Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity

Archives of Toxicology

Volumn 88, Issue 1, 2014, Pages 127-136

  Stern, Michael ^a   Gierse, Andrea ^a   Tan, Saime ^a   Bicker, Gerd ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Differentiation; DNT; Human cell line; Migration

Indexed keywords

ARSENITE SODIUM; BETA TUBULIN; GLUTAMATE SODIUM; METHYLAZOXYMETHANOL; METHYLMERCURIC CHLORIDE; PARACETAMOL; PENICILLIN G; VALPROIC ACID;

ARTICLE; BRAIN DEVELOPMENT; CELL MIGRATION; CELL VIABILITY; DEVELOPMENTAL NEUROTOXICITY; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TERATOMA;

ANIMALIA; RODENTIA;

ARSENITES; BRAIN; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; METHYLAZOXYMETHANOL ACETATE; METHYLMERCURY COMPOUNDS; NEURONS; NEUROTOXICITY SYNDROMES; SODIUM COMPOUNDS; TOXICITY TESTS; TUBULIN; VALPROIC ACID;

EID: 84892612206     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1098-1     Document Type: Article

References (47)

1. Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AEM, Kreysa J (2012) Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. Altex 29:202-215
2. Bassanini S, Hallene K, Battaglia G, Finardi A, Santaguida S, Cipolla M, Janigro D (2007) Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol. Neurobiol Dis 26:481-495
3. Berry HK, Butcher RE, Elliott LA, Brunner RL (1974) The effect of monosodium glutamate on the early biochemical and behavioral development of the rat. Develop Psychobiol 7:165-173
4. Breier JM, Gassmann K, Kayser R, Stegeman H, de Groot D, Fritsche E, Shafer TJ (2010) Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science. Neurotoxicol Teratol 32:4-15
5. Buzanska L, Sypecka J, Nerini-Molteni S, Compagnoni A, Hogberg HT, del Torchio R, Domanska-Janik K, Zimmer J, Coecke S (2009) A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system. Stem Cells 27:2591-2601
6. Casanova MF, Buxhoeveden D, Gomez J (2003) Disruption in the inhibitory architecture of the cell minicolumn: implications for autism. Neuroscientist 9:496-507
7. Cattabeni F, de Luca M (1997) Developmental models of brain dysfunctions induced by targeted cell ablations with methylazoxymethanol. Physiol Rev 77:199-213
8. Coecke S, Goldberg AM, Allen S, Buzanska L, Calamandrei G, Crofton K, Hareng L, Hartung T, Knaut H, Honegger P, Jacobs M, Lein P, Li A, Mundy W, Owen D, Schneider S, Silbergeld E, Reum T, Trnovec T, Monnet-Tschudi F, Bal-Price A (2007) Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ Health Perspect 115:924-931
9. Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Seiler AEM, Knaut H, Buzanska L, Goldberg A (2011) Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. ALTEX 28:9-14
10. Forsby A, Bal-Price AK, Camins A, Coecke S, Fabre N, Gustafsson H, Honegger P, Kinsner-Ovaskainen A, Pallas M, Rimbau V, Rodríguez- Farré E, Suñol C, Vericat JA, Zurich MG (2009) Neuronal in vitro models for the estimation of acute systemic toxicity. Toxicol In Vitro 23:1564-1569
11. Goldman LR, Koduru S (2000) Chemicals in the environment and developmental toxicity to children: a public health and policy perspective. Environ Health Perspect 108(Suppl 3):443-448
12. Grandjean P, Landrigan PJ (2006) Developmental neurotoxicity of industrial chemicals. Lancet 368:2167-2178
13. Hatten ME (1999) Central nervous system neuronal migration. Annu Rev Neurosci 22:511-539
14. Herrera A, Pineda J, Antonio MT (2013) Toxic effects of perinatal arsenic exposure on the brain of developing rats and the beneficial role of natural antioxidants. Environ Toxicol Pharmacol 36:73-79
15. Hill EJ, Woehrling EK, Prince M, Coleman MD (2008) Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing. Toxicology 249:243-250
16. Kadereit S, Zimmer B, van Thriel C, Hengstler JG, Leist M (2012) Compound selection for in vitro modeling of developmental neurotoxicity. Front Biosci 17:2442-2460
17. Karlsson M, Hammers S, Nilsson-Ehle I, Malmborg AS, Wretlind B (1996) Concentrations of doxycycline and penicillin G in sera and cerebrospinal fluid of patients treated for neuroborreliosis. Antimicrob Agents Chemother 40:1104-1107
18. Kisby GE, Olivas A, Park T, Churchwell M, Doerge D, Samson LD, Gerson SL, Turker MS (2009) DNA repair modulates the vulnerability of the developing brain to alkylating agent. DNA Repair (Amst) 8:400-412
19. Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn L, Bremer S, van Thriel C, Krause K, Hengstler JG, Rahnenführer J, Leist M, Sachinidis A (2013) Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol 87:123-143
20. Lein P, Silbergeld E, Locke P, Goldberg AM (2005) In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environ Toxicol Pharmacol 19:735-744
