Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel

Journal of Biological Chemistry

Volumn 282, Issue 16, 2007, Pages 12038-12047

  Bright, Damian P ^a   Adham, Sara D ^a   Lemaire, Lucienne C J M ^a,b   Benavides, Rodrigo ^a   Gruss, Marco ^a,c   Taylor, Graham W ^a,d   Smith, Edward H ^a   Franks, Nicholas P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

^d ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; ENANTIOMERS; MASS SPECTROMETRY; MUTAGENESIS; PHARMACOKINETICS; PLASMA (HUMAN); RATS; STEREOSELECTIVITY;

HUMAN SERUM ALBUMIN; PHOTOLABELS; POINT MUTATION; TADPOLES;

ANESTHETICS;

4 AMINOBUTYRIC ACID A RECEPTOR; ETOMIDATE; HUMAN SERUM ALBUMIN; ACYL AZIDE ETOMIDATE; ANESTHETIC AGENT; AZIDE; DRUG DERIVATIVE; SERUM ALBUMIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING SITE; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; EMBRYO; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MASS SPECTROMETER; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; ANIMAL; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; FROG; MALE; PROTEIN BINDING; RAT; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

RATTUS;

ANESTHETICS; ANIMALS; AZIDES; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOMIDATE; HUMANS; MALE; MODELS, CHEMICAL; PROTEIN BINDING; RANA TEMPORARIA; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN; STEREOISOMERISM;

EID: 34249748906     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700479200     Document Type: Article

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