메뉴 건너뛰기




Volumn 239, Issue 9, 2014, Pages 1096-1107

Biological and medical applications of a brain-on-a-chip

Author keywords

human on a chip; Induced pluripotent stem cells; neural models; three dimensional; Tox 21 c

Indexed keywords

BIOLOGICAL MARKER;

EID: 84907010370     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214537738     Document Type: Article
Times cited : (102)

References (146)
  • 1
    • 84907014474 scopus 로고    scopus 로고
    • FDA accessed 15 October 2013
    • FDA. Federal Register. FDA 2002, http://www.gpo.gov/fdsys/pkg/FR-2002-05-31/pdf/02-13583.pdf (accessed 15 October 2013).
    • Federal Register. FDA 2002
  • 3
    • 67650445156 scopus 로고    scopus 로고
    • Toxicology for the twenty-first century
    • Hartung T.Toxicology for the twenty-first century.Nature. 2009;460:208-12
    • (2009) Nature , vol.460 , pp. 208-212
    • Hartung, T.1
  • 5
    • 84883880887 scopus 로고    scopus 로고
    • Look back in anger – what clinical studies tell us about preclinical work
    • Hartung T.Look back in anger – what clinical studies tell us about preclinical work.Altex. 2013;30:275-91
    • (2013) Altex , vol.30 , pp. 275-291
    • Hartung, T.1
  • 10
    • 84864582983 scopus 로고    scopus 로고
    • Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare
    • Hartung T,Zurlo J.Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare.Altex. 2012;29:251-60
    • (2012) Altex , vol.29 , pp. 251-260
    • Hartung, T.1    Zurlo, J.2
  • 11
    • 0028157593 scopus 로고
    • Prevalence and health impact of developmental disabilities in US children
    • Boyle CA,Decoufle P,Yeargin-Allsopp M.Prevalence and health impact of developmental disabilities in US children.Pediatrics. 1994;93:399-403
    • (1994) Pediatrics , vol.93 , pp. 399-403
    • Boyle, C.A.1    Decoufle, P.2    Yeargin-Allsopp, M.3
  • 12
    • 33845424655 scopus 로고    scopus 로고
    • Developmental neurotoxicity of industrial chemicals
    • Grandjean P,Landrigan PJ.Developmental neurotoxicity of industrial chemicals.Lancet. 2006;368:2167-78
    • (2006) Lancet , vol.368 , pp. 2167-2178
    • Grandjean, P.1    Landrigan, P.J.2
  • 13
    • 0035684801 scopus 로고    scopus 로고
    • Toxic threats to neurologic development of children
    • Schettler T.Toxic threats to neurologic development of children.Environmental health perspectives. 2001;109:813-6
    • (2001) Environmental health perspectives , vol.109 , pp. 813-816
    • Schettler, T.1
  • 14
    • 34248377285 scopus 로고    scopus 로고
    • Comments from the developmental neurotoxicology committee of the Japanese teratology society on the OECD guideline for the testing of chemicals, proposal for a new guideline 426, developmental neurotoxicity study, draft document (October 2006 version), and on the draft document of the retrospective performance assessment of the draft test guideline 426 on developmental neurotoxicity
    • Ema M,Fukui Y,Aoyama H,Fujiwara M,Fuji J,Inouye M,Iwase T,Kihara T,Oi A,Otani H,Shinomiya M,Sugioka K,Yamano T,Yamashita KH,Tanimura T.Comments from the developmental neurotoxicology committee of the Japanese teratology society on the OECD guideline for the testing of chemicals, proposal for a new guideline 426, developmental neurotoxicity study, draft document (October 2006 version), and on the draft document of the retrospective performance assessment of the draft test guideline 426 on developmental neurotoxicity.Congenit Anom (Kyoto). 2007;47:74-6
    • (2007) Congenit Anom (Kyoto) , vol.47 , pp. 74-76
    • Ema, M.1    Fukui, Y.2    Aoyama, H.3    Fujiwara, M.4    Fuji, J.5    Inouye, M.6    Iwase, T.7    Kihara, T.8    Oi, A.9    Otani, H.10    Shinomiya, M.11    Sugioka, K.12    Yamano, T.13    Yamashita, K.H.14    Tanimura, T.15
  • 15
    • 77954356638 scopus 로고    scopus 로고
    • Increased risk of ADHD associated with early exposure to pesticides, PCBs
    • Kuehn BM.Increased risk of ADHD associated with early exposure to pesticides, PCBs.JAMA. 2010;304:27-8
    • (2010) JAMA , vol.304 , pp. 27-28
    • Kuehn, B.M.1
  • 16
    • 77249162685 scopus 로고    scopus 로고
    • Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children
    • Sagiv SK,Thurston SW,Bellinger DC,Tolbert PE,Altshul LM,Korrick SA.Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children.Am J Epidemiol. 2010;171:593-601
    • (2010) Am J Epidemiol , vol.171 , pp. 593-601
    • Sagiv, S.K.1    Thurston, S.W.2    Bellinger, D.C.3    Tolbert, P.E.4    Altshul, L.M.5    Korrick, S.A.6
