-
1
-
-
0012119330
-
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration
-
Allikmets R, Shroyer NF, Singh N, Seddon JM, Lewis RA, Bernstein PS, Peiffer A, Zabriskie NA, Li Y, Hutchinson A, Dean M, Lupski JR, Leppert M. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277: 1805-1807, 1997.
-
(1997)
Science
, vol.277
, pp. 1805-1807
-
-
Allikmets, R.1
Shroyer, N.F.2
Singh, N.3
Seddon, J.M.4
Lewis, R.A.5
Bernstein, P.S.6
Peiffer, A.7
Zabriskie, N.A.8
Li, Y.9
Hutchinson, A.10
Dean, M.11
Lupski, J.R.12
Leppert, M.13
-
2
-
-
0025784535
-
Defective acidification of intracellular organelles in cystic fibrosis
-
Barasch J, Kiss B, Prince A, Saiman L, Gruenert D, al-Awqati Q. Defective acidification of intracellular organelles in cystic fibrosis. Nature 352: 70-73, 1991.
-
(1991)
Nature
, vol.352
, pp. 70-73
-
-
Barasch, J.1
Kiss, B.2
Prince, A.3
Saiman, L.4
Gruenert, D.5
Al-Awqati, Q.6
-
3
-
-
2442648066
-
Inhibition of the ATPdriven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration
-
Bergmann M, Schutt F, Holz FG, Kopitz J. Inhibition of the ATPdriven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J 18: 562-564, 2004.
-
(2004)
FASEB J
, vol.18
, pp. 562-564
-
-
Bergmann, M.1
Schutt, F.2
Holz, F.G.3
Kopitz, J.4
-
4
-
-
0037230875
-
Retinal pigment epithelial function: A role for CFTR?
-
Blaug S, Quinn R, Quong J, Jalickee S, Miller SS. Retinal pigment epithelial function: a role for CFTR? Doc Ophthalmol 106: 43-50, 2003.
-
(2003)
Doc Ophthalmol
, vol.106
, pp. 43-50
-
-
Blaug, S.1
Quinn, R.2
Quong, J.3
Jalickee, S.4
Miller, S.S.5
-
5
-
-
0027402472
-
Phagocytosis of outer segments by retinal pigment epithelium: Phagosome-lysosome interaction
-
Bosch E, Horwitz J, Bok D. Phagocytosis of outer segments by retinal pigment epithelium: phagosome-lysosome interaction. J Histochem Cytochem 41: 253-263, 1993.
-
(1993)
J Histochem Cytochem
, vol.41
, pp. 253-263
-
-
Bosch, E.1
Horwitz, J.2
Bok, D.3
-
6
-
-
0033603586
-
A mechanism for tamoxifen-mediated inhibition of acidification
-
Chen Y, Schindler M, Simon SM. A mechanism for tamoxifen-mediated inhibition of acidification. J Biol Chem 274: 18364-18373, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 18364-18373
-
-
Chen, Y.1
Schindler, M.2
Simon, S.M.3
-
8
-
-
33748146503
-
CFTR regulates phagosome acidification in macrophages and alters bactericidal activity
-
Di A, Brown ME, Deriy LV, Li C, Szeto FL, Chen Y, Huang P, Tong J, Naren AP, Bindokas V, Palfrey HC, Nelson DJ. CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol 8: 933-944, 2006.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 933-944
-
-
Di, A.1
Brown, M.E.2
Deriy, L.V.3
Li, C.4
Szeto, F.L.5
Chen, Y.6
Huang, P.7
Tong, J.8
Naren, A.P.9
Bindokas, V.10
Palfrey, H.C.11
Nelson, D.J.12
-
9
-
-
0028328645
-
Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator
-
Dulhanty AM, Riordan JR. Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator. Biochemistry 33: 4072-4079, 1994.
-
(1994)
Biochemistry
, vol.33
, pp. 4072-4079
-
-
Dulhanty, A.M.1
Riordan, J.R.2
-
10
-
-
1842725749
-
Intracellular chloride channels: Determinants of function in the endosomal pathway
-
Faundez V, Hartzell HC. Intracellular chloride channels: determinants of function in the endosomal pathway. Sci STKE 2004: re8, 2004.
-
(2004)
Sci STKE
, vol.2004
-
-
Faundez, V.1
Hartzell, H.C.2
-
11
-
-
0021334196
-
pH in the endosome. Measurements during pinocytosis and receptor-mediated endocytosis
-
Geisow MJ, Evans WH. pH in the endosome. Measurements during pinocytosis and receptor-mediated endocytosis. Exp Cell Res 150: 36-46, 1984.
