메뉴 건너뛰기




Volumn 7, Issue , 2012, Pages 1851-1863

Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: Preparation and in vitro study

Author keywords

Anticancer; Chitosan; Gemcitabine; Ionic gelation; Mucoadhesion; Nanoparticles; Oral drug delivery

Indexed keywords

CHITOSAN; GEMCITABINE; MUCIN; NANOPARTICLE; POLOXAMER; TRIPOLYPHOSPHATE;

EID: 84870360366     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S26365     Document Type: Article
Times cited : (171)

References (52)
  • 1
    • 38849149655 scopus 로고    scopus 로고
    • Nanotechnology-based drug delivery systems
    • Suri S, Fenniri H, Singh B. Nanotechnology-based drug delivery systems. J Occup Med Toxicol. 2007;2(1):16.
    • (2007) J Occup Med Toxicol. , vol.2 , Issue.1 , pp. 16
    • Suri, S.1    Fenniri, H.2    Singh, B.3
  • 2
    • 42049110950 scopus 로고    scopus 로고
    • Application of nanotechnology in cancer therapy and imaging
    • Wang X, Yang L, Chen ZG, Shin DM. Application of nanotechnology in cancer therapy and imaging. CA Cancer J Clin. 2008;58(2): 97-110.
    • (2008) CA Cancer J Clin. , vol.58 , Issue.2 , pp. 97-110
    • Wang, X.1    Yang, L.2    Chen, Z.G.3    Shin, D.M.4
  • 3
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer. 2006;6(8):583-592.
    • (2006) Nat Rev Cancer. , vol.6 , Issue.8 , pp. 583-592
    • Minchinton, A.I.1    Tannock, I.F.2
  • 4
    • 84455180686 scopus 로고    scopus 로고
    • Polyanionic carbohydrate doxorubicin-dextran nanocomplex as a delivery system for anticancer drugs: In vitro analysis and evaluations
    • Yousefpour P, Atyabi F, Vasheghani Farahani E, Sakhtianchi R, Dinarvand R. Polyanionic carbohydrate doxorubicin-dextran nanocomplex as a delivery system for anticancer drugs: in vitro analysis and evaluations. Int J Nanomedicine. 2011;6:1487-1496.
    • (2011) Int J Nanomedicine. , vol.6 , pp. 1487-1496
    • Yousefpour, P.1    Atyabi, F.2    Vasheghani Farahani, E.3    Sakhtianchi, R.4    Dinarvand, R.5
  • 5
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: Opportunities and challenges
    • Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer. 2005;5(3):161-171.
    • (2005) Nat Rev Cancer. , vol.5 , Issue.3 , pp. 161-171
    • Ferrari, M.1
  • 6
    • 33746319850 scopus 로고    scopus 로고
    • Emerging implications of nanotechnology on cancer diagnostics and therapeutics
    • Cuenca AG, Jiang H, Hochwald SN, et al. Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer. 2006;107(3):459-466.
    • (2006) Cancer. , vol.107 , Issue.3 , pp. 459-466
    • Cuenca, A.G.1    Jiang, H.2    Hochwald, S.N.3
  • 7
    • 7444268954 scopus 로고    scopus 로고
    • Recent advances on chitosan-based micro-and nanoparticles in drug delivery
    • Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. J Control Release. 2004;100(1):5-28.
    • (2004) J Control Release. , vol.100 , Issue.1 , pp. 5-28
    • Agnihotri, S.A.1    Mallikarjuna, N.N.2    Aminabhavi, T.M.3
  • 8
    • 0031550212 scopus 로고    scopus 로고
    • Novel hydrophilic chitosan polyethylene oxide nanoparticles as protein carriers
    • Calvo P, Remuñán López C, Vila Jato J, Alonso M. Novel hydrophilic chitosan polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci. 1997;63(1):125-132.
    • (1997) J Appl Polym Sci. , vol.63 , Issue.1 , pp. 125-132
    • Calvo, P.1    Remuñán López, C.2    Vila Jato, J.3    Alonso, M.4
  • 9
    • 64249096993 scopus 로고    scopus 로고
    • Preparation and characterization of venlafaxine hydrochloride loaded chitosan nanoparticles and in vitro release of drug
    • Shah S, Pal A, Kaushik V, Devi S. Preparation and characterization of venlafaxine hydrochloride loaded chitosan nanoparticles and in vitro release of drug. J Appl Polym Sci. 2009;112(5):2876-2887.
