Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: Evidence for a role in retinal degenerations

Experimental Eye Research

Volumn 126, Issue , 2014, Pages 68-76

  Guha, Sonia ^a,b   Coffey, Erin E ^a   Lu, Wennan ^a   Lim, Jason C ^a   Beckel, Jonathan M ^a,c   Laties, Alan M ^a   Boesze Battaglia, Kathleen ^a   Mitchell, Claire H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Aging; Alzheimer's disease; Autophagy; Cathepsin D; Lipofuscin; Lysosome; Retinal pigmented epithelium

Indexed keywords

CATHEPSIN D; CHLOROQUINE; LYSOSOME ENZYME; PRESENILIN 1;

ALKALINIZATION; ALZHEIMER DISEASE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; IN VITRO STUDY; LYSOSOMAL ALKALINIZATION; LYSOSOME STORAGE DISEASE; NONHUMAN; PH MEASUREMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA DEGENERATION; RETINA MACULA DEGENERATION; STEADY STATE; UPREGULATION;

AGING; ALZHEIMER'S DISEASE; AUTOPHAGY; CATHEPSIN D; LIPOFUSCIN; LYSOSOME; RETINAL PIGMENTED EPITHELIUM;

ANIMALS; AUTOPHAGY; EPITHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LYSOSOMES; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM;

EID: 84906516250     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2014.05.013     Document Type: Article

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