Neurosteroids allosterically modulate binding of the anesthetic etomidate to γ-aminobutyric acid type A receptors

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 11771-11775

  Li, Guo Dong ^a   Chiara, David C ^b   Cohen, Jonathan B ^b   Olsen, Richard W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOBUTYRIC ACIDS; DIRECT ACTIVATION; HOMOLOGY MODELS; LIGAND-BINDING SITES; MICROSEQUENCING; MUTATIONAL ANALYSIS; NEUROSTEROIDS; NICOTINIC ACETYLCHOLINE RECEPTORS; PENTAMER; PHOTOLABELING; SDS-PAGE; SUBUNIT INTERFACES; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; AMINATION; AMINES; AMINO ACIDS; ANESTHETICS; BINDING ENERGY; DIFFUSERS (OPTICAL); LABELING; LIPIDS; ORGANIC ACIDS;

BINDING SITES;

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; AMINO ACID DERIVATIVE; ANESTHETIC AGENT; ETOMIDATE; NEUROSTEROID; NICOTINIC RECEPTOR; TETRAHYDRODEOXYCORTICOSTERONE; INTRAVENOUS ANESTHETIC AGENT; PROTEIN SUBUNIT; STEROID;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CONTROLLED STUDY; CROSS LINKING; DRUG BINDING SITE; DRUG RECEPTOR BINDING; LIGAND BINDING; MUTATIONAL ANALYSIS; NEUROMODULATION; NONHUMAN; PHOTOAFFINITY LABELING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; ALLOSTERISM; ANIMAL; BINDING SITE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; METHODOLOGY; PEPTIDE MAPPING; PHYSIOLOGY; PROTEIN BINDING; STRUCTURAL HOMOLOGY;

ALLOSTERIC REGULATION; ANESTHETICS, INTRAVENOUS; ANIMALS; BINDING SITES; CATTLE; ETOMIDATE; MODELS, MOLECULAR; PEPTIDE MAPPING; PHOTOAFFINITY LABELS; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, GABA-A; STEROIDS; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 66449123447     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C900016200     Document Type: Article

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