  • 17
    • 0028291958 scopus 로고
    • Vulnerable periods and processes during central nervous system development
    • Rodier PM.Vulnerable periods and processes during central nervous system development.Environ Health Perspect. 1994;102:121-4
    • (1994) Environ Health Perspect , vol.102 , pp. 121-124
    • Rodier, P.M.1
  • 19
    • 0035066639 scopus 로고    scopus 로고
    • Biology of oligodendrocyte and myelin in the mammalian central nervous system
    • Baumann N,Pham-Dinh D.Biology of oligodendrocyte and myelin in the mammalian central nervous system.Physiol Rev. 2001;81:871-927
    • (2001) Physiol Rev , vol.81 , pp. 871-927
    • Baumann, N.1    Pham-Dinh, D.2
  • 21
    • 28244472094 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation
    • Kinsner A,Pilotto V,Deininger S,Brown GC,Coecke S,Hartung T,Bal-Price A.Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation.J Neurochem. 2005;95:1132-43
    • (2005) J Neurochem , vol.95 , pp. 1132-1143
    • Kinsner, A.1    Pilotto, V.2    Deininger, S.3    Brown, G.C.4    Coecke, S.5    Hartung, T.6    Bal-Price, A.7
  • 22
    • 73949115799 scopus 로고    scopus 로고
    • Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered
    • Bal-Price AK,Hogberg HT,Buzanska L,Coecke S.Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered.Neurotoxicol Teratol. 2010;32:36-41
    • (2010) Neurotoxicol Teratol , vol.32 , pp. 36-41
    • Bal-Price, A.K.1    Hogberg, H.T.2    Buzanska, L.3    Coecke, S.4
  • 23
    • 0037704306 scopus 로고    scopus 로고
    • Extracellular matrix molecules and synaptic plasticity
    • Dityatev A,Schachner M.Extracellular matrix molecules and synaptic plasticity.Nat Rev Neurosci. 2003;4:456-68
    • (2003) Nat Rev Neurosci , vol.4 , pp. 456-468
    • Dityatev, A.1    Schachner, M.2
  • 24
    • 0034024027 scopus 로고    scopus 로고
    • Lecticans: organizers of the brain extracellular matrix
    • Yamaguchi Y.Lecticans: organizers of the brain extracellular matrix.Cell Mol Life Sci: CMLS. 2000;57:276-89
    • (2000) Cell Mol Life Sci: CMLS , vol.57 , pp. 276-289
    • Yamaguchi, Y.1
  • 25
    • 0033778942 scopus 로고    scopus 로고
    • Proteoglycans in the developing brain: new conceptual insights for old proteins
    • Bandtlow CE,Zimmermann DR.Proteoglycans in the developing brain: new conceptual insights for old proteins.Physiol Rev. 2000;80:1267-90
    • (2000) Physiol Rev , vol.80 , pp. 1267-1290
    • Bandtlow, C.E.1    Zimmermann, D.R.2
  • 26
    • 0025976838 scopus 로고
    • Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
    • Yayon A,Klagsbrun M,Esko JD,Leder P,Ornitz DM.Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.Cell. 1991;64:841-8
    • (1991) Cell , vol.64 , pp. 841-848
    • Yayon, A.1    Klagsbrun, M.2    Esko, J.D.3    Leder, P.4    Ornitz, D.M.5
  • 27
    • 0030905752 scopus 로고    scopus 로고
    • HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts
    • Rauvala H,Peng HB.HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts.Prog Neurobiol. 1997;52:127-44
    • (1997) Prog Neurobiol , vol.52 , pp. 127-144
    • Rauvala, H.1    Peng, H.B.2
  • 28
    • 0033611939 scopus 로고    scopus 로고
    • Functional synapses are formed between human NTera2 (NT2N, hNT) neurons grown on astrocytes
    • Hartley RS,Margulis M,Fishman PS,Lee VM,Tang CM.Functional synapses are formed between human NTera2 (NT2N, hNT) neurons grown on astrocytes.J Comp Neurol. 1999;407:1-10
    • (1999) J Comp Neurol , vol.407 , pp. 1-10
    • Hartley, R.S.1    Margulis, M.2    Fishman, P.S.3    Lee, V.M.4    Tang, C.M.5
  • 29
    • 84873730046 scopus 로고    scopus 로고
    • Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells
    • Liu Q,Spusta SC,Mi R,Lassiter RN,Stark MR,Hoke A,Rao MS,Zeng X.Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells.Stem Cells Transl Med. 2012;1:266-78
    • (2012) Stem Cells Transl Med , vol.1 , pp. 266-278
    • Liu, Q.1    Spusta, S.C.2    Mi, R.3    Lassiter, R.N.4    Stark, M.R.5    Hoke, A.6    Rao, M.S.7    Zeng, X.8
  • 31
    • 34147210364 scopus 로고    scopus 로고
    • Superior survival and durability of neurons and astrocytes on 3-dimensional aragonite biomatrices
    • Peretz H,Talpalar AE,Vago R,Baranes D.Superior survival and durability of neurons and astrocytes on 3-dimensional aragonite biomatrices.Tissue Eng. 2007;13:461-72
    • (2007) Tissue Eng , vol.13 , pp. 461-472
    • Peretz, H.1    Talpalar, A.E.2    Vago, R.3    Baranes, D.4
  • 33
    • 70350726541 scopus 로고    scopus 로고
