-
1
-
-
33645302360
-
Recent advances in Cysloop receptor structure and function
-
Sine, S. M., and Engel, A. G. (2006) Recent advances in Cysloop receptor structure and function, Nature 440, 448-455.
-
(2006)
Nature
, vol.440
, pp. 448-455
-
-
Sine, S.M.1
Engel, A.G.2
-
2
-
-
0036480194
-
Emerging structure of the nicotinic acetylcholine receptors
-
Karlin, A. (2002) Emerging structure of the nicotinic acetylcholine receptors, Nat. Rev. Neurosci. 3, 102-114.
-
(2002)
Nat. Rev. Neurosci
, vol.3
, pp. 102-114
-
-
Karlin, A.1
-
3
-
-
13444271681
-
Refined structure of the nicotinic acetylcholine receptor at 4Å resolution
-
Unwin, N. (2005) Refined structure of the nicotinic acetylcholine receptor at 4Å resolution, J . Mol. Biol. 346, 967-989.
-
(2005)
J . Mol. Biol
, vol.346
, pp. 967-989
-
-
Unwin, N.1
-
4
-
-
0035902009
-
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
-
Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., van Der Oost, J., Smit, A. B., and Sixma, T. K. (2001) Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors, Nature 411, 269-276.
-
(2001)
Nature
, vol.411
, pp. 269-276
-
-
Brejc, K.1
van Dijk, W.J.2
Klaassen, R.V.3
Schuurmans, M.4
van Der Oost, J.5
Smit, A.B.6
Sixma, T.K.7
-
5
-
-
33750530190
-
Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor
-
Elenes, S., Ni, Y., Cymes, G. D., and Grosman, C. (2006) Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor, J. Gen. Physiol. 128, 615-627.
-
(2006)
J. Gen. Physiol
, vol.128
, pp. 615-627
-
-
Elenes, S.1
Ni, Y.2
Cymes, G.D.3
Grosman, C.4
-
6
-
-
20744449198
-
Desensitization of nicotinic ACh receptors: Shaping cholinergic signaling
-
Giniatullin, R., Nistri, A., and Yakel, J. L. (2005) Desensitization of nicotinic ACh receptors: shaping cholinergic signaling, Trends Neurosci. 28, 371-378.
-
(2005)
Trends Neurosci
, vol.28
, pp. 371-378
-
-
Giniatullin, R.1
Nistri, A.2
Yakel, J.L.3
-
8
-
-
33847351996
-
Schizophrenia and the alpha7 Nicotinic Acetylcholine Receptor
-
Martin, L. F., and Freedman, R. (2007) Schizophrenia and the alpha7 Nicotinic Acetylcholine Receptor, Int. Rev. Neurobiol. 78, 225-246.
-
(2007)
Int. Rev. Neurobiol
, vol.78
, pp. 225-246
-
-
Martin, L.F.1
Freedman, R.2
-
9
-
-
0036891571
-
Desensitization of neuronal nicotinic receptors
-
Quick, M. W., and Lester, R. A. (2002) Desensitization of neuronal nicotinic receptors, J. Neurobiol. 53, 457-478.
-
(2002)
J. Neurobiol
, vol.53
, pp. 457-478
-
-
Quick, M.W.1
Lester, R.A.2
-
10
-
-
0033606987
-
Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic
-
Husain, S. S., Forman, S. A., Kloczewiak, M. A., Addona, G. H., Olsen, R. W., Pratt, M. B., Cohen, J. B., and Miller, K. W. (1999) Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic, J. Med. Chem. 42, 3300-3307.
-
(1999)
J. Med. Chem
, vol.42
, pp. 3300-3307
-
-
Husain, S.S.1
Forman, S.A.2
Kloczewiak, M.A.3
Addona, G.H.4
Olsen, R.W.5
Pratt, M.B.6
Cohen, J.B.7
Miller, K.W.8
-
11
-
-
0034703007
-
Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic
-
Pratt, M. B., Husain, S. S., Miller, K. W., and Cohen, J. B. (2000) Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic, J. Biol. Chem. 275, 29441-29451.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 29441-29451
-
-
Pratt, M.B.1
Husain, S.S.2
Miller, K.W.3
Cohen, J.B.4
-
12
-
-
0028848223
-
A discrete site for general anesthetics on a postsynaptic receptor
-
Forman, S. A., Miller, K. W., and Yellen, G. (1995) A discrete site for general anesthetics on a postsynaptic receptor, Mol. Pharmacol. 48, 574-581.
