메뉴 건너뛰기




Volumn 4, Issue 1, 2014, Pages 57-66

Mechanisms Revealed Through General Anesthetic Photolabeling

Author keywords

Anesthesia; Anesthetic; Diazirine; Ion channel; Photoaffinity labeling; Photolabel

Indexed keywords


EID: 84906499007     PISSN: 21676275     EISSN: 15233855     Source Type: Journal    
DOI: 10.1007/s40140-013-0040-7     Document Type: Article
Times cited : (22)

References (85)
  • 1
    • 0020045075 scopus 로고
    • Binding of halothane-free radicals to fatty acids following UV irradiation
    • PID: 6280516
    • Bösterling B, Trevor A, Trudell JR. Binding of halothane-free radicals to fatty acids following UV irradiation. Anesthesiology. 1982;56:380–4. DOI: 10.1097/00000542-198205000-00010
    • (1982) Anesthesiology. , vol.56 , pp. 380-384
    • Bösterling, B.1    Trevor, A.2    Trudell, J.R.3
  • 2
    • 0026579347 scopus 로고
    • Saturable binding of halothane to rat brain synaptosomes
    • COI: 1:CAS:528:DyaK38XksVShtLg%3D, PID: 1584767
    • el-Maghrabi EA, Eckenhoff RG, Shuman H. Saturable binding of halothane to rat brain synaptosomes. Proc Natl Acad Sci USA. 1992;89:4329–32. DOI: 10.1073/pnas.89.10.4329
    • (1992) Proc Natl Acad Sci USA. , vol.89 , pp. 4329-4332
    • el-Maghrabi, E.A.1    Eckenhoff, R.G.2    Shuman, H.3
  • 3
    • 0029865484 scopus 로고    scopus 로고
    • An inhalational anesthetic binding domain in the nicotinic acetylcholine receptor
    • COI: 1:CAS:528:DyaK28XitVCisbc%3D, PID: 8610122
    • Eckenhoff RG. An inhalational anesthetic binding domain in the nicotinic acetylcholine receptor. Proc Natl Acad Sci USA. 1996;93:2807–10. DOI: 10.1073/pnas.93.7.2807
    • (1996) Proc Natl Acad Sci USA. , vol.93 , pp. 2807-2810
    • Eckenhoff, R.G.1
  • 4
    • 0029900543 scopus 로고    scopus 로고
    • Amino acid resolution of halothane binding sites in serum albumin
    • COI: 1:CAS:528:DyaK28XjvFWiu7w%3D, PID: 8663164
    • Eckenhoff RG. Amino acid resolution of halothane binding sites in serum albumin. J Biol Chem. 1996;271:15521–6.
    • (1996) J Biol Chem. , vol.271 , pp. 15521-15526
    • Eckenhoff, R.G.1
  • 5
    • 0034730631 scopus 로고    scopus 로고
    • Inhaled anesthetic binding sites in human serum albumin
    • COI: 1:CAS:528:DC%2BD3cXnt1agsbk%3D, PID: 10896670
    • Eckenhoff RG, Petersen CE, Ha CE, Bhagavan NV. Inhaled anesthetic binding sites in human serum albumin. J Biol Chem. 2000;275:30439–44. DOI: 10.1074/jbc.M005052200
    • (2000) J Biol Chem. , vol.275 , pp. 30439-30444
    • Eckenhoff, R.G.1    Petersen, C.E.2    Ha, C.E.3    Bhagavan, N.V.4
  • 6
    • 0034071759 scopus 로고    scopus 로고
    • General anesthetic binding to gramicidin A: the structural requirements
    • COI: 1:CAS:528:DC%2BD3cXisVWgtrk%3D, PID: 10733961
    • Tang P, Eckenhoff RG, Xu Y. General anesthetic binding to gramicidin A: the structural requirements. Biophys J. 2000;78:1804–9. DOI: 10.1016/S0006-3495(00)76730-0
    • (2000) Biophys J , vol.78 , pp. 1804-1809
    • Tang, P.1    Eckenhoff, R.G.2    Xu, Y.3
  • 7
    • 0035845588 scopus 로고    scopus 로고
    • Anesthetic stabilization of protein intermediates: myoglobin and halothane
    • COI: 1:CAS:528:DC%2BD3MXlvVymsbg%3D, PID: 11535057
    • Eckenhoff RG, Pidikiti R, Reddy KS. Anesthetic stabilization of protein intermediates: myoglobin and halothane. Biochemistry. 2001;40:10819–24. DOI: 10.1021/bi010691r
    • (2001) Biochemistry. , vol.40 , pp. 10819-10824
    • Eckenhoff, R.G.1    Pidikiti, R.2    Reddy, K.S.3
  • 8
    • 0036232886 scopus 로고    scopus 로고
    • G protein-coupled receptors as direct targets of inhaled anesthetics
    • COI: 1:CAS:528:DC%2BD38XjtlGltLY%3D, PID: 11961111
    • Ishizawa Y, Pidikiti R, Liebman PA, Eckenhoff RG. G protein-coupled receptors as direct targets of inhaled anesthetics. Mol Pharmacol. 2002;61:945–52. DOI: 10.1124/mol.61.5.945
    • (2002) Mol Pharmacol. , vol.61 , pp. 945-952
    • Ishizawa, Y.1    Pidikiti, R.2    Liebman, P.A.3    Eckenhoff, R.G.4
  • 9
    • 0345686447 scopus 로고    scopus 로고
    • Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane
    • COI: 1:CAS:528:DC%2BD3sXosVCqt7s%3D, PID: 14621991
    • Chiara DC, Dangott LJ, Eckenhoff RG, Cohen JB. Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane. Biochemistry. 2003;42:13457–67. DOI: 10.1021/bi0351561
    • (2003) Biochemistry. , vol.42 , pp. 13457-13467
    • Chiara, D.C.1    Dangott, L.J.2    Eckenhoff, R.G.3    Cohen, J.B.4
  • 10
    • 0037171769 scopus 로고    scopus 로고
    • Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics
    • COI: 1:CAS:528:DC%2BD38XitlCku7w%3D, PID: 11960499
    • Eckenhoff RG, Knoll FJ, Greenblatt EP, Dailey WP. Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics. J Med Chem. 2002;45:1879–86. DOI: 10.1021/jm0104926
    • (2002) J Med Chem. , vol.45 , pp. 1879-1886
    • Eckenhoff, R.G.1    Knoll, F.J.2    Greenblatt, E.P.3    Dailey, W.P.4
  • 11
    • 0033606987 scopus 로고    scopus 로고
    • Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic
    • COI: 1:CAS:528:DyaK1MXksl2lsLY%3D, PID: 10464016
