Characterization of particle translocation through mucin hydrogels

Biophysical Journal

Volumn 98, Issue 9, 2010, Pages 1782-1789

  Lieleg, Oliver ^a,b   Vladescu, Ioana ^a,b   Ribbeck, Katharina ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS);

EID: 77952261296     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.01.012     Document Type: Article

References (32)

1. Thornton, D. J., and J. K. Sheehan. 2004. From mucins to mucus: toward a more coherent understanding of this essential barrier. Proc. Am. Thorac. Soc. 1:54-61.
2. Thornton, D. J., K. Rousseau, and M. A. McGuckin. 2008. Structure and function of the polymeric mucins in airways mucus. Annu. Rev. Physiol. 70:459-486.
3. Linden, S. K., P. Sutton, M. A. McGuckin. 2008. Mucins in the mucosal barrier to infection. Mucosal Immunol. 1:183-197.
4. Strous, G. J., and J. Dekker. 1992. Mucin-type glycoproteins. Crit. Rev. Biochem. 27:57-92.
5. Sellers,L.A.,A.Allen,S.B.Ross-Murphy.1987. Mechanicalcharacterizationandpropertiesofgastrointestinalmucusgel.Biorheology. 24:615-623.(Pubitemid18021587)
6. Matsui, H., V. E. Wagner, R. C. Boucher. 2006. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proc. Natl. Acad. Sci. USA. 103:18131-18136.
7. Dawson, M., D. Wirtz, and J. Hanes. 2003. Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport. J. Biol. Chem. 278:50393-50401.
8. Lai, S. K., D. E. O'Hanlon, J. Hanes. 2007. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc. Natl. Acad. Sci. USA. 104:1482-1487.
9. Saltzman, W. M., M. L. Radomsky, R. A. Cone. 1994. Antibody diffusion in human cervical mucus. Biophys. J. 66:508-515.
10. Wang, Y. Y., S. K. Lai, J. Hanes. 2008. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angew. Chem. Int. Ed. Engl. 47:9726-9729.
11. Cu, Y., and W. M. Saltzman. 2009. Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus. Mol. Pharm. 6:173-181.
12. Gendler, S. J., and A. P. Spicer. 1995. Epithelial mucin genes. Annu. Rev. Physiol. 57:607-634.
13. Snary, D., and A. Allen. 1971. Studies on gastric mucoproteins. The isolation and characterization of the mucoprotein of the water-soluble mucus from pig cardiac gastric mucosa. Biochem. J. 123:845-853.
14. Cao,X.,R.Bansil,N.H.Afdhal.1999.pH-dependent conformational change of gastric mucin leads-sol-geltransition.Biophys.J.76:1250-1258.(Pubitemid29262607)
15. Celli, J. P., B. S. Turner, S. Erramilli. 2007. Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. Biomacromolecules. 8:1580-1586.
16. Celli, J. P., B. S. Turner, R. Bansil. 2009. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc. Natl. Acad. Sci. USA. 106:14321-14326.
17. Valentine, M. T., Z. E. Perlman, D. A. Weitz. 2004. Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Biophys. J. 86:4915-4923.
18. Schilling, J., E. Sackmann, and A. R. Bausch. 2004. Digital imaging processing for biophysical applications. Rev. Sci. Instrum. 75:2822-2827.
19. Luan, Y., O. Lieleg, A. R. Bausch. 2008. Micro- and macrorheological properties of isotropically cross-linked actin networks. Biophys. J. 94:688-693.
20. Soyenkoff, B. C., and C. F. Hinck. 1935. The measurement of pH and acid-neutralizing power of saliva. J. Biol. Chem. 109:467-475.
21. Washington, N., R. J. C. Steele, D. A. Rawlins. 2000. Determination of baseline human nasal pH and the effect of intranasally administered buffers. Int. J. Pharm. 198:139-146.
22. Karnad, D. R., D. G. Mhaisekar, and K. V. Moralwar. 1990. Respiratory mucus pH in tracheostomized intensive care unit patients: Effects of colonization and pneumonia. Crit. Care Med. 18:699-701.
23. Ovesen,L.,F.Bendtsen,S.J.Rune.1986.Intraluminal pH in the stomach, duodenum, and proximal jejunum in normal subjects and patients with exocrine pancreatic insufficiency.Gastroenterology.90:958-962.(Pubitemid16124773)
24. Suarez, S. S., and A. A. Pacey. 2006. Sperm transport in the female reproductive tract. Hum. Reprod. Update. 12:23-37.
25. Brunelli, R., M. Papi, M. De Spirito. 2007. Globular structure of human ovulatory cervical mucus. FASEB J. 21:3872-3876. (Pubitemid 350232344)
26. Norris, D. A., and P. J. Sinko. 1997. Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin. J. Appl. Polym. Sci. 63:1481-1492.
27. Celli, J., B. Gregor, S. Erramilli. 2005. Viscoelastic properties and dynamics of porcine gastric mucin. Biomacromolecules. 6:1329-1333. (Pubitemid 40775049)
28. Hong, Z., B. Chasan, N. H. Afdhal. 2005. Atomic force microscopy reveals aggregation of gastric mucin at low pH. Biomacromolecules. 6:3458-3466. (Pubitemid 41764111)
29. 2+] reduce the swelling of mucins in primary cultures of human cervical cells. Hum. Reprod. 17:1964-1972.
30. Carlstedt, I., and J. K. Sheehan. 1984. Macromolecular properties and polymeric structure of mucus glycoproteins. Ciba Found. Symp. 109:157-172.
31. Lieleg, O., R. M. Baumgärtel, and A. R. Bausch. 2009. Selective filtering of particles by the extracellular matrix: an electrostatic bandpass. Biophys. J. 97:1569-1577.
32. Reference deleted in proof.