-
(1984)
Exp Cell Res
, vol.150
, pp. 36-46
-
-
Geisow, M.J.1
Evans, W.H.2
-
12
-
-
35748973573
-
Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages
-
Haggie PM, Verkman AS. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J Biol Chem 282: 31422-31428, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 31422-31428
-
-
Haggie, P.M.1
Verkman, A.S.2
-
13
-
-
65549134742
-
Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis
-
Haggie PM, Verkman AS. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. J Biol Chem 284: 7681-7686, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 7681-7686
-
-
Haggie, P.M.1
Verkman, A.S.2
-
14
-
-
0027255084
-
The phagocytosis of rod outer segments is inhibited by drugs linked to cyclic adenosine monophosphate production
-
Hall MO, Abrams TA, Mittag TW. The phagocytosis of rod outer segments is inhibited by drugs linked to cyclic adenosine monophosphate production. Invest Ophthalmol Vis Sci 34: 2392-2401, 1993.
-
(1993)
Invest Ophthalmol Vis Sci
, vol.34
, pp. 2392-2401
-
-
Hall, M.O.1
Abrams, T.A.2
Mittag, T.W.3
-
15
-
-
0033017053
-
Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin
-
Holz FG, Schutt F, Kopitz J, Eldred GE, Kruse FE, Volcker HE, Cantz M. Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 40: 737-743, 1999.
-
(1999)
Invest Ophthalmol Vis Sci
, vol.40
, pp. 737-743
-
-
Holz, F.G.1
Schutt, F.2
Kopitz, J.3
Eldred, G.E.4
Kruse, F.E.5
Volcker, H.E.6
Cantz, M.7
-
16
-
-
33846517681
-
Chloride and the endosomal-lysosomal pathway: Emerging roles of CLC chloride transporters
-
Jentsch TJ. Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters. J Physiol 578: 633-640, 2007.
-
(2007)
J Physiol
, vol.578
, pp. 633-640
-
-
Jentsch, T.J.1
-
17
-
-
0035951282
-
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man
-
Kornak U, Kasper D, Bosl MR, Kaiser E, Schweizer M, Schulz A, Friedrich W, Delling G, Jentsch TJ. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104: 205-215, 2001.
-
(2001)
Cell
, vol.104
, pp. 205-215
-
-
Kornak, U.1
Kasper, D.2
Bosl, M.R.3
Kaiser, E.4
Schweizer, M.5
Schulz, A.6
Friedrich, W.7
Delling, G.8
Jentsch, T.J.9
-
18
-
-
58949097885
-
Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophages
-
Lamothe J, Valvano MA. Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophages. Microbiology 154: 3825-3834, 2008.
-
(2008)
Microbiology
, vol.154
, pp. 3825-3834
-
-
Lamothe, J.1
Valvano, M.A.2
-
19
-
-
0017144922
-
Rod outer segment disc shedding in relation to cyclic lighting
-
LaVail MM. Rod outer segment disc shedding in relation to cyclic lighting. Exp Eye Res 23: 277-280, 1976.
-
(1976)
Exp Eye Res
, vol.23
, pp. 277-280
-
-
LaVail, M.M.1
-
21
-
-
34548833332
-
Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells
-
Lu W, Reigada D, Sevigny J, Mitchell CH. Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J Pharmacol Exp Ther 323: 157-164, 2007.
-
(2007)
J Pharmacol Exp Ther
, vol.323
, pp. 157-164
-
-
Lu, W.1
Reigada, D.2
Sevigny, J.3
Mitchell, C.H.4
-
22
-
-
0036896008
-
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion
-
Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest 110: 1651-1658, 2002.
-
(2002)
J Clin Invest
, vol.110
, pp. 1651-1658
-
-
Ma, T.1
Thiagarajah, J.R.2
Yang, H.3
Sonawane, N.D.4
Folli, C.5
Galietta, L.J.6
Verkman, A.S.7
-
23
-
-
0037020097
-
High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening
-
Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS. High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem 277: 37235-37241, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 37235-37241
-
-
Ma, T.1
Vetrivel, L.2
Yang, H.3
Pedemonte, N.4
Zegarra-Moran, O.5
Galietta, L.J.6
Verkman, A.S.7
-
24
-
-
1842866266
-
Chloroquine causes lysosomal dysfunction in neural retina and RPE: Implications for retinopathy
-
Mahon GJ, Anderson HR, Gardiner TA, McFarlane S, Archer DB, Stitt AW. Chloroquine causes lysosomal dysfunction in neural retina and RPE: implications for retinopathy. Curr Eye Res 28: 277-284, 2004.
-
(2004)
Curr Eye Res
, vol.28
, pp. 277-284
-
-
Mahon, G.J.1
Anderson, H.R.2
Gardiner, T.A.3
McFarlane, S.4
Archer, D.B.5
Stitt, A.W.6
-
25
-
-
33745023775
-
Chaperone-mediated autophagy in aging and disease
-
Massey AC, Zhang C, Cuervo AM. Chaperone-mediated autophagy in aging and disease. Curr Top Dev Biol 73: 205-235, 2006.
