메뉴 건너뛰기




Volumn 10, Issue 6, 2013, Pages 2176-2182

Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues

Author keywords

drug delivery; mucus penetrating particles; particle tracking

Indexed keywords

MEDROXYPROGESTERONE ACETATE; NANOPARTICLE;

EID: 84878663137     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400087y     Document Type: Article
Times cited : (85)

References (42)
  • 1
    • 84862519335 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus
    • Ensign, L. M. Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus Sci. Transl. Med. 2012, 4 (138) 138ra179
    • (2012) Sci. Transl. Med. , vol.4 , Issue.138
    • Ensign, L.M.1
  • 2
    • 59549095796 scopus 로고    scopus 로고
    • Altering mucus rheology to "solidify" human mucus at the nanoscale
    • Lai, S. K.; Wang, Y. Y.; Cone, R.; Wirtz, D.; Hanes, J. Altering mucus rheology to "solidify" human mucus at the nanoscale PLoS One 2009, 4 (1) e4294
    • (2009) PLoS One , vol.4 , Issue.1 , pp. 4294
    • Lai, S.K.1    Wang, Y.Y.2    Cone, R.3    Wirtz, D.4    Hanes, J.5
  • 3
    • 33751253462 scopus 로고    scopus 로고
    • Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
    • des Rieux, A.; Fievez, V.; Garinot, M.; Schneider, Y. J.; Preat, V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach J. Controlled Release 2006, 116 (1) 1-27
    • (2006) J. Controlled Release , vol.116 , Issue.1 , pp. 1-27
    • Des Rieux, A.1    Fievez, V.2    Garinot, M.3    Schneider, Y.J.4    Preat, V.5
  • 4
    • 73649121308 scopus 로고    scopus 로고
    • Nanoparticle-based vaginal drug delivery systems for HIV prevention
    • Mallipeddi, R.; Rohan, L. C. Nanoparticle-based vaginal drug delivery systems for HIV prevention Expert Opin. Drug Delivery 2010, 7 (1) 37-48
    • (2010) Expert Opin. Drug Delivery , vol.7 , Issue.1 , pp. 37-48
    • Mallipeddi, R.1    Rohan, L.C.2
  • 5
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone, R. A. Barrier properties of mucus Adv. Drug Delivery Rev. 2009, 61 (2) 75-85
    • (2009) Adv. Drug Delivery Rev. , vol.61 , Issue.2 , pp. 75-85
    • Cone, R.A.1
  • 6
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • Lai, S. K.; Wang, Y. Y.; Hanes, J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Adv. Drug Delivery Rev. 2009, 61 (2) 158-171
    • (2009) Adv. Drug Delivery Rev. , vol.61 , Issue.2 , pp. 158-171
    • Lai, S.K.1    Wang, Y.Y.2    Hanes, J.3
  • 7
    • 76249115874 scopus 로고    scopus 로고
    • Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
    • Lai, S. K.; Wang, Y. Y.; Hida, K.; Cone, R.; Hanes, J. Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses Proc. Natl. Acad. Sci. U.S.A. 2010, 107 (2) 598-603
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , Issue.2 , pp. 598-603
    • Lai, S.K.1    Wang, Y.Y.2    Hida, K.3    Cone, R.4    Hanes, J.5
  • 8
    • 33846841057 scopus 로고    scopus 로고
    • Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
    • Lai, S. K. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (5) 1482-1487
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.5 , pp. 1482-1487
    • Lai, S.K.1
  • 9
    • 0346749507 scopus 로고    scopus 로고
    • Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport
    • Dawson, M.; Wirtz, D.; Hanes, J. Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport J. Biol. Chem. 2003, 278 (50) 50393-50401
    • (2003) J. Biol. Chem. , vol.278 , Issue.50 , pp. 50393-50401
    • Dawson, M.1    Wirtz, D.2    Hanes, J.3
  • 10
    • 0029055473 scopus 로고
    • Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
    • Kararli, T. T. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals Biopharm. Drug Dispos. 1995, 16 (5) 351-380
    • (1995) Biopharm. Drug Dispos. , vol.16 , Issue.5 , pp. 351-380
    • Kararli, T.T.1
  • 11
    • 80455155066 scopus 로고    scopus 로고