    • Integrating human stem cell expansion and neuronal differentiation in bioreactors
    • Serra M,Brito C,Costa EM,Sousa MF,Alves PM.Integrating human stem cell expansion and neuronal differentiation in bioreactors.BMC Biotechnol. 2009;9:82-82
    • (2009) BMC Biotechnol , vol.9 , pp. 82
    • Serra, M.1    Brito, C.2    Costa, E.M.3    Sousa, M.F.4    Alves, P.M.5
  • 35
    • 78951483473 scopus 로고    scopus 로고
    • Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons
    • Hogberg HT,Sobanski T,Novellino A,Whelan M,Weiss DG,Bal-Price AK.Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons.Neurotoxicology. 2011;32:158-68
    • (2011) Neurotoxicology , vol.32 , pp. 158-168
    • Hogberg, H.T.1    Sobanski, T.2    Novellino, A.3    Whelan, M.4    Weiss, D.G.5    Bal-Price, A.K.6
  • 36
    • 0035215499 scopus 로고    scopus 로고
    • NMDA receptor-dependent periodic oscillations in cultured spinal cord networks
    • Keefer EW,Gramowski A,Gross GW.NMDA receptor-dependent periodic oscillations in cultured spinal cord networks.J Neurophysiol. 2001;86:3030-42
    • (2001) J Neurophysiol , vol.86 , pp. 3030-3042
    • Keefer, E.W.1    Gramowski, A.2    Gross, G.W.3
  • 39
    • 0037451859 scopus 로고    scopus 로고
    • Functional synapse formation among rat cortical neurons grown on three-dimensional collagen gels
    • O’Shaughnessy TJ,Lin HJ,Ma W.Functional synapse formation among rat cortical neurons grown on three-dimensional collagen gels.Neurosci Lett. 2003;340:169-72
    • (2003) Neurosci Lett , vol.340 , pp. 169-172
    • O’Shaughnessy, T.J.1    Lin, H.J.2    Ma, W.3
  • 40
    • 33750706174 scopus 로고    scopus 로고
    • An artificial three-dimensional matrix promotes ramification in the microglial cell-line, BV-2
    • Pottler M,Zierler S,Kerschbaum HH.An artificial three-dimensional matrix promotes ramification in the microglial cell-line, BV-2.Neurosc Lett. 2006;410:137-40
    • (2006) Neurosc Lett , vol.410 , pp. 137-140
    • Pottler, M.1    Zierler, S.2    Kerschbaum, H.H.3
  • 41
    • 0042358985 scopus 로고    scopus 로고
    • Cell culture: biology’s new dimension
    • Abbott A.Cell culture: biology’s new dimension.Nature. 2003;424:870-2
    • (2003) Nature , vol.424 , pp. 870-872
    • Abbott, A.1
  • 42
    • 0035941075 scopus 로고    scopus 로고
    • Taking cell-matrix adhesions to the third dimension
    • Cukierman E,Pankov R,Stevens DR,Yamada KM.Taking cell-matrix adhesions to the third dimension.Science. 2001;294:1708-12
    • (2001) Science , vol.294 , pp. 1708-1712
    • Cukierman, E.1    Pankov, R.2    Stevens, D.R.3    Yamada, K.M.4
  • 43
    • 84863835842 scopus 로고    scopus 로고
    • Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications
    • Gassmann K,Baumann J,Giersiefer S,Schuwald J,Schreiber T,Merk HF,Fritsche E.Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications.Toxicol In Vitro. 2012;26:993-1000
    • (2012) Toxicol In Vitro , vol.26 , pp. 993-1000
    • Gassmann, K.1    Baumann, J.2    Giersiefer, S.3    Schuwald, J.4    Schreiber, T.5    Merk, H.F.6    Fritsche, E.7
  • 44
    • 37849024323 scopus 로고    scopus 로고
    • A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine
    • Van Vliet E,Morath S,Eskes C,Linge J,Rappsilber J,Honegger P,Hartung T,Coecke S.A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine.Neurotoxicology. 2008;29:1-12
    • (2008) Neurotoxicology , vol.29 , pp. 1-12
    • Van Vliet, E.1    Morath, S.2    Eskes, C.3    Linge, J.4    Rappsilber, J.5    Honegger, P.6    Hartung, T.7    Coecke, S.8
  • 47
    • 34249100959 scopus 로고    scopus 로고
    • Meeting report: alternatives for developmental neurotoxicity testing
    • Lein P,Locke P,Goldberg A.Meeting report: alternatives for developmental neurotoxicity testing.Environ Health Perspect. 2007;115:764-8
    • (2007) Environ Health Perspect , vol.115 , pp. 764-768
    • Lein, P.1    Locke, P.2    Goldberg, A.3
  • 48
    • 17044431495 scopus 로고    scopus 로고
    • In vitro and other alternative approaches to developmental neurotoxicity testing (DNT)
    • Lein P,Silbergeld E,Locke P,Goldberg AM.In vitro and other alternative approaches to developmental neurotoxicity testing (DNT).Environ Toxicol Pharmacol. 2005;19:735-44
    • (2005) Environ Toxicol Pharmacol , vol.19 , pp. 735-744
    • Lein, P.1    Silbergeld, E.2    Locke, P.3    Goldberg, A.M.4
  • 49
    • 0037441458 scopus 로고    scopus 로고
