메뉴 건너뛰기




Volumn 67, Issue 15, 2007, Pages 7247-7255

The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

DYRK1B PROTEIN KINASE; MIRK PROTEIN KINASE; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RAC1 PROTEIN; UNCLASSIFIED DRUG;

EID: 34547630697     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-4099     Document Type: Article
Times cited : (46)

References (36)
  • 1
    • 33745700257 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma - genetic portrait from chromosomes to microarrays
    • Karhu R, Mahlamaki E, Kallioniemi A. Pancreatic adenocarcinoma - genetic portrait from chromosomes to microarrays. Genes Chromosomes Cancer 2006;45:721-30.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 721-730
    • Karhu, R.1    Mahlamaki, E.2    Kallioniemi, A.3
  • 2
    • 2342569751 scopus 로고    scopus 로고
    • Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines
    • Heidenblad M, Schoenmakers E, Jonson T, et al. Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Cancer Res 2004;64:3052-9.
    • (2004) Cancer Res , vol.64 , pp. 3052-3059
    • Heidenblad, M.1    Schoenmakers, E.2    Jonson, T.3
  • 3
    • 33646247855 scopus 로고    scopus 로고
    • The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma
    • Deng X, Ewton DZ, Li S, et al. The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. Cancer Res 2006;66:4149-58.
    • (2006) Cancer Res , vol.66 , pp. 4149-4158
    • Deng, X.1    Ewton, D.Z.2    Li, S.3
  • 4
    • 29644442895 scopus 로고    scopus 로고
    • The survival kinase Mirk/dyrk1B is activated through Rac1-3 signaling
    • Jin K, Lim S, Mercer SE, Friedman E. The survival kinase Mirk/dyrk1B is activated through Rac1-3 signaling. J Biol Chem 2005;280:42097-105.
    • (2005) J Biol Chem , vol.280 , pp. 42097-42105
    • Jin, K.1    Lim, S.2    Mercer, S.E.3    Friedman, E.4
  • 5
    • 0034235542 scopus 로고    scopus 로고
    • Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells
    • Lee K, Deng X, Friedman E. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. Cancer Res 2000;60:3631-7.
    • (2000) Cancer Res , vol.60 , pp. 3631-3637
    • Lee, K.1    Deng, X.2    Friedman, E.3
  • 6
    • 0037067736 scopus 로고    scopus 로고
    • Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1α
    • Lim S, Jin K, Friedman E. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1α. J Biol Chem 2002;277:25040-6.
    • (2002) J Biol Chem , vol.277 , pp. 25040-25046
    • Lim, S.1    Jin, K.2    Friedman, E.3
  • 7
    • 14244258401 scopus 로고    scopus 로고
    • Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation
    • Deng X, Ewton DZ, Mercer SE, Friedman E. Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation. J Biol Chem 2005;280:4894-905.
    • (2005) J Biol Chem , vol.280 , pp. 4894-4905
    • Deng, X.1    Ewton, D.Z.2    Mercer, S.E.3    Friedman, E.4
  • 8
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos J. Ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.1
  • 10
    • 0142071703 scopus 로고    scopus 로고
    • Mirk/dyrk1B Is a Rho-induced kinase active in skeletal muscle differentiation
    • Deng X, Ewton DZ, Pawlikowski B, Maimone M, Friedman E. Mirk/dyrk1B Is a Rho-induced kinase active in skeletal muscle differentiation. J Biol Chem 2003;278:41347-54.
    • (2003) J Biol Chem , vol.278 , pp. 41347-41354
    • Deng, X.1    Ewton, D.Z.2    Pawlikowski, B.3    Maimone, M.4    Friedman, E.5
  • 11
    • 2542489078 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G0 by Mirk/dyrk1B kinase
    • Deng X, Mercer SE, Shah S, Ewton DZ, Friedman E. The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G0 by Mirk/dyrk1B kinase. J Biol Chem 2004;279:22498-504.
    • (2004) J Biol Chem , vol.279 , pp. 22498-22504
    • Deng, X.1    Mercer, S.E.2    Shah, S.3    Ewton, D.Z.4    Friedman, E.5
  • 12
    • 0037591588 scopus 로고    scopus 로고
    • Alternative splicing variants of the protein kinase DYRK1B exhibit distinct patterns of expression and functional properties
    • Leder S, Czajkowska H, Maenz B, et al. Alternative splicing variants of the protein kinase DYRK1B exhibit distinct patterns of expression and functional properties. Biochem J 2003;372:881-8.
    • (2003) Biochem J , vol.372 , pp. 881-888
    • Leder, S.1    Czajkowska, H.2    Maenz, B.3
  • 13
    • 0036051325 scopus 로고    scopus 로고
    • Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
    • Lambert JM, Lambert QT, Reuther GW, et al. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol 2002;4:621-5.
    • (2002) Nat Cell Biol , vol.4 , pp. 621-625
    • Lambert, J.M.1    Lambert, Q.T.2    Reuther, G.W.3
  • 14
    • 33644859051 scopus 로고    scopus 로고
    • The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development
    • Malliri A, Rygiel TP, van der Kammen RA, et al. The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 2006;281:543-8.
    • (2006) J Biol Chem , vol.281 , pp. 543-548
    • Malliri, A.1    Rygiel, T.P.2    van der Kammen, R.A.3
  • 15
    • 33744516825 scopus 로고    scopus 로고
    • Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and Ras effector expression to human tumor cell growth
    • Academic Press;
    • Baines AT, Lim K, Shields JM, et al. Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and Ras effector expression to human tumor cell growth. In: Methods in enzymology: Academic Press; 2006. p. 556.
    • (2006) Methods in enzymology , pp. 556