    • (2009) J Appl Polym Sci. , vol.112 , Issue.5 , pp. 2876-2887
    • Shah, S.1    Pal, A.2    Kaushik, V.3    Devi, S.4
  • 10
    • 70350362951 scopus 로고    scopus 로고
    • Thiolated chitosan nanoparticles as an oral delivery system for amikacin: In vitro and ex vivo evaluations
    • Atyabi F, Talaie F, Dinarvand R. Thiolated chitosan nanoparticles as an oral delivery system for amikacin: in vitro and ex vivo evaluations. J Nanosci Nanotechnol. 2009;9(8):4593-4603.
    • (2009) J Nanosci Nanotechnol. , vol.9 , Issue.8 , pp. 4593-4603
    • Atyabi, F.1    Talaie, F.2    Dinarvand, R.3
  • 11
    • 79251511860 scopus 로고    scopus 로고
    • Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: Preparation, in vitro and ex vivo evaluation
    • Saremi S, Atyabi F, Akhlaghi SP, Ostad SN, Dinarvand R. Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation. Int J Nanomedicine. 2011;6:119-128.
    • (2011) Int J Nanomedicine. , vol.6 , pp. 119-128
    • Saremi, S.1    Atyabi, F.2    Akhlaghi, S.P.3    Ostad, S.N.4    Dinarvand, R.5
  • 12
    • 0037027876 scopus 로고    scopus 로고
    • Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo
    • Pan Y, Li Y, Zhao H, et al. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm. 2002;249(1-2):139-147.
    • (2002) Int J Pharm. , vol.249 , Issue.1-2 , pp. 139-147
    • Pan, Y.1    Li, Y.2    Zhao, H.3
  • 13
    • 55849105226 scopus 로고    scopus 로고
    • In situ gel forming systems of poloxamer 407 and hydroxypropyl cellulose or hydroxypropyl methyl cellulose mixtures for controlled delivery of vancomycin
    • Talasaz AHH, Ghahremankhani AA, Moghadam SH, et al. In situ gel forming systems of poloxamer 407 and hydroxypropyl cellulose or hydroxypropyl methyl cellulose mixtures for controlled delivery of vancomycin. J Appl Polym Sci. 2008;109(4):2369-2374.
    • (2008) J Appl Polym Sci. , vol.109 , Issue.4 , pp. 2369-2374
    • Talasaz, A.H.H.1    Ghahremankhani, A.A.2    Moghadam, S.H.3
  • 14
    • 79955503035 scopus 로고    scopus 로고
    • Temperature-responsive and biodegradable PVA: PVP k30: Poloxamer 407 hydrogel for controlled delivery of human growth hormone (hGH)
    • Taheri A, Atyabi F, Dinarvnd R. Temperature-responsive and biodegradable PVA: PVP k30: poloxamer 407 hydrogel for controlled delivery of human growth hormone (hGH). J Pediatr Endocrinol Metab. 2011;24(3-4):175-179.
    • (2011) J Pediatr Endocrinol Metab. , vol.24 , Issue.3-4 , pp. 175-179
    • Taheri, A.1    Atyabi, F.2    Dinarvnd, R.3
  • 15
    • 0027726705 scopus 로고
    • Block copolymer in aqueous solution: Micelle formation and hard-sphere crystallization
    • Mortensen K. Block copolymer in aqueous solution: Micelle formation and hard-sphere crystallization. Trends in Colloid and Interface Science VII. 1993:72-75.
    • (1993) Trends in Colloid and Interface Science VII. , pp. 72-75
    • Mortensen, K.1
  • 16
    • 0024107097 scopus 로고
    • Light-scattering study on the association behavior of triblock polymers of ethylene oxide and propylene oxide in aqueous solution
    • Zhou Z, Chu B. Light-scattering study on the association behavior of triblock polymers of ethylene oxide and propylene oxide in aqueous solution. J Colloid Interf Sci. 1988;126(1):171-180.
