Allyl m -trifluoromethyldiazirine mephobarbital: An unusually potent enantioselective and photoreactive barbiturate general anesthetic

Journal of Medicinal Chemistry

Volumn 55, Issue 14, 2012, Pages 6554-6565

  Savechenkov, Pavel Y ^c   Zhang, Xi ^a   Chiara, David C ^b   Stewart, Deirdre S ^a   Ge, Rile ^a   Zhou, Xiaojuan ^a   Raines, Douglas E ^a   Cohen, Jonathan B ^b   Forman, Stuart A ^a   Miller, Keith W ^a,b   Bruzik, Karol S ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 5 ALLYL 1 METHYL 5 (3 TRIFLUOROMETHYLDIAZIRYNYLPHENYL)BARBITURIC ACID; BARBITURIC ACID DERIVATIVE; ETOMIDATE; MUSCIMOL; PROPOFOL; THIOPENTAL; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; FEMALE; GENERAL ANESTHESIA; ISOTOPE LABELING; NONHUMAN; OOCYTE; RACEMIC MIXTURE; TADPOLE; X RAY CRYSTALLOGRAPHY; XENOPUS LAEVIS;

ANESTHETICS, GENERAL; AZIRINES; HUMANS; LIGHT; MEPHOBARBITAL; RECEPTORS, GABA-A; SOLUBILITY; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84864191258     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300631e     Document Type: Article

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