Lysosomal alkalization and dysfunction in human fibroblasts with the alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP

Neuroscience

Volumn 263, Issue , 2014, Pages 111-124

  Coffey, E E ^a   Beckel, J M ^a   Laties, A M ^a   Mitchell, C H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Age related macular degeneration (AMD); Alzheimer's disease; Autophagy; Lysosomal pH; Presenilin 1

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CATHEPSIN D; CHLOROQUINE; CYCLIC AMP; MESSENGER RNA; PEPSTATIN DERIVATIVE; PEPTIDES AND PROTEINS; PRESENILIN 1; PROTEIN LC3B I; PROTEIN LC3B II; PROTEIN P62; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; ATG5 GENE; ATP6V1B2 GENE; AUTOPHAGY; BECN1 GENE; BINDING SITE; CELL FUNCTION; CONTROLLED STUDY; CYTOPATHOLOGY; DISEASE ASSOCIATION; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; HUMAN; HUMAN CELL; LYSOSOME; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN BINDING; RETINA MACULA DEGENERATION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; TFEB GENE; TRANSGENE;

AGE-RELATED MACULAR DEGENERATION (AMD); ALZHEIMER'S DISEASE; AUTOPHAGY; CATHEPSIN D; LYSOSOMAL PH; PRESENILIN 1;

ALZHEIMER DISEASE; CATHEPSIN E; CELLS, CULTURED; CYCLIC AMP; FIBROBLASTS; HUMANS; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MUTATION; PRESENILIN-1;

EID: 84896730305     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.01.001     Document Type: Article

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