    • (1988) J Colloid Interf Sci. , vol.126 , Issue.1 , pp. 171-180
    • Zhou, Z.1    Chu, B.2
  • 17
    • 0025387867 scopus 로고
    • The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution
    • Wanka G, Hoffmann H, Ulbricht W. The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution. Colloid Polym Sci. 1990;268(2):101-117.
    • (1990) Colloid Polym Sci. , vol.268 , Issue.2 , pp. 101-117
    • Wanka, G.1    Hoffmann, H.2    Ulbricht, W.3
  • 18
    • 0033180016 scopus 로고    scopus 로고
    • A study of the temperature-dependent micellization of Pluronic F127
    • Bohorquez M, Koch C, Trygstad T, Pandit N. A study of the temperature-dependent micellization of Pluronic F127. J Colloid Interf Sci. 1999;216(1):34-40.
    • (1999) J Colloid Interf Sci. , vol.216 , Issue.1 , pp. 34-40
    • Bohorquez, M.1    Koch, C.2    Trygstad, T.3    Pandit, N.4
  • 19
    • 0031570657 scopus 로고    scopus 로고
    • Study of the gelation process of polyethylene oxidea-polypropylene oxideb-polyethylene oxideacopolymer (poloxamer 407) aqueous solutions
    • Cabana A, Aït-Kadi A, Juhász J. Study of the gelation process of polyethylene oxidea-polypropylene oxideb-polyethylene oxideacopolymer (poloxamer 407) aqueous solutions. J Colloid Interf Sci. 1997;190(2):307-312.
    • (1997) J Colloid Interf Sci. , vol.190 , Issue.2 , pp. 307-312
    • Cabana, A.1    Aït-Kadi, A.2    Juhász, J.3
  • 20
    • 0037073641 scopus 로고    scopus 로고
    • Pluronic® F127 gel formulations of Deslorelin and GnRH reduce drug degradation and sustain drug release and effect in cattle
    • Wenzel JGW, Balaji K, Koushik K, et al. Pluronic® F127 gel formulations of Deslorelin and GnRH reduce drug degradation and sustain drug release and effect in cattle. J Control Release. 2002;85(1-3):51-59.
    • (2002) J Control Release. , vol.85 , Issue.1-3 , pp. 51-59
    • Wenzel, J.G.W.1    Balaji, K.2    Koushik, K.3
  • 21
    • 0032754827 scopus 로고    scopus 로고
    • Controlled release of vancomycin from poloxamer 407 gels
    • Veyries M, Couarraze G, Geiger S, et al. Controlled release of vancomycin from poloxamer 407 gels. Int J Pharm. 1999;192(2):183-193.
    • (1999) Int J Pharm. , vol.192 , Issue.2 , pp. 183-193
    • Veyries, M.1    Couarraze, G.2    Geiger, S.3
  • 22
    • 36148942471 scopus 로고    scopus 로고
    • A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types
    • Reddy LH, Dubernet C, Mouelhi SL, et al. A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types. J Control Release. 2007;124(1-2):20-27.
    • (2007) J Control Release. , vol.124 , Issue.1-2 , pp. 20-27
    • Reddy, L.H.1    Dubernet, C.2    Mouelhi, S.L.3
  • 23
    • 9644302465 scopus 로고    scopus 로고
    • Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs
    • Immordino ML, Brusa P, Rocco F, et al. Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs. J Control Release. 2004;100(3):331-346.
    • (2004) J Control Release. , vol.100 , Issue.3 , pp. 331-346
    • Immordino, M.L.1    Brusa, P.2    Rocco, F.3
  • 24
    • 70349202500 scopus 로고    scopus 로고
    • Sonochemically prepared BSA microspheres containing Gemcitabine, and their potential application in renal cancer therapeutics
    • Grinberg O, Gedanken A, Patra CR, et al. Sonochemically prepared BSA microspheres containing Gemcitabine, and their potential application in renal cancer therapeutics. Acta Biomater. 2009;5(8):3031-3037.
    • (2009) Acta Biomater. , vol.5 , Issue.8 , pp. 3031-3037
    • Grinberg, O.1    Gedanken, A.2    Patra, C.R.3
  • 25
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Selner M, et al. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res. 1998;58(19):4349.