    • Baines, A.T.1    Lim, K.2    Shields, J.M.3
  • 16
    • 2442664118 scopus 로고    scopus 로고
    • Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Aacd Sci U S A 2004;101:7618-23.
    • Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Aacd Sci U S A 2004;101:7618-23.
  • 17
    • 4143146567 scopus 로고    scopus 로고
    • Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells
    • Agbunag C, Bar-Sagi D. Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res 2004;64:5659-63.
    • (2004) Cancer Res , vol.64 , pp. 5659-5663
    • Agbunag, C.1    Bar-Sagi, D.2
  • 19
    • 0030044182 scopus 로고    scopus 로고
    • Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
    • Han J, Lee J, Jiang Y, Li Z, Feng L, Ulevitch R. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem 1996;271:2886-91.
    • (1996) J Biol Chem , vol.271 , pp. 2886-2891
    • Han, J.1    Lee, J.2    Jiang, Y.3    Li, Z.4    Feng, L.5    Ulevitch, R.6
  • 20
    • 0027217533 scopus 로고
    • Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2
    • Zheng C, Guan K. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem 1993;268:11435-9.
    • (1993) J Biol Chem , vol.268 , pp. 11435-11439
    • Zheng, C.1    Guan, K.2
  • 21
    • 0027202110 scopus 로고
    • Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2
    • Wu J, Harrison J, Dent P, Lynch K, Weber M, Sturgill T. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. Mol Cell Biol 1993;13:4539-48.
    • (1993) Mol Cell Biol , vol.13 , pp. 4539-4548
    • Wu, J.1    Harrison, J.2    Dent, P.3    Lynch, K.4    Weber, M.5    Sturgill, T.6
  • 22
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy N, DePinho R. Pancreatic cancer biology and genetics. Nat Rev Cancer 2002;2:897-909.
    • (2002) Nat Rev Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.2
  • 23
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman D, Karhadkar S, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003;425:846-50.
    • (2003) Nature , vol.425 , pp. 846-850
    • Berman, D.1    Karhadkar, S.2    Maitra, A.3
  • 24
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer S, di Magliano M, Heiser P, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003;425:851-6.
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.1    di Magliano, M.2    Heiser, P.3
  • 25
    • 0028081120 scopus 로고
    • K-ras mutations in pancreatic ductal proliferative lesions
    • Klimstra D, Longnecker DS. K-ras mutations in pancreatic ductal proliferative lesions. Am J Pathol 1994;145:1547-50.
    • (1994) Am J Pathol , vol.145 , pp. 1547-1550
    • Klimstra, D.1    Longnecker, D.S.2
  • 26
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani S, Petricoin E, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50.
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.1    Petricoin, E.2    Maitra, A.3
  • 27
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre AJ, Bardeesy N, Sinha M, et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 2003;17:3112-26.
    • (2003) Genes Dev , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3
  • 28
    • 20444410041 scopus 로고    scopus 로고
    • Activation of RalA is critical for Ras-induced tumorigenesis of human cells
    • Lim K-H, Baines AT, Fiordalisi JJ, et al. Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell 2005;7:533.
    • (2005) Cancer Cell , vol.7 , pp. 533
    • Lim, K.-H.1    Baines, A.T.2    Fiordalisi, J.J.3
  • 30
    • 0035504739 scopus 로고    scopus 로고
    • Gene expression profiles of pancreatic cancer and stromal desmoplasia
    • Crnogorac-Jurcevic T, Efthimiou E, Capelli P, et al. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 2001;20:4737-46.
    • (2001) Oncogene , vol.20 , pp. 4737-4746
    • Crnogorac-Jurcevic, T.1    Efthimiou, E.2    Capelli, P.3
  • 31
    • 33644849221 scopus 로고    scopus 로고
    • A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase
    • Collins CS, Hong J, Sapinoso L, et al. A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci U S A 2006;103:3775-80.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3775-3780
    • Collins, C.S.1    Hong, J.2    Sapinoso, L.3
  • 32
    • 0033517244 scopus 로고    scopus 로고
    • Akt is more than just a Bad kinase
    • Khwaja A. Akt is more than just a Bad kinase. Nature 1999;401:33-4.
    • (1999) Nature , vol.401 , pp. 33-34
    • Khwaja, A.1
  • 33
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta S, Brunet A, Greenberg M. Cellular survival: a play in three Akts. Genes Dev 1999;13:2905-27.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.1    Brunet, A.2    Greenberg, M.3
  • 35
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-B and c-Myc in pancreatic cancer cells
    • Asano T, Yao Y, Zhu J, Abbruzzese J, Reddy S. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-B and c-Myc in pancreatic cancer cells. Oncogene 2004;23:8571-80.
    • (2004) Oncogene , vol.23 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3    Abbruzzese, J.4    Reddy, S.5
  • 36
    • 25444482608 scopus 로고    scopus 로고
    • Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines
    • Locke M, Heywood M, Fawell S, Mackenzie IC. Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines. Cancer Res 2005;65:8944-50.
    • (2005) Cancer Res , vol.65 , pp. 8944-8950
    • Locke, M.1    Heywood, M.2    Fawell, S.3    Mackenzie, I.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.