88: 265-275. (Pubitemid 28015875)
25. New JH, Sugiyama T, Zaitseva E, Kowalczykowski SC. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein. Nature 1998; 391: 407-410. (Pubitemid 28093518)
26. Benson FE, Baumann P, West SC. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair. Nature 1998; 391: 401-404. (Pubitemid 28093516)
27. Pierce AJ, Johnson RD, Thompson LH, Jasin M. XRCC3 promotes homologydirected repair of DNA damage in mammalian cells. Genes Dev 1999; 13: 2633-2638. (Pubitemid 29508550)
28. Shi W, Ma Z, Willers H, Akhtar K, Scott SP, Zhang J et al. Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation. J Biol Chem 2008; 283: 31608-31616.
29. Sugiyama T, New JH, Kowalczykowski SC. DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA. Proc Natl Acad Sci USA 1998; 95: 6049-6054. (Pubitemid 28248962)
30. Singleton MR, Wentzell LM, Liu Y, West SC, Wigley DB. Structure of the singlestrand annealing domain of human RAD52 protein. Proc Natl Acad Sci USA 2002; 99: 13492-13497. (Pubitemid 35215409)
31. Kojic M, Zhou Q, Fan J, Holloman WK. Mutational analysis of Brh2 reveals requirements for compensating mediator functions. Mol Microbiol 2011; 79: 180-191.
32. Qing Y, Yamazoe M, Hirota K, Dejsuphong D, Sakai W, Yamamoto KN et al. The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PloS Genet 2011; 7: e1002148.
33. Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T, Fountzilas E, Francoeur N et al. Gene expression profile of BRC Aness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J Clin Oncol 2010; 28: 3555-3561.
34. Willers H, Taghian AG, Luo CM, Treszezamsky A, Sgroi DC, Powell SN. Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. Mol Cancer Res 2009; 7: 1304-1309.
35. Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 2000; 404: 201-204. (Pubitemid 30154490)