    • (1998) Cancer Res. , vol.58 , Issue.19 , pp. 4349
    • McKey, J.R.1    Mani, R.S.2    Selner, M.3
  • 26
    • 0034327360 scopus 로고    scopus 로고
    • Equilibrativesensitive nucleoside transporter and its role in gemcitabine sensitivity
    • Rauchwerger DR, Firby PS, Hedley DW, Moore MJ. Equilibrativesensitive nucleoside transporter and its role in gemcitabine sensitivity. Cancer Res. 2000;60(21):6075.
    • (2000) Cancer Res. , vol.60 , Issue.21 , pp. 6075
    • Rauchwerger, D.R.1    Firby, P.S.2    Hedley, D.W.3    Moore, M.J.4
  • 27
    • 45549086469 scopus 로고    scopus 로고
    • Novel approaches to deliver gemcitabine to cancers
    • Reddy LH, Couvreur P. Novel approaches to deliver gemcitabine to cancers. Curr Pharm Des. 2008;14(11):1124-1137.
    • (2008) Curr Pharm Des. , vol.14 , Issue.11 , pp. 1124-1137
    • Reddy, L.H.1    Couvreur, P.2
  • 28
    • 77950915051 scopus 로고    scopus 로고
    • Chitosan and glyceryl monooleate nanostructures containing gemcitabine: Potential delivery system for pancreatic cancer treatment
    • Trickler WJ, Khurana J, Nagvekar AA, Dash AK. Chitosan and glyceryl monooleate nanostructures containing gemcitabine: potential delivery system for pancreatic cancer treatment. AAPS PharmSciTech. 2010;11(1):392-401.
    • (2010) AAPS PharmSciTech. , vol.11 , Issue.1 , pp. 392-401
    • Trickler, W.J.1    Khurana, J.2    Nagvekar, A.A.3    Dash, A.K.4
  • 29
    • 70350443227 scopus 로고    scopus 로고
    • Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine
    • Arias JL, Reddy LH, Couvreur P. Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine. J of Drug Target. 2009;17(8):586-598.
    • (2009) J of Drug Target. , vol.17 , Issue.8 , pp. 586-598
    • Arias, J.L.1    Reddy, L.H.2    Couvreur, P.3
  • 30
    • 61549106604 scopus 로고    scopus 로고
    • Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model
    • Wang CX, Huang LS, Hou LB, et al. Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model. Brain research. 2009;1261:91-99.
    • (2009) Brain research. , vol.1261 , pp. 91-99
    • Wang, C.X.1    Huang, L.S.2    Hou, L.B.3
  • 31
    • 40949151239 scopus 로고    scopus 로고
    • Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent
    • Patra CR, Bhattacharya R, Wang E, et al. Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent. Cancer Res. 2008;68(6):1970-1978.
    • (2008) Cancer Res. , vol.68 , Issue.6 , pp. 1970-1978
    • Patra, C.R.1    Bhattacharya, R.2    Wang, E.3
  • 32
    • 34447518563 scopus 로고    scopus 로고
    • Magnetic poly epsilon-caprolactone nanoparticles containing Fe3O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model
    • Gang J, Park SB, Hyung W, et al. Magnetic poly epsilon-caprolactone nanoparticles containing Fe3O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model. J Drug Target. 2007;15(6):445-453.
    • (2007) J Drug Target. , vol.15 , Issue.6 , pp. 445-453
    • Gang, J.1    Park, S.B.2    Hyung, W.3
  • 33
    • 67349238210 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles
    • Moghaddam FA, Atyabi F, Dinarvand R. Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles. Nanomedicine. 2009;5(2):208-215.
    • (2009) Nanomedicine. , vol.5 , Issue.2 , pp. 208-215
    • Moghaddam, F.A.1    Atyabi, F.2    Dinarvand, R.3
  • 34
    • 77957155414 scopus 로고    scopus 로고
    • Discriminated effects of thiolated chitosan-coated pMMA paclitaxelloaded nanoparticles on different normal and cancer cell lines
    • Akhlaghi SP, Saremi S, Ostad SN, Dinarvand R, Atyabi F. Discriminated effects of thiolated chitosan-coated pMMA paclitaxelloaded nanoparticles on different normal and cancer cell lines. Nanomedicine. 2010;6(5):689-697.
