메뉴 건너뛰기




Volumn 48, Issue 2-3, 2001, Pages 173-193

Drug transfer through mucus

Author keywords

Diffusion; Drug absorption; Mucin; Mucosal absorption; Mucus

Indexed keywords

DEBRIS; DIFFUSION; ENZYMES; GELS; LIPIDS; SALTS; TISSUE;

EID: 0035844741     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(01)00115-6     Document Type: Review
Times cited : (284)

References (129)
  • 1
    • 0030683512 scopus 로고    scopus 로고
    • Airway liquid: A barrier to drug diffusion?
    • Widdicombe J.G. Airway liquid: a barrier to drug diffusion? Eur. Respir. J. 10:1997;2194-2197.
    • (1997) Eur. Respir. J. , vol.10 , pp. 2194-2197
    • Widdicombe, J.G.1
  • 2
    • 0017334594 scopus 로고
    • Derivation of the kinetics that describe the effects of unstirred water layers on the kinetic parameters of active transport processes in the intestine
    • Thomson A.B., Dietschy J.M. Derivation of the kinetics that describe the effects of unstirred water layers on the kinetic parameters of active transport processes in the intestine. J. Theor. Biol. 64:1977;277-294.
    • (1977) J. Theor. Biol. , vol.64 , pp. 277-294
    • Thomson, A.B.1    Dietschy, J.M.2
  • 3
    • 0021664988 scopus 로고
    • Effects of the anti-oestrogens, clomiphene and tamoxifen, on the cervical factor in female infertility
    • London: Pitman
    • Elstein M., Fawcett G.M. Effects of the anti-oestrogens, clomiphene and tamoxifen, on the cervical factor in female infertility. Mucus and Mucosa, Ciba Foundation Symposium, Vol. 109:1984;173-179 Pitman, London.
    • (1984) Mucus and Mucosa, Ciba Foundation Symposium, Vol. 109 , vol.109 , pp. 173-179
    • Elstein, M.1    Fawcett, G.M.2
  • 4
    • 0017810686 scopus 로고
    • Human cervical mucus IV. Viscoelasticity and sperm penetrability during the ovulatory menstrual cycle
    • Wolf D.P., Blasco L., Khan M.A., Litt M. Human cervical mucus IV. Viscoelasticity and sperm penetrability during the ovulatory menstrual cycle. Fertil. Steril. 30:1978;163-169.
    • (1978) Fertil. Steril. , vol.30 , pp. 163-169
    • Wolf, D.P.1    Blasco, L.2    Khan, M.A.3    Litt, M.4
  • 5
    • 0021916758 scopus 로고
    • Bioadhesive polymers as platforms for oral controlled drug delivery. III. Oral delivery of chlorothiazide using a bioadhesive polymer
    • Longer M.A., Ch'ng H.S., Robinson J.R. Bioadhesive polymers as platforms for oral controlled drug delivery. III. Oral delivery of chlorothiazide using a bioadhesive polymer. J. Pharm. Sci. 74:1985;406-411.
    • (1985) J. Pharm. Sci. , vol.74 , pp. 406-411
    • Longer, M.A.1    Ch'ng, H.S.2    Robinson, J.R.3
  • 8
    • 0025864459 scopus 로고
    • Absorption of drugs from the human oral cavity
    • Rathbone M.J., Hadgraft J. Absorption of drugs from the human oral cavity. Int. J. Pharm. 74:1991;9-24.
    • (1991) Int. J. Pharm. , vol.74 , pp. 9-24
    • Rathbone, M.J.1    Hadgraft, J.2
  • 10
    • 0017912973 scopus 로고
    • Constituents of mucus and their separation
    • Creeth J.M. Constituents of mucus and their separation. Br. Med. Bull. 34:1978;17-24.
    • (1978) Br. Med. Bull. , vol.34 , pp. 17-24
    • Creeth, J.M.1
  • 11
    • 0017843713 scopus 로고
    • Biochemical definition of human tracheobronchial mucus
    • Roussel P., Degand P., Lamblin G., Laine A., Lafitte J.J. Biochemical definition of human tracheobronchial mucus. Lung. 154:1978;241-260.
    • (1978) Lung , vol.154 , pp. 241-260
    • Roussel, P.1    Degand, P.2    Lamblin, G.3    Laine, A.4    Lafitte, J.J.5
  • 12
    • 0023576263 scopus 로고
    • The origins of secretions in the lower respiratory tract
    • Jeffery P.K. The origins of secretions in the lower respiratory tract. Eur. J. Respir. Dis. 71:(Suppl. 153):1987;34-42.
    • (1987) Eur. J. Respir. Dis. , vol.71 , Issue.SUPPL. 153 , pp. 34-42
    • Jeffery, P.K.1
  • 13
    • 0024848507 scopus 로고
    • Macromolecular and lipid constituents of bronchial epithelial mucus
    • E. Chantler, & N.A. Ratcliffe. Cambridge: The Company of Biologists
    • Reid L.M., Bhaskar K.R. Macromolecular and lipid constituents of bronchial epithelial mucus. Chantler E., Ratcliffe N.A., Mucus and Related Topics. 1989;201-219 The Company of Biologists, Cambridge.
    • (1989) Mucus and Related Topics , pp. 201-219
    • Reid, L.M.1    Bhaskar, K.R.2
  • 14
    • 0015752334 scopus 로고
    • Quantitative immunoelectrophoretic analysis of the plasma proteins in the sol phase of sputum from patients with chronic bronchitis
    • Ryley H.C., Brogan T.D. Quantitative immunoelectrophoretic analysis of the plasma proteins in the sol phase of sputum from patients with chronic bronchitis. J. Clin. Pathol. 26:1973;852-856.