    • N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles
    • Suk, J. S. N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles Mol. Ther. 2011, 19 (11) 1981-1989
    • (2011) Mol. Ther. , vol.19 , Issue.11 , pp. 1981-1989
    • Suk, J.S.1
  • 12
    • 78649835810 scopus 로고    scopus 로고
    • Barrier properties of gastrointestinal mucus to nanoparticle transport
    • Crater, J. S.; Carrier, R. L. Barrier properties of gastrointestinal mucus to nanoparticle transport Macromol. Biosci. 2010, 10 (12) 1473-1483
    • (2010) Macromol. Biosci. , vol.10 , Issue.12 , pp. 1473-1483
    • Crater, J.S.1    Carrier, R.L.2
  • 13
    • 0034816264 scopus 로고    scopus 로고
    • Diffusion of macromolecules and virus-like particles in human cervical mucus
    • Olmsted, S. S. Diffusion of macromolecules and virus-like particles in human cervical mucus Biophys. J. 2001, 81 (4) 1930-1937
    • (2001) Biophys. J. , vol.81 , Issue.4 , pp. 1930-1937
    • Olmsted, S.S.1
  • 14
    • 84865820981 scopus 로고    scopus 로고
    • A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue
    • Nance, E. A. A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue Sci. Transl. Med. 2012, 4 (149) 149ra119
    • (2012) Sci. Transl. Med. , vol.4 , Issue.149
    • Nance, E.A.1
  • 15
    • 57049085726 scopus 로고    scopus 로고
    • Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier
    • Wang, Y. Y. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier Angew. Chem., Int. Ed. 2008, 47 (50) 9726-9729
    • (2008) Angew. Chem., Int. Ed. , vol.47 , Issue.50 , pp. 9726-9729
    • Wang, Y.Y.1
  • 16
    • 7044269314 scopus 로고    scopus 로고
    • Real-time multiple-particle tracking: Applications to drug and gene delivery
    • Suh, J.; Dawson, M.; Hanes, J. Real-time multiple-particle tracking: applications to drug and gene delivery Adv. Drug Delivery Rev. 2005, 57 (1) 63-78
    • (2005) Adv. Drug Delivery Rev. , vol.57 , Issue.1 , pp. 63-78
    • Suh, J.1    Dawson, M.2    Hanes, J.3
  • 17
    • 84875716054 scopus 로고    scopus 로고
    • Use of Single-Site-Functionalized PEG Dendrons to Prepare Gene Vectors that Penetrate Human Mucus Barriers
    • Kim, A. J. Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers Angew. Chem., Int. Ed. 2013, 52 (14) 3985-3988
    • (2013) Angew. Chem., Int. Ed. , vol.52 , Issue.14 , pp. 3985-3988
    • Kim, A.J.1
  • 18
    • 0014236728 scopus 로고
    • The functional structure of human cervical mucus
    • Odeblad, E. The functional structure of human cervical mucus Acta Obstet. Gynecol. Scand. 1968, 47, 57-79
    • (1968) Acta Obstet. Gynecol. Scand. , vol.47 , pp. 57-79
    • Odeblad, E.1
  • 19
    • 0033407142 scopus 로고    scopus 로고
    • Immune responses and protection against vaginal infection after nasal or vaginal immunization with attenuated herpes simplex virus type-2
    • Parr, E. L.; Parr, M. B. Immune responses and protection against vaginal infection after nasal or vaginal immunization with attenuated herpes simplex virus type-2 Immunology 1999, 98 (4) 639-645
    • (1999) Immunology , vol.98 , Issue.4 , pp. 639-645
    • Parr, E.L.1    Parr, M.B.2
  • 20
    • 0017912924 scopus 로고
    • Functions and physical properties of mucus in the female genital tract
    • Elstein, M. Functions and physical properties of mucus in the female genital tract Br. Med. Bull. 1978, 34 (1) 83-88
    • (1978) Br. Med. Bull. , vol.34 , Issue.1 , pp. 83-88
    • Elstein, M.1
  • 22
    • 84859719708 scopus 로고    scopus 로고
    • Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
    • Ensign, L. M.; Cone, R.; Hanes, J. Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers Adv. Drug Delivery Rev. 2012, 64 (6) 557-570
    • (2012) Adv. Drug Delivery Rev. , vol.64 , Issue.6 , pp. 557-570
    • Ensign, L.M.1    Cone, R.2    Hanes, J.3
