Nasal drug delivery - Evaluation of an in vitro model using porcine nasal mucosa

European Journal of Pharmaceutical Sciences

Volumn 7, Issue 3, 1999, Pages 197-206

  Wadell, Cecilia ^a,b,c   Björk, Erik ^b   Camber, Ola ^c  

^a PFIZER INC   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

^c Astra Arcus AB   (Sweden)

Author keywords

Electrophysiology; Nasal mucosa; Permeability; Pig; Ussing chamber; Viability

Indexed keywords

GLUCOSE; MANNITOL; OUABAIN;

ACTIVE TRANSPORT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; ELECTROPHYSIOLOGY; IN VITRO STUDY; MEMBRANE PERMEABILITY; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL;

ADMINISTRATION, INTRANASAL; ANIMALS; MODELS, BIOLOGICAL; NASAL MUCOSA; SWINE;

EID: 0344141322     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(98)00023-2     Document Type: Article

References (45)

1. Bechgaard E., Gizurarson S., Jørgensen L., Larsen R. The viability of isolated rabbit nasal mucosa in the Ussing chamber, and the permeability of insulin across the membrane. Int. J. Pharm. 87:1992;125-132.
2. Bechgaard E., Jørgensen L., Larsen R., Gizurarson S., Carstensen J., Hvass A. Insulin and didecanoyl-L-alfa-phosphatidylcholine: in vitro study of transport through rabbit nasal mucosal tissue. Int. J. Pharm. 89:1993;147-153.
3. Bjerre C., Björk E., Camber O. Bioavailability of the sedative propiomazine after nasal administration in rats. Int. J. Pharm. 144:1996;217-224.
4. Björk E., Edman P. Degradable starch microspheres as a nasal delivery system for insulin. Int. J. Pharm. 47:1988;233-238.
5. Camber O., Edman P. Factors influencing the corneal permeability of prostaglandin F2alfa and its isopropyl ester in vitro. Int. J. Pharm. 37:1987;27-32.
6. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47:1987;936-942.
7. Corbo D.C., Liu J.-C., Chien Y.W. Characterization of the barrier properties of mucosal membranes. J. Pharm. Sci. 79(3):1990;202-206.
8. Cornaz A.-L., Buri P. Nasal mucosa as an absorption barrier. Eur. J. Pharm. Biopharm. 40:1994;261-270.
9. Cotton C.U., Stutts M.J., Knowles M.R., Gatzy J.T., Boucher R.C. Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. J. Clin. Invest. 79:1987;80-85.
10. Cremaschi D., Rossetti C., Draghetti M.T., Manzoni C., Aliverti V. Active transport of polypeptides in rabbit nasal mucosa: Possible role in the sampling of potential antigens. Pflügers Archiv. 419:1991;425-432.
11. Cremaschi D., Rossetti C., Draghetti M.T., Manzoni C., Porta C., Aliverti V. Transepithelial electrophysiological parameters in rabbit respiratory nasal mucosa isolated in vitro. Comp. Biochem. Physiol. 99A(3):1991;361-364.
12. Denizot F., Lang R. Rapid colorimetric assay for cell growth and survival. J. Immunol. Methods. 89:1986;271-277.
13. Edman P., Björk E. Routes of delivery: case studies. Adv. Drug Del. Rev. 8:1992;165-177.
14. Fujii M., Yamanouchi S., Hori N., Iwanaga N., Kawaguchi N., Matsumoto M. Evaluation of Yucatan Micropig skin for use as an in vitro model for skin permeation study. Biol. Pharm. Bull. 20(3):1997;249-254.
15. Gardner N., Haresign W., Spiller R., Farraj N., Wiseman J., Norbury H., Illum L. Development and validation of a pig model for colon-specific drug delivery. J. Pharm. Pharmacol. 48:1996;689-693.
16. Gizurarson S., Tamura S-i., Kurata T., Hasiguchi K., Ogawa H. The effect of cholera toxin and cholera toxin B subunit on the nasal mucosal membrane. Vaccine. 9:1991;825-832.
17. Hansen M.B., Thorboll J.E., Christensen P., Bindslev N., Skadhauge E. Serotonin-induced short-circuit current in pig jejunum. J. Vet. Med. Assoc. 41(2):1994;110-120.
18. Hare, W.C.D., 1975. General respiratory system. In: Sisson, S., Grossman, J.D. (Eds.), The Anatomy of the Domestic Animals. W. B. Saunders, Philadelphia, London, Toronto, pp 113-144.
19. Harris A.S. Review: Clinical opportunities provided by the nasal administration of peptides. J. Drug Target. 1:1993;101-116.
20. Hemlin M., Jodal M., Lundgren O., Sjövall H., Stage L. The importance of the subepithelial resistance for the electrical properties of the rat jejunum in vitro. Acta Physiol. Scand. 134:1988;79-88.
21. Hoogstraate A.J., Verhoef J.C., Pijpers A.et al. In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs. Pharm. Res. 13(8):1996;1233-1237.
