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Volumn 33, Issue 34, 2014, Pages 4352-4358

Pivotal role of augmented αb-crystallin in tumor development induced by deficient TSC1/2 complex

Author keywords

mTOR; NF B; TSC; tumor; B crystallin

Indexed keywords

ALPHAB CRYSTALLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MULTIPROTEIN COMPLEX; PEPTIDES AND PROTEINS; SMALL HEAT SHOCK PROTEIN; TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1; UNCLASSIFIED DRUG;

EID: 84906939933     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.401     Document Type: Article
Times cited : (9)

References (49)
  • 1
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007; 12: 9-22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 2
    • 84862777192 scopus 로고    scopus 로고
    • The translational landscape of mTOR signalling steers cancer initiation and metastasis
    • Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012; 485: 55-61
    • (2012) Nature , vol.485 , pp. 55-61
    • Hsieh, A.C.1    Liu, Y.2    Edlind, M.P.3    Ingolia, N.T.4    Janes, M.R.5    Sher, A.6
  • 3
    • 82455212854 scopus 로고    scopus 로고
    • Avian influenza A virus H5N1 causes autophagymediated cell death through suppression of mTOR signaling
    • Ma J, Sun Q, Mi R, Zhang H. Avian influenza A virus H5N1 causes autophagymediated cell death through suppression of mTOR signaling. J Genet Genomics 2011; 38: 533-537
    • (2011) J Genet Genomics , vol.38 , pp. 533-537
    • Ma, J.1    Sun, Q.2    Mi, R.3    Zhang, H.4
  • 4
    • 79952749503 scopus 로고    scopus 로고
    • Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
    • Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X et al. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 2011; 108: 4129-4134
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4129-4134
    • Sun, Q.1    Chen, X.2    Ma, J.3    Peng, H.4    Wang, F.5    Zha, X.6
  • 5
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
    • Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 2002; 11: 525-534
    • (2002) Hum Mol Genet , vol.11 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3    Heiberger, K.M.4    Glogauer, M.5    El-Hashemite, N.6
  • 6
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 2002; 4: 658-665
    • (2002) Nat Cell Biol , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 7
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002; 4: 648-657
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 8
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002; 10: 151-162
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 9
    • 27744569843 scopus 로고    scopus 로고
    • Mtor and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005; 123: 569-580
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 10
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002; 10: 457-468
    • (2002) Mol Cell , vol.10 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3    Lorberg, A.4    Crespo, J.L.5    Bonenfant, D.6
  • 11
    • 0037178781 scopus 로고    scopus 로고
    • Raptor a binding partner of target of rapamycin (TOR Mediates TOR action
    • Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002; 110: 177-189
    • (2002) Cell , vol.110 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.4    Oshiro, N.5    Hidayat, S.6
  • 12
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110: 163-175
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 13
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/ mTOR
    • Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/ mTOR. Genes Dev 2001; 15: 807-826
    • (2001) Genes Dev , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 14
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14: 1296-1302
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 15
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • The European Chromosome 16 Tuberous Sclerosis Consortium
    • The European Chromosome 16 Tuberous Sclerosis Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 1993; 75: 1305-1315
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 17
    • 0347988005 scopus 로고    scopus 로고
    • Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
    • Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N et al. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 2003; 112: 1223-1233
    • (2003) J Clin Invest , vol.112 , pp. 1223-1233
    • Zhang, H.1    Cicchetti, G.2    Onda, H.3    Koon, H.B.4    Asrican, K.5    Bajraszewski, N.6
  • 18
    • 0037454409 scopus 로고    scopus 로고
    • Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma
    • El-Hashemite N, Zhang H, Henske EP, Kwiatkowski DJ. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet 2003; 361: 1348-1349
    • (2003) Lancet , vol.361 , pp. 1348-1349
    • El-Hashemite, N.1    Zhang, H.2    Henske, E.P.3    Kwiatkowski, D.J.4
  • 19
    • 0032438210 scopus 로고    scopus 로고
    • Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria
    • Roach ES, Gomez MR, Northrup H. Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria. J Child Neurol 1998; 13: 624-628
    • (1998) J Child Neurol , vol.13 , pp. 624-628
    • Roach, E.S.1    Gomez, M.R.2    Northrup, H.3
  • 20
    • 0034705207 scopus 로고    scopus 로고
    • Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis
    • Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci USA 2000; 97: 6085-6090
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6085-6090
    • Carsillo, T.1    Astrinidis, A.2    Henske, E.P.3
  • 21
    • 0037255952 scopus 로고    scopus 로고
    • Recurrence of lymphangioleiomyomatosis after single lung transplantation: New insights into pathogenesis
    • Bittmann I, Rolf B, Amann G, Lohrs U. Recurrence of lymphangioleiomyomatosis after single lung transplantation: New insights into pathogenesis. Hum Pathol 2003; 34: 95-98
    • (2003) Hum Pathol , vol.34 , pp. 95-98
    • Bittmann, I.1    Rolf, B.2    Amann, G.3    Lohrs, U.4
  • 22
    • 0026348465 scopus 로고
    • Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis
    • Iwaki T, Tateishi J. Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis. Am J Pathol 1991; 139: 1303-1308
