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Volumn 46, Issue 42, 2007, Pages 11911-11918

Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at αE262

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL BLOCK; DESENSITIZATION; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); PHOTOLABELING;

EID: 35448958166     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701287a     Document Type: Article
Times cited : (16)

References (33)
  • 1
    • 33645302360 scopus 로고    scopus 로고
    • Recent advances in Cysloop receptor structure and function
    • Sine, S. M., and Engel, A. G. (2006) Recent advances in Cysloop receptor structure and function, Nature 440, 448-455.
    • (2006) Nature , vol.440 , pp. 448-455
    • Sine, S.M.1    Engel, A.G.2
  • 2
    • 0036480194 scopus 로고    scopus 로고
    • Emerging structure of the nicotinic acetylcholine receptors
    • Karlin, A. (2002) Emerging structure of the nicotinic acetylcholine receptors, Nat. Rev. Neurosci. 3, 102-114.
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 102-114
    • Karlin, A.1
  • 3
    • 13444271681 scopus 로고    scopus 로고
    • Refined structure of the nicotinic acetylcholine receptor at 4Å resolution
    • Unwin, N. (2005) Refined structure of the nicotinic acetylcholine receptor at 4Å resolution, J . Mol. Biol. 346, 967-989.
    • (2005) J . Mol. Biol , vol.346 , pp. 967-989
    • Unwin, N.1
  • 4
    • 0035902009 scopus 로고    scopus 로고
    • Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
    • Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., van Der Oost, J., Smit, A. B., and Sixma, T. K. (2001) Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors, Nature 411, 269-276.
    • (2001) Nature , vol.411 , pp. 269-276
    • Brejc, K.1    van Dijk, W.J.2    Klaassen, R.V.3    Schuurmans, M.4    van Der Oost, J.5    Smit, A.B.6    Sixma, T.K.7
  • 5
    • 33750530190 scopus 로고    scopus 로고
    • Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor
    • Elenes, S., Ni, Y., Cymes, G. D., and Grosman, C. (2006) Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor, J. Gen. Physiol. 128, 615-627.
    • (2006) J. Gen. Physiol , vol.128 , pp. 615-627
    • Elenes, S.1    Ni, Y.2    Cymes, G.D.3    Grosman, C.4
  • 6
    • 20744449198 scopus 로고    scopus 로고
    • Desensitization of nicotinic ACh receptors: Shaping cholinergic signaling
    • Giniatullin, R., Nistri, A., and Yakel, J. L. (2005) Desensitization of nicotinic ACh receptors: shaping cholinergic signaling, Trends Neurosci. 28, 371-378.
    • (2005) Trends Neurosci , vol.28 , pp. 371-378
    • Giniatullin, R.1    Nistri, A.2    Yakel, J.L.3
  • 8
    • 33847351996 scopus 로고    scopus 로고
    • Schizophrenia and the alpha7 Nicotinic Acetylcholine Receptor
    • Martin, L. F., and Freedman, R. (2007) Schizophrenia and the alpha7 Nicotinic Acetylcholine Receptor, Int. Rev. Neurobiol. 78, 225-246.
    • (2007) Int. Rev. Neurobiol , vol.78 , pp. 225-246
    • Martin, L.F.1    Freedman, R.2
  • 9
    • 0036891571 scopus 로고    scopus 로고
    • Desensitization of neuronal nicotinic receptors
    • Quick, M. W., and Lester, R. A. (2002) Desensitization of neuronal nicotinic receptors, J. Neurobiol. 53, 457-478.
    • (2002) J. Neurobiol , vol.53 , pp. 457-478
    • Quick, M.W.1    Lester, R.A.2
  • 11
    • 0034703007 scopus 로고    scopus 로고
    • Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic
    • Pratt, M. B., Husain, S. S., Miller, K. W., and Cohen, J. B. (2000) Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic, J. Biol. Chem. 275, 29441-29451.
    • (2000) J. Biol. Chem , vol.275 , pp. 29441-29451
    • Pratt, M.B.1    Husain, S.S.2    Miller, K.W.3    Cohen, J.B.4
  • 12
    • 0028848223 scopus 로고
    • A discrete site for general anesthetics on a postsynaptic receptor
    • Forman, S. A., Miller, K. W., and Yellen, G. (1995) A discrete site for general anesthetics on a postsynaptic receptor, Mol. Pharmacol. 48, 574-581.
