A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

NeuroToxicology

Volumn 29, Issue 1, 2008, Pages 1-12

  van Vliet, Erwin ^a   Morath, Siegfried ^a   Eskes, Chantra ^a   Linge, Jens ^a   Rappsilber, Juri ^b   Honegger, Paul ^c   Hartung, Thomas ^a   Coecke, Sandra ^a  

^a JOINT RESEARCH CENTRE   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Biomarkers; Caffeine; Metabolomics; Methyl mercury chloride; Principal component analysis; Re aggregating brain cell cultures

Indexed keywords

4 AMINOBUTYRIC ACID; CAFFEINE; CHOLINE; CREATINE; GLUTAMINE; METHYLMERCURIC CHLORIDE; SPERMINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN TOXICITY; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; LIVER TOXICITY; MASS SPECTROMETRY; METABOLOMICS; NEPHROTOXICITY; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANIMALS; CAFFEINE; CELL SURVIVAL; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM STIMULANTS; CHOLINE; CREATINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; GAMMA-AMINOBUTYRIC ACID; GLUTAMINE; KIDNEY; L-LACTATE DEHYDROGENASE; LIVER; MERCURIC CHLORIDE; NEURONS; NEUROTOXINS; PRINCIPAL COMPONENT ANALYSIS; RATS; SPERMINE; TANDEM MASS SPECTROMETRY; TELENCEPHALON;

RATTUS;

EID: 37849024323     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2007.09.007     Document Type: Article

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