    • Involvement of microglia-neuron interactions in the tumor necrosis factor-alpha release, microglial activation, and neurodegeneration induced by trimethyltin
    • Eskes C,Juillerat-Jeanneret L,Leuba G,Honegger P,Monnet-Tschudi F.Involvement of microglia-neuron interactions in the tumor necrosis factor-alpha release, microglial activation, and neurodegeneration induced by trimethyltin.J Neurosci Res. 2003;71:583-90
    • (2003) J Neurosci Res , vol.71 , pp. 583-590
    • Eskes, C.1    Juillerat-Jeanneret, L.2    Leuba, G.3    Honegger, P.4    Monnet-Tschudi, F.5
  • 50
    • 79960699068 scopus 로고    scopus 로고
    • Ochratoxin A at nanomolar concentration perturbs the homeostasis of neural stem cells in highly differentiated but not in immature three-dimensional brain cell cultures
    • Zurich MG,Honegger P.Ochratoxin A at nanomolar concentration perturbs the homeostasis of neural stem cells in highly differentiated but not in immature three-dimensional brain cell cultures.Toxicol Lett. 2011;205:203-8
    • (2011) Toxicol Lett , vol.205 , pp. 203-208
    • Zurich, M.G.1    Honegger, P.2
  • 52
    • 75249106472 scopus 로고    scopus 로고
    • mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach
    • Hogberg HT,Kinsner-Ovaskainen A,Coecke S,Hartung T,Bal-Price AK.mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach.Toxicol Sci. 2010;113:95-115
    • (2010) Toxicol Sci , vol.113 , pp. 95-115
    • Hogberg, H.T.1    Kinsner-Ovaskainen, A.2    Coecke, S.3    Hartung, T.4    Bal-Price, A.K.5
  • 53
    • 61349100071 scopus 로고    scopus 로고
    • Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides
    • Hogberg HT,Kinsner-Ovaskainen A,Hartung T,Coecke S,Bal-Price AK.Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides.Toxicol Appl Pharmacol. 2009;235:268-86
    • (2009) Toxicol Appl Pharmacol , vol.235 , pp. 268-286
    • Hogberg, H.T.1    Kinsner-Ovaskainen, A.2    Hartung, T.3    Coecke, S.4    Bal-Price, A.K.5
  • 56
    • 0018598487 scopus 로고
    • Growth and differentiation of aggregating fetal brain cells in a serum-free defined medium
    • Honegger P,Lenoir D,Favrod P.Growth and differentiation of aggregating fetal brain cells in a serum-free defined medium.Nature. 1979;282:305-8
    • (1979) Nature , vol.282 , pp. 305-308
    • Honegger, P.1    Lenoir, D.2    Favrod, P.3
  • 57
    • 80052919976 scopus 로고    scopus 로고
    • Neurospheres as a model for developmental neurotoxicity testing
    • Fritsche E,Gassmann K,Schreiber T.Neurospheres as a model for developmental neurotoxicity testing.Methods Mol Biol. 2011;758:99-114
    • (2011) Methods Mol Biol , vol.758 , pp. 99-114
    • Fritsche, E.1    Gassmann, K.2    Schreiber, T.3
  • 59
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
    • Abbott NJ.Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology.Neurochem Int. 2004;45:545-52
    • (2004) Neurochem Int , vol.45 , pp. 545-552
    • Abbott, N.J.1
  • 60
    • 0032754657 scopus 로고    scopus 로고
    • Microvessel organization and structure in experimental brain tumors: microvessel populations with distinctive structural and functional properties
    • Schlageter KE,Molnar P,Lapin GD,Groothuis DR.Microvessel organization and structure in experimental brain tumors: microvessel populations with distinctive structural and functional properties.Microvasc Res. 1999;58:312-28
    • (1999) Microvasc Res , vol.58 , pp. 312-328
    • Schlageter, K.E.1    Molnar, P.2    Lapin, G.D.3    Groothuis, D.R.4
  • 61
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: development, composition and regulation
    • Wolburg H,Lippoldt A.Tight junctions of the blood-brain barrier: development, composition and regulation.Vasc Pharmacol. 2002;38:323-37
    • (2002) Vasc Pharmacol , vol.38 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 62
    • 10344259085 scopus 로고    scopus 로고
    • The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology
    • Krizanac-Bengez L,Mayberg MR,Janigro D.The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology.Neurol Res. 2004;26:846-53
    • (2004) Neurol Res , vol.26 , pp. 846-853
    • Krizanac-Bengez, L.1    Mayberg, M.R.2    Janigro, D.3
  • 63
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • Abbott NJ.Astrocyte-endothelial interactions and blood-brain barrier permeability.J Anat. 2002;200:629-38
    • (2002) J Anat , vol.200 , pp. 629-638
    • Abbott, N.J.1
  • 65
    • 73249122034 scopus 로고    scopus 로고
    • Vascular mechanobiology: endothelial cell responses to fluid shear stress