    • (1973) J. Clin. Pathol. , vol.26 , pp. 852-856
    • Ryley, H.C.1    Brogan, T.D.2
  • 15
    • 0016424943 scopus 로고
    • Soluble proteins of bronchopulmonary secretions from patients with cystic fibrosis, asthma, and chronic bronchitis
    • Brogan T.D., Ryley H.C., Neale L., Yassa J. Soluble proteins of bronchopulmonary secretions from patients with cystic fibrosis, asthma, and chronic bronchitis. Thorax. 30:1975;72-79.
    • (1975) Thorax , vol.30 , pp. 72-79
    • Brogan, T.D.1    Ryley, H.C.2    Neale, L.3    Yassa, J.4
  • 16
    • 0015518550 scopus 로고
    • An immunoelectrophoretic study of the soluble secretory proteins of sputum
    • Ryley H.C. An immunoelectrophoretic study of the soluble secretory proteins of sputum. Biochim. Biophys. Acta. 271:1972;300-309.
    • (1972) Biochim. Biophys. Acta , vol.271 , pp. 300-309
    • Ryley, H.C.1
  • 17
    • 0023462429 scopus 로고
    • Role of lipids in airway function
    • Widdicombe J.G. Role of lipids in airway function. Eur. J. Respir. Dis. 71:(Suppl. 153):1987;197-204.
    • (1987) Eur. J. Respir. Dis. , vol.71 , Issue.SUPPL. 153 , pp. 197-204
    • Widdicombe, J.G.1
  • 18
    • 0001307488 scopus 로고
    • Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis
    • Chernick W.S., Barbero G.J. Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis. Pediatrics. 24:1959;739-745.
    • (1959) Pediatrics , vol.24 , pp. 739-745
    • Chernick, W.S.1    Barbero, G.J.2
  • 19
    • 0020025026 scopus 로고
    • Lipid composition of tracheobronchial secretions from normal individuals and patients with cystic fibrosis
    • Slomiany A., Murty V.L.N., Aono M., Snyder C.E., Herp A., Slomiany B.L. Lipid composition of tracheobronchial secretions from normal individuals and patients with cystic fibrosis. Biochim. Biophys. Acta. 710:1982;106-111.
    • (1982) Biochim. Biophys. Acta , vol.710 , pp. 106-111
    • Slomiany, A.1    Murty, V.L.N.2    Aono, M.3    Snyder, C.E.4    Herp, A.5    Slomiany, B.L.6
  • 20
    • 0021288080 scopus 로고
    • Mucin biosynthesis and secretion in the respiratory tract
    • Spicer S.S., Martinez J.R. Mucin biosynthesis and secretion in the respiratory tract. Environ. Health Perspect. 55:1984;193-204.
    • (1984) Environ. Health Perspect. , vol.55 , pp. 193-204
    • Spicer, S.S.1    Martinez, J.R.2
  • 21
    • 0342949598 scopus 로고
    • Distribution of surfactants in the canine GI tract and their ability to lubricate
    • Butler B.D., Lichtenberger L.M., Hills B.A. Distribution of surfactants in the canine GI tract and their ability to lubricate. Am. J. Physiol. 244:1983;G645-G651.
    • (1983) Am. J. Physiol. , vol.244
    • Butler, B.D.1    Lichtenberger, L.M.2    Hills, B.A.3
  • 24
    • 0021364396 scopus 로고
    • The role of covalently bound fatty acids in the degradation of human gastric mucus glycoprotein
    • Slomiany A., Jozwiak Z., Takagi A., Slomiany B.L. The role of covalently bound fatty acids in the degradation of human gastric mucus glycoprotein. Arch. Biochem. Biophys. 229:1984;560-567.
    • (1984) Arch. Biochem. Biophys. , vol.229 , pp. 560-567
    • Slomiany, A.1    Jozwiak, Z.2    Takagi, A.3    Slomiany, B.L.4
  • 25
    • 0024397873 scopus 로고
    • Lipolytic activity of Campylobacter pylori: Effect of colloidal bismuth subcitrate (De-Nol)
    • Slomiany B.L., Kasinanthan C., Slomiany A. Lipolytic activity of Campylobacter pylori: effect of colloidal bismuth subcitrate (De-Nol). Am. J. Gastroenterol. 84:1989;1273-1277.
    • (1989) Am. J. Gastroenterol. , vol.84 , pp. 1273-1277
    • Slomiany, B.L.1    Kasinanthan, C.2    Slomiany, A.3
  • 27
    • 0026167171 scopus 로고
    • Role of mucus in gastric mucosal protection
    • Slomiany B.L., Slomiany A. Role of mucus in gastric mucosal protection. J. Physiol. Pharmacol. 42:1991;147-161.
    • (1991) J. Physiol. Pharmacol. , vol.42 , pp. 147-161
    • Slomiany, B.L.1    Slomiany, A.2
  • 28
    • 0017848807 scopus 로고
    • Lipid composition of the gastric mucous barrier in the rat
    • Slomiany A., Yano S., Slomiany B.L., Glass G.B.J. Lipid composition of the gastric mucous barrier in the rat. J. Biol. Chem. 253:1978;3785-3791.
    • (1978) J. Biol. Chem. , vol.253 , pp. 3785-3791
    • Slomiany, A.1    Yano, S.2    Slomiany, B.L.3    Glass, G.B.J.4
  • 29
    • 0013562371 scopus 로고    scopus 로고
    • The influence of intestinal mucus components on the diffusion of drugs
    • Larhed A.W., Artursson P., Bjork E. The influence of intestinal mucus components on the diffusion of drugs. Pharm. Res. 15:1998;66-71.
    • (1998) Pharm. Res. , vol.15 , pp. 66-71
    • Larhed, A.W.1    Artursson, P.2    Bjork, E.3
  • 31
    • 0018670460 scopus 로고
    • Mucins in the human gastrointestinal epithelium: A review
    • Filipe M.I. Mucins in the human gastrointestinal epithelium: a review. Invest. Cell Pathol. 2:1979;195-216.
