Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells

Advances in Experimental Medicine and Biology

Volumn 801, Issue , 2014, Pages 105-111

  Guha, Sonia ^a   Liu, Ji ^a   Baltazar, Gabe ^a   Laties, Alan M ^a   Mitchell, Claire H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Age related macular degeneration (AMD); Autophagy; Enzymatic degradation; Lipofuscin; Lysosomal pH; Nanoparticles; Retinal pigment epithelium (RPE); Signal transduction; Stargardt s disease

Indexed keywords

ADENOSINE A2A RECEPTOR; BETA ADRENERGIC RECEPTOR; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOPAMINE 5 RECEPTOR; FLUORESCENT DYE; LIPOFUSCIN; N RETINYLIDENE N RETINYLETHINOLAMIDE; NANOPARTICLE; UNCLASSIFIED DRUG;

ACIDIFICATION; ACIDITY; AGE RELATED MACULAR DEGENERATION; ALKALINIZATION; ARTICLE; AUTOFLUORESCENCE; BIODEGRADATION; LYSOSOME; NONHUMAN; PHOTORECEPTOR OUTER SEGMENT; PRIORITY JOURNAL; RETINA PIGMENT CELL; SIGNAL TRANSDUCTION; ANIMAL; FLUORESCENCE IMAGING; HUMAN; METABOLISM; PHAGOCYTOSIS; PHYSIOLOGY; PIGMENT EPITHELIUM; REVIEW;

MUS;

ANIMALS; HUMANS; LIPOFUSCIN; LYSOSOMES; OPTICAL IMAGING; PHAGOCYTOSIS; RETINAL PHOTORECEPTOR CELL OUTER SEGMENT; RETINAL PIGMENT EPITHELIUM;

EID: 84904807416     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3209-8_14     Document Type: Article

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