-
(2006)
Curr Top Dev Biol
, vol.73
, pp. 205-235
-
-
Massey, A.C.1
Zhang, C.2
Cuervo, A.M.3
-
26
-
-
0034944895
-
Delayed dark-adaptation and lipofuscin accumulation in abcr+/-mice: Implications for involvement of ABCR in age-related macular degeneration
-
Mata NL, Tzekov RT, Liu X, Weng J, Birch DG, Travis GH. Delayed dark-adaptation and lipofuscin accumulation in abcr+/-mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci 42: 1685-1690, 2001.
-
(2001)
Invest Ophthalmol Vis Sci
, vol.42
, pp. 1685-1690
-
-
Mata, N.L.1
Tzekov, R.T.2
Liu, X.3
Weng, J.4
Birch, D.G.5
Travis, G.H.6
-
27
-
-
0034691089
-
Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration
-
Mata NL, Weng J, Travis GH. Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration. Proc Natl Acad Sci USA 97: 7154-7159, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7154-7159
-
-
Mata, N.L.1
Weng, J.2
Travis, G.H.3
-
29
-
-
33644648218
-
Inhibition of lysosomal degradation in retinal pigment epithelium cells induces exocytosis of phagocytic residual material at the basolateral plasma membrane
-
Peters S, Reinthal E, Blitgen-Heinecke P, Bartz-Schmidt KU, Schraermeyer U. Inhibition of lysosomal degradation in retinal pigment epithelium cells induces exocytosis of phagocytic residual material at the basolateral plasma membrane. Ophthalmic Res 38: 83-88, 2006.
-
(2006)
Ophthalmic Res
, vol.38
, pp. 83-88
-
-
Peters, S.1
Reinthal, E.2
Blitgen-Heinecke, P.3
Bartz-Schmidt, K.U.4
Schraermeyer, U.5
-
30
-
-
0019887961
-
ATP-dependent acidification of intact and disrupted lysosomes. Evidence for an ATP-driven proton pump
-
Schneider DL. ATP-dependent acidification of intact and disrupted lysosomes. Evidence for an ATP-driven proton pump. J Biol Chem 256: 3858-3864, 1981.
-
(1981)
J Biol Chem
, vol.256
, pp. 3858-3864
-
-
Schneider, D.L.1
-
31
-
-
0029984180
-
Evidence against defective trans-Golgi acidification in cystic fibrosis
-
Seksek O, Biwersi J, Verkman AS. Evidence against defective trans-Golgi acidification in cystic fibrosis. J Biol Chem 271: 15542-15548, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 15542-15548
-
-
Seksek, O.1
Biwersi, J.2
Verkman, A.S.3
-
33
-
-
1342310842
-
Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms, with special emphasis on vacuolar-type proton ATPase
-
Sun-Wada GH, Wada Y, Futai M. Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms, with special emphasis on vacuolar-type proton ATPase. Cell Struct Funct 28: 455-463, 2003.
-
(2003)
Cell Struct Funct
, vol.28
, pp. 455-463
-
-
Sun-Wada, G.H.1
Wada, Y.2
Futai, M.3
-
34
-
-
4143102419
-
Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation
-
Vais H, Zhang R, Reenstra WW. Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation. Am J Physiol Cell Physiol 287: C737-C745, 2004.
-
(2004)
Am J Physiol Cell Physiol
, vol.287
-
-
Vais, H.1
Zhang, R.2
Reenstra, W.W.3
-
35
-
-
0026770971
-
Role of CFTR in lysosome acidification
-
Van Dyke RW, Root KV, Schreiber JH, Wilson JM. Role of CFTR in lysosome acidification. Biochem Biophys Res Commun 184: 300-305, 1992.
-
(1992)
Biochem Biophys Res Commun
, vol.184
, pp. 300-305
-
-
van Dyke, R.W.1
Root, K.V.2
Schreiber, J.H.3
Wilson, J.M.4
-
36
-
-
0036720506
-
Oxidant and antioxidant modulation of chloride channels expressed in human retinal pigment epithelium
-
Weng TX, Godley BF, Jin GF, Mangini NJ, Kennedy BG, Yu AS, Wills NK. Oxidant and antioxidant modulation of chloride channels expressed in human retinal pigment epithelium. Am J Physiol Cell Physiol 283: C839-C849, 2002.
-
(2002)
Am J Physiol Cell Physiol
, vol.283
-
-
Weng, T.X.1
Godley, B.F.2
Jin, G.F.3
Mangini, N.J.4
Kennedy, B.G.5
Yu, A.S.6
Wills, N.K.7
-
37
-
-
33646144314
-
Functional abnormalities in the retinal pigment epithelium of CFTR mutant mice
-
Wu J, Marmorstein AD, Peachey NS. Functional abnormalities in the retinal pigment epithelium of CFTR mutant mice. Exp Eye Res 83: 424-428, 2006.
-
(2006)
Exp Eye Res
, vol.83
, pp. 424-428
-
-
Wu, J.1
Marmorstein, A.D.2
Peachey, N.S.3
|