Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

Lancet

Volumn 361, Issue 9366, 2003, Pages 1348-1349

  El Hashemite, Nisreen ^a   Zhang, Hongbing ^a   Henske, Elizabeth P ^b   Kwiatkowski, David J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HAMARTIN; PROTEIN P70; RAPAMYCIN; RIBOSOME PROTEIN; S6 KINASE; TUBERIN;

ANGIOMYOLIPOMA; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0037454409     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)13044-9     Document Type: Article

References (5)

1. Tapon N., Ito N., Dickson B.J., Treisman J.E., Hariharan I.K. The Drosophila tuberous sclerosis complex gene homologues restrict cell growth and cell proliferation. Cell. 105:2001;345-355.
2. Potter C.J., Huang H., Xu T. Drosophila Tsc1 functions with Tsc2/gigas to antagonize insulin signaling in the regulation of cell growth, cell proliferation and organ size. Cell. 105:2001;357-368.
3. Gao X., Pan D. TSC1 and TSC2 tumour suppressors antagonize insulin signaling in cell growth. Genes Dev. 15:2001;1383-1392.
4. Kwiatkowski D.J., Zhang H., Bandura J.L., et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet. 11:2002;525-534.
5. Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826.