22. Hosoya K., Kubo H., Natsume H., Sugibayashi K., Morimoto Y. Evaluation of enhancers to increase nasal absorption using Ussing chamber technique. Biol Pharm Bull. 17(2):1994;316-322.
23. Hosoya K.-I., Kubo H., Natsume H., Sugibayashi K., Morimoto Y., Yamashita S. The structural barrier of absorptive mucosae: site difference of the permeability of fluoroscein isothiocyanate-labelled dextran in rabbits. Biopharm. Drug Disp. 14:1993;685-696.
24. Illum L., Davis S.S. Intranasal insulin. Clin. Pharmacokinet. 23(1):1992;30-41.
25. Imbert, D., Cullander, C., 1996. Rapid assessment of tissue viability limits by laser scanning confocal microscopy. Pharm Res., 13(9) (1996) S-335.
26. Imbert D., Cullander C. Assessment of cornea viability by confocal laser scanning microscopy and MTT assay. Cornea. 16(6):1997;666-674.
27. Jörgensen L., Bechgaard E. Intranasal permeation of thyrotropin-releasing hormone: in vitro study of permeation and enzymatic degradation. Int. J. Pharm. 107:1994;231-237.
28. Kubo H., Hosoya K.-I., Natsume H., Sugibayashi K., Morimoto Y. In vitro permeation of several model drugs across rabbit nasal mucosa. Int. J. Pharm. 103:1994;27-36.
29. Lang S., Langguth P., Oschmann R., Traving B., Merkle H.P. Transport and metabolic pathway of thymocartin (TP4) in excised bovine nasal mucosa. J. Pharm. Pharmacol. 48:1996;1190-1196.
30. Lee C.-P., de Vrueh R.L.A., Smith P.L. Selection of development candidates based on in vitro permeability measurements. Adv. Drug Del. Rev. 23:1997;47-62.
31. Maitani Y., Uchida N., Nakagaki M., Nagai T. Effect of bile salts on the nasal mucosa: Membrane potential measurement. Int. J. Pharm. 69:1991;21-27.
32. Maitani Y., Ishigaki K., Takayama K., Nagai T. In vitro nasal transport across rabbit mucosa: effect of oxygen bubbling, pH and hypertonic pressure on permeability of lucifer yellow, diazepam and 17 beta-estradiol. Int. J. Pharm. 146:1997;11-19.
33. McMartin C., Hutchinson L.E.F., Hyde R., Peters G.E. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J. Pharm. Sci. 76(7):1987;535-540.
34. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
35. Nair M.K., Chetty D.J., Ho H., Chien Y.W. Biomembrane permeation of nicotine: mechanistic studies with porcine mucosae and skin. J. Pharm. Sci. 86(2):1997;257-262.
36. Petruson B., Hansson H.-A., Karlsson G. Structural and functional aspects of cells in the nasal mucociliary system. Arch. Otolaryngol. 110:1984;576-581.
37. Pond, W.G., Houpt, K.A., 1978. The pig as a model in biomedical research. In: The biology of the pig. Comstock Publishing Associates, Cornell University Press, Ithaca, London, pp 13-64.
38. Reardon P.M., Gochoco C.H., Audus K.L., Wilson G., Smith P.L. In vitro nasal transport across ovine mucosa: effects of ammonium glycyrrhizinate on electrical properties and permeability of growth hormone releasing peptide, mannitol, and lucifer yellow. Pharm. Res. 10:1993;553-561.
39. Reardon P.M., Wall D.A., Hart T.K., Smith P.L., Gochoco C.H. Lack of effect of ammonium glycyrrhizinate on the morphology of ovine nasal mucosa in vitro. Pharm. Res. 10(9):1993;1301-1307.
40. Ungell A.L., Andreasson A., Lundin K., Utter L. Effects of enzymatic inhibition and increased paracellular shunting on transport of vasopressin analogues in the rat. J. Pharm. Sci. 81(7):1992;640-645.
41. Werner U., Kissel T. Development of a human nasal epithelial cell culture model and its suitability for transport and metabolism studies under in vitro conditions. Pharm. Res. 12(4):1995;565-571.
42. Werner U., Kissel T. In vitro cell culture models of the nasal epithelium: a comparative histochemical investigation of their suitability for drug transport studies. Pharm. Res. 13(7):1996;978-988.
43. Wheatley M.A., Dent J., Wheeldon E.B., Smith P.L. Nasal drug delivery: an in vitro characterization of transepithelial electrical properties and fluxes in the presence or absence of enhancers. J. Control. Rel. 8:1988;167-177.
44. Wikman-Larhed A., Artursson P. Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption. Eur. J. Pharm. Sci. 3(1995):1995;171-183.
45. Zia H., Dondeti P., Needham T.E. Intranasal drug delivery. Clin. Res. Reg. Affairs. 10(2):1993;99-135.