    • Husain SS, Forman SA, Kloczewiak MA, Addona GH, Olsen RW, Pratt MB, et al. Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. J Med Chem. 1999;42:3300–7. DOI: 10.1021/jm9806300
    • (1999) J Med Chem. , vol.42 , pp. 3300-3307
    • Husain, S.S.1    Forman, S.A.2    Kloczewiak, M.A.3    Addona, G.H.4    Olsen, R.W.5    Pratt, M.B.6
  • 12
    • 0037067695 scopus 로고    scopus 로고
    • Geometric isomers of a photoactivable general anesthetic delineate a binding site on adenylate kinase
    • COI: 1:CAS:528:DC%2BD38XlsVWhtrg%3D, PID: 11976328
    • Addona GH, Husain SS, Stehle T, Miller KW. Geometric isomers of a photoactivable general anesthetic delineate a binding site on adenylate kinase. J Biol Chem. 2002;277:25685–91. DOI: 10.1074/jbc.M201303200
    • (2002) J Biol Chem. , vol.277 , pp. 25685-25691
    • Addona, G.H.1    Husain, S.S.2    Stehle, T.3    Miller, K.W.4
  • 13
    • 0345269286 scopus 로고    scopus 로고
    • 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels
    • COI: 1:CAS:528:DC%2BD3sXhslSlsbk%3D, PID: 12646036
    • Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, et al. 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem. 2003;46:1257–65. DOI: 10.1021/jm020465v
    • (2003) J Med Chem. , vol.46 , pp. 1257-1265
    • Husain, S.S.1    Ziebell, M.R.2    Ruesch, D.3    Hong, F.4    Arevalo, E.5    Kosterlitz, J.A.6
  • 14
    • 33746864076 scopus 로고    scopus 로고
    • Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels
    • COI: 1:CAS:528:DC%2BD28Xms1Slurg%3D, PID: 16884293
    • Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li G-D, et al. Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. J Med Chem. 2006;49:4818–25. DOI: 10.1021/jm051207b
    • (2006) J Med Chem. , vol.49 , pp. 4818-4825
    • Husain, S.S.1    Nirthanan, S.2    Ruesch, D.3    Solt, K.4    Cheng, Q.5    Li, G.-D.6
  • 15
    • 34249748906 scopus 로고    scopus 로고
    • Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel
    • COI: 1:CAS:528:DC%2BD2sXktFeltrk%3D, PID: 17311911
    • Bright DP, Adham SD, Lemaire LCJM, Benavides R, Gruss M, Taylor GW, et al. Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel. J Biol Chem. 2007;282:12038–47. DOI: 10.1074/jbc.M700479200
    • (2007) J Biol Chem. , vol.282 , pp. 12038-12047
    • Bright, D.P.1    Adham, S.D.2    Lemaire, L.C.J.M.3    Benavides, R.4    Gruss, M.5    Taylor, G.W.6
  • 16
    • 77956330454 scopus 로고    scopus 로고
    • p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels
    • COI: 1:CAS:528:DC%2BC3cXhtVSmsb7I, PID: 20704351
    • Husain SS, Stewart D, Desai R, Hamouda AK, Li SG-D, Kelly E, et al. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010;53:6432–44. DOI: 10.1021/jm100498u
    • (2010) J Med Chem. , vol.53 , pp. 6432-6444
    • Husain, S.S.1    Stewart, D.2    Desai, R.3    Hamouda, A.K.4    Li, S.G.-D.5    Kelly, E.6
  • 17
    • 0038644947 scopus 로고    scopus 로고
    • Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain
    • COI: 1:CAS:528:DC%2BD3sXislGrur8%3D, PID: 12560326
    • Darbandi-Tonkabon R, Hastings WR, Zeng C-M, Akk G, Manion BD, Bracamontes JR, et al. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. J Biol Chem. 2003;278:13196–206. DOI: 10.1074/jbc.M213168200
    • (2003) J Biol Chem. , vol.278 , pp. 13196-13206
    • Darbandi-Tonkabon, R.1    Hastings, W.R.2    Zeng, C.-M.3    Akk, G.4    Manion, B.D.5    Bracamontes, J.R.6
  • 18
    • 39049192841 scopus 로고    scopus 로고
    • Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions
    • COI: 1:CAS:528:DC%2BD28XmvFSksbo%3D, PID: 17163775
    • Xi J, Liu R, Rossi MJ, Yang J, Loll PJ, Dailey WP, et al. Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions. ACS Chem Biol. 2006;1:377–84. DOI: 10.1021/cb600207d
    • (2006) ACS Chem Biol. , vol.1 , pp. 377-384
    • Xi, J.1    Liu, R.2    Rossi, M.J.3    Yang, J.4    Loll, P.J.5    Dailey, W.P.6
  • 19
    • 77952938473 scopus 로고    scopus 로고
    • Azi-isoflurane, a photolabel analog of the commonly used inhaled general anesthetic isoflurane
    • COI: 1:CAS:528:DC%2BD1MXhtlKmsr%2FO, PID: 20228895
    • Eckenhoff RG, Xi J, Shimaoka M, Bhattacharji A, Covarrubias M, Dailey WP. Azi-isoflurane, a photolabel analog of the commonly used inhaled general anesthetic isoflurane. ACS Chem Neurosci. 2010;1:139–45. DOI: 10.1021/cn900014m
    • (2010) ACS Chem Neurosci. , vol.1 , pp. 139-145
    • Eckenhoff, R.G.1    Xi, J.2    Shimaoka, M.3    Bhattacharji, A.4    Covarrubias, M.5    Dailey, W.P.6
  • 20
    • 84876014310 scopus 로고    scopus 로고
    • Direct modulation of microtubule stability contributes to anthracene general anesthesia
    • An approach to uncovering anesthetic mechanisms (i.e., probe synthesis, target identification, and in vivo implication of the target) is implemented here
    • •• Emerson DJ, Weiser BP, Psonis J, Liao Z, Taratula O, Fiamengo A, et al. Direct modulation of microtubule stability contributes to anthracene general anesthesia. J Am Chem Soc. 2013;135:5389–98. An approach to uncovering anesthetic mechanisms (i.e., probe synthesis, target identification, and in vivo implication of the target) is implemented here.
