An artificial three-dimensional matrix promotes ramification in the microglial cell-line, BV-2

Neuroscience Letters

Volumn 410, Issue 2, 2006, Pages 137-140

  Pöttler, Marina ^a   Zierler, Susanna ^a   Kerschbaum, Hubert H ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Microenvironment; Microglia; Phenotype; Ramification; Three dimensional matrix

Indexed keywords

COLLAGEN TYPE 1; DEXTRO LYSINE; FIBRONECTIN; SCLEROPROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL TYPE; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; EXTRACELLULAR MATRIX; FREQUENCY ANALYSIS; MICROGLIA; NEUROANATOMY; NEUROCHEMISTRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ANIMALS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL LINE; CHI-SQUARE DISTRIBUTION; COLLAGEN TYPE I; EXTRACELLULAR MATRIX; FIBRONECTINS; MICE; MICROGLIA;

EID: 33750706174     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.09.082     Document Type: Article

References (17)

1. Ayoub A.E., and Salm A.K. Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus. J. Neurosi. 23 (2003) 7759-7766
2. Blasi E., Barluzzi R., Bocchini V., Mazzolla R., and Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neuroimmunol. 27 (1990) 229-237
3. Del-Rio Hortega P. Microglia. In: Penfield W. (Ed). Cytology and Cellular Pathology of the Nervous System vol. 2 (1932), Paul B. Hoeber, New York 481-543
4. Giulian D. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 18 (1987) 132-153
5. Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol. 13 (2003) 264-269
6. Jones L.L., and Tuszynski M.H. Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors. J. Neurosci. 22 (2002) 4611-4624
7. Kiefer R., Gold R., Gehrmann J., Lindholm D., Wekerle H., and Kreutzberg G.W. Transforming growth factor beta expression in reactive spinal cord microglia and meningeal inflammatory cells during experimental allergic neuritis. J. Neurosci. Res. 36 (1993) 391-398
8. Lawson L.J., Perry V.H., Dri P., and Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39 (1990) 51-170
9. Lefcort F., Venstrom K., McDonald J.A., and Reichardt L.F. Regulation of expression of fibronectin and its receptor, alpha 5 beta 1, during development and regeneration of peripheral nerve. Development 116 (1992) 767-782
10. Ling E.A., and Wong W.C. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 7 (1993) 9-18
11. Milner R., and Campbell I.L. The extracellular matrix and cytokines regulate microglial integrin expression and activation. J. Immunol. 170 (2003) 3850-3858
12. Monning U., Sandbrink R., Weidemann A., Banati R.B., Masters C.L., and Beyreuther K. Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells. J. Biol. Chem. 270 (1995) 7104-7110
13. Nakajima K., and Kohsaka S. Microglia: activation and their significance in the central nervous system. J. Biochem. 130 (2001) 169-175
14. Rock R.B., Gekker G., Hu S., Sheng W.S., Cheeran M., Lokensgard J.R., and Peterson P.K. Role of microglia in central nervous system infections. Clin. Microbiol. Rev. 17 (2004) 942-964
15. Thomas W.E. Brain macrophages: evaluation of microglia and their functions. Brain Res. Rev. 17 (1992) 61-74
16. van Horssen J., Bo L., Vos C.M., Virtanen I., and de Vries H.E. Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes. J. Neuropathol. Exp. Neurol. 64 (2005) 722-729
17. Zierler S., and Kerschbaum H.H. Blockade of chloride conductance antagonizes PMA-induced ramification in the murine microglial cell line, BV-2. Brain Res. 1039 (2005) 162-170