    • (2010) Nanomedicine. , vol.6 , Issue.5 , pp. 689-697
    • Akhlaghi, S.P.1    Saremi, S.2    Ostad, S.N.3    Dinarvand, R.4    Atyabi, F.5
  • 36
    • 0032507738 scopus 로고    scopus 로고
    • In vitro evaluation of the mucoadhesive properties of chitosan microspheres
    • He P, Davis SS, Illum L. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int J Pharm. 1998;166(1): 75-88.
    • (1998) Int J Pharm. , vol.166 , Issue.1 , pp. 75-88
    • He, P.1    Davis, S.S.2    Illum, L.3
  • 37
    • 0032484162 scopus 로고    scopus 로고
    • Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery
    • MacLaughlin FC, Mumper RJ, Wang J, et al. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release. 1998;56(1-3):259-272.
    • (1998) J Control Release. , vol.56 , Issue.1-3 , pp. 259-272
    • MacLaughlin, F.C.1    Mumper, R.J.2    Wang, J.3
  • 38
    • 57749182923 scopus 로고    scopus 로고
    • Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study
    • Ajun W, Yan S, Li G, Huili L. Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study. Carbohyd Polym. 2009;75(4):566-574.
    • (2009) Carbohyd Polym. , vol.75 , Issue.4 , pp. 566-574
    • Ajun, W.1    Yan, S.2    Li, G.3    Huili, L.4
  • 39
    • 33749844509 scopus 로고    scopus 로고
    • Development and characterisation of chitosan nanoparticles for siRNA delivery
    • Katas H, Alpar HO. Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release. 2006;115(2):216-225.
    • (2006) J Control Release. , vol.115 , Issue.2 , pp. 216-225
    • Katas, H.1    Alpar, H.O.2
  • 40
    • 33645237156 scopus 로고    scopus 로고
    • Preparation, characterization, and drug release in vitro of chitosan glycyrrhetic acid nanoparticles
    • Zheng Y, Wu Y, Yang W, et al. Preparation, characterization, and drug release in vitro of chitosan glycyrrhetic acid nanoparticles. J Pharm Sci. 2006;95(1):181-191.
    • (2006) J Pharm Sci. , vol.95 , Issue.1 , pp. 181-191
    • Zheng, Y.1    Wu, Y.2    Yang, W.3
  • 41
    • 34347324085 scopus 로고    scopus 로고
    • Chitosan nanoparticle as protein delivery carrier-systematic examination of fabrication conditions for efficient loading and release
    • Gan Q, Wang T. Chitosan nanoparticle as protein delivery carrier-systematic examination of fabrication conditions for efficient loading and release. Colloids Surf B Biointerf. 2007;59(1):24-34.
    • (2007) Colloids Surf B Biointerf. , vol.59 , Issue.1 , pp. 24-34
    • Gan, Q.1    Wang, T.2
  • 42
    • 57749182923 scopus 로고    scopus 로고
    • Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study
    • Ajun W, Yan S, Li G, Huili L. Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study. Carbohyd Polym. 2009;75(4):566-574.
    • (2009) Carbohyd Polym. , vol.75 , Issue.4 , pp. 566-574
    • Ajun, W.1    Yan, S.2    Li, G.3    Huili, L.4
  • 43
    • 34147172851 scopus 로고    scopus 로고
    • Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil
    • Rokhade AP, Shelke NB, Patil SA, Aminabhavi TM. Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil. J Microencapsul. 2007;24(3):274-288.
    • (2007) J Microencapsul. , vol.24 , Issue.3 , pp. 274-288
    • Rokhade, A.P.1    Shelke, N.B.2    Patil, S.A.3    Aminabhavi, T.M.4
  • 44
    • 0031472527 scopus 로고    scopus 로고
    • Thermorheologic properties of aqueous solutions and gels of poloxamer 407
    • Cho CW, Shin S, Oh IJ. Thermorheologic properties of aqueous solutions and gels of poloxamer 407. Drug Dev Ind Pharm. 1997;23(12):1227-1232.