    • (1979) Invest. Cell Pathol. , vol.2 , pp. 195-216
    • Filipe, M.I.1
  • 34
    • 0005018827 scopus 로고
    • The nature and function of the epithelial mucous glycoproteins
    • R.J. Blandau, & K. Moghissi. Chicago: University of Chicago Press
    • Pigman W., Moshera J.L. The nature and function of the epithelial mucous glycoproteins. Blandau R.J., Moghissi K., The Biology of the Cervix. 1973;143-172 University of Chicago Press, Chicago.
    • (1973) The Biology of the Cervix , pp. 143-172
    • Pigman, W.1    Moshera, J.L.2
  • 35
  • 36
    • 0016904277 scopus 로고
    • Comparative aspects of glycoprotein structure
    • Kornfeld R., Kornfeld S. Comparative aspects of glycoprotein structure. Annu. Rev. Biochem. 45:1976;217-237.
    • (1976) Annu. Rev. Biochem. , vol.45 , pp. 217-237
    • Kornfeld, R.1    Kornfeld, S.2
  • 38
    • 0013864168 scopus 로고
    • Polysaccharides
    • Sharon N. Polysaccharides. Annu. Rev. Biochem. 35:1966;485-520.
    • (1966) Annu. Rev. Biochem , vol.35 , pp. 485-520
    • Sharon, N.1
  • 39
    • 0016063279 scopus 로고
    • Further investigations into the structure of human gastric mucin: The structural configuration of the oligosaccharide chains
    • Oates M.D., Rosbottom A.C., Schrager J. Further investigations into the structure of human gastric mucin: the structural configuration of the oligosaccharide chains. Carbohydrate Res. 34:1974;115-137.
    • (1974) Carbohydrate Res. , vol.34 , pp. 115-137
    • Oates, M.D.1    Rosbottom, A.C.2    Schrager, J.3
  • 40
    • 0014027764 scopus 로고
    • Oligosaccharides isolated from pig submaxillary mucin
    • Carlson D.M. Oligosaccharides isolated from pig submaxillary mucin. J. Biol. Chem. 241:1966;2984-2986.
    • (1966) J. Biol. Chem. , vol.241 , pp. 2984-2986
    • Carlson, D.M.1
  • 41
    • 0014408452 scopus 로고
    • Structures and immunochemical properties of oligosaccharides isolated from pig submaxillary mucins
    • Carlson D.M. Structures and immunochemical properties of oligosaccharides isolated from pig submaxillary mucins. J. Biol. Chem. 243:(3):1968;616-626.
    • (1968) J. Biol. Chem. , vol.243 , Issue.3 , pp. 616-626
    • Carlson, D.M.1
  • 43
    • 0005017609 scopus 로고
    • Polydispersity
    • Gibbons R.A. Polydispersity. Nature. 200:1963;665-666.
    • (1963) Nature , vol.200 , pp. 665-666
    • Gibbons, R.A.1
  • 44
    • 84914505727 scopus 로고
    • Biophysical characteristics of the blood
    • D. Aminoff. New York: Academic Press
    • Gibbons R.A., Creeth J.M., Denborough M.A. Biophysical characteristics of the blood. Aminoff D., Blood and Tissue Antigens. 1970;307-324 Academic Press, New York.
    • (1970) Blood and Tissue Antigens , pp. 307-324
    • Gibbons, R.A.1    Creeth, J.M.2    Denborough, M.A.3
  • 45
    • 0024327317 scopus 로고
    • Isolation and structural analysis of rat gastric mucus glycoprotein suggests a homogeneous protein backbone
    • Dekker J., Van Beurden-Lamers W.M., Oprins A., Straus G.J. Isolation and structural analysis of rat gastric mucus glycoprotein suggests a homogeneous protein backbone. Biochem. J. 260:1989;717-723.
    • (1989) Biochem. J. , vol.260 , pp. 717-723
    • Dekker, J.1    Van Beurden-Lamers, W.M.2    Oprins, A.3    Straus, G.J.4
  • 46
    • 0019488322 scopus 로고
    • Human ocular mucus - Chemical studies
    • Moore J.C., Tiffany J.M. Human ocular mucuschemical studies. Exp. Eye Res. 33:1981;203-212.
    • (1981) Exp. Eye Res. , vol.33 , pp. 203-212
    • Moore, J.C.1    Tiffany, J.M.2
  • 47
    • 0017360157 scopus 로고
    • Human cervical mucus III: Isolation and characterization of rheologically active mucin
    • Wolf D.P., Sokoloski J., Khan M.A., Litt M. Human cervical mucus III: Isolation and characterization of rheologically active mucin. Fertil. Steril. 28:1977;53-58.
    • (1977) Fertil. Steril. , vol.28 , pp. 53-58
    • Wolf, D.P.1    Sokoloski, J.2    Khan, M.A.3    Litt, M.4
  • 48
    • 0019426322 scopus 로고
    • Control of mucus hydration as a Donnan equilibrium process
    • Tam P.Y., Verdugo P. Control of mucus hydration as a Donnan equilibrium process. Nature. 292:1981;340-342.
    • (1981) Nature , vol.292 , pp. 340-342
    • Tam, P.Y.1    Verdugo, P.2
  • 49
    • 0025017363 scopus 로고
    • Luminal surface hydrophobicity of canine gastric mucosa is dependent on a surface mucus gel
    • Goddard P.J., Kao Y.-C., Lichtenberger L.M. Luminal surface hydrophobicity of canine gastric mucosa is dependent on a surface mucus gel. Gastroenterology. 98:1990;361-370.
    • (1990) Gastroenterology , vol.98 , pp. 361-370
    • Goddard, P.J.1    Kao, Y.-C.2    Lichtenberger, L.M.3
  • 50
    • 0030468661 scopus 로고    scopus 로고
    • Gastric surfactant and the hydrophobic mucosal barrier
    • Hills B.A. Gastric surfactant and the hydrophobic mucosal barrier. Gut. 39:1996;621-624.