    • Ando J,Yamamoto K.Vascular mechanobiology: endothelial cell responses to fluid shear stress.Circ J. 2009;73:1983-92
    • (2009) Circ J , vol.73 , pp. 1983-1992
    • Ando, J.1    Yamamoto, K.2
  • 67
    • 84887987425 scopus 로고    scopus 로고
    • Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
    • Eigenmann DE,Xue G,Kim KS,Moses AV,Hamburger M,Oufir M.Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies.Fluids Barriers CNS. 2013;10:33-33
    • (2013) Fluids Barriers CNS , vol.10 , pp. 33
    • Eigenmann, D.E.1    Xue, G.2    Kim, K.S.3    Moses, A.V.4    Hamburger, M.5    Oufir, M.6
  • 68
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • Daneman R,Zhou L,Kebede AA,Barres BA.Pericytes are required for blood-brain barrier integrity during embryogenesis.Nature. 2010;468:562-6
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 69
    • 17644363679 scopus 로고    scopus 로고
    • In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro
    • Haseloff RF,Blasig IE,Bauer HC,Bauer H.In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro.Cell Mol Neurobiol. 2005;25:25-39
    • (2005) Cell Mol Neurobiol , vol.25 , pp. 25-39
    • Haseloff, R.F.1    Blasig, I.E.2    Bauer, H.C.3    Bauer, H.4
  • 73
    • 79551646454 scopus 로고    scopus 로고
    • Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult
    • Al Ahmad A,Taboada CB,Gassmann M,Ogunshola OO.Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult.J Cereb Blood Flow Metab. 2011;31:693-705
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 693-705
    • Al Ahmad, A.1    Taboada, C.B.2    Gassmann, M.3    Ogunshola, O.O.4
  • 74
    • 79960279229 scopus 로고    scopus 로고
    • Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models
    • Hatherell K,Couraud PO,Romero IA,Weksler B,Pilkington GJ.Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models.J Neurosci Methods. 2011;199:223-9
    • (2011) J Neurosci Methods , vol.199 , pp. 223-229
    • Hatherell, K.1    Couraud, P.O.2    Romero, I.A.3    Weksler, B.4    Pilkington, G.J.5
  • 76
    • 84873255363 scopus 로고    scopus 로고
    • A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box
    • Cucullo L,Hossain M,Tierney W,Janigro D.A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box.BMC Neurosci. 2013;14:18-18
    • (2013) BMC Neurosci , vol.14 , pp. 18
    • Cucullo, L.1    Hossain, M.2    Tierney, W.3    Janigro, D.4
  • 77
    • 84876704168 scopus 로고    scopus 로고
    • Engineering of functional, perfusable 3D microvascular networks on a chip
    • Kim S,Lee H,Chung M,Jeon NL.Engineering of functional, perfusable 3D microvascular networks on a chip.Lab Chip. 2013;13:1489-500
    • (2013) Lab Chip , vol.13 , pp. 1489-1500
    • Kim, S.1    Lee, H.2    Chung, M.3    Jeon, N.L.4
  • 81
    • 84877043911 scopus 로고    scopus 로고
    • Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures
    • Yeon JH,Na D,Choi K,Ryu SW,Choi C,Park JK.Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures.Biomed Microdevices. 2012;14:1141-8
    • (2012) Biomed Microdevices , vol.14 , pp. 1141-1148
    • Yeon, J.H.1    Na, D.2    Choi, K.3    Ryu, S.W.4    Choi, C.5    Park, J.K.6
  • 82
    • 84860366574 scopus 로고    scopus 로고
    • Characterization of a microfluidic in vitro model of the blood-brain barrier (muBBB)
    • Booth R,Kim H.Characterization of a microfluidic in vitro model of the blood-brain barrier (muBBB).Lab Chip. 2012;12:1784-92
    • (2012) Lab Chip , vol.12 , pp. 1784-1792
    • Booth, R.1    Kim, H.2
  • 83
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K,Yamanaka S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Cell. 2006;126:663-76
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 87
    • 84868197853 scopus 로고    scopus 로고
    • Progress made in the reprogramming field: new factors, new strategies and a new outlook
    • Hussein SM,Nagy AA.Progress made in the reprogramming field: new factors, new strategies and a new outlook.Curr Opin Genet Dev. 2012;22:435-43
    • (2012) Curr Opin Genet Dev , vol.22 , pp. 435-443
    • Hussein, S.M.1    Nagy, A.A.2
  • 88
    • 84886730320 scopus 로고    scopus 로고
    • Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain
    • Barker RA,De Beaufort I.Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain.Prog Neurobiol. 2013;110:63-73
    • (2013) Prog Neurobiol , vol.110 , pp. 63-73
    • Barker, R.A.1    De Beaufort, I.2
  • 89
    • 84855416431 scopus 로고    scopus 로고
    • Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart?