    • (2013) J am Chem Soc , vol.135 , pp. 5389-5398
    • Emerson, D.J.1    Weiser, B.P.2    Psonis, J.3    Liao, Z.4    Taratula, O.5    Fiamengo, A.6
  • 21
    • 77955403530 scopus 로고    scopus 로고
    • m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol
    • COI: 1:CAS:528:DC%2BC3cXotlSnsr0%3D, PID: 20597506
    • Hall MA, Xi J, Lor C, Dai S, Pearce R, Dailey WP, et al. m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol. J Med Chem. 2010;53:5667–75. DOI: 10.1021/jm1004072
    • (2010) J Med Chem. , vol.53 , pp. 5667-5675
    • Hall, M.A.1    Xi, J.2    Lor, C.3    Dai, S.4    Pearce, R.5    Dailey, W.P.6
  • 22
    • 82555187402 scopus 로고    scopus 로고
    • p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol
    • COI: 1:CAS:528:DC%2BC3MXhtlOgu7fO, PID: 22029276
    • Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, et al. p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem. 2011;54:8124–35. DOI: 10.1021/jm200943f
    • (2011) J Med Chem. , vol.54 , pp. 8124-8135
    • Stewart, D.S.1    Savechenkov, P.Y.2    Dostalova, Z.3    Chiara, D.C.4    Ge, R.5    Raines, D.E.6
  • 24
    • 84864191258 scopus 로고    scopus 로고
    • Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic
    • COI: 1:CAS:528:DC%2BC38XptF2nur8%3D, PID: 22734650
    • Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, et al. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012;55:6554–65. DOI: 10.1021/jm300631e
    • (2012) J Med Chem , vol.55 , pp. 6554-6565
    • Savechenkov, P.Y.1    Zhang, X.2    Chiara, D.C.3    Stewart, D.S.4    Ge, R.5    Zhou, X.6
  • 26
    • 84876483344 scopus 로고    scopus 로고
    • Computational methods for contemporary carbene chemistry
    • This provides a review of computational practices for predicting carbene reactivity within ligand design
    • • Gerbig D, Ley D. Computational methods for contemporary carbene chemistry. WIREs Comput Mol Sci. 2013;3:242–72. This provides a review of computational practices for predicting carbene reactivity within ligand design.
    • (2013) Wires Comput Mol Sci , vol.3 , pp. 242-272
  • 27
    • 61349141828 scopus 로고    scopus 로고
    • Carbenes: Synthesis, properties, and organometallic chemistry
    • De Frémont P, Marion N, Nolan SP. Carbenes: Synthesis, properties, and organometallic chemistry. Coord Chem Rev. 2009;253:862–92. DOI: 10.1016/j.ccr.2008.05.018
    • (2009) Coord Chem Rev , vol.253 , pp. 862-892
    • De Frémont, P.1    Marion, N.2    Nolan, S.P.3
  • 28
    • 0000716001 scopus 로고    scopus 로고
    • Fluorinated carbenes
    • COI: 1:CAS:528:DyaK28XktFOqsLc%3D, PID: 11848805
    • Brahms DLS, Dailey WP. Fluorinated carbenes. Chem Rev. 1996;96:1585–632. DOI: 10.1021/cr941141k
    • (1996) Chem Rev. , vol.96 , pp. 1585-1632
    • Brahms, D.L.S.1    Dailey, W.P.2
  • 29
    • 2342429687 scopus 로고    scopus 로고
    • Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic
    • COI: 1:CAS:528:DC%2BD2cXjt1Gntbw%3D, PID: 14761946
    • Ziebell MR, Nirthanan S, Husain SS, Miller KW, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic. J Biol Chem. 2004;279:17640–9. DOI: 10.1074/jbc.M313886200
    • (2004) J Biol Chem. , vol.279 , pp. 17640-17649
    • Ziebell, M.R.1    Nirthanan, S.2    Husain, S.S.3    Miller, K.W.4    Cohen, J.B.5
  • 30
    • 85140967002 scopus 로고    scopus 로고
    • • Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB. Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [(3)H]TDBzl-etomidate, a photoreactive etomidate analogue. Biochemistry. 2012;51:836–47. Consideration of the chemical reactivity of photolysis intermediates when interpreting binding site identification is addressed here.
    • (2012)
    • Chiara, D.C.1    Dostalova, Z.2    Jayakar, S.S.3    Zhou, X.4    Miller, K.W.5    Cohen, J.B.6
  • 31
    • 84865244600 scopus 로고    scopus 로고
    • Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor
    • COI: 1:CAS:528:DC%2BC38XhtlShu7bL, PID: 22648971
    • Chen Z-W, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, et al. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Mol Pharmacol. 2012;82:408–19. DOI: 10.1124/mol.112.078410
    • (2012) Mol Pharmacol. , vol.82 , pp. 408-419
    • Chen, Z.-W.1    Manion, B.2    Townsend, R.R.3    Reichert, D.E.4    Covey, D.F.5    Steinbach, J.H.6
  • 33
    • 0031969505 scopus 로고    scopus 로고
    • Quantitative autoradiography of halothane binding in rat brain
    • COI: 1:CAS:528:DyaK1cXisVCqt70%3D, PID: 9536033
    • Eckenhoff MF, Eckenhoff RG. Quantitative autoradiography of halothane binding in rat brain. J Pharmacol Exp Ther. 1998;285:371–6.