    • (1996) Gut , vol.39 , pp. 621-624
    • Hills, B.A.1
  • 51
    • 0033979999 scopus 로고    scopus 로고
    • The gastric mucosal barrier
    • Werther J.L. The gastric mucosal barrier. Mount Sinai J. Med. 67:2000;41-53.
    • (2000) Mount Sinai J. Med. , vol.67 , pp. 41-53
    • Werther, J.L.1
  • 52
    • 0028915433 scopus 로고
    • The hydrophobic barrier properties of gastrointestinal mucus
    • Lichtenberger L.M. The hydrophobic barrier properties of gastrointestinal mucus. Annu. Rev. Physiol. 57:1995;565-583.
    • (1995) Annu. Rev. Physiol. , vol.57 , pp. 565-583
    • Lichtenberger, L.M.1
  • 54
    • 0022999347 scopus 로고
    • Electron microscopy of cervical, gastric and bronchial mucus glycoproteins
    • Sheehan J.K., Oates K., Carlstedt I. Electron microscopy of cervical, gastric and bronchial mucus glycoproteins. Biochem. J. 239:1986;147-153.
    • (1986) Biochem. J. , vol.239 , pp. 147-153
    • Sheehan, J.K.1    Oates, K.2    Carlstedt, I.3
  • 55
    • 0017676390 scopus 로고
    • A tentative model for the structure of bovine oestrus cervical mucus
    • M. Elstein, & D.V. Paske. New York: Plenum Press
    • Bhushana-Rao K.S.P., Masson P.L. A tentative model for the structure of bovine oestrus cervical mucus. Elstein M., Paske D.V., Mucus in Health and Disease I. 1977;275-282 Plenum Press, New York.
    • (1977) Mucus in Health and Disease I , pp. 275-282
    • Bhushana-Rao, K.S.P.1    Masson, P.L.2
  • 58
    • 0001473038 scopus 로고
    • Structure and function of gastrointestinal mucus
    • L.R. Johnson. New York: Raven Press
    • Allen A. Structure and function of gastrointestinal mucus. Johnson L.R., Physiology of the Gastrointestinal Tract. 1981;617-639 Raven Press, New York.
    • (1981) Physiology of the Gastrointestinal Tract , pp. 617-639
    • Allen, A.1
  • 59
    • 0020630662 scopus 로고
    • Conformational structure of respiratory mucus studied by laser correlation spectroscopy
    • Verdugo P., Tam P.Y., Butler J. Conformational structure of respiratory mucus studied by laser correlation spectroscopy. Biorheology. 20:1983;223-230.
    • (1983) Biorheology , vol.20 , pp. 223-230
    • Verdugo, P.1    Tam, P.Y.2    Butler, J.3
  • 61
    • 0019903597 scopus 로고
    • A simple method for measuring the thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: Influence of feeding, prostaglandin, N-acetylcysteine and other agents
    • Kerss S., Allen A., Garner A. A simple method for measuring the thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: influence of feeding, prostaglandin, N-acetylcysteine and other agents. Clin. Sci. 63:1982;187-195.
    • (1982) Clin. Sci. , vol.63 , pp. 187-195
    • Kerss, S.1    Allen, A.2    Garner, A.3
  • 62
    • 0019862246 scopus 로고
    • Luminal mucin in the large intestine of mice, rats and guinea pigs
    • Sakata T., Engelhardt W.V. Luminal mucin in the large intestine of mice, rats and guinea pigs. Cell Tissue Res. 219:1981;629-635.
    • (1981) Cell Tissue Res. , vol.219 , pp. 629-635
    • Sakata, T.1    Engelhardt, W.V.2
  • 63
    • 0019984034 scopus 로고
    • Microbial flora of the mouse ileum mucous layer and epithelial surface
    • Rozee K.R., Cooper D., Lam K., Costerton J.W. Microbial flora of the mouse ileum mucous layer and epithelial surface. Appl. Environ. Microbiol. 43:1982;1451-1463.
    • (1982) Appl. Environ. Microbiol. , vol.43 , pp. 1451-1463
    • Rozee, K.R.1    Cooper, D.2    Lam, K.3    Costerton, J.W.4
  • 66
    • 0023892746 scopus 로고
    • Pharmaceutical and medical aspects of bioadhesive systems for drug administration
    • Duchene D., Touchard F., Peppas N.A. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev. Ind. Pharm. 14:1988;283-318.
    • (1988) Drug Dev. Ind. Pharm. , vol.14 , pp. 283-318
    • Duchene, D.1    Touchard, F.2    Peppas, N.A.3
  • 67
    • 0021963276 scopus 로고
    • Bioadhesive polymers as platforms for oral controlled drug delivery. II: Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers
    • Ch'ng H.S., Park H., Kelly P., Robinson J.R. Bioadhesive polymers as platforms for oral controlled drug delivery. II: synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J. Pharm. Sci. 74:1985;399-405.
    • (1985) J. Pharm. Sci. , vol.74 , pp. 399-405
    • Ch'ng, H.S.1    Park, H.2    Kelly, P.3    Robinson, J.R.4
  • 68
    • 0005018829 scopus 로고
    • Mucus: Its structure, function and evaluation
    • D. Ganderton, & T.M. Jones. Chichester, UK: Ellis Harwood
    • Marriott C. Mucus: its structure, function and evaluation. Ganderton D., Jones T.M., Drug Delivery to the Respiratory Tract. 1987;68-76 Ellis Harwood, Chichester, UK.
    • (1987) Drug Delivery to the Respiratory Tract , pp. 68-76
    • Marriott, C.1
  • 69
    • 0023494768 scopus 로고
    • Management of mucus hypersecretion
    • Clarke S.W. Management of mucus hypersecretion. Eur. J. Respir. Dis. 71:(S153):1987;136-144.