-
(1995)
Mol. Pharmacol
, vol.48
, pp. 574-581
-
-
Forman, S.A.1
Miller, K.W.2
Yellen, G.3
-
13
-
-
0028080354
-
Evidence for direct actions of general anesthetics on an ion channel protein. A new look at a unified mechanism of action
-
Dilger, J. P., Vidal, A. M., Mody, H. I., and Liu, Y. (1994) Evidence for direct actions of general anesthetics on an ion channel protein. A new look at a unified mechanism of action, Anesthesiology 81, 431-442.
-
(1994)
Anesthesiology
, vol.81
, pp. 431-442
-
-
Dilger, J.P.1
Vidal, A.M.2
Mody, H.I.3
Liu, Y.4
-
14
-
-
0034610350
-
The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch
-
Zhou, Q. L., Zhou, Q., and Forman, S. A. (2000) The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch. Biochemistry 39, 14920-14926.
-
(2000)
Biochemistry
, vol.39
, pp. 14920-14926
-
-
Zhou, Q.L.1
Zhou, Q.2
Forman, S.A.3
-
15
-
-
0030933010
-
Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore
-
Forman, S. A. (1997) Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore, Biophys. J. 72, 2170-2179.
-
(1997)
Biophys. J
, vol.72
, pp. 2170-2179
-
-
Forman, S.A.1
-
16
-
-
0028030777
-
Does general anesthetic-induced desensitization of the Torpedo acetylcholine receptor correlate with lipid disordering?
-
Firestone, L. L., Alifimoff, J. K., and Miller, K. W. (1994) Does general anesthetic-induced desensitization of the Torpedo acetylcholine receptor correlate with lipid disordering?, Mol. Pharmacol. 46, 508-515.
-
(1994)
Mol. Pharmacol
, vol.46
, pp. 508-515
-
-
Firestone, L.L.1
Alifimoff, J.K.2
Miller, K.W.3
-
17
-
-
0023748825
-
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
-
Imoto, K., Busch, C., Sakmann, B., Mishina, M., Konno, T., Nakai, J., Bujo, H., Mori, Y., Fukuda, K., and Numa, S. (1988) Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance, Nature 335, 645-648.
-
(1988)
Nature
, vol.335
, pp. 645-648
-
-
Imoto, K.1
Busch, C.2
Sakmann, B.3
Mishina, M.4
Konno, T.5
Nakai, J.6
Bujo, H.7
Mori, Y.8
Fukuda, K.9
Numa, S.10
-
18
-
-
0033811476
-
The extracellular linker of muscle acetylcholine receptor channels is a gating control element
-
Grosman, C., Salamone, F. N., Sine, S. M., and Auerbach, A. (2000) The extracellular linker of muscle acetylcholine receptor channels is a gating control element, J. Gen. Physiol. 116, 327-340.
-
(2000)
J. Gen. Physiol
, vol.116
, pp. 327-340
-
-
Grosman, C.1
Salamone, F.N.2
Sine, S.M.3
Auerbach, A.4
-
19
-
-
0037448581
-
Coupling of agonist binding to channel gating in the GABA(A) receptor
-
Kash, T. L., Jenkins, A., Kelley, J. C., Trudell, J. R., and Harrison, N. L. (2003) Coupling of agonist binding to channel gating in the GABA(A) receptor, Nature 421, 272-275.
-
(2003)
Nature
, vol.421
, pp. 272-275
-
-
Kash, T.L.1
Jenkins, A.2
Kelley, J.C.3
Trudell, J.R.4
Harrison, N.L.5
-
20
-
-
0033517736
-
A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step
-
Forman, S. A. (1999) A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step, Biochemistry 38, 14559-14564.
-
(1999)
Biochemistry
, vol.38
, pp. 14559-14564
-
-
Forman, S.A.1
-
21
-
-
0036813523
-
Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors
-
Scheller, M., and Forman, S. A. (2002) Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors, J. Neurosci. 22, 8411-8421.
-
(2002)
J. Neurosci
, vol.22
, pp. 8411-8421
-
-
Scheller, M.1
Forman, S.A.2
-
22
-
-
0027319773
-
Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP
-
Brown, R. L., Gerber, W. V., and Karpen, J. W. (1993) Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP, Proc. Natl. Acad. Sci. U.S.A. 90, 5369-5373.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A
, vol.90
, pp. 5369-5373
-
-
Brown, R.L.1
Gerber, W.V.2
Karpen, J.W.3
-
23
-
-
0035830399
-
Probing the interactions between cAMP and cGMP in cyclic nucleotide-gated channels using covalently tethered ligands
-
He, Y., and Karpen, J. W. (2001) Probing the interactions between cAMP and cGMP in cyclic nucleotide-gated channels using covalently tethered ligands, Biochemistry 40, 286-295.
