Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor

FASEB Journal

Volumn 27, Issue 11, 2013, Pages 4500-4509

  Guha, Sonia ^a   Baltazar, Gabriel C ^a   Coffey, Erin E ^a   Tu, Leigh Anne ^a   Lim, Jason C ^a   Beckel, Jonathan M ^a   Patel, Shaun ^a   Eysteinsson, Thor ^b   Lu, Wennan ^a   O'Brien Jenkins, Ann ^a   Laties, Alan M ^a   Mitchell, Claire H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Autophagy; Lipofuscin; Purinergic signaling; Retinal degeneration

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATHEPSIN D; LIPID; MESSENGER RNA; PURINERGIC P2X7 RECEPTOR;

ALKALINIZATION; ANIMAL CELL; ARTICLE; AUTOFLUORESCENCE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; LIPID OXIDATION; LYSOSOME; MOUSE; NONHUMAN; PH; PHAGOSOME; PHOTORECEPTOR OUTER SEGMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA CELL; STARGARDT DISEASE;

AUTOPHAGY; LIPOFUSCIN; PURINERGIC SIGNALING; RETINAL DEGENERATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; CALCIUM; CATTLE; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; CYTOPLASM; HUMANS; HYDROGEN-ION CONCENTRATION; LIPID METABOLISM; LYSOSOMES; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PHAGOSOMES; RECEPTORS, PURINERGIC P2X7; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM; TRANSCRIPTION, GENETIC;

EID: 84887029616     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-236166     Document Type: Article

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