    • (1991) Am J Pathol , vol.139 , pp. 1303-1308
    • Iwaki, T.1    Tateishi, J.2
  • 23
    • 0027359323 scopus 로고
    • Tuberous sclerosis variant with production of Rosenthal fibers (alpha B-crystallin
    • Kupsky WJ, Frosch M. Tuberous sclerosis variant with production of Rosenthal fibers (alpha B-crystallin). Pediatr Pathol 1993; 13: 869-873
    • (1993) Pediatr Pathol , vol.13 , pp. 869-873
    • Kupsky, W.J.1    Frosch, M.2
  • 25
    • 2442681777 scopus 로고    scopus 로고
    • Human alphaA-And alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
    • Mao YW, Liu JP, Xiang H, Li DW. Human alphaA-And alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine- induced apoptosis. Cell Death Differ 2004; 11: 512-526
    • (2004) Cell Death Differ , vol.11 , pp. 512-526
    • Mao, Y.W.1    Liu, J.P.2    Xiang, H.3    Li, D.W.4
  • 26
    • 20144374696 scopus 로고    scopus 로고
    • The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3
    • Kamradt MC, Lu M, Werner ME, Kwan T, Chen F, Strohecker A et al. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. J Biol Chem 2005; 280: 11059-11066
    • (2005) J Biol Chem , vol.280 , pp. 11059-11066
    • Kamradt, M.C.1    Lu, M.2    Werner, M.E.3    Kwan, T.4    Chen, F.5    Strohecker, A.6
  • 30
    • 38049146371 scopus 로고    scopus 로고
    • Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis
    • Young LR, Inoue Y, McCormack FX. Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis. N Engl J Med 2008; 358: 199-200
    • (2008) N Engl J Med , vol.358 , pp. 199-200
    • Young, L.R.1    Inoue, Y.2    McCormack, F.X.3
  • 31
    • 0029036505 scopus 로고
    • Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines
    • Howe SR, Gottardis MM, Everitt JI, Goldsworthy TL, Wolf DC, Walker C. Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. Am J Pathol 1995; 146: 1568-1579
    • (1995) Am J Pathol , vol.146 , pp. 1568-1579
    • Howe, S.R.1    Gottardis, M.M.2    Everitt, J.I.3    Goldsworthy, T.L.4    Wolf, D.C.5    Walker, C.6
  • 32
    • 68049137608 scopus 로고    scopus 로고
    • Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
    • Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res 2009; 69: 6232-6240
    • (2009) Cancer Res , vol.69 , pp. 6232-6240
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3    Zhang, W.G.4    Lucas, J.5    Shor, B.6
  • 34
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431-436
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 35
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-Threonine kinase
    • Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-kappaB activation by tumour necrosis factor requires the Akt serine-Threonine kinase. Nature 1999; 401: 82-85
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 36
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    • Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, Baldwin AS. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev 2008; 22: 1490-1500
    • (2008) Genes Dev , vol.22 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3    Duncan, J.A.4    Ting, J.P.5    Baldwin, A.S.6
  • 37
    • 74949092824 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/ Jagged/Notch cascade
    • Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, Sun Q et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/ Jagged/Notch cascade. J Clin Invest 2010; 120: 103-114
    • (2010) J Clin Invest , vol.120 , pp. 103-114
    • Ma, J.1    Meng, Y.2    Kwiatkowski, D.J.3    Chen, X.4    Peng, H.5    Sun, Q.6
  • 38
    • 77950371095 scopus 로고    scopus 로고
    • Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells
    • Lang SA, Hackl C, Moser C, Fichtner-Feigl S, Koehl GE, Schlitt HJ et al. Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells. Biochim Biophys Acta 2010; 1803: 435-442
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 435-442
    • Lang, S.A.1    Hackl, C.2    Moser, C.3    Fichtner-Feigl, S.4    Koehl, G.E.5    Schlitt, H.J.6
  • 39
    • 84860816141 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance
    • Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B et al. Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance. Cancer Discov 2011; 1: 524-538
    • (2011) Cancer Discov , vol.1 , pp. 524-538
    • Tanaka, K.1    Babic, I.2    Nathanson, D.3    Akhavan, D.4    Guo, D.5    Gini, B.6
  • 41
    • 70249146172 scopus 로고    scopus 로고
    • Mtorc1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression sustained Mcl-1 expression and glycogen synthase kinase 3beta inhibition
    • Bhaskar PT, Nogueira V, Patra KC, Jeon SM, Park Y, Robey RB et al. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Mol Cell Biol 2009; 29: 5136-5147
    • (2009) Mol Cell Biol , vol.29 , pp. 5136-5147
    • Bhaskar, P.T.1    Nogueira, V.2    Patra, K.C.3    Jeon, S.M.4    Park, Y.5    Robey, R.B.6
  • 42
    • 0033775869 scopus 로고    scopus 로고
    • The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
    • Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG et al. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol 2000; 2: 281-287
    • (2000) Nat Cell Biol , vol.2 , pp. 281-287
    • Lamb, R.F.1    Roy, C.2    Diefenbach, T.J.3    Vinters, H.V.4    Johnson, M.W.5    Jay, D.G.6
  • 43
    • 0037028305 scopus 로고    scopus 로고
    • Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration
    • Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene 2002; 21: 8470-8476
    • (2002) Oncogene , vol.21 , pp. 8470-8476
    • Astrinidis, A.1    Cash, T.P.2    Hunter, D.S.3    Walker, C.L.4    Chernoff, J.5    Henske, E.P.6
  • 44
    • 19944431403 scopus 로고    scopus 로고
    • Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models
    • Lee L, Sudentas P, Donohue B, Asrican K, Worku A, Walker V et al. Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer 2005; 42: 213-227
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 213-227
    • Lee, L.1    Sudentas, P.2    Donohue, B.3    Asrican, K.4    Worku, A.5    Walker, V.6


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