Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake

Biomaterials

Volumn 34, Issue 28, 2013, Pages 6922-6929

  Ensign, Laura M ^a,b   Hoen, Timothy E ^a   Maisel, Katharina ^a   Cone, Richard A ^a   Hanes, Justin S ^a,b,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Johns Hopkins University   (United States)

Author keywords

Hypotonic delivery; Microbicides; Mucosal delivery; Mucus penetrating particles

Indexed keywords

HYPOTONIC DELIVERY; LONG-TERM RETENTION; MICROBICIDES; MUCOSAL DELIVERY; MUCUS-PENETRATING PARTICLES; SMALL-MOLECULE DRUGS; VAGINAL DRUG DELIVERY; VAGINAL EPITHELIUM;

BODY FLUIDS; DRUG DELIVERY; MAMMALS; NANOPARTICLES;

DRUG PRODUCTS;

DOXORUBICIN; HYPOTONIC SOLUTION; ISOTONIC SOLUTION; NANOCARRIER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RETENTION; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; INTRAVAGINAL DRUG ADMINISTRATION; MOUSE; MUCOADHESION; NONHUMAN; OSMOLALITY; PRIORITY JOURNAL; VAGINA EPITHELIUM;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-INFECTIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; FEMALE; MICE; VAGINA;

HERPES; MUS;

EID: 84879464127     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.05.039     Document Type: Article

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