    • (1997) Drug Dev Ind Pharm. , vol.23 , Issue.12 , pp. 1227-1232
    • Cho, C.W.1    Shin, S.2    Oh, I.J.3
  • 45
    • 17644384322 scopus 로고    scopus 로고
    • Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate
    • Wu Y, Yang W, Wang C, Hu J, Fu S. Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate. Int J Pharm. 2005;295(1-2):235-245.
    • (2005) Int J Pharm. , vol.295 , Issue.1-2 , pp. 235-245
    • Wu, Y.1    Yang, W.2    Wang, C.3    Hu, J.4    Fu, S.5
  • 46
    • 34147172851 scopus 로고    scopus 로고
    • Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil
    • Rokhade AP, Shelke NB, Patil SA, Aminabhavi TM. Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil. J Microencapsul. 2007;24(3):274-288.
    • (2007) J Microencapsul. , vol.24 , Issue.3 , pp. 274-288
    • Rokhade, A.P.1    Shelke, N.B.2    Patil, S.A.3    Aminabhavi, T.M.4
  • 47
    • 33846799473 scopus 로고    scopus 로고
    • Mucoadhesion mechanism of chitosan and thiolated chitosan-poly (isobutyl cyanoacrylate) core-shell nanoparticles
    • Bravo-Osuna I, Vauthier C, Farabollini A, Palmieri GF, Ponchel G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly (isobutyl cyanoacrylate) core-shell nanoparticles. Biomaterials. 2007;28(13):2233-2243.
    • (2007) Biomaterials. , vol.28 , Issue.13 , pp. 2233-2243
    • Bravo-Osuna, I.1    Vauthier, C.2    Farabollini, A.3    Palmieri, G.F.4    Ponchel, G.5
  • 48
    • 0037148662 scopus 로고    scopus 로고
    • Characterization of nanoparticle uptake by endothelial cells
    • Davda J, Labhasetwar V. Characterization of nanoparticle uptake by endothelial cells. Int J Pharm. 2002;233(1-2):51-59.
    • (2002) Int J Pharm. , vol.233 , Issue.1-2 , pp. 51-59
    • Davda, J.1    Labhasetwar, V.2
  • 49
    • 0036804673 scopus 로고    scopus 로고
    • Uptake of FITC-chitosan nanoparticles by A549 cells
    • Huang M, Ma Z, Khor E, Lim LY. Uptake of FITC-chitosan nanoparticles by A549 cells. Pharm Res. 2002;19(10):1488-1494.
    • (2002) Pharm Res. , vol.19 , Issue.10 , pp. 1488-1494
    • Huang, M.1    Ma, Z.2    Khor, E.3    Lim, L.Y.4
  • 50
    • 0030069928 scopus 로고    scopus 로고
    • Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines* 1
    • Shekels LL, Lyftogt CT, Ho SB. Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines* 1. Int J Biochem Cell Biol. 1996;28(2):193-201.
    • (1996) Int J Biochem Cell Biol. , vol.28 , Issue.2 , pp. 193-201
    • Shekels, L.L.1    Lyftogt, C.T.2    Ho, S.B.3
  • 51
    • 0026502517 scopus 로고
    • Mucin synthesis and secretion in relation to spontaneous differentiation of colon cancer cells in vitro
    • Niv Y, Byrd JC, Ho SB, Dahiya R, Kim YS. Mucin synthesis and secretion in relation to spontaneous differentiation of colon cancer cells in vitro. Int J Cancer. 1992;50(1):147-152.
    • (1992) Int J Cancer. , vol.50 , Issue.1 , pp. 147-152
    • Niv, Y.1    Byrd, J.C.2    Ho, S.B.3    Dahiya, R.4    Kim, Y.S.5
  • 52
    • 33644922361 scopus 로고    scopus 로고
    • Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery
    • Prego C, Fabre M, Torres D, Alonso M. Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery. Pharm Res. 2006;23(3):549-556.
    • (2006) Pharm Res. , vol.23 , Issue.3 , pp. 549-556
    • Prego, C.1    Fabre, M.2    Torres, D.3    Alonso, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.