    • (1998) J Pharmacol Exp Ther. , vol.285 , pp. 371-376
    • Eckenhoff, M.F.1    Eckenhoff, R.G.2
  • 34
    • 0036139417 scopus 로고    scopus 로고
    • Multiple specific binding targets for inhaled anesthetics in the mammalian brain
    • COI: 1:CAS:528:DC%2BD38Xht1Wnuw%3D%3D, PID: 11752113
    • Eckenhoff MF, Chan K, Eckenhoff RG. Multiple specific binding targets for inhaled anesthetics in the mammalian brain. J Pharmacol Exp Ther. 2002;300:172–9. DOI: 10.1124/jpet.300.1.172
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 172-179
    • Eckenhoff, M.F.1    Chan, K.2    Eckenhoff, R.G.3
  • 35
    • 0025738459 scopus 로고
    • Localization of volatile anesthetic molecules at the subcellular and molecular level
    • COI: 1:STN:280:DyaK3M3ot1ejuw%3D%3D, PID: 2058925
    • Eckenhoff RG, Shuman H. Localization of volatile anesthetic molecules at the subcellular and molecular level. Ann NY Acad Sci. 1991;625:755–9. DOI: 10.1111/j.1749-6632.1991.tb33910.x
    • (1991) Ann NY Acad Sci. , vol.625 , pp. 755-759
    • Eckenhoff, R.G.1    Shuman, H.2
  • 36
    • 0025162222 scopus 로고
    • Subcellular distribution of an inhalational anesthetic in situ
    • COI: 1:STN:280:DyaK3c7hsFyqtA%3D%3D, PID: 2296601
    • Eckenhoff RG, Shuman H. Subcellular distribution of an inhalational anesthetic in situ. Proc Natl Acad Sci USA. 1990;87:454–7. DOI: 10.1073/pnas.87.1.454
    • (1990) Proc Natl Acad Sci USA. , vol.87 , pp. 454-457
    • Eckenhoff, R.G.1    Shuman, H.2
  • 37
    • 2442620345 scopus 로고    scopus 로고
    • Inhalational anesthetic-binding proteins in rat neuronal membranes
    • COI: 1:CAS:528:DC%2BD2cXjs1Wis7g%3D, PID: 14988400
    • Xi J, Liu R, Asbury GR, Eckenhoff MF, Eckenhoff RG. Inhalational anesthetic-binding proteins in rat neuronal membranes. J Biol Chem. 2004;279:19628–33. DOI: 10.1074/jbc.M313864200
    • (2004) J Biol Chem. , vol.279 , pp. 19628-19633
    • Xi, J.1    Liu, R.2    Asbury, G.R.3    Eckenhoff, M.F.4    Eckenhoff, R.G.5
  • 38
    • 33847388015 scopus 로고    scopus 로고
    • Halothane binding proteome in human brain cortex
    • COI: 1:CAS:528:DC%2BD28Xhtlaru7jN, PID: 17269715
    • Pan JZ, Xi J, Tobias JW, Eckenhoff MF, Eckenhoff RG. Halothane binding proteome in human brain cortex. J Proteome Res. 2007;6:582–92. DOI: 10.1021/pr060311u
    • (2007) J Proteome Res. , vol.6 , pp. 582-592
    • Pan, J.Z.1    Xi, J.2    Tobias, J.W.3    Eckenhoff, M.F.4    Eckenhoff, R.G.5
  • 39
    • 0344287290 scopus 로고
    • Uncoupling of oxidative phosphorylation in rat liver mitochondria by general anesthetics
    • COI: 1:CAS:528:DyaL3sXksVOrsb4%3D, PID: 6574486
    • Rottenberg H. Uncoupling of oxidative phosphorylation in rat liver mitochondria by general anesthetics. Proc Natl Acad Sci USA. 1983;80:3313–7. DOI: 10.1073/pnas.80.11.3313
    • (1983) Proc Natl Acad Sci USA. , vol.80 , pp. 3313-3317
    • Rottenberg, H.1
  • 40
    • 79958153921 scopus 로고    scopus 로고
    • Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BC3MXms1aisrc%3D, PID: 21467554
    • Kayser E-B, Suthammarak W, Morgan PG, Sedensky MM. Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans. Anesth Analg. 2011;112:1321–9. DOI: 10.1213/ANE.0b013e3182121d37
    • (2011) Anesth Analg. , vol.112 , pp. 1321-1329
    • Kayser, E.-B.1    Suthammarak, W.2    Morgan, P.G.3    Sedensky, M.M.4
  • 41
    • 84865086994 scopus 로고    scopus 로고
    • Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I
    • COI: 1:CAS:528:DC%2BC38Xht1Cntr7O, PID: 22912761
    • Quintana A, Morgan PG, Kruse SE, Palmiter RD, Sedensky MM. Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. PLoS One. 2012;7:e42904. DOI: 10.1371/journal.pone.0042904
    • (2012) PLoS One. , vol.7
    • Quintana, A.1    Morgan, P.G.2    Kruse, S.E.3    Palmiter, R.D.4    Sedensky, M.M.5
  • 42
    • 13444271681 scopus 로고    scopus 로고
    • Refined structure of the nicotinic acetylcholine receptor at 4A resolution
    • COI: 1:CAS:528:DC%2BD2MXhtFGrsbs%3D, PID: 15701510
    • Unwin N. Refined structure of the nicotinic acetylcholine receptor at 4A resolution. J Mol Biol. 2005;346:967–89. DOI: 10.1016/j.jmb.2004.12.031
    • (2005) J Mol Biol. , vol.346 , pp. 967-989
    • Unwin, N.1
  • 43
    • 84862776644 scopus 로고    scopus 로고
    • NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor
    • COI: 1:CAS:528:DC%2BC38XhvFeisLw%3D, PID: 22155685
    • Cui T, Mowrey D, Bondarenko V, Tillman T, Ma D, Landrum E, et al. NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochim Biophys Acta. 2012;1818:617–26. DOI: 10.1016/j.bbamem.2011.11.021
    • (2012) Biochim Biophys Acta. , vol.1818 , pp. 617-626
    • Cui, T.1    Mowrey, D.2    Bondarenko, V.3    Tillman, T.4    Ma, D.5    Landrum, E.6
  • 44
    • 78751673139 scopus 로고    scopus 로고
    • X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
    • COI: 1:CAS:528:DC%2BC3MXnvVOgtg%3D%3D, PID: 21248852
    • Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, et al. X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature. 2011;469:428–31. DOI: 10.1038/nature09647
    • (2011) Nature , vol.469 , pp. 428-431
    • Nury, H.1    Van Renterghem, C.2    Weng, Y.3    Tran, A.4    Baaden, M.5    Dufresne, V.6
  • 45
    • 79958000661 scopus 로고    scopus 로고