    • (1987) Eur. J. Respir. Dis. , vol.71 , Issue.S153 , pp. 136-144
    • Clarke, S.W.1
  • 70
    • 0019419071 scopus 로고
    • Effects of arachidonic acid, monohydroxyeicosatetraenoic acid and prostaglandins on the release of mucous glycoprotein from human airways in vitro
    • Marom Z., Shelhamer J.H., Kaliner M. Effects of arachidonic acid, monohydroxyeicosatetraenoic acid and prostaglandins on the release of mucous glycoprotein from human airways in vitro. J. Clin. Invest. 67:1981;1695-1702.
    • (1981) J. Clin. Invest. , vol.67 , pp. 1695-1702
    • Marom, Z.1    Shelhamer, J.H.2    Kaliner, M.3
  • 71
    • 0020642779 scopus 로고
    • Effects of leukotrienes C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosa
    • Coles S.J., Neill K.H., Reid L.M., Austen K.F., Nii Y., Corey E.J., Lewis R.A. Effects of leukotrienes C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosa. Prostaglandins. 25:1983;155-170.
    • (1983) Prostaglandins , vol.25 , pp. 155-170
    • Coles, S.J.1    Neill, K.H.2    Reid, L.M.3    Austen, K.F.4    Nii, Y.5    Corey, E.J.6    Lewis, R.A.7
  • 74
    • 0018172765 scopus 로고
    • Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall
    • Uddman R., Alumets J., Densert O., Halcanson R., Sundler F. Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall. Acta Otolaryngol. 86:1978;443-448.
    • (1978) Acta Otolaryngol. , vol.86 , pp. 443-448
    • Uddman, R.1    Alumets, J.2    Densert, O.3    Halcanson, R.4    Sundler, F.5
  • 75
    • 0005044094 scopus 로고
    • Vagal substance P nerves involved in control of vascular permeability and smooth muscle tone in trachea and bronchi
    • Lundberg J.M., Saria A. Vagal substance P nerves involved in control of vascular permeability and smooth muscle tone in trachea and bronchi. Br. J. Pharmacol. 77:1982;441P.
    • (1982) Br. J. Pharmacol. , vol.77
    • Lundberg, J.M.1    Saria, A.2
  • 76
    • 0025846959 scopus 로고
    • An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop
    • Lehr C.-M., Poelma F.G.J., Junginger H.E., Tukker J.J. An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop. Int. J. Pharm. 70:1991;235-240.
    • (1991) Int. J. Pharm. , vol.70 , pp. 235-240
    • Lehr, C.-M.1    Poelma, F.G.J.2    Junginger, H.E.3    Tukker, J.J.4
  • 77
    • 0017634182 scopus 로고
    • Derangements of biosynthesis, production and secretion of mucus in gastrointestinal injury and disease
    • M. Elstein, & D.V. Parke. New York: Plenum Press
    • Glass G.B.J., Slomiany G.L. Derangements of biosynthesis, production and secretion of mucus in gastrointestinal injury and disease. Elstein M., Parke D.V., Mucus in Health and Disease. 1977;311-347 Plenum Press, New York.
    • (1977) Mucus in Health and Disease , pp. 311-347
    • Glass, G.B.J.1    Slomiany, G.L.2
  • 78
    • 0016561968 scopus 로고
    • Proceedings: Changes in human colonic mucus in ulcerative colitis
    • Fraser G.M., Clamp J.R. Proceedings: changes in human colonic mucus in ulcerative colitis. Gut. 16:1975;832-833.
    • (1975) Gut , vol.16 , pp. 832-833
    • Fraser, G.M.1    Clamp, J.R.2
  • 79
    • 0016560171 scopus 로고
    • Proceedings: Glucosamine synthetase activity in the colonic mucosa in ulcerative colitis and Crohn's disease
    • Goodman M.J., Kent P.W., Truelove S.C. Proceedings: glucosamine synthetase activity in the colonic mucosa in ulcerative colitis and Crohn's disease. Gut. 16:1975;833.
    • (1975) Gut , vol.16 , pp. 833
    • Goodman, M.J.1    Kent, P.W.2    Truelove, S.C.3
  • 80
    • 0029979921 scopus 로고    scopus 로고
    • Drug diffusion through cystic fibrotic mucus: Steady-state permeation, rheologic properties, and glycoprotein morphology
    • Bhat P.G., Flanagan D.R., Donovan M.D. Drug diffusion through cystic fibrotic mucus: steady-state permeation, rheologic properties, and glycoprotein morphology. J. Pharm. Sci. 85:1996;624-630.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 624-630
    • Bhat, P.G.1    Flanagan, D.R.2    Donovan, M.D.3
  • 81
    • 0017696352 scopus 로고
    • Glycoprotein alteration in human colonic adenocarcinoma
    • M. Elstein, & D.V. Parke. New York: Plenum Press
    • Kim Y.S. Glycoprotein alteration in human colonic adenocarcinoma. Elstein M., Parke D.V., Mucus in Health and Disease I. 1977;443-468 Plenum Press, New York.
    • (1977) Mucus in Health and Disease I , pp. 443-468
    • Kim, Y.S.1
  • 82
    • 0014542135 scopus 로고
    • Value of histochemical reaction from mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum
    • Filipe M.I. Value of histochemical reaction from mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum. Gut. 10:1969;577-586.
    • (1969) Gut , vol.10 , pp. 577-586
    • Filipe, M.I.1
  • 83
    • 0016200769 scopus 로고
    • Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma
    • Filipe M.I., Branfoot A.C. Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer. 3492:1974;282-290.
    • (1974) Cancer , vol.3492 , pp. 282-290
    • Filipe, M.I.1    Branfoot, A.C.2
  • 84
    • 0017633624 scopus 로고
    • The evaluation and treatment of cervical mucus diseases leading to infertility
    • M. Elstein, & D.V. Parke. New York: Plenum Press
    • Insler V. The evaluation and treatment of cervical mucus diseases leading to infertility. Elstein M., Parke D.V., Mucus in Health and Disease I. 1977;477-488 Plenum Press, New York.