21. Lein P, Locke P, Goldberg A (2007) Meeting report: alternatives for developmental neurotoxicity testing. Environ Health Perspect 115:764-768
22. Liu JS (2011) Molecular genetics of neuronal migration disorders. Curr Neurol Neurosci Rep 11:171-178
23. Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, Schuwald J, Weinmann N, Fritsche E (2009) Human neurospheres as three dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect 117:1131-1138
24. Nelson PT, Kondziolka D, Wechsler L, Goldstein S, Gebel J, DeCesare S, Elder EM, Zhang PJ, Jacobs A, McGrogan M, Lee VM, Trojanowski JQ (2002) Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation. Am J Pathol 160:1201-1206
25. OECD (2007) Test Guideline 426. OECD guideline for testing of chemicals. Developmental neurotoxicity study. http://www.oecd.org/document/55/0,3343,en- 2649-34377-2349687-1-1-1-1,00.html. Accessed 5 March 2013
26. Ornoy A (2009) Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reprod Toxicol 28:1-10
27. Paquet-Durand F, Bicker G (2007) Human model neurons in studies of brain cell damage and neural repair. Curr Mol Med 7:541-554
28. Paquet-Durand F, Tan S, Bicker G (2003) Turning teratocarcinoma cells into neurons: rapid differentiation of NT-2 cells in floating spheres. Brain Res Dev Brain Res 142:161-167
29. Pleasure SJ, Page CP, Lee VM (1992) Pure, postmitotic, polarized human neurons derived from NTera2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 12:1802-1815
30. Podrygajlo G, Tegenge MA, Gierse A, Paquet-Durand F, Tan S, Bicker G, Stern M (2009) Cellular phenotypes of human model neurons (NT2) after differentiation in aggregate culture. Cell Tissue Res 336:439-452
31. Podrygajlo G, Song Y, Schlesinger F, Krampfl K, Bicker G (2010) Synaptic currents and transmitter responses in human NT2 neurons differentiated in aggregate culture. Neurosci Lett 468:207-210
32. Radio NM, Breier JM, Shafer TJ, Mundy WR (2008) Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening. Toxicol Sci 105:106-118
33. Rakic P (1988) Specification of cerebral cortical areas. Science 241:170-176
34. Russel WMS, Burch RL (1959) The principles of humane experimental technique. Methuen, London
35. Schettler T (2001) Toxic threats to neurologic development of children. Environ Health Perspect 109(Suppl 6):813-816
36. Scholz D, Poltl D, Genewsky A, Wenig M, Walmann T, Schildknecht S, Leist M (2011) Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. J Neurochem 119:957-971
37. Sison-Young RL, Kia R, Heslop J, Kelly L, Rowe C, Cross MJ, Kitteringham NR, Hanley N, Park BK, Goldring CE (2012) Human pluripotent stem cells for modeling toxicity. Adv Pharmacol 63:207-256
38. Stapleton SL, Thompson PA, Ou CN, Berg SL, McGuffey L, Gibson B, Blaney SM (2008) Plasma and cerebrospinal fluid pharmacokinetics of valproic acid after oral administration in non-human primates. Cancer Chemother Pharmacol 61:647-652
39. Tamm C, Duckworth J, Hermanson O, Ceccatelli S (2006) High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J Neurochem 97:69-78
40. Tegenge MA, Bicker G (2009) Nitric oxide and cGMP signal transduction positively regulates the motility of human neuronal precursor (NT2) cells. J Neurochem 110:1828-1841
41. Tegenge MA, Stern M, Bicker G (2009) Nitric oxide and cyclic nucleotide signal transduction modulates synaptic vesicle turnover in human model neurons. J Neurochem 111:1434-1446
42. Tegenge MA, Rockel TD, Fritsche E, Bicker G (2011) Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction. Cell Mol Life Sci 68:2089-2099
43. Tsai SY, Chou HY, The HW, Chen CM, Chen CJ (2003) The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 24:747-753
44. US EPA - United States Environmental Protection Agency (1998) Health effects test guidelines OPPTS 870.6300 developmental neurotoxicity study. Washington DC, United States Environmental Protection Agency Office of Prevention, Pesticides and Toxic Substances. http://www.regulations.gov/ #!documentDetail;D=EPA-HQ-OPPT-2009-0156-0042. Accessed 5 March 2013
45. van der Marel CD, Anderson BJ, Pluim MA, de Jong TH, Gonzalez A, Tibboel D (2003) Acetaminophen in cerebrospinal fluid in children. Eur J Clin Pharmacol 59:297-302
46. Visan A, Hayess K, Sittner D, Pohl EE, Riebeling C, Slawik B, Gulich K, Oelgeschläger M, Luch A, Seiler AE (2012) Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro. Neurotoxicology 33:1135-1146
47. Xi S, Jin Y, Lv X, Sun G (2010) Distribution and speciation of arsenic by transplacental and early life exposure to inorganic arsenic in offspring rats. Biol Trace Elem Res 134:84-97