    • Multiple transmembrane binding sites for p-trifluoromethyldiazirinyl-etomidate, a photoreactive Torpedo nicotinic acetylcholine receptor allosteric inhibitor
    • COI: 1:CAS:528:DC%2BC3MXmvFCgt7s%3D, PID: 21498509
    • Hamouda AK, Stewart DS, Husain SS, Cohen JB. Multiple transmembrane binding sites for p-trifluoromethyldiazirinyl-etomidate, a photoreactive Torpedo nicotinic acetylcholine receptor allosteric inhibitor. J Biol Chem. 2011;286:20466–77. DOI: 10.1074/jbc.M111.219071
    • (2011) J Biol Chem. , vol.286 , pp. 20466-20477
    • Hamouda, A.K.1    Stewart, D.S.2    Husain, S.S.3    Cohen, J.B.4
  • 46
    • 84874766162 scopus 로고    scopus 로고
    • Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog
    • COI: 1:CAS:528:DC%2BC3sXjtlKntr0%3D, PID: 23300078
    • Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB. Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog. J Biol Chem. 2013;288:6178–89. DOI: 10.1074/jbc.M112.435909
    • (2013) J Biol Chem. , vol.288 , pp. 6178-6189
    • Jayakar, S.S.1    Dailey, W.P.2    Eckenhoff, R.G.3    Cohen, J.B.4
  • 47
    • 52049101190 scopus 로고    scopus 로고
    • Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector
    • COI: 1:CAS:528:DC%2BD1cXpt1artrc%3D, PID: 18524766
    • Nirthanan S, Garcia G 3rd, Chiara DC, Husain SS, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector. J Biol Chem. 2008;283:22051–62. DOI: 10.1074/jbc.M801332200
    • (2008) J Biol Chem. , vol.283 , pp. 22051-22062
    • Nirthanan, S.1    Garcia, G.2    Chiara, D.C.3    Husain, S.S.4    Cohen, J.B.5
  • 48
    • 0034703007 scopus 로고    scopus 로고
    • Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic
    • COI: 1:CAS:528:DC%2BD3cXmvFKjs7Y%3D, PID: 10859324
    • Pratt MB, Husain SS, Miller KW, Cohen JB. Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic. J Biol Chem. 2000;275:29441–51. DOI: 10.1074/jbc.M004710200
    • (2000) J Biol Chem. , vol.275 , pp. 29441-29451
    • Pratt, M.B.1    Husain, S.S.2    Miller, K.W.3    Cohen, J.B.4
  • 49
    • 35448958166 scopus 로고    scopus 로고
    • Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262
    • COI: 1:CAS:528:DC%2BD2sXhtFSnsLvP, PID: 17910479
    • Forman SA, Zhou QL, Stewart DS. Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262. Biochemistry. 2007;46:11911–8. DOI: 10.1021/bi701287a
    • (2007) Biochemistry , vol.46 , pp. 11911-11918
    • Forman, S.A.1    Zhou, Q.L.2    Stewart, D.S.3
  • 50
    • 66049157194 scopus 로고    scopus 로고
    • Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor
    • COI: 1:CAS:528:DC%2BD1MXlsFSlsrg%3D, PID: 19218367
    • Chiara DC, Hong FH, Arevalo E, Husain SS, Miller KW, Forman SA, et al. Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor. Mol Pharmacol. 2009;75:1084–95. DOI: 10.1124/mol.108.054353
    • (2009) Mol Pharmacol. , vol.75 , pp. 1084-1095
    • Chiara, D.C.1    Hong, F.H.2    Arevalo, E.3    Husain, S.S.4    Miller, K.W.5    Forman, S.A.6
  • 51
    • 0030958134 scopus 로고    scopus 로고
    • Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics
    • COI: 1:CAS:528:DyaK2sXivVehur8%3D, PID: 9105231
    • Violet JM, Downie DL, Nakisa RC, Lieb WR, Franks NP. Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics. Anesthesiology. 1997;86:866–74. DOI: 10.1097/00000542-199704000-00017
    • (1997) Anesthesiology. , vol.86 , pp. 866-874
    • Violet, J.M.1    Downie, D.L.2    Nakisa, R.C.3    Lieb, W.R.4    Franks, N.P.5
  • 52
    • 54049137689 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update
    • COI: 1:CAS:528:DC%2BD1MXmsVChtrY%3D, PID: 18790874
    • Olsen RW, Sieghart W. International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev. 2008;60:243–60. DOI: 10.1124/pr.108.00505
    • (2008) Pharmacol Rev. , vol.60 , pp. 243-260
    • Olsen, R.W.1    Sieghart, W.2
  • 53
    • 33751119897 scopus 로고    scopus 로고
    • Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog
    • COI: 1:CAS:528:DC%2BD28Xht1Glu7rL, PID: 17093081
    • Li G-D, Chiara DC, Sawyer GW, Husain SS, Olsen RW, Cohen JB. Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog. J Neurosci. 2006;26:11599–605. DOI: 10.1523/JNEUROSCI.3467-06.2006
    • (2006) J Neurosci. , vol.26 , pp. 11599-11605
    • Li, G.-D.1    Chiara, D.C.2    Sawyer, G.W.3    Husain, S.S.4    Olsen, R.W.5    Cohen, J.B.6
  • 55
    • 77950557636 scopus 로고    scopus 로고
    • Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors
    • COI: 1:CAS:528:DC%2BC3cXjtFShsrg%3D, PID: 20083606
    • Li G-D, Chiara DC, Cohen JB, Olsen RW. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors. J Biol Chem. 2010;285:8615–20. DOI: 10.1074/jbc.M109.074708
    • (2010) J Biol Chem , vol.285 , pp. 8615-8620
    • Li, G.-D.1    Chiara, D.C.2    Cohen, J.B.3    Olsen, R.W.4
  • 56
    • 0034595716 scopus 로고    scopus 로고
    • γ-Aminobutyric acid enhancement of halothane binding in rat cerebellum
    • COI: 1:CAS:528:DC%2BD3cXjsVGhu7w%3D, PID: 10825649
    • Eckenhoff M, Eckenhoff R. γ-Aminobutyric acid enhancement of halothane binding in rat cerebellum. Neurosci Lett. 2000;286:111–4. DOI: 10.1016/S0304-3940(00)01105-8
    • (2000) Neurosci Lett , vol.286 , pp. 111-114
    • Eckenhoff, M.1    Eckenhoff, R.2
  • 57
    • 66449123447 scopus 로고    scopus 로고
    • Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors
    • COI: 1:CAS:528:DC%2BD1MXltVCmtrg%3D, PID: 19282280
    • Li G-D, Chiara DC, Cohen JB, Olsen RW. Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors. J Biol Chem. 2009;284:11771–5. DOI: 10.1074/jbc.C900016200
    • (2009) J Biol Chem. , vol.284 , pp. 11771-11775
    • Li, G.-D.1    Chiara, D.C.2    Cohen, J.B.3    Olsen, R.W.4
  • 58
    • 84876547974 scopus 로고    scopus 로고
    • Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol
    • COI: 1:CAS:528:DC%2BC3sXhtl2js77F, PID: 23616535
    • Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, et al. Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J Neurosci. 2013;33:7264–73. DOI: 10.1523/JNEUROSCI.5475-12.2013
    • (2013) J Neurosci. , vol.33 , pp. 7264-7273
    • Kretschmannova, K.1    Hines, R.M.2    Revilla-Sanchez, R.3    Terunuma, M.4    Tretter, V.5    Jurd, R.6
  • 59
    • 9144238664 scopus 로고    scopus 로고
    • Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABAA receptor modulation and anesthesia
    • COI: 1:CAS:528:DC%2BD2cXhtlSqtb8%3D, PID: 14593090
    • Darbandi-Tonkabon R, Manion BD, Hastings WR, Craigen WJ, Akk G, Bracamontes JR, et al. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABAA receptor modulation and anesthesia. J Pharmacol Exp Ther. 2004;308:502–11. DOI: 10.1124/jpet.103.058123
    • (2004) J Pharmacol Exp Ther. , vol.308 , pp. 502-511
    • Darbandi-Tonkabon, R.1    Manion, B.D.2    Hastings, W.R.3    Craigen, W.J.4    Akk, G.5    Bracamontes, J.R.6
  • 60
    • 84872304392 scopus 로고    scopus 로고
    • In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets
    • COI: 1:CAS:528:DC%2BC3sXosFertA%3D%3D, PID: 23184948
    • Weiser BP, Kelz MB, Eckenhoff RG. In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets. J Biol Chem. 2013;288:1279–85. DOI: 10.1074/jbc.M112.413989
    • (2013) J Biol Chem. , vol.288 , pp. 1279-1285
    • Weiser, B.P.1    Kelz, M.B.2    Eckenhoff, R.G.3
  • 61
    • 0026730773 scopus 로고
    • Isolation and cloning of a voltage-dependent anion channel-like Mr 36,000 polypeptide from mammalian brain
    • COI: 1:CAS:528:DyaK3sXhvVKjtbg%3D, PID: 1373732
    • Bureau MH, Khrestchatisky M, Heeren MA, Zambrowicz EB, Kim H, Grisar TM, et al. Isolation and cloning of a voltage-dependent anion channel-like Mr 36,000 polypeptide from mammalian brain. J Biol Chem. 1992;267:8679–84.
    • (1992) J Biol Chem. , vol.267 , pp. 8679-8684
    • Bureau, M.H.1    Khrestchatisky, M.2    Heeren, M.A.3    Zambrowicz, E.B.4    Kim, H.5    Grisar, T.M.6
  • 62
    • 84857132887 scopus 로고    scopus 로고
    • Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2 + accumulation and cytochrome c release: study on isolated mitochondria
    • COI: 1:CAS:528:DC%2BC38XjtVektLk%3D, PID: 22359587
    • Gergalova G, Lykhmus O, Kalashnyk O, Koval L, Chernyshov V, Kryukova E, et al. Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2 + accumulation and cytochrome c release: study on isolated mitochondria. PLoS One. 2012;7:e31361. DOI: 10.1371/journal.pone.0031361
    • (2012) PLoS One. , vol.7
    • Gergalova, G.1    Lykhmus, O.2    Kalashnyk, O.3    Koval, L.4    Chernyshov, V.5    Kryukova, E.6
  • 63
    • 0036139094 scopus 로고    scopus 로고
    • Conduction pathways in microtubules, biological quantum computation, and consciousness
    • PID: 11755497
    • Hameroff S, Nip A, Porter M, Tuszynski J. Conduction pathways in microtubules, biological quantum computation, and consciousness. BioSystems. 2002;64:149–68. DOI: 10.1016/S0303-2647(01)00183-6
    • (2002) BioSystems. , vol.64 , pp. 149-168
    • Hameroff, S.1    Nip, A.2    Porter, M.3    Tuszynski, J.4
  • 64
    • 84858983826 scopus 로고    scopus 로고
    • A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis
    • COI: 1:CAS:528:DC%2BC38XksV2hsbs%3D, PID: 22451060
    • Chen Z-W, Chen L-H, Akentieva N, Lichti CF, Darbandi R, Hastings R, et al. A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis. 2012;33:666–74. DOI: 10.1002/elps.201100434
    • (2012) Electrophoresis. , vol.33 , pp. 666-674
    • Chen, Z.-W.1    Chen, L.-H.2    Akentieva, N.3    Lichti, C.F.4    Darbandi, R.5    Hastings, R.6
  • 65
    • 66149142795 scopus 로고    scopus 로고
    • Identification of a fluorescent general anesthetic, 1-aminoanthracene
    • COI: 1:CAS:528:DC%2BD1MXlsFCrs7c%3D, PID: 19346473
    • Butts CA, Xi J, Brannigan G, Saad AA, Venkatachalan SP, Pearce RA, et al. Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proc Natl Acad Sci USA. 2009;106:6501–6. DOI: 10.1073/pnas.0810590106
    • (2009) Proc Natl Acad Sci USA. , vol.106 , pp. 6501-6506
    • Butts, C.A.1    Xi, J.2    Brannigan, G.3    Saad, A.A.4    Venkatachalan, S.P.5    Pearce, R.A.6
  • 66
    • 84862700282 scopus 로고    scopus 로고
    • Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia
    • COI: 1:CAS:528:DC%2BC38XpsFyhs78%3D, PID: 22761654
    • Craddock TJA, St George M, Freedman H, Barakat KH, Damaraju S, Hameroff S, et al. Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia. PLoS One. 2012;7:e37251. DOI: 10.1371/journal.pone.0037251
    • (2012) PLoS One. , vol.7
    • Craddock, T.J.A.1    St George, M.2    Freedman, H.3    Barakat, K.H.4    Damaraju, S.5    Hameroff, S.6
  • 67
    • 0029670030 scopus 로고    scopus 로고
    • Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities
    • COI: 1:CAS:528:DyaK28XhtlOnsbg%3D, PID: 8617724
    • Slater SJ, Ho C, Kelly MB, Larkin JD, Taddeo FJ, Yeager MD, et al. Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities. J Biol Chem. 1996;271:4627–31. DOI: 10.1074/jbc.271.9.4627
    • (1996) J Biol Chem. , vol.271 , pp. 4627-4631
    • Slater, S.J.1    Ho, C.2    Kelly, M.B.3    Larkin, J.D.4    Taddeo, F.J.5    Yeager, M.D.6
  • 68
    • 0035996639 scopus 로고    scopus 로고
    • Anaesthetic actions on other targets: protein kinase C and guanine nucleotide-binding proteins
    • COI: 1:CAS:528:DC%2BD38XlvFKmu74%3D, PID: 12173242
    • Rebecchi MJ, Pentyala SN. Anaesthetic actions on other targets: protein kinase C and guanine nucleotide-binding proteins. Br J Anaesth. 2002;89:62–78. DOI: 10.1093/bja/aef160
    • (2002) Br J Anaesth. , vol.89 , pp. 62-78
    • Rebecchi, M.J.1    Pentyala, S.N.2
  • 69
    • 0027216340 scopus 로고
    • Inhibition of protein kinase C by alcohols and anaesthetics
    • COI: 1:CAS:528:DyaK3sXkvVGruro%3D, PID: 8316305
    • Slater SJ, Cox KJ, Lombardi JV, Ho C, Kelly MB, Rubin E, et al. Inhibition of protein kinase C by alcohols and anaesthetics. Nature. 1993;364:82–4. DOI: 10.1038/364082a0
    • (1993) Nature. , vol.364 , pp. 82-84
    • Slater, S.J.1    Cox, K.J.2    Lombardi, J.V.3    Ho, C.4    Kelly, M.B.5    Rubin, E.6
  • 70
    • 0030934651 scopus 로고    scopus 로고
    • Interaction of alcohols and anesthetics with protein kinase Calpha
    • COI: 1:CAS:528:DyaK2sXhvVOkt78%3D, PID: 9045629
    • Slater SJ, Kelly MB, Larkin JD, Ho C, Mazurek A, Taddeo FJ, et al. Interaction of alcohols and anesthetics with protein kinase Calpha. J Biol Chem. 1997;272:6167–73. DOI: 10.1074/jbc.272.10.6167
    • (1997) J Biol Chem. , vol.272 , pp. 6167-6173
    • Slater, S.J.1    Kelly, M.B.2    Larkin, J.D.3    Ho, C.4    Mazurek, A.5    Taddeo, F.J.6
  • 71
    • 4444368781 scopus 로고    scopus 로고
    • Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta
    • COI: 1:CAS:528:DC%2BD2cXntFSntrc%3D, PID: 15234976
    • Das J, Addona GH, Sandberg WS, Husain SS, Stehle T, Miller KW. Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta. J Biol Chem. 2004;279:37964–72. DOI: 10.1074/jbc.M405137200
    • (2004) J Biol Chem. , vol.279 , pp. 37964-37972
    • Das, J.1    Addona, G.H.2    Sandberg, W.S.3    Husain, S.S.4    Stehle, T.5    Miller, K.W.6
  • 72
    • 33748155296 scopus 로고    scopus 로고
    • Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta
    • COI: 1:CAS:528:DC%2BD28Xpt1ejsb4%3D, PID: 16943444
    • Das J, Zhou X, Miller KW. Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase Cdelta. Protein Sci. 2006;15:2107–19. DOI: 10.1110/ps.062237606
    • (2006) Protein Sci. , vol.15 , pp. 2107-2119
    • Das, J.1    Zhou, X.2    Miller, K.W.3
  • 73
    • 84870505178 scopus 로고    scopus 로고
    • Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*
    • COI: 1:CAS:528:DC%2BC38Xhslymt7%2FF, PID: 23283232
    • Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, et al. Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*. Biophys J. 2012;103:2331–40. DOI: 10.1016/j.bpj.2012.10.034
    • (2012) Biophys J. , vol.103 , pp. 2331-2340
    • Shanmugasundararaj, S.1    Das, J.2    Sandberg, W.S.3    Zhou, X.4    Wang, D.5    Messing, R.O.6
  • 74
    • 0031027845 scopus 로고    scopus 로고
    • Halothane, isoflurane, and sevoflurane reduce postischemic adhesion of neutrophils in the coronary system
    • COI: 1:CAS:528:DyaK2sXosl2ktA%3D%3D, PID: 9009954
    • Kowalski C, Zahler S, Becker BF, Flaucher A, Conzen PF, Gerlach E, et al. Halothane, isoflurane, and sevoflurane reduce postischemic adhesion of neutrophils in the coronary system. Anesthesiology. 1997;86:188–95. DOI: 10.1097/00000542-199701000-00023
    • (1997) Anesthesiology. , vol.86 , pp. 188-195
    • Kowalski, C.1    Zahler, S.2    Becker, B.F.3    Flaucher, A.4    Conzen, P.F.5    Gerlach, E.6
  • 75
    • 0344731418 scopus 로고    scopus 로고
    • Inhibition of neutrophil activation by volatile anesthetics decreases adhesion to cultured human endothelial cells
    • PID: 10319786
    • Möbert J, Zahler S, Becker BF, Conzen PF. Inhibition of neutrophil activation by volatile anesthetics decreases adhesion to cultured human endothelial cells. Anesthesiology. 1999;90:1372–81. DOI: 10.1097/00000542-199905000-00022
    • (1999) Anesthesiology. , vol.90 , pp. 1372-1381
    • Möbert, J.1    Zahler, S.2    Becker, B.F.3    Conzen, P.F.4
  • 76
    • 84868299990 scopus 로고    scopus 로고
    • Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1
    • COI: 1:CAS:528:DC%2BC38Xhs1CjurfJ, PID: 22815384
    • Yuki K, Bu W, Xi J, Sen M, Shimaoka M, Eckenhoff RG. Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J. 2012;26:4408–17. DOI: 10.1096/fj.12-212746
    • (2012) FASEB J. , vol.26 , pp. 4408-4417
    • Yuki, K.1    Bu, W.2    Xi, J.3    Sen, M.4    Shimaoka, M.5    Eckenhoff, R.G.6
  • 77
    • 77956991873 scopus 로고    scopus 로고
    • Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1
    • COI: 1:CAS:528:DC%2BC3cXhtVKjurfP, PID: 20693879
    • Yuki K, Astrof NS, Bracken C, Soriano SG, Shimaoka M. Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010;113:600–9.
