Brief report: A human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors

Stem Cells

Volumn 31, Issue 9, 2013, Pages 2015-2023

  Tilgner, Katarzyna ^a   Neganova, Irina ^a,b   Singhapol, Chatchawan ^a   Saretzki, Gabriele ^a   Al Aama, Jumana Yousuf ^c   Evans, Jerome ^a   Gorbunova, Vera ^d   Gennery, Andrew ^a   Przyborski, Stefan ^e   Stojkovic, Miodrag ^f   Armstrong, Lyle ^a   Jeggo, Penny ^g   Lako, Majlinda ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^d UNIVERSITY OF ROCHESTER   (United States)

^e DURHAM UNIVERSITY   (United Kingdom)

^f UNIVERSITY OF KRAGUJEVAC   (Serbia)

^g UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Cernunnos syndrome; Double strand break; Human pluripotent stem cells; Induced pluripotent stem cells; Nonhomologous end joining

Indexed keywords

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL DIFFERENTIATION; CELL SURVIVAL; CERNUNNOS DEFICIENCY SYNDROME; CONTROLLED STUDY; DNA DAMAGE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; GERM LAYER; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IONIZING RADIATION; METABOLISM; PHYSIOLOGICAL STRESS; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; TERATOMA;

CERNUNNOS SYNDROME; DOUBLE-STRAND BREAK; HUMAN PLURIPOTENT STEM CELLS; INDUCED PLURIPOTENT STEM CELLS; NONHOMOLOGOUS END JOINING;

BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA;

EID: 84885138964     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1456     Document Type: Article

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