A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Anderson, Owen A ^a   Finkelstein, Arthur ^a   Shima, David T ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CHEMOKINE; CRYOPYRIN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; LIPOFUSCIN; MONOCYTE CHEMOTACTIC PROTEIN 1; N RETINYLIDENE N RETINYLETHANOLAMINE; PATTERN RECOGNITION RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN A; VITRONECTIN;

AGING; ARTICLE; BRUCH MEMBRANE; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUSEN; ENDOCYTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LYSOSOME; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MULTIPLEX POLYMERASE CHAIN REACTION; PATTERN RECOGNITION; PIGMENT EPITHELIUM; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; RETINA MACULA AGE RELATED DEGENERATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CARRIER PROTEINS; CELL LINE; CYTOPLASM; ENDOCYTOSIS; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; GEOGRAPHIC ATROPHY; HUMANS; INFLAMMASOMES; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; PROTEIN PRECURSORS; PROTEIN TRANSPORT; RETINAL PIGMENT EPITHELIUM; RETINOIDS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

MUS;

EID: 84879540747     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067263     Document Type: Article

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