Neurospheres as a model for developmental neurotoxicity testing

Methods in Molecular Biology

Volumn 758, Issue , 2011, Pages 99-114

  Fritsche, Ellen ^a,b   Gassmann, Kathrin ^c   Schreiber, Timm ^c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c NONE

Author keywords

Brain development; Developmental neurotoxicity; Human; In vitro; Mouse; Neural progenitor cell; Neurosphere

Indexed keywords

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; BRAIN DEVELOPMENT; CELL ASSAY; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NEURAL STEM CELL; NEUROSPHERE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; ANIMAL; BRAIN; CELL AGGREGATION; CELL SURVIVAL; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; ENZYME ASSAY; FEMALE; FLOW CYTOMETRY; METABOLISM; METHODOLOGY; POLLUTANT; PREGNANCY; PRENATAL DEVELOPMENT;

ANIMALIA; RATTUS;

CASPASE; LACTATE DEHYDROGENASE;

ANIMALS; BRAIN; CASPASES; CELL AGGREGATION; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; ENZYME ASSAYS; FEMALE; FLOW CYTOMETRY; HUMANS; L-LACTATE DEHYDROGENASE; MICE; NEURAL STEM CELLS; PREGNANCY; TOXICITY TESTS;

EID: 80052919976     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-170-3_7     Document Type: Article

References (7)

1. Reynolds BA, Tetzlaff W and Weiss S (1992) A Multipotent EGF-Responsive Striatal Embryonic Progenitor Cell Produces Neurons and Astrocytes. J Neurosci 12:4565-4574.
2. Reynolds BA and Weiss S (1992) Generation of Neurons and Astrocytes From Isolated Cells of the Adult Mammalian Central Nervous System. Science 255:1707-1710.
3. Reynolds BA and Rietze R L (2005) Neural Stem Cells and Neurospheres-Re-Evaluating the Relationship. Nat Methods 2:333-336.
4. Moors M, Rockel TD, Abel J et al. (2009) Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect 117:1131-1138.
5. Fritsche E, Cline JE, Nguyen NH et al. (2005) Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect 113:871-876.
6. Moors M, Cline JE, Abel J and Fritsche E. (2007) ERK-dependent and-independent pathways trigger human neural progenitor cell migration. Toxicol Appl Pharmacol 221:57-67.
7. Schreiber T, Gassmann K, Götz C et al. (2010) Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption. Environ Health Perspect 118:572-578.