    • (1977) Mucus in Health and Disease I , pp. 477-488
    • Insler, V.1
  • 85
    • 0017135055 scopus 로고
    • Effect of mucolytic agents on the rheological properties of tracheal mucus
    • Khan M.A., Wolf D.P., Litt M. Effect of mucolytic agents on the rheological properties of tracheal mucus. Biochim. Biophys. Acta. 444:1976;369-373.
    • (1976) Biochim. Biophys. Acta , vol.444 , pp. 369-373
    • Khan, M.A.1    Wolf, D.P.2    Litt, M.3
  • 88
    • 0024995927 scopus 로고
    • Diffusion coefficient in native mucus gel of rat small intestine
    • Winne D., Verheyen W. Diffusion coefficient in native mucus gel of rat small intestine. J. Pharm. Pharmacol. 42:1990;517-519.
    • (1990) J. Pharm. Pharmacol. , vol.42 , pp. 517-519
    • Winne, D.1    Verheyen, W.2
  • 89
    • 0031810654 scopus 로고    scopus 로고
    • Factors affecting solubility and penetration of clarithromycin through gastric mucus
    • Grubel P., Cave D.R. Factors affecting solubility and penetration of clarithromycin through gastric mucus. Aliment. Pharmacol. Ther. 12:1998;569-576.
    • (1998) Aliment. Pharmacol. Ther. , vol.12 , pp. 569-576
    • Grubel, P.1    Cave, D.R.2
  • 90
    • 0029593339 scopus 로고
    • The limiting role of mucus in drug absorption: Drug permeation through mucus solution
    • Bhat P.G., Flanagan D.R., Donovan M.D. The limiting role of mucus in drug absorption: drug permeation through mucus solution. Int. J. Pharmaceutics. 126:1995;179-187.
    • (1995) Int. J. Pharmaceutics , vol.126 , pp. 179-187
    • Bhat, P.G.1    Flanagan, D.R.2    Donovan, M.D.3
  • 92
    • 0026601671 scopus 로고
    • A study of macromolecular diffusion through native porcine mucus
    • Desai M.A., Mutlu M., Vadgama P. A study of macromolecular diffusion through native porcine mucus. Experientia. 48:1992;22-26.
    • (1992) Experientia , vol.48 , pp. 22-26
    • Desai, M.A.1    Mutlu, M.2    Vadgama, P.3
  • 93
    • 0026739095 scopus 로고
    • Mucus models for investigation of intestinal absorption mechanisms. 1 Validation and optimization of the model
    • Matthes I., Nimmerfall F., Sucker H. Mucus models for investigation of intestinal absorption mechanisms. 1 Validation and optimization of the model. Pharmazie. 47:1992;505-515.
    • (1992) Pharmazie , vol.47 , pp. 505-515
    • Matthes, I.1    Nimmerfall, F.2    Sucker, H.3
  • 94
    • 0016053262 scopus 로고
    • Mass transport phenomena and models: Theoretical concepts
    • Flynn G.L., Yalkowsky S.H., Roseman T.J. Mass transport phenomena and models: theoretical concepts. J. Pharm. Sci. 63:1974;479-510.
    • (1974) J. Pharm. Sci. , vol.63 , pp. 479-510
    • Flynn, G.L.1    Yalkowsky, S.H.2    Roseman, T.J.3
  • 96
    • 0033025362 scopus 로고    scopus 로고
    • Factors influencing nonoxynol-9 permeation and bioactivity in cervical mucus
    • Owen D.H., Dunmire E.N., Plenys A.M., Katz D.F. Factors influencing nonoxynol-9 permeation and bioactivity in cervical mucus. J. Controlled Release. 60:1999;23-34.
    • (1999) J. Controlled Release , vol.60 , pp. 23-34
    • Owen, D.H.1    Dunmire, E.N.2    Plenys, A.M.3    Katz, D.F.4
  • 97
    • 0030981578 scopus 로고    scopus 로고
    • Diffusion of drugs in native and purified gastrointestinal mucus
    • Larhed A.W., Artursson P., Grasjo J., Bjork E. Diffusion of drugs in native and purified gastrointestinal mucus. J. Pharm. Sci. 86:1997;660-665.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 660-665
    • Larhed, A.W.1    Artursson, P.2    Grasjo, J.3    Bjork, E.4
  • 99
    • 0032784401 scopus 로고    scopus 로고
    • Fluorescence recovery after photobleaching: A versatile tool for mobility and interaction measurements in pharmaceutical research
    • Meyvis T.K.L., DeSmedt S.C., VanOostveldt P., Demeester J. Fluorescence recovery after photobleaching: a versatile tool for mobility and interaction measurements in pharmaceutical research. Pharm. Res. 16:1999;1153-1162.
    • (1999) Pharm. Res. , vol.16 , pp. 1153-1162
    • Meyvis, T.K.L.1    DeSmedt, S.C.2    VanOostveldt, P.3    Demeester, J.4
  • 100
    • 0026059771 scopus 로고
    • Electrochemical determination of the permeability of porcine mucus to model solute compounds
    • Desai M.A., Nicholas C.V., Vadgama P. Electrochemical determination of the permeability of porcine mucus to model solute compounds. J. Pharm. Pharmacol. 43:1991;124-127.
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 124-127
    • Desai, M.A.1    Nicholas, C.V.2    Vadgama, P.3
  • 101
    • 0027441125 scopus 로고
    • The mucus layer as a barrier to drug absorption in monolayers of human intestinal epithelial HT29-H goblet cells
    • Karlsson J., Wikman A., Artursson P. The mucus layer as a barrier to drug absorption in monolayers of human intestinal epithelial HT29-H goblet cells. Int. J. Pharmaceutics. 99:1993;209-218.