    • (1995) Mol. Pharmacol , vol.48 , pp. 574-581
    • Forman, S.A.1    Miller, K.W.2    Yellen, G.3
  • 13
    • 0028080354 scopus 로고
    • Evidence for direct actions of general anesthetics on an ion channel protein. A new look at a unified mechanism of action
    • Dilger, J. P., Vidal, A. M., Mody, H. I., and Liu, Y. (1994) Evidence for direct actions of general anesthetics on an ion channel protein. A new look at a unified mechanism of action, Anesthesiology 81, 431-442.
    • (1994) Anesthesiology , vol.81 , pp. 431-442
    • Dilger, J.P.1    Vidal, A.M.2    Mody, H.I.3    Liu, Y.4
  • 14
    • 0034610350 scopus 로고    scopus 로고
    • The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch
    • Zhou, Q. L., Zhou, Q., and Forman, S. A. (2000) The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch. Biochemistry 39, 14920-14926.
    • (2000) Biochemistry , vol.39 , pp. 14920-14926
    • Zhou, Q.L.1    Zhou, Q.2    Forman, S.A.3
  • 15
    • 0030933010 scopus 로고    scopus 로고
    • Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore
    • Forman, S. A. (1997) Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore, Biophys. J. 72, 2170-2179.
    • (1997) Biophys. J , vol.72 , pp. 2170-2179
    • Forman, S.A.1
  • 16
    • 0028030777 scopus 로고
    • Does general anesthetic-induced desensitization of the Torpedo acetylcholine receptor correlate with lipid disordering?
    • Firestone, L. L., Alifimoff, J. K., and Miller, K. W. (1994) Does general anesthetic-induced desensitization of the Torpedo acetylcholine receptor correlate with lipid disordering?, Mol. Pharmacol. 46, 508-515.
    • (1994) Mol. Pharmacol , vol.46 , pp. 508-515
    • Firestone, L.L.1    Alifimoff, J.K.2    Miller, K.W.3
  • 18
    • 0033811476 scopus 로고    scopus 로고
    • The extracellular linker of muscle acetylcholine receptor channels is a gating control element
    • Grosman, C., Salamone, F. N., Sine, S. M., and Auerbach, A. (2000) The extracellular linker of muscle acetylcholine receptor channels is a gating control element, J. Gen. Physiol. 116, 327-340.
    • (2000) J. Gen. Physiol , vol.116 , pp. 327-340
    • Grosman, C.1    Salamone, F.N.2    Sine, S.M.3    Auerbach, A.4
  • 19
    • 0037448581 scopus 로고    scopus 로고
    • Coupling of agonist binding to channel gating in the GABA(A) receptor
    • Kash, T. L., Jenkins, A., Kelley, J. C., Trudell, J. R., and Harrison, N. L. (2003) Coupling of agonist binding to channel gating in the GABA(A) receptor, Nature 421, 272-275.
    • (2003) Nature , vol.421 , pp. 272-275
    • Kash, T.L.1    Jenkins, A.2    Kelley, J.C.3    Trudell, J.R.4    Harrison, N.L.5
  • 20
    • 0033517736 scopus 로고    scopus 로고
    • A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step
    • Forman, S. A. (1999) A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step, Biochemistry 38, 14559-14564.
    • (1999) Biochemistry , vol.38 , pp. 14559-14564
    • Forman, S.A.1
  • 21
    • 0036813523 scopus 로고    scopus 로고
    • Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors
    • Scheller, M., and Forman, S. A. (2002) Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors, J. Neurosci. 22, 8411-8421.
    • (2002) J. Neurosci , vol.22 , pp. 8411-8421
    • Scheller, M.1    Forman, S.A.2
  • 22
    • 0027319773 scopus 로고
    • Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP
    • Brown, R. L., Gerber, W. V., and Karpen, J. W. (1993) Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP, Proc. Natl. Acad. Sci. U.S.A. 90, 5369-5373.
    • (1993) Proc. Natl. Acad. Sci. U.S.A , vol.90 , pp. 5369-5373
    • Brown, R.L.1    Gerber, W.V.2    Karpen, J.W.3
  • 23
    • 0035830399 scopus 로고    scopus 로고
    • Probing the interactions between cAMP and cGMP in cyclic nucleotide-gated channels using covalently tethered ligands
    • He, Y., and Karpen, J. W. (2001) Probing the interactions between cAMP and cGMP in cyclic nucleotide-gated channels using covalently tethered ligands, Biochemistry 40, 286-295.
