Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cδ

Journal of Biological Chemistry

Volumn 279, Issue 36, 2004, Pages 37964-37972

  Das, Joydip ^a,b   Addona, George H ^a,b,c   Sandberg, Warren S ^a   Husain, S Shaukat ^a   Stehle, Thilo ^a,b   Miller, Keith W ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Praecis Pharmaceuticals Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC ALCOHOLS; PROTEIN KINASE C (PKC);

ALCOHOLS; CHROMATOGRAPHY; ESTERS; MASS SPECTROMETRY; STOICHIOMETRY;

PROTEINS;

3 AZIBUTANOL; 3 AZIOCTANOL; 7 AZIOCTANOL; ALCOHOL; ALCOHOL DERIVATIVE; ANESTHETIC AGENT; AZIRINE DERIVATIVE; BUTANOL; CYSTEINE; DIACYLGLYCEROL; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C DELTA; SAPINTOXIN D; TOXIN; TYROSINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CHROMATOGRAPHY; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME STRUCTURE; FLUORESCENCE; MASS SPECTROMETRY; MOUSE; NONHUMAN; ONLINE ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STOICHIOMETRY;

AMINO ACID SEQUENCE; ANESTHETICS, GENERAL; ANIMALS; BINDING SITES; CIRCULAR DICHROISM; DIGLYCERIDES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TETRADECANOYLPHORBOL ACETATE; TYROSINE;

EID: 4444368781     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405137200     Document Type: Article

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