  • 23
    • 0028915433 scopus 로고
    • The hydrophobic barrier properties of gastrointestinal mucus
    • Lichtenberger, L. M. The hydrophobic barrier properties of gastrointestinal mucus Annu. Rev. Physiol. 1995, 57, 565-583
    • (1995) Annu. Rev. Physiol. , vol.57 , pp. 565-583
    • Lichtenberger, L.M.1
  • 24
    • 80052543501 scopus 로고    scopus 로고
    • Adsorption of bile salts to particles allows penetration of intestinal mucus
    • Macierzanka, A. Adsorption of bile salts to particles allows penetration of intestinal mucus Soft Matter 2011, 7 (18) 8077-8084
    • (2011) Soft Matter , vol.7 , Issue.18 , pp. 8077-8084
    • MacIerzanka, A.1
  • 25
    • 77952261296 scopus 로고    scopus 로고
    • Characterization of particle translocation through mucin hydrogels
    • Lieleg, O.; Vladescu, I.; Ribbeck, K. Characterization of particle translocation through mucin hydrogels Biophys. J. 2010, 98 (9) 1782-1789
    • (2010) Biophys. J. , vol.98 , Issue.9 , pp. 1782-1789
    • Lieleg, O.1    Vladescu, I.2    Ribbeck, K.3
  • 26
    • 84913428522 scopus 로고
    • The oestrous cycle in the mouse
    • Allen, E. The oestrous cycle in the mouse Am. J. Anat. 1922, 30 (3) 297-371
    • (1922) Am. J. Anat. , vol.30 , Issue.3 , pp. 297-371
    • Allen, E.1
  • 27
    • 0035290171 scopus 로고    scopus 로고
    • Standardization of the Whitten Effect to induce susceptibility to Neisseria gonorrhoeae in female mice
    • Dalal, S. J.; Estep, J. S.; Valentin-Bon, I. E.; Jerse, A. E. Standardization of the Whitten Effect to induce susceptibility to Neisseria gonorrhoeae in female mice Contemp. Top. Lab. Anim. Sci. 2001, 40 (2) 13-17
    • (2001) Contemp. Top. Lab. Anim. Sci. , vol.40 , Issue.2 , pp. 13-17
    • Dalal, S.J.1    Estep, J.S.2    Valentin-Bon, I.E.3    Jerse, A.E.4
  • 28
    • 0031451532 scopus 로고    scopus 로고
    • Tests of vaginal microbicides in the mouse genital herpes model
    • Zeitlin, L.; Whaley, K. J.; Hegarty, T. A.; Moench, T. R.; Cone, R. A. Tests of vaginal microbicides in the mouse genital herpes model Contraception 1997, 56 (5) 329-335
    • (1997) Contraception , vol.56 , Issue.5 , pp. 329-335
    • Zeitlin, L.1    Whaley, K.J.2    Hegarty, T.A.3    Moench, T.R.4    Cone, R.A.5
  • 29
    • 77049268413 scopus 로고
    • Cornification of the Human Vaginal Epithelium
    • Asscher, A. W.; Turner, C. J.; Deboer, C. H. Cornification of the Human Vaginal Epithelium J. Anat. 1956, 90 (4) 547-552-1
    • (1956) J. Anat. , vol.90 , Issue.4 , pp. 547-5521
    • Asscher, A.W.1    Turner, C.J.2    Deboer, C.H.3
  • 30
    • 84862577981 scopus 로고
    • The structure of the human vaginal mucosa in relation to the menstrual cycle and to pregnancy
    • Smith, B. G.; Brunner, E. K. The structure of the human vaginal mucosa in relation to the menstrual cycle and to pregnancy Am. J. Anat. 1934, 54 (1) 27-85
    • (1934) Am. J. Anat. , vol.54 , Issue.1 , pp. 27-85
    • Smith, B.G.1    Brunner, E.K.2
  • 31
    • 78349239340 scopus 로고    scopus 로고
    • Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    • 10.1186/1471-2334-10-331
    • Moench, T. R.; Mumper, R. J.; Hoen, T. E.; Sun, M.; Cone, R. A. Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse BMC Infect. Dis. 2010, 10.1186/1471-2334-10-331
    • (2010) BMC Infect. Dis.
    • Moench, T.R.1    Mumper, R.J.2    Hoen, T.E.3    Sun, M.4    Cone, R.A.5
  • 32
    • 73449131509 scopus 로고    scopus 로고
    • Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: Expansion of a murine model of microbicide safety
    • Wilson, S. S. Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety Antiviral Ther. 2009, 14 (8) 1113-1124
    • (2009) Antiviral Ther. , vol.14 , Issue.8 , pp. 1113-1124
    • Wilson, S.S.1
  • 33
    • 66249083866 scopus 로고    scopus 로고
    • Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