    • (2001) Biochemistry , vol.40 , pp. 286-295
    • He, Y.1    Karpen, J.W.2
  • 24
    • 31044451076 scopus 로고    scopus 로고
    • Probing the reorganization of the nicotinic acetylcholine receptor during desensitization by time-resolved covalent labeling using [3H]AC5, a photoactivatable agonist
    • Mourot, A., Rodrigo, J., Kotzyba-Hibert, F., Bertrand, S., Bertrand, D., and Goeldner, M. (2006) Probing the reorganization of the nicotinic acetylcholine receptor during desensitization by time-resolved covalent labeling using [3H]AC5, a photoactivatable agonist, Mol. Pharmacol. 69, 452-461.
    • (2006) Mol. Pharmacol , vol.69 , pp. 452-461
    • Mourot, A.1    Rodrigo, J.2    Kotzyba-Hibert, F.3    Bertrand, S.4    Bertrand, D.5    Goeldner, M.6
  • 25
    • 33845947442 scopus 로고    scopus 로고
    • Photo-induced covalent attachment of agonists as a tool to study allosteric mechanisms of nicotinic acetylcholine receptors
    • Mourot, A., Kotzyba-Hibert, F., Goeldner, M., and Bamberg, E. (2006) Photo-induced covalent attachment of agonists as a tool to study allosteric mechanisms of nicotinic acetylcholine receptors, J. Mol. Neurosci. 30, 3-4.
    • (2006) J. Mol. Neurosci , vol.30 , pp. 3-4
    • Mourot, A.1    Kotzyba-Hibert, F.2    Goeldner, M.3    Bamberg, E.4
  • 26
    • 2342429687 scopus 로고    scopus 로고
    • Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic
    • Ziebell, M. R., Nirthanan, S., Husain, S. S., Miller, K. W., and Cohen, J. B. (2004) Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic, J. Biol. Chem. 279, 17640-17649.
    • (2004) J. Biol. Chem , vol.279 , pp. 17640-17649
    • Ziebell, M.R.1    Nirthanan, S.2    Husain, S.S.3    Miller, K.W.4    Cohen, J.B.5
  • 27
    • 0034925442 scopus 로고    scopus 로고
    • The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors
    • Spitzmaul, G., Dilger, J. P., and Bouzat, C. (2001) The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors, Mol. Pharmacol. 60, 235-243.
    • (2001) Mol. Pharmacol , vol.60 , pp. 235-243
    • Spitzmaul, G.1    Dilger, J.P.2    Bouzat, C.3
  • 28
    • 33144482573 scopus 로고    scopus 로고
    • Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors
    • Arias, H. R., Bhumireddy, P., Spitzmaul, G., Trudell, J. R., and Bouzat, C. (2006) Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors, Biochemistry 45, 2014-2026.
    • (2006) Biochemistry , vol.45 , pp. 2014-2026
    • Arias, H.R.1    Bhumireddy, P.2    Spitzmaul, G.3    Trudell, J.R.4    Bouzat, C.5
  • 29
    • 0031870973 scopus 로고    scopus 로고
    • Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
    • Auerbach, A., and Akk, G. (1998) Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism, J. Gen. Physiol. 112, 181-197.
    • (1998) J. Gen. Physiol , vol.112 , pp. 181-197
    • Auerbach, A.1    Akk, G.2
  • 30
    • 0034677524 scopus 로고    scopus 로고
    • Mapping the conformational wave of acetylcholine receptor channel gating
    • Grosman, C., Zhou, M., and Auerbach, A. (2000) Mapping the conformational wave of acetylcholine receptor channel gating, Nature 403, 773-776.
    • (2000) Nature , vol.403 , pp. 773-776
    • Grosman, C.1    Zhou, M.2    Auerbach, A.3
  • 31
    • 0034740987 scopus 로고    scopus 로고
    • Mutation of the 9′ leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states
    • Bianchi, M. T., and Macdonald, R. L. (2001) Mutation of the 9′ leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states, Neuropharmacology 41, 737-744.
    • (2001) Neuropharmacology , vol.41 , pp. 737-744
    • Bianchi, M.T.1    Macdonald, R.L.2
  • 32
    • 0032728861 scopus 로고    scopus 로고
    • Allosteric activation mechanism of the alpha1beta2gamma2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine
    • Chang, Y., and Weiss, D. S. (1999) Allosteric activation mechanism of the alpha1beta2gamma2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine, Biophys. J. 77, 2542-2551.
    • (1999) Biophys. J , vol.77 , pp. 2542-2551
    • Chang, Y.1    Weiss, D.S.2
  • 33
    • 33744477329 scopus 로고    scopus 로고
    • Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities
    • Purohit, Y., and Grosman, C. (2006) Block of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities, J. Gen. Physiol. 127, 703-717.
    • (2006) J. Gen. Physiol , vol.127 , pp. 703-717
    • Purohit, Y.1    Grosman, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.