-
(2001)
Biochemistry
, vol.40
, pp. 286-295
-
-
He, Y.1
Karpen, J.W.2
-
24
-
-
31044451076
-
Probing the reorganization of the nicotinic acetylcholine receptor during desensitization by time-resolved covalent labeling using [3H]AC5, a photoactivatable agonist
-
Mourot, A., Rodrigo, J., Kotzyba-Hibert, F., Bertrand, S., Bertrand, D., and Goeldner, M. (2006) Probing the reorganization of the nicotinic acetylcholine receptor during desensitization by time-resolved covalent labeling using [3H]AC5, a photoactivatable agonist, Mol. Pharmacol. 69, 452-461.
-
(2006)
Mol. Pharmacol
, vol.69
, pp. 452-461
-
-
Mourot, A.1
Rodrigo, J.2
Kotzyba-Hibert, F.3
Bertrand, S.4
Bertrand, D.5
Goeldner, M.6
-
25
-
-
33845947442
-
Photo-induced covalent attachment of agonists as a tool to study allosteric mechanisms of nicotinic acetylcholine receptors
-
Mourot, A., Kotzyba-Hibert, F., Goeldner, M., and Bamberg, E. (2006) Photo-induced covalent attachment of agonists as a tool to study allosteric mechanisms of nicotinic acetylcholine receptors, J. Mol. Neurosci. 30, 3-4.
-
(2006)
J. Mol. Neurosci
, vol.30
, pp. 3-4
-
-
Mourot, A.1
Kotzyba-Hibert, F.2
Goeldner, M.3
Bamberg, E.4
-
26
-
-
2342429687
-
Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic
-
Ziebell, M. R., Nirthanan, S., Husain, S. S., Miller, K. W., and Cohen, J. B. (2004) Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic, J. Biol. Chem. 279, 17640-17649.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 17640-17649
-
-
Ziebell, M.R.1
Nirthanan, S.2
Husain, S.S.3
Miller, K.W.4
Cohen, J.B.5
-
27
-
-
0034925442
-
The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors
-
Spitzmaul, G., Dilger, J. P., and Bouzat, C. (2001) The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors, Mol. Pharmacol. 60, 235-243.
-
(2001)
Mol. Pharmacol
, vol.60
, pp. 235-243
-
-
Spitzmaul, G.1
Dilger, J.P.2
Bouzat, C.3
-
28
-
-
33144482573
-
Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors
-
Arias, H. R., Bhumireddy, P., Spitzmaul, G., Trudell, J. R., and Bouzat, C. (2006) Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors, Biochemistry 45, 2014-2026.
-
(2006)
Biochemistry
, vol.45
, pp. 2014-2026
-
-
Arias, H.R.1
Bhumireddy, P.2
Spitzmaul, G.3
Trudell, J.R.4
Bouzat, C.5
-
29
-
-
0031870973
-
Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
-
Auerbach, A., and Akk, G. (1998) Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism, J. Gen. Physiol. 112, 181-197.
-
(1998)
J. Gen. Physiol
, vol.112
, pp. 181-197
-
-
Auerbach, A.1
Akk, G.2
-
30
-
-
0034677524
-
Mapping the conformational wave of acetylcholine receptor channel gating
-
Grosman, C., Zhou, M., and Auerbach, A. (2000) Mapping the conformational wave of acetylcholine receptor channel gating, Nature 403, 773-776.
-
(2000)
Nature
, vol.403
, pp. 773-776
-
-
Grosman, C.1
Zhou, M.2
Auerbach, A.3
-
31
-
-
0034740987
-
Mutation of the 9′ leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states
-
Bianchi, M. T., and Macdonald, R. L. (2001) Mutation of the 9′ leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states, Neuropharmacology 41, 737-744.
-
(2001)
Neuropharmacology
, vol.41
, pp. 737-744
-
-
Bianchi, M.T.1
Macdonald, R.L.2
-
32
-
-
0032728861
-
Allosteric activation mechanism of the alpha1beta2gamma2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine
-
Chang, Y., and Weiss, D. S. (1999) Allosteric activation mechanism of the alpha1beta2gamma2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine, Biophys. J. 77, 2542-2551.
-
(1999)
Biophys. J
, vol.77
, pp. 2542-2551
-
-
Chang, Y.1
Weiss, D.S.2
-
33
-
-
33744477329
-
Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities
-
Purohit, Y., and Grosman, C. (2006) Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities, J. Gen. Physiol. 127, 703-717.
-
(2006)
J. Gen. Physiol
, vol.127
, pp. 703-717
-
-
Purohit, Y.1
Grosman, C.2
|