Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein Kinase Cδ*

Biophysical Journal

Volumn 103, Issue 11, 2012, Pages 2331-2340

  Shanmugasundararaj, Sivananthaperumal ^a   Das, Joydip ^a   Sandberg, Warren S ^a,b   Zhou, Xiaojuan ^a   Wang, Dan ^c   Messing, Robert O ^c   Bruzik, Karol S ^d   Stehle, Thilo ^a   Miller, Keith W ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CYCLOPROPANE DERIVATIVE; CYCLOPROPYLCARBINOL; CYSTEINE; DRUG DERIVATIVE; ETHER DERIVATIVE; METHANOL; PROTEIN KINASE C DELTA;

ARTICLE; BINDING SITE; CHEMISTRY; HUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE;

ANESTHETICS, GENERAL; BINDING SITES; CYCLOPROPANES; CYSTEINE; ETHERS; HUMANS; METHANOL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE C-DELTA; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870505178     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2012.10.034     Document Type: Article

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