    • Woodrow, K. A. Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA Nat. Mater. 2009, 8 (6) 526-533
    • (2009) Nat. Mater. , vol.8 , Issue.6 , pp. 526-533
    • Woodrow, K.A.1
  • 34
    • 81255127657 scopus 로고    scopus 로고
    • In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery
    • Cu, Y.; Booth, C. J.; Saltzman, W. M. In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery J. Controlled Release 2011, 156 (2) 258-264
    • (2011) J. Controlled Release , vol.156 , Issue.2 , pp. 258-264
    • Cu, Y.1    Booth, C.J.2    Saltzman, W.M.3
  • 35
    • 75749134156 scopus 로고    scopus 로고
    • Effective vaginal DNA delivery with high transfection efficiency is a good system for induction of higher local vaginal immune responses
    • Kanazawa, T. Effective vaginal DNA delivery with high transfection efficiency is a good system for induction of higher local vaginal immune responses J. Pharm. Pharmacol. 2009, 61 (11) 1457-1463
    • (2009) J. Pharm. Pharmacol. , vol.61 , Issue.11 , pp. 1457-1463
    • Kanazawa, T.1
  • 36
    • 62249124687 scopus 로고    scopus 로고
    • Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization
    • Seavey, M. M.; Mosmann, T. R. Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization Vaccine 2009, 27 (17) 2342-2349
    • (2009) Vaccine , vol.27 , Issue.17 , pp. 2342-2349
    • Seavey, M.M.1    Mosmann, T.R.2
  • 37
    • 84868599371 scopus 로고    scopus 로고
    • Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus
    • Kirch, J. Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus Proc. Natl. Acad. Sci. U.S.A. 2012, 109 (45) 18355-18360
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , Issue.45 , pp. 18355-18360
    • Kirch, J.1
  • 38
    • 60149110687 scopus 로고    scopus 로고
    • The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles
    • Suk, J. S. The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles Biomaterials 2009, 30 (13) 2591-2597
    • (2009) Biomaterials , vol.30 , Issue.13 , pp. 2591-2597
    • Suk, J.S.1
  • 39
    • 84874239794 scopus 로고    scopus 로고
    • Nanoparticle diffusion in respiratory mucus from humans without lung disease
    • Schuster, B. S.; Suk, J. S.; Woodworth, G. F.; Hanes, J. Nanoparticle diffusion in respiratory mucus from humans without lung disease Biomaterials 2013, 34 (13) 3439-3446
    • (2013) Biomaterials , vol.34 , Issue.13 , pp. 3439-3446
    • Schuster, B.S.1    Suk, J.S.2    Woodworth, G.F.3    Hanes, J.4
  • 40
    • 79959868168 scopus 로고    scopus 로고
    • Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus
    • Lai, S. K. Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus Biomaterials 2011, 32 (26) 6285-6290
    • (2011) Biomaterials , vol.32 , Issue.26 , pp. 6285-6290
    • Lai, S.K.1
  • 41
    • 84863122682 scopus 로고    scopus 로고
    • Distribution of cell-free and cell-associated HIV surrogates in the female genital tract after simulated vaginal intercourse
    • Louissaint, N. A. Distribution of cell-free and cell-associated HIV surrogates in the female genital tract after simulated vaginal intercourse J. Infect. Dis. 2012, 205 (5) 725-732
    • (2012) J. Infect. Dis. , vol.205 , Issue.5 , pp. 725-732
    • Louissaint, N.A.1
  • 42
    • 83655191970 scopus 로고    scopus 로고
    • Distribution of Cell-Free and Cell-Associated HIV Surrogates in the Colon after Simulated Receptive Anal Intercourse in Men Who Have Sex with Men
    • Louissaint, N. A. Distribution of Cell-Free and Cell-Associated HIV Surrogates in the Colon After Simulated Receptive Anal Intercourse in Men Who Have Sex With Men JAIDS, J. Acquired Immune Defic. Syndr. 2012, 59 (1) 10-17
    • (2012) JAIDS, J. Acquired Immune Defic. Syndr. , vol.59 , Issue.1 , pp. 10-17
    • Louissaint, N.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.