    • (1993) Int. J. Pharmaceutics , vol.99 , pp. 209-218
    • Karlsson, J.1    Wikman, A.2    Artursson, P.3
  • 102
    • 0027222947 scopus 로고
    • A drug absorption model based on the mucus layer producing human intestinal goblet cell line HT29-H
    • Wikman A., Karlsson J., Carlstedt I., Artursson P. A drug absorption model based on the mucus layer producing human intestinal goblet cell line HT29-H. Pharm. Res. 10:1993;843-852.
    • (1993) Pharm. Res. , vol.10 , pp. 843-852
    • Wikman, A.1    Karlsson, J.2    Carlstedt, I.3    Artursson, P.4
  • 103
    • 0025931664 scopus 로고
    • Drug transport across a novel mucin secreting cell model: Comparison with the Caco-2 cell system
    • Allen J.D., Martin G.P., Marriott C., Hassan I., Williamson I. Drug transport across a novel mucin secreting cell model: comparison with the Caco-2 cell system. J. Pharm. Pharmacol. 43:1991;63P.
    • (1991) J. Pharm. Pharmacol. , vol.43
    • Allen, J.D.1    Martin, G.P.2    Marriott, C.3    Hassan, I.4    Williamson, I.5
  • 105
    • 0016646588 scopus 로고
    • Influence of a mucin model system upon the bioavailability of phenylbutazone and warfarin sodium from the small intestine
    • Barry B.W., Braybrooks M.P. Influence of a mucin model system upon the bioavailability of phenylbutazone and warfarin sodium from the small intestine. J. Pharm. Pharmacol. 26:1975;74P.
    • (1975) J. Pharm. Pharmacol. , vol.26
    • Barry, B.W.1    Braybrooks, M.P.2
  • 106
    • 0016681345 scopus 로고
    • The effect of mucin on the bioavailability of tetracycline from the gastrointestinal tract: In vivo, in vitro correlations
    • Braybrooks M.P., Barry B.W., Abbs E.T. The effect of mucin on the bioavailability of tetracycline from the gastrointestinal tract: in vivo, in vitro correlations. J. Pharm. Pharmacol. 27:1975;508-515.
    • (1975) J. Pharm. Pharmacol. , vol.27 , pp. 508-515
    • Braybrooks, M.P.1    Barry, B.W.2    Abbs, E.T.3
  • 107
    • 0023125991 scopus 로고
    • The effects of mucus glycoproteins on the bioavailability of tetracycline. 2. Binding
    • Kearney P., Marriott C. The effects of mucus glycoproteins on the bioavailability of tetracycline. 2. Binding. Int. J. Pharmaceutics. 35:1987;211-220.
    • (1987) Int. J. Pharmaceutics , vol.35 , pp. 211-220
    • Kearney, P.1    Marriott, C.2
  • 108
    • 0027670545 scopus 로고
    • Mucus on the epidermis of fish and its influence on drug delivery
    • Stephen K.L. Mucus on the epidermis of fish and its influence on drug delivery. Adv. Drug Del. Rev. 11:1993;403-417.
    • (1993) Adv. Drug Del. Rev. , vol.11 , pp. 403-417
    • Stephen, K.L.1
  • 109
    • 0033823140 scopus 로고    scopus 로고
    • The physical properties of biogels and their permeability for macromolecular drugs and colloidal drug carriers
    • Sanders N.N., DeSmedt S.C., Demeester J. The physical properties of biogels and their permeability for macromolecular drugs and colloidal drug carriers. J. Pharm. Sci. 89:2000;835-849.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 835-849
    • Sanders, N.N.1    DeSmedt, S.C.2    Demeester, J.3
  • 111
    • 0030948511 scopus 로고    scopus 로고
    • Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon
    • Szentkuti L. Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon. J. Controlled Release. 46:1997;233-242.
    • (1997) J. Controlled Release , vol.46 , pp. 233-242
    • Szentkuti, L.1
  • 112
    • 0031104076 scopus 로고    scopus 로고
    • Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin
    • Norris D.A., Sinko P.J. Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin. J. Appl. Polymer Sci. 63:1997;1481-1492.
    • (1997) J. Appl. Polymer Sci. , vol.63 , pp. 1481-1492
    • Norris, D.A.1    Sinko, P.J.2
  • 113
    • 0026684056 scopus 로고
    • The binding of amikacin to macromolecules from the sputum of patients suffering from respiratory diseases
    • Bataillon V., Lhermitte M., Lafitte J.J., Pommery J., Roussel P. The binding of amikacin to macromolecules from the sputum of patients suffering from respiratory diseases. J. Antimicrob. Chemother. 29:1992;499-508.
    • (1992) J. Antimicrob. Chemother. , vol.29 , pp. 499-508
    • Bataillon, V.1    Lhermitte, M.2    Lafitte, J.J.3    Pommery, J.4    Roussel, P.5
  • 114
    • 0025896742 scopus 로고
    • The diffusion of beta-lactam antibiotics through mixed gels of cystic fibrosis-derived mucin and Pseudomonas aeruginosa alginate
    • Bolister N., Basker M., Hodges N.A., Marriott C. The diffusion of beta-lactam antibiotics through mixed gels of cystic fibrosis-derived mucin and Pseudomonas aeruginosa alginate. J. Antimicrob. Chemother. 27:1991;285-293.
    • (1991) J. Antimicrob. Chemother. , vol.27 , pp. 285-293
    • Bolister, N.1    Basker, M.2    Hodges, N.A.3    Marriott, C.4
  • 115
    • 0018850819 scopus 로고
    • Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as nodel solutes
    • Komiya I., Park J.Y., Kamani A., Ho N.F.H., Higuchi W.I. Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as nodel solutes. Int. J. Pharmaceutics. 4:1980;249-262.