    • Bilic J,Izpisua Belmonte JC.Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart?.Stem Cells. 2012;30:33-41
    • (2012) Stem Cells , vol.30 , pp. 33-41
    • Bilic, J.1    Izpisua Belmonte, J.C.2
  • 92
    • 68949130137 scopus 로고    scopus 로고
    • A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells
    • Vazin T,Becker KG,Chen J,Spivak CE,Lupica CR,Zhang Y,Worden L,Freed WJ.A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.PLoS One. 2009;4:e6606-e6606
    • (2009) PLoS One , vol.4 , pp. e6606-e6606
    • Vazin, T.1    Becker, K.G.2    Chen, J.3    Spivak, C.E.4    Lupica, C.R.5    Zhang, Y.6    Worden, L.7    Freed, W.J.8
  • 93
    • 75649107230 scopus 로고    scopus 로고
    • Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells
    • Zhang XQ,Zhang SC.Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells.Methods Mol Biol. 2010;584:355-66
    • (2010) Methods Mol Biol , vol.584 , pp. 355-366
    • Zhang, X.Q.1    Zhang, S.C.2
  • 94
    • 84861203696 scopus 로고    scopus 로고
    • Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells
    • Juopperi TA,Kim WR,Chiang CH,Yu H,Margolis RL,Ross CA,Ming GL,Song H.Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells.Mol Brain. 2012;5:17-17
    • (2012) Mol Brain , vol.5 , pp. 17
    • Juopperi, T.A.1    Kim, W.R.2    Chiang, C.H.3    Yu, H.4    Margolis, R.L.5    Ross, C.A.6    Ming, G.L.7    Song, H.8
  • 95
    • 80051794021 scopus 로고    scopus 로고
    • Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells
    • Ogawa S,Tokumoto Y,Miyake J,Nagamune T.Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells.In Vitro Cell Dev Biol Anim. 2011;47:464-9
    • (2011) In Vitro Cell Dev Biol Anim , vol.47 , pp. 464-469
    • Ogawa, S.1    Tokumoto, Y.2    Miyake, J.3    Nagamune, T.4
  • 101
    • 67649382407 scopus 로고    scopus 로고
    • Differentiation of neuroepithelia from human embryonic stem cells
    • Xia X,Zhang SC.Differentiation of neuroepithelia from human embryonic stem cells.Methods Mol Biol. 2009;549:51-8
    • (2009) Methods Mol Biol , vol.549 , pp. 51-58
    • Xia, X.1    Zhang, S.C.2
  • 102
    • 84884885007 scopus 로고    scopus 로고
    • Cerebral organoids in a dish: progress and prospects
    • Bershteyn M,Kriegstein AR.Cerebral organoids in a dish: progress and prospects.Cell. 2013;155:19-20
    • (2013) Cell , vol.155 , pp. 19-20
    • Bershteyn, M.1    Kriegstein, A.R.2
  • 103
    • 70249133666 scopus 로고    scopus 로고
    • Differentiation of spinal motor neurons from pluripotent human stem cells
    • Hu BY,Zhang SC.Differentiation of spinal motor neurons from pluripotent human stem cells.Nat Protoc. 2009;4:1295-304
    • (2009) Nat Protoc , vol.4 , pp. 1295-1304
    • Hu, B.Y.1    Zhang, S.C.2
  • 106
    • 84885724899 scopus 로고    scopus 로고
    • Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons
    • Jiao J,Yang Y,Shi Y,Chen J,Gao R,Fan Y,Yao H,Liao W,Sun X,Gao S.Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons.Hum Mol Genet. 2013;1:4241-52
    • (2013) Hum Mol Genet , vol.1 , pp. 4241-4252
    • Jiao, J.1    Yang, Y.2    Shi, Y.3    Chen, J.4    Gao, R.5    Fan, Y.6    Yao, H.7    Liao, W.8    Sun, X.9    Gao, S.10
  • 107
    • 80053948646 scopus 로고    scopus 로고
    • Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome
    • Sheridan SD,Theriault KM,Reis SA,Zhou F,Madison JM,Daheron L,Loring JF,Haggarty SJ.Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.PLoS One. 2011;6:e26203-e26203
    • (2011) PLoS One , vol.6 , pp. e26203-e26203
    • Sheridan, S.D.1    Theriault, K.M.2    Reis, S.A.3    Zhou, F.4    Madison, J.M.5    Daheron, L.6    Loring, J.F.7    Haggarty, S.J.8
  • 108
    • 80053143413 scopus 로고    scopus 로고
    • Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model
    • Ananiev G,Williams EC,Li H,Chang Q.Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model.PLoS One. 2011;6:e25255-e25255
    • (2011) PLoS One , vol.6 , pp. e25255-e25255
    • Ananiev, G.1    Williams, E.C.2    Li, H.3    Chang, Q.4
  • 109
    • 84884221870 scopus 로고    scopus 로고
    • Investigation of Rett syndrome using pluripotent stem cells
    • Dajani R,Koo SE,Sullivan GJ,Park IH.Investigation of Rett syndrome using pluripotent stem cells.J Cell Biochem. 2013;114:2446-53
    • (2013) J Cell Biochem , vol.114 , pp. 2446-2453