    • (2010) Anesthesiology , vol.113 , pp. 600-609
    • Yuki, K.1    Astrof, N.S.2    Bracken, C.3    Soriano, S.G.4    Shimaoka, M.5
  • 78
    • 79953220429 scopus 로고    scopus 로고
    • Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function
    • COI: 1:CAS:528:DC%2BC3MXjslKrsbc%3D, PID: 21385989
    • Yuki K, Soriano SG, Shimaoka M. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011;112:830–8. DOI: 10.1213/ANE.0b013e31820dcabb
    • (2011) Anesth Analg , vol.112 , pp. 830-838
    • Yuki, K.1    Soriano, S.G.2    Shimaoka, M.3
  • 79
    • 57349176497 scopus 로고    scopus 로고
    • The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity
    • COI: 1:CAS:528:DC%2BD1cXhsVKgu77N, PID: 18708587
    • Yuki K, Astrof NS, Bracken C, Yoo R, Silkworth W, Soriano SG, et al. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008;22:4109–16. DOI: 10.1096/fj.08-113324
    • (2008) FASEB J. , vol.22 , pp. 4109-4116
    • Yuki, K.1    Astrof, N.S.2    Bracken, C.3    Yoo, R.4    Silkworth, W.5    Soriano, S.G.6
  • 80
    • 68849109971 scopus 로고    scopus 로고
    • Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems
    • COI: 1:CAS:528:DC%2BD1MXpvFOltbw%3D, PID: 19332643
    • Zhang H, Astrof NS, Liu J-H, Wang J, Shimaoka M. Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB J. 2009;23:2735–40. DOI: 10.1096/fj.09-129908
    • (2009) FASEB J. , vol.23 , pp. 2735-2740
    • Zhang, H.1    Astrof, N.S.2    Liu, J.-H.3    Wang, J.4    Shimaoka, M.5
  • 81
    • 84885021866 scopus 로고    scopus 로고
    • Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1
    • COI: 1:CAS:528:DC%2BC3sXhsFSms7fF, PID: 23960033
    • Yuki K, Bu W, Xi J, Shimaoka M, Eckenhoff R. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesth Analg. 2013;117:803–11. DOI: 10.1213/ANE.0b013e3182a00ae0
    • (2013) Anesth Analg. , vol.117 , pp. 803-811
    • Yuki, K.1    Bu, W.2    Xi, J.3    Shimaoka, M.4    Eckenhoff, R.5
  • 82
    • 84875757380 scopus 로고    scopus 로고
    • Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3
    • COI: 1:CAS:528:DC%2BC3sXmtFWqsL4%3D, PID: 23573252
    • Yuki K, Bu W, Shimaoka M, Eckenhoff R. Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. PLoS One. 2013;8:e60415. DOI: 10.1371/journal.pone.0060415
    • (2013) PLoS One. , vol.8
    • Yuki, K.1    Bu, W.2    Shimaoka, M.3    Eckenhoff, R.4
  • 84
    • 37549068910 scopus 로고    scopus 로고
    • Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of γ-aminobutyric acid type A receptors
    • COI: 1:CAS:528:DC%2BD2sXhsVGgtb%2FP, PID: 18156888
    • Zhong H, Rüsch D, Forman SA. Photo-activated azi-etomidate, a general anesthetic photolabel, irreversibly enhances gating and desensitization of γ-aminobutyric acid type A receptors. Anesthesiology. 2008;108:103–12. DOI: 10.1097/01.anes.0000296074.33999.52
    • (2008) Anesthesiology. , vol.108 , pp. 103-112
    • Zhong, H.1    Rüsch, D.2    Forman, S.A.3
  • 85
    • 20744432156 scopus 로고    scopus 로고
    • R (+) Etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265 M point mutation in the gamma-aminobutyric acid receptor β3 subunit
    • COI: 1:CAS:528:DC%2BD2MXlsVertL4%3D, PID: 15976219
    • Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, et al. R (+) Etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265 M point mutation in the gamma-aminobutyric acid receptor β3 subunit. Anesth Analg. 2005;101:131–5. DOI: 10.1213/01.ANE.0000153011.64764.6F
    • (2005) Anesth Analg. , vol.101 , pp. 131-135
    • Liao, M.1    Sonner, J.M.2    Husain, S.S.3    Miller, K.W.4    Jurd, R.5    Rudolph, U.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.