    • (1980) Int. J. Pharmaceutics , vol.4 , pp. 249-262
    • Komiya, I.1    Park, J.Y.2    Kamani, A.3    Ho, N.F.H.4    Higuchi, W.I.5
  • 116
    • 0019256107 scopus 로고
    • Contribution to the intestinal absorption of ergot peptide alkaloids
    • Franz J.M., Vonderscher J.P., Voges R. Contribution to the intestinal absorption of ergot peptide alkaloids. Int. J. Pharmaceutics. 7:1980;19-28.
    • (1980) Int. J. Pharmaceutics , vol.7 , pp. 19-28
    • Franz, J.M.1    Vonderscher, J.P.2    Voges, R.3
  • 117
    • 0026446209 scopus 로고
    • Mucus models for investigation of intestinal absorption mechanisms. 2. Mechanisms of drug interactions with intestinal mucus
    • Matthes I., Nimmerfall F., Sucker H. Mucus models for investigation of intestinal absorption mechanisms. 2. Mechanisms of drug interactions with intestinal mucus. Pharmazie. 47:1992;609-613.
    • (1992) Pharmazie , vol.47 , pp. 609-613
    • Matthes, I.1    Nimmerfall, F.2    Sucker, H.3
  • 118
    • 0027670876 scopus 로고
    • The effect of gastro-intestinal mucus on drug absorption
    • MacAdam A. The effect of gastro-intestinal mucus on drug absorption. Adv. Drug Del. Rev. 11:1993;201-220.
    • (1993) Adv. Drug Del. Rev. , vol.11 , pp. 201-220
    • MacAdam, A.1
  • 119
    • 0014296306 scopus 로고
    • The binding of drugs by plasma proteins
    • Meyer M.C., Guttman D.E. The binding of drugs by plasma proteins. J. Pharm. Sci. 57:1968;895-918.
    • (1968) J. Pharm. Sci. , vol.57 , pp. 895-918
    • Meyer, M.C.1    Guttman, D.E.2
  • 121
    • 0017756159 scopus 로고
    • Evaluation of methods to determine protein-binding of drugs. Equilibrium dialysis, ultrafiltration, ultracentrifugation, gel filtration
    • Kurz H., Trunk N., Weitz B. Evaluation of methods to determine protein-binding of drugs. Equilibrium dialysis, ultrafiltration, ultracentrifugation, gel filtration. Arzneim.-Forsch. 27:1977;1373-1380.
    • (1977) Arzneim.-Forsch. , vol.27 , pp. 1373-1380
    • Kurz, H.1    Trunk, N.2    Weitz, B.3
  • 122
    • 0017481335 scopus 로고
    • Binding of drugs by albumin and plasma protein
    • Vallner J.J. Binding of drugs by albumin and plasma protein. J. Pharm. Sci. 66:1977;447-465.
    • (1977) J. Pharm. Sci. , vol.66 , pp. 447-465
    • Vallner, J.J.1
  • 123
    • 0018564905 scopus 로고
    • Studies of drug-protein binding by affinity chromatography: Interactions of bovine serum albumin and various ligands
    • Nakano N.I., Oshio T., Sato N., Shimamori Y., Yamaguchi S. Studies of drug-protein binding by affinity chromatography: interactions of bovine serum albumin and various ligands. Chem. Pharm. Bull. 27:1979;2048-2055.
    • (1979) Chem. Pharm. Bull. , vol.27 , pp. 2048-2055
    • Nakano, N.I.1    Oshio, T.2    Sato, N.3    Shimamori, Y.4    Yamaguchi, S.5
  • 124
    • 0015936843 scopus 로고
    • Physicochemical aspects of drug-protein interactions: A general perspective
    • Klotz I.M. Physicochemical aspects of drug-protein interactions: a general perspective. Ann. N.Y. Acad. Sci. 226:1973;18-35.
    • (1973) Ann. N.Y. Acad. Sci. , vol.226 , pp. 18-35
    • Klotz, I.M.1
  • 126
    • 0021242662 scopus 로고
    • A theory of molecular diffusion in the intestinal mucus
    • Peppas N.A., Hansen P.J., Buri P.A. A theory of molecular diffusion in the intestinal mucus. Int. J. Pharm. 20:1984;107-118.
    • (1984) Int. J. Pharm. , vol.20 , pp. 107-118
    • Peppas, N.A.1    Hansen, P.J.2    Buri, P.A.3
  • 127
    • 0026706665 scopus 로고
    • Mucus models for investigation of intestinal absorption. Part 3: A mathematical simulation model of drug diffusion through the centeral mucus
    • Fahr A., Guitard P., Matthes I., Nimmerfall F., Nuesch E., Sucker H. Mucus models for investigation of intestinal absorption. Part 3: A mathematical simulation model of drug diffusion through the centeral mucus. Pharmazie. 47:1992;699-704.
    • (1992) Pharmazie , vol.47 , pp. 699-704
    • Fahr, A.1    Guitard, P.2    Matthes, I.3    Nimmerfall, F.4    Nuesch, E.5    Sucker, H.6
  • 128
    • 0026769370 scopus 로고
    • Epi-fluorescence microscopy and image analysis used to measure diffusion coefficients in gel systems
    • Henry B.T., Adler J., Hibberd S., Cheema M.S., Davis S.S., Rogers T.G. Epi-fluorescence microscopy and image analysis used to measure diffusion coefficients in gel systems. J. Pharm. Pharmacol. 44:1992;543-549.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 543-549
    • Henry, B.T.1    Adler, J.2    Hibberd, S.3    Cheema, M.S.4    Davis, S.S.5    Rogers, T.G.6
  • 129
    • 0004020231 scopus 로고
    • 2nd Edition, Oxford University Press, Brendon
    • Crank J.S. Mathematics of Diffusion. 2nd Edition :1975;44-68 Oxford University Press, Brendon.
    • (1975) Mathematics of Diffusion , pp. 44-68
    • Crank, J.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.