    • Dajani, R.1    Koo, S.E.2    Sullivan, G.J.3    Park, I.H.4
  • 111
    • 81855206164 scopus 로고    scopus 로고
    • Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient
    • Chang T,Zheng W,Tsark W,Bates S,Huang H,Lin RJ,Yee JK.Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient.Stem Cells. 2011;29:2090-3
    • (2011) Stem Cells , vol.29 , pp. 2090-2093
    • Chang, T.1    Zheng, W.2    Tsark, W.3    Bates, S.4    Huang, H.5    Lin, R.J.6    Yee, J.K.7
  • 114
    • 84869065193 scopus 로고    scopus 로고
    • Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells
    • Yi F,Qu J,Li M,Suzuki K,Kim NY,Liu GH,Belmonte JC.Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells.Protein Cell. 2012;3:855-63
    • (2012) Protein Cell , vol.3 , pp. 855-863
    • Yi, F.1    Qu, J.2    Li, M.3    Suzuki, K.4    Kim, N.Y.5    Liu, G.H.6    Belmonte, J.C.7
  • 115
    • 84864628471 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from patients with Huntington’s disease show CAG-repeat-expansion-associated phenotypes
    • Consortium THi.Induced pluripotent stem cells from patients with Huntington’s disease show CAG-repeat-expansion-associated phenotypes.Cell Stem Cell. 2012;11:264-78
    • (2012) Cell Stem Cell , vol.11 , pp. 264-278
    • Consortium, T.H.1
  • 117
    • 64849101671 scopus 로고    scopus 로고
    • Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration
    • De la Monte SM,Tong M,Carlson RI,Carter JJ,Longato L,Silbermann E,Wands JR.Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration.Alcohol. 2009;43:225-40
    • (2009) Alcohol , vol.43 , pp. 225-240
    • De la Monte, S.M.1    Tong, M.2    Carlson, R.I.3    Carter, J.J.4    Longato, L.5    Silbermann, E.6    Wands, J.R.7
  • 119
    • 84892612206 scopus 로고    scopus 로고
    • Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity
    • Stern M,Gierse A,Tan S,Bicker G.Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity.Arch Toxicol. 2014;88:127-36
    • (2014) Arch Toxicol , vol.88 , pp. 127-136
    • Stern, M.1    Gierse, A.2    Tan, S.3    Bicker, G.4
  • 120
    • 84890566643 scopus 로고    scopus 로고
    • Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants
    • Krug AK,Balmer NV,Matt F,Schonenberger F,Merhof D,Leist M.Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants.Arch Toxicol. 2013;87:2215-31
    • (2013) Arch Toxicol , vol.87 , pp. 2215-2231
    • Krug, A.K.1    Balmer, N.V.2    Matt, F.3    Schonenberger, F.4    Merhof, D.5    Leist, M.6
  • 122
    • 78650524432 scopus 로고    scopus 로고
    • Use of high content image analysis to detect chemical-induced changes in synaptogenesis in vitro
    • Harrill JA,Robinette BL,Mundy WR.Use of high content image analysis to detect chemical-induced changes in synaptogenesis in vitro.Toxicol In Vitro. 2011;25:368-87
    • (2011) Toxicol In Vitro , vol.25 , pp. 368-387
    • Harrill, J.A.1    Robinette, B.L.2    Mundy, W.R.3
  • 124
    • 0035129282 scopus 로고    scopus 로고
    • A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein
    • Nakai J,Ohkura M,Imoto K.A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein.Nat Biotechnol. 2001;19:137-41
    • (2001) Nat Biotechnol , vol.19 , pp. 137-141
    • Nakai, J.1    Ohkura, M.2    Imoto, K.3
  • 126
    • 2942559178 scopus 로고    scopus 로고
    • Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays
    • Gramowski A,Jugelt K,Weiss DG,Gross GW.Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays.Eur J Neurosci. 2004;19:2815-25
    • (2004) Eur J Neurosci , vol.19 , pp. 2815-2825
    • Gramowski, A.1    Jugelt, K.2    Weiss, D.G.3    Gross, G.W.4
  • 128
    • 84875797909 scopus 로고    scopus 로고
    • Fluorescent probes as a tool for cell population tracking in spontaneously active neural networks derived from human pluripotent stem cells
    • Makinen M,Joki T,Yla-Outinen L,Skottman H,Narkilahti S,Aanismaa R.Fluorescent probes as a tool for cell population tracking in spontaneously active neural networks derived from human pluripotent stem cells.J Neurosci Methods. 2013;215:88-96
    • (2013) J Neurosci Methods , vol.215 , pp. 88-96
    • Makinen, M.1    Joki, T.2    Yla-Outinen, L.3    Skottman, H.4    Narkilahti, S.5    Aanismaa, R.6
  • 130
    • 0346668359 scopus 로고    scopus 로고
    • Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes
    • Bal-Price A,Moneer Z,Brown GC.Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes.Glia. 2002;40:312-23
    • (2002) Glia , vol.40 , pp. 312-323
    • Bal-Price, A.1    Moneer, Z.2    Brown, G.C.3
  • 131
    • 0033806589 scopus 로고    scopus 로고
    • Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes
    • Ross IA,Johnson W,Sapienza PP,Kim CS.Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes.Food Chem Toxicol. 2000;38:1005-11
    • (2000) Food Chem Toxicol , vol.38 , pp. 1005-1011
    • Ross, I.A.1    Johnson, W.2    Sapienza, P.P.3    Kim, C.S.4
  • 132
    • 73849133701 scopus 로고    scopus 로고
    • Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis
    • Radio NM,Freudenrich TM,Robinette BL,Crofton KM,Mundy WR.Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis.Neurotoxicol Teratol. 2010;32:25-35
    • (2010) Neurotoxicol Teratol , vol.32 , pp. 25-35
    • Radio, N.M.1    Freudenrich, T.M.2    Robinette, B.L.3    Crofton, K.M.4    Mundy, W.R.5
  • 133
    • 84867142135 scopus 로고    scopus 로고
    • Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems
    • Meli L,Jordan ET,Clark DS,Linhardt RJ,Dordick JS.Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems.Biomaterials. 2012;33:9087-96
    • (2012) Biomaterials , vol.33 , pp. 9087-9096
    • Meli, L.1    Jordan, E.T.2    Clark, D.S.3    Linhardt, R.J.4    Dordick, J.S.5
  • 135
    • 60649116624 scopus 로고    scopus 로고
    • Micropatterning of human embryonic stem cells dissects the mesoderm and endoderm lineages
    • Lee LH,Peerani R,Ungrin M,Joshi C,Kumacheva E,Zandstra P.Micropatterning of human embryonic stem cells dissects the mesoderm and endoderm lineages.Stem Cell Res. 2009;2:155-62
    • (2009) Stem Cell Res , vol.2 , pp. 155-162
    • Lee, L.H.1    Peerani, R.2    Ungrin, M.3    Joshi, C.4    Kumacheva, E.5    Zandstra, P.6
  • 136
    • 77956472311 scopus 로고    scopus 로고
    • Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture
    • Lampe KJ,Mooney RG,Bjugstad KB,Mahoney MJ.Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture.J Biomed Materials Res Part A. 2010;94:1162-71
    • (2010) J Biomed Materials Res Part A , vol.94 , pp. 1162-1171
    • Lampe, K.J.1    Mooney, R.G.2    Bjugstad, K.B.3    Mahoney, M.J.4
  • 137
    • 77953995631 scopus 로고    scopus 로고
    • Lessons learned from alternative methods and their validation for a new toxicology in the 21st century
    • Hartung T.Lessons learned from alternative methods and their validation for a new toxicology in the 21st century.J Toxicol Environ Health B Crit Rev. 2010;13:277-90
    • (2010) J Toxicol Environ Health B Crit Rev , vol.13 , pp. 277-290
    • Hartung, T.1
  • 140
    • 34249915306 scopus 로고    scopus 로고
    • Food for thought…on validation
    • Hartung T.Food for thought…on validation.Altex. 2007;24:67-80
    • (2007) Altex , vol.24 , pp. 67-80
    • Hartung, T.1
  • 141
    • 84864593532 scopus 로고    scopus 로고
    • Validation and quality control of replacement alternatives – current status and future challenges
    • Leist M,Hasiwa N,Daneshian M,Hartung T.Validation and quality control of replacement alternatives – current status and future challenges.Toxicol Res. 2012;1:8-22
    • (2012) Toxicol Res , vol.1 , pp. 8-22
    • Leist, M.1    Hasiwa, N.2    Daneshian, M.3    Hartung, T.4
  • 142
    • 79952311389 scopus 로고    scopus 로고
    • Evidence-based toxicology – the toolbox of validation for the 21st century?
    • Hartung T.Evidence-based toxicology – the toolbox of validation for the 21st century?.Altex. 2010;27:253-63
    • (2010) Altex , vol.27 , pp. 253-263
    • Hartung, T.1
  • 143
    • 33748801463 scopus 로고    scopus 로고
    • Toward an evidence-based toxicology
    • Hoffmann S,Hartung T.Toward an evidence-based toxicology.Hum Exp Toxicol. 2006;25:497-513
    • (2006) Hum Exp Toxicol , vol.25 , pp. 497-513
    • Hoffmann, S.1    Hartung, T.2
  • 144
    • 84907009056 scopus 로고    scopus 로고
    • accessed 15 OCtober 2013
    • EBTC, http://ebtox.com/ (accessed 15 OCtober 2013).
    • EBTC
  • 145
    • 80053557096 scopus 로고    scopus 로고
    • Evidence-based toxicology collaboration kick-off meeting
    • Zurlo J,Hartung T.Evidence-based toxicology collaboration kick-off meeting.Altex. 2011;28:152-152
    • (2011) Altex , vol.28 , pp. 152